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Ketosis In An Evolutionary Context

Ketogenic Diet Plan

Ketogenic Diet Plan

A ketogenic diet plan improves your health through a metabolic switch in the primary cellular fuel source to which your body and brain are adapted. When your metabolism switches from relying on carbohydrate-based fuels (glucose from starch and sugar) to fat-based fuels and fat metabolism products called ketones, positive changes in the health of your cells occur, and this translates into better overall health. A metabolic process called ketogenesis and a body state called ketosis are responsible. Ketosis is simply a normal metabolic pathway in which body and brain cells utilize ketones to make energy, instead of relying on only sugar (i.e., carbohydrate). In fact, humans developed an evolutionary ability to burn ketones as an adaptation to periods of time when food was unavailable, and being in nutritional ketosis is a beneficial body state. A great deal of research is being done on ketosis as it relates to disease. Ketone bodies have some very beneficial effects on the human body, and elevating one's blood levels of ketone bodies is an effective treatment for many disease conditions because it improves the function of cellular energy pathways and mitochondrial health. Ketogenic diets are now being used to treat medical conditions such as diabetes, epilepsy, autism, Alzheimer's, cancer and others and much of the success of these treatments is rooted in these cellular effects. This page will answer some questions you may have about a ketogenic diet plan including: Who should NOT follow a ketogenic diet: list of medical contraindications. How do I start a ketogenic diet plan? Do I need to worry about the "dangers of low carb diets"? What are the side effects of a ketogenic diet? What are the benefits of a ketogenic diet? But first a little legal and medical coverage: Alth Continue reading >>

Dom D’agostino Ketogenic Diets : Exogenous Fat-burning Ketones

Dom D’agostino Ketogenic Diets : Exogenous Fat-burning Ketones

As A Bonus The Old Guy will send you his very introspective 5 Rules Of Life and Info on other KOOL STUFF →For Links To Products Discussed In Video, Scroll Down Below← Dr. Dominic D’Agostino is an Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine. He is also a Visiting Senior Research Scientist at the Institute for Human and Machine Cognition (IHMC). His laboratory develops and tests metabolic-based strategies for targeting CNS oxygen toxicity (seizures), epilepsy, neurodegenerative diseases, brain cancer and metastatic cancer. The approach to utilizing metabolic-based strategies can be applied to a wide variety of pathologies linked to metabolic dysregulation. His research is supported by the Office of Naval Research (ONR), Department of Defense (DoD), private organizations and foundations. The Old Guy Is Compensated If You Purchase Any Of The Products Below Global interest in ketogenic dieting, exogenous ketones and the effects of ketosis continues to grow exponentially, with new pathways and discoveries showing that it benefits people looking to boost energy, control appetite, and live healthier lives, as well as people who struggle with metabolic disorders. Dr. Dominic D’Agostino broke down the benefits of the ketogenic diet and the effects of ketosis on fat metabolism and fat loss. How does the diet aid in fat burning? “When you stop eating, you essentially start to liberate your body fat stores. You liberate fatty acids from your fat stores called adipose. These fatty acids are actually the preferred fuel for your body.” Putting ketosis in an evolutionary context, it was a natural state to be in due to food availability. Hunting males had to be in survival mode b Continue reading >>

Your Brain On Ketones

Your Brain On Ketones

Ketogenic diets have been prescribed for seizures for a long time. The actual research diets used in the past were pretty dismal and seemed to involve drinking a lot of cream and eating a lot of mayonnaise. At Johns Hopkins, pediatric patients were admitted to the hospital for a 48 hour fast and then given eggnog (minus the rum and sugar, I'm guessing) until ketosis was achieved (usually took about 4 days). In addition, ketogenic diets were calorie restricted to just 75-90% of what would be considered a child's usual calorie intake, and often they were fluid-restricted too (1)! If we're talking soybean oil mayonnaise, you could see how someone could get into trouble with mineral deficiencies and liver problems pretty quickly. To understand "dismal," some of the latest research showed that a "modified Atkins protocol" was just as good as the classic ketogenic diet, and so much more liberating, as the patients were allowed up to 10 grams of carbohydrates daily, and they didn't begin with the fast, and they weren't calorie restricted (2)(3). While the classic ketogenic diet was 4:1:1 fat to carbs to protein. If you use MCT oil for 50% of your calories (have to add it in slowly though to prevent vomiting, diarrhea, and cramping!), you could increase the carbohydrates and proteins to a 1.2:1:1 fat:carb:protein and still get the same numbers of magical ketones circulating. And while "MCT oil" sounds nice and yummy when it is gorgeous coconut milk, this MCT Oil 100% Pure 32 fl.oz doesn't look quite as appetizing, especially when that is going the be half of what you eat for the foreseeable future (4). You can see why researchers consider ketogenic diets (especially the original versions) to be extremely difficult and unappetizing (they were), whereas seasoned low-carbers (who Continue reading >>

Ketosis In An Evolutionary Context

Ketosis In An Evolutionary Context

Humans are unique in their remarkable ability to enter ketosis. They’re also situated near the top of the food chain. Coincidence? During starvation, humans rapidly enter ketosis; they do this better than king penguins, and bears don’t do it at all. Starvation ketosis Humans maintain a high level of functionality during starvation. We can still hunt & plan; some would even argue it’s a more finely tuned state, cognitively. And that’s important, because if we became progressively weaker and slower, chances of acquiring food would rapidly decline. Perhaps this is why fasting bears just sleep most of the time: no ketones = no bueno..? Animals with a low brain/carcass weight ratio (ie, small brain) don’t need it. Babies and children have a higher brain/carcass weight ratio, so they develop ketosis more rapidly than adults. Is this a harmful process? No, more likely an evolutionary adaptation which supports the brain. The brain of newborn babies consumes a huge amount of total daily energy, and nearly half comes from ketones. A week or so later, even after the carbohydrate content of breast milk increases, they still don’t get “kicked out of ketosis” (Bourneres et al., 1986). If this were a harmful state, why would Nature have done this? …and all those anecdotes, like babies learn at incredibly rapid rates… coincidence? Maybe they’re myths. Maybe not. Ketosis in the animal kingdom Imagine a hibernating bear: huge adipose tissue but small brain fuel requirement relative to body size and total energy expenditure. No ketosis, because brain accounts for less than 5% of total metabolism. In adult humans, this is around 19-23%, and babies are much higher (eg, Cahill and Veech, 2003 & Hayes et al., 2012). For the rest of this article and more, head over to Pat Continue reading >>

Do Ketogenic Diets Have A Place In Human Evolution?

Do Ketogenic Diets Have A Place In Human Evolution?

Part 1: How to think about ketogenic diets within human evolutionary history In the past decade ketogenic diets in humans have started to attract the attention of a few forward thinking researchers as well as a small number of online health enthusiasts. In any diet there are three main elements called macronutrients – fat, protein and carbohydrate. On a ketogenic diet most calories come from fat (65-90%), a moderate amount from protein (<10-25%) and a small amount from carbohydrate (0-15%). A ketogenic diet is often mistaken for a high-protein diet. This is not accurate. A ketogenic diet means eating food that produces ketones, a kind of molecule in the blood that provides energy, like glucose does. Producing a high enough level of ketones is called being in ketosis and it is a metabolic state in which the body relies much less on glucose. The who’s who of low-carbohydrate ketogenic research, headed by Accuros et al. in 2008 (1), defined ketogenic diets as containing <10% of calories from carbohydrates. There are two reasons that I prefer to give a range of 0-15%. First, scientists have not fed large populations in a controlled manner to see how much of each macronutrient is needed to shift more than half of them into nutritional ketosis (we lack empirical data on this). This is complicated by that fact that different people get into nutritional ketosis more or less easily because of various factors, like their level of insulin resistance for example. Second, scientists have not yet defined what the nutritional ketosis threshold is exactly, despite their being good approximations. Before exploring the appropriateness of ketogenic diets for humans, I’d like to justify why I approach questions of human health and nutrition the way I do by introducing 2 concepts; evo Continue reading >>

Tpns 58-61: Ketosis Is Natural. Natural Is Good.

Tpns 58-61: Ketosis Is Natural. Natural Is Good.

Primitive Nutrition 58: Ketosis Is Natural. Natural Is Good. Part I So far in my examination of low-carb diets I've shown you that they are nutritionally deficient, metabolically damaging, and unlikely to produce weight loss, if only because fats are so calorically dense. For the low-carbers, the solution to this last problem is ketosis. For them, this special metabolic state is the ultimate goal of their diets. They imagine it will effortlessly melt away all the fat they've accumulated from their prior unhealthy eating behavior. Low carbers' zeal for ketosis has lead some to make a questionable claim which I'd like to ponder in this section. Michael Eades presents it here in his blog explaining ketosis. Of course, like many other primitive fad diet promoters, he wants you to start from the assumption that the activity pictured to the left somehow represents man's true nature and the way he has historically obtained food. I don't see any women in that photo, which should give you a clue that this isn't the whole story. According to The Economist, among the hunter gatherers who provide the Paleo model, "men usually bring fewer calories than women, and have a tiresome tendency to prefer catching big and infrequent prey so they can show off." Eades is tapping into the same old macho vanity that has worked so well in marketing Paleo. If you'd like to see what a group spear hunt really looks like in live action, watch this video. Somehow the artist who created Dr Eades picture forgot to include all the blood. Having read a bit about how intelligent and social elephants are, I find this unappealing to say the least. If you watch it, see if you can imagine Michael Eades participating in such a hunt. But back to ketosis, despite his acknowledgement that ketogenic diets create a Continue reading >>

Episode 27: Robb Wolf Discusses The Paleo Diet, Ketosis, Exercise, Nicotine … And Much More!

Episode 27: Robb Wolf Discusses The Paleo Diet, Ketosis, Exercise, Nicotine … And Much More!

For fitness and Paleo Diet aficionados—and perhaps regular STEM-talk listeners—Robb Wolf is the type of esteemed guest who needs no introduction. Many people already know him by his best-selling book, “The Paleo Solution: The Original Human Diet,” (or his top-ranked podcast by that same name. (But what some people may not know is that Wolf also started the world’s first cross-fit affiliate gym; that he’s raising his young daughters on a paleo diet—which may account for their mouths having a similar phenotypical expression as hunters and gatherers; and that nicotine—yes, nicotine—can actually be good for you (just not delivered by cigarette) in some contexts. STEM-Talk Host Dawn Kernagis and IHMC Founder Ken Ford talk to Wolf about these and other fascinating insights in this episode. Wolf hailed from a relatively unhealthy family, which pushed him towards discovering good health on his own terms. A keen interest and aptitude in science (he was a biochemistry major at California State University-Chico) set Wolf on the path of evolutionary medicine. He began thinking seriously about pre-agricultural diets in response to his mother’s poor reaction to her consumption of grains, legumes, and dairy. Since that time, Wolf has become an expert, researcher, and self-experimenter of the Paleo Diet. His expertise has led him to become a review editor for Journal of Nutrition and Metabolism; co-founder of The Performance Menu, a nutrition and athletic training journal; and co-owner of NorCal, one of Men’s Health magazine’s top thirty gyms in America. He is also a consultant for the Naval Special Warfare Resiliency Program. Wolf recently gave a lecture entitled “Darwinian Medicine: Maybe There IS Something to This Evolution Thing” at IHMC: 2:10: Dawn read Continue reading >>

The Ketogenic Diet 101: Everything You Need To Know About The Diet That’s Taking The World By Storm.

The Ketogenic Diet 101: Everything You Need To Know About The Diet That’s Taking The World By Storm.

The ketogenic diet is a remarkable way of eating with numerous health benefits. With the ketogenic diet, you switch your body’s preferred source of fuel from carbohydrate to stored fat, which is a cleaner fuel, more healthful fuel, that the body and the brain loves. For some people, this takes more time than others. But at most 6 weeks (if you’ve really been hitting the carbs). By then, if you stick to the diet, you can know, with all absolute certainty, that you are running on fat solely. The Keto Philosophy It is a state in which we switch our body’s prefered source of energy from sugar to fat. Of course, this is what we want to do. We want to burn excess fat off the body and get lean, right? Most people eat a carbohydrate rich diet, consistently spiking insulin and running on glucose. Glucose, in fact, is the preferred source of energy for the body. It’s easy. The body will use whatever is within easy reach—which is why when it’s starving it turns to nutrient rich muscle. It wants that immediate energy glucose gives it. Ketosis happens when we effectively switch our body’s source of energy to our fat stores instead of an instream of glucose by eating a low carbohydrate diet. We can, however, push our body to run on fat and the body thrives on fat. Let me give you the more textbook definition of the ketogenic diet before we move on: The ketogenic diet is a very low carb, high fat, moderate protein diet. Eating a diet this low in carbohydrate pushes your body into a new metabolic framework called “ketosis” – when your body finally makes that switch (which takes about 4 to 6 weeks) to burning fat for energy, it becomes very efficient at burning fat for energy and urns fat into ketones within the liver, which fuels energy to the brain (instead of gluc Continue reading >>

Combine Nootropics & Ketosis For Peak Performance

Combine Nootropics & Ketosis For Peak Performance

Ketosis describes a metabolic state where the level of ketones in your bloodstream elevate and the body burns fat for energy. Ketosis may sound like a strange and exotic phenomenon, but it is quite natural - humans evolved to use fat as energy. Nowadays this seems weird because we are over-consumers of carbohydrate and live sedentary lifestyles. A state in which we are never short of a carb refuel. The rule of thumb for Nutritional Ketosis is that caloric intake is determined as follows: Carbohydrate (total, not “net”): less than 50 gm/day, but ideally closer to 30 gm/day Protein: up to 1 to 1.5 gm/kg, but ideally below about 120 gm/day Fat: to satiety People enter ketosis through some combination of intermittent fasting, endurance training, carbohydrate avoidance, increased fat consumption or ketone supplementation. Ketosis & Nootropics for Peak Mental Performance On some level, the brain-boosting power of ketosis is intuitive. In the evolutionary context, an organism without an abundance of energy sources had to be sharper and more focused to survive. I contend that ketosis can give people 'empty stomach intelligence.' The body burns stored fat for energy. This is good because excess stored fat is linked to reduced memory capacity and impaired learning. Ketosis returns the body to an optimal state. Just like a car getting a tune-up. During ketosis, the body relies on ketones (broken down fatty acid molecules) for energy throughout the body, including the brain. Think of this as switching the body's fuel from low-octane carbohydrate-based glucose to the high-octane fatty fuel it evolved to run on. Clinical studies have found that ketosis improves cognitive abilities like memory and reduces symptoms of Alzheimer's and epilepsy. Subjective reporting from n=1 biohacke Continue reading >>

Acute Nutritional Ketosis: Implications For Exercise Performance And Metabolism

Acute Nutritional Ketosis: Implications For Exercise Performance And Metabolism

Go to: Dietary intake influences metabolism An ancient Spanish proverb ‘Diet cures more than the lancet’ suggests that the importance of diet in maintaining good health is an age-old concept. Mechanisms by which the body uses the fuels we eat to sustain life, or in the case of excess, store the surplus energy, have fascinated generations of scientists. Carbohydrates, fat, protein and, for some, alcohol are the fundamental sources of dietary energy. Whilst the numbers of dietary macronutrients (food groups) are limited, the particular composition and relative contribution of these dietary groups to our calorific needs vary widely. Until recently, little was known of the metabolic systems that linked diet with human function. In 1937, Krebs made arguably the most important breakthrough in biochemistry [1], describing a cycle of enzymatic reactions uniting dietary fuel combustion with cellular energy provision. This final common pathway for substrate metabolism has allowed the detailed study of the flow of energy transformation (energetics) from dietary sources to the ‘energy currency’ adenosine triphosphate (ATP). Exercise the litmus of metabolic performance Over the last century, our understanding of the fundamental processes underlying human performance has expanded greatly. At the intersection of elite sport and substrate, metabolism lays the potential to investigate the processes that define the limits of human physiology. The onset of acute exercise triggers a rapid increase in demand for substrate and oxygen (mediated via an increase in cardiac output), with metabolic rate raised up to 100-fold above resting conditions during high-intensity exercise [2]. Depending on the relative intensity of exercise, durations of physical effort may last for minutes, hours Continue reading >>

Nutritional Ketosis In Animals

Nutritional Ketosis In Animals

Nutritional Ketosis In Animals - Ketosis | ketosis? | nutritional ketosis, Ketosis is a metabolic condition often caused by carbohydrate restriction and starvation. it should not be confused with ketoacidosis which may be harmful. Ketosis - wikipedia, Ketosis is a metabolic state in which some of the body's energy supply comes from ketone bodies in the blood, in contrast to a state of glycolysis in which blood. Is ketosis dangerous? - eating academy, You may have heard from your doctor that ketosis is a life-threatening condition. if so, your doctor is confusing diabetic ketoacidosis (dka) with nutritional ketosis. Ketosis | eat meat. drink water., I was beginning to think it was just me! after the first 2 weeks of starting nutritional ketosis i was in the “zone” – blood ketone scores of over 2.4.. What ketogenic paleo diet ? - paleoplan, I’ve had a similar experience to what daytona describes above. i’ve been in nutritional ketosis since early july and typically eat about 35 g carbohydrate each day.. Ketosis fundamentals | hvmn library, Ketosis is the physiological state where the concentration of ketone bodies in the blood is higher than normal. this is generally agreed to be at beta-hydroxybutyrate. Ketones carbohydrates: -exist?, For reasons i’m still struggling to understand, the idea of “nutritional ketosis” (nk, to be distinguished from starvation ketosis, sk or diabetic ketoacidosis. Pregnancy toxemia (ketosis) goats - aces., Unp-106 alabama a&m and auburn universities pregnancy toxemia (ketosis) in goats introduction pregnancy toxemia is a metabolic disorder that occurs in does during the. The beginner' guide exogenous ketones (2018), Why exogenous ketones? exogenous ketones are a great addition to anyone attempting to achieve the benefits of ke Continue reading >>

What Is A Ketogenic Diet?

What Is A Ketogenic Diet?

How do low-carb keto diets work, and what do ketosis and ketones mean? We look at their efficiency for weight loss and the potential side effects. If you’ve ever considered following a diet, make sure you have all the facts first. BBC Good Food and nutritional therapist Kerry Torrens take a closer look at ketogenic diets – what are they, what are the health claims behind the headlines, and are they healthy? How does the ketogenic diet work? The aim of ketogenic diets is to send the body into a state of ‘ketosis’ by using a very strict low-carb diet. This umbrella term can include diets such as the Atkins diet, Dukan diet and LCHF (low carb, high fat) diets, although the ratios of fat, protein and carbs and other specific features of each diet (e.g. ‘phases’) can vary. What is ketosis? Under normal circumstances our body uses glucose from carbohydrate foods for energy. In the absence of glucose a process called ketosis occurs. This is a state in which the body burns fats instead of carbohydrates as its main fuel source. When we don’t eat carbs, the liver breaks down fat stores to produce energy. This energy is in the form of (and also creates) molecules called ‘ketones’. How are ketogenic diets used in a medical setting? Ketogenic diets were originally developed to treat epilepsy in children as it appears to reduce the frequency of seizures. It should be noted that using the diet in this context should not be attempted without the supervision of a specialised doctor. From these medical origins, the diet was picked up by the mainstream media and marketed as a weight loss regime – it is in this context that we will be discussing the diet for the purpose of this article. What foods are allowed on a ketogenic diet? Foods that are generally allowed include Continue reading >>

Intermittent Fasting And Ketosis – Different Perspectives

Intermittent Fasting And Ketosis – Different Perspectives

My belief is that we are not meant to eat 3 times a day, which is the general R(x) in most countries. People eat much more than that, as you see the ones near you always having something to put in their mouths, always craving for something. It’s extremely easy to get food these days, with basically 0 effort. I do not want to be a critic but look at the Chawners for example, the fattest British family. They are not employed and they live off the government receiving approximately $20,000. Again, the purpose is not to criticize but to point out how easy it is to receive food. I don’t wanna say that their morbidly obese status has something to do with the amount of food they eat, but in some part, it has. Currently and as far as I know, there are more obese people than starving people in the world. Not wanting to derive away from the subject, let me give you some examples why I think it’s no good for us to eat at least 3 times a day and to eat every day. Let’s start with some history. Early Ancestors Enter the Australopiths (a.k.a. Australopithecus). They have been a hominid species living mostly in Africa between 4.2 to 1.5 million years ago. First of all, their upper body size is much more developed (larger) compared to the lower body size. These images (even though they may not 100% reflect the reality of the past) show that their hands were bigger than their feet. You cannot see in these images, but the Australopiths had flat feet, making them less adapted to moving faster and over larger distances. You may have heard of Lucy, the recently discovered fossil. She was an Australopith female living in Ethiopia 3.2 million years ago. They’ve evolved from earlier primates and they could spend time both in trees and on the ground, constantly reaching for food (henc Continue reading >>

Optimal Weaning From An Evolutionary Perspective:

Optimal Weaning From An Evolutionary Perspective:

The evolution of our brains, meat eating, and a reliance on ketogenic metabolism I recently had the privilege of presenting a talk, with the same title as this post, at the Ancestral Health Symposium. I am posting the video here, with a transcript, some references, and related material. This is what I said for each slide, with comments / clarifications in square brackets. Times are approximate. Optimal Weaning from an Evolutionary Perspective 0:00 My talk is called Optimal Weaning from an Evolutionary Perspective and I'd like to break down that title a little bit. 'Optimal' implies best for something, and here that something is going to be brain development. The word 'weaning' can also benefit from clarification, because we often use it to mean the end of breastfeeding, but I use the convention meaning the beginning of the end, with the introduction of first foods. For 'evolutionary perspective', I just want to point out that what we know about our past can inform our understanding of physiology, but our physiology can also constrain the possibilities of the past. Overview 0:36 I've concluded that weaning infants onto an animal based diet best meets their nutritional needs, and the rest of this talk will be about why. Primarily I'll be talking about the unique properties that resulted from the evolution of our brains. I'll also give a bit of evidence from modern health studies and trials, and then finally I'll give a little bit of the how, based on my own experience in weaning one of my children onto animal based foods. Human brains are unique 1:08 Human brains are unique in many ways, but one of the most striking things is their sheer size, especially relative to our bodies. In particular, when you take into account that we are primates, it's really quite extraordinary Continue reading >>

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