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Hyperuricemia

Not to be confused with hypouricemia or uremia. Hyperuricemia is an abnormally high level of uric acid in the blood. In the pH conditions of body fluid, uric acid exists largely as urate, the ion form.[1][2] The amount of urate in the body depends on the balance between the amount of purines eaten in food, the amount of urate synthesised within the body (e.g., through cell turnover), and the amount of urate that is excreted in urine or through the gastrointestinal tract.[2] In humans, the upper end of the normal range is 360 µmol/L (6 mg/dL) for women and 400 µmol/L (6.8 mg/dL) for men.[3] Causes[edit] Many factors contribute to hyperuricemia, including genetics, insulin resistance, hypertension, hypothyroidism, hyperthyroidism, renal insufficiency, obesity, diet, use of diuretics (e.g. thiazides, loop diuretics), and consumption of excess alcoholic beverages.[4] Of these, alcohol consumption is the most important.[5] Causes of hyperuricemia can be classified into three functional types:[6] increased production of uric acid, decreased excretion of uric acid, and mixed type. Causes of increased production include high levels of purine in the diet and increased purine metabolism. C Continue reading >>

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Popular Questions

  1. Christian

    I'm in the middle of a major Gout attack. As I've become 'more mature', these attacks happen more frequently when I attempt to do Keto. In my 'less mature' days I never had a problem with gout. Although I know gout is caused by high consumption of foods that contain 'purines' Most of these foods are the foods I love on Keto. I can't say I've been eating much meat, in fact it's just the opposite. I've been rather conscientious about not consuming too much protein. I've been testing consistently between 1.0 and 2.0 mml Ketones twice daily for just over 2 weeks (lost about 14 lbs.), so I was hoping if anybody could give me advice on preventing gout or supplements that would help prevent gout so I don't have to go through this pain in the future.

    PS -I've been to the doctor to get the meds to reduce the Uric acid in my blood (Colchine). And the pain is slowly subsiding. I love eating Keto, and short of having to go on Alipurinol the rest of my life I was looking for an alternative.

  2. jfricke

    Note from Steve Phinney: What this shows is that uric acid goes up promptly in the same time frame that ketones go up, but after 4-6 weeks, despite ketones staying up, uric acid starts to come back down. Based on these data and my clinical observations in thousands of patients, uric acid returns to or below pre-diet baseline within 6-12 weeks despite the person remaining is a state of nutritional ketosis. Thus, when I’m asked how long ketoadaptation aks, I generally respond that some aspects of it take 6 weeks or more.
    meandmydiabetes.com
    32
    Steve Phinney and Richard Johnson: Ketones, Uric Acid, High Fat and Health
    STEVE PHINNEY - "When I’m asked how long ketoadaptation takes, I generally respond that some aspects of it take 6 weeks or more." RICK JOHNSON "Low carb diets (might be improving) insulin resistance in part because of reduction of dietary glucose...

  3. Christian

    Thanks for the info! I'm going to have my uric acid levels tested in a couple of weeks after this attack is gone to see how I'm doing. I guess the answer (as it almost always seems to be) is:

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