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Ketones Gout

Gout And Keto

Gout And Keto

There’s loads more to it than simply blaming red meat or whatever is this weeks uric acid demon food. Some people with high uric acid never experience gout, whilst others with low levels get it often – and vice versa, it’s all about CLEARANCE and avoiding the feedback loop. Simply put – swapping out pig for fish won’t fix the clearance issue, it may reduce the build-up ever so slightly, but I seriously doubt it. Short version for ketards is ketones compete with uric acid for flushing, so that period where you are just acclimatising is when it’s most likely. Once you are using your ketones effectively the uric clearance thing isn’t an issue. The worst thing someone susceptible to gout can do is go back and forth from carby to keto and never fully adapt – this is gout limbo, and I’m guessing a good way to develop kidney stones in the long term. As it stands I consider it a catalyst feature – as in whatever susceptibility I have toward joint issues lays dormant until something ELSE happens. One catalyst that semi-correlates is food, each of the last few times I’ve experienced pain it’s been within a day or two of Thai food – but a confounder is that each time I also drank a bunch of beer too. Another is 12+ hours on a chair when I’m in research and writing mode that promotes poor circulation, so probably inducing some kind of mild thrombosis which is enough to start a cascade of events that end up in inflammation of a joint/nerve. And each time seems to be within days where I’ve experienced a twisting/whatever of an ankle/knee too for some reason. It’s a reflective problem which gets itself into a feedback loop. I’ve researched far and beyond the whole “it’s cos you eat red meat and wine brah” thing from years ago, it’s nothing to Continue reading >>

Sore Joints From Too Much Protein

Sore Joints From Too Much Protein

Eating a large amount of protein will not directly cause your joints to become sore. However, regularly consuming protein in excess of your body's need for the nutrient can contribute to the development of medical problems that result in sore joints. You can decrease your risk of these conditions by staying within the recommended daily allowance of protein specified by the Centers for Disease Control and Prevention for your age and gender, and by choosing low-fat or plant-based protein sources. Video of the Day A high-protein, low-carbohydrate diet can cause your body's concentration of ketone compounds to rise as fat instead of glucose is metabolized for energy. High levels of ketones increase the risk of gout by increasing the amount of uric acid in your blood. Excess uric acid builds up in the joints -- particularly the joints in the feet, toes and knees -- and causes them to become painfully inflamed. People who suffer from gout are advised to limit the amount of animal-based protein they consume since meat, poultry and fish are rich in purines, the substances that the body breaks down into uric acid. MayoClinic.com recommends that you eat no more than 4 to 6 ounces of fish, poultry or meat daily if you have gout. Joint Inflammation Animal proteins like meat and eggs contain large amounts of omega-6 fatty acids. High intake of these fatty acids causes an increase in the activity of cyclooxygenase-1 and cyclooxygenase-2, two enzymes that are responsible for triggering inflammation within joints. Arthritis Today reports that eating too much omega-6 fatty acid-containing foods can increase the pain and inflammation that people with arthritis experience in their joints. To decrease the soreness, individuals with arthritis should focus on eating plant-based proteins in p Continue reading >>

1: Kidney Stones, Gout, & Heart Palpitations On Keto

1: Kidney Stones, Gout, & Heart Palpitations On Keto

Today we officially kickoff this brand new podcast dedicated to answering listeners questions about the low-carb, moderate protein, high-fat, ketogenic diet. It’s called Keto Talk with Jimmy Moore & The Doc (now available to listen and subscribe on iTunes) featuring 10-year veteran health podcaster Jimmy Moore from “Livin’ La Vida Low-Carb” and Arizona osteopath and bariatric physician Dr. Adam Nally from “Doc Muscles.” These two are a keto power pair ready to take on your most pressing questions about this way of eating. KEY QUOTE: “If you cheat on your ketogenic diet, then you are at risk of a kidney stone or gout. The point is if you’re gonna cheat, you’re gonna pay for it.” — Dr. Adam Nally Here’s what Jimmy and Adam talked about in Episode 1: – The beginning of this new podcast devoted to keto – How Adam uses ketogenic diets with his patients – Adam’s father who died early from diabetes issues – Follow Jimmy and Adam on Periscope – Whether keto creates or prevents kidney stones – Why it’s not a good idea to cheat on your low-carb diet – How cheating, not keto, is what leads to gout – Whether a ketogenic diet causes heart palpitations – How to best balance your electrolytes starting keto – The problem with caffeine on your cortisol levels WORLD’S 1ST REUSABLE BREATH KETONE ANALYZER NOTICE OF DISCLOSURE: Paid sponsorshipTHE WORLD’S FIRST EXOGENOUS KETONES SUPPLEMENT NOTICE OF DISCLOSURE: Paid sponsorshipLINKS MENTIONED IN EPISODE 1 – SUPPORT OUR SPONSOR: Get the 2015 Ketonix breath ketone analyzer from Ketonix.com – SUPPORT OUR SPONSOR: Try the KETO//OS exogenous ketones supplement – Jimmy Moore from “Livin’ La Vida Low-Carb” – Dr. Adam Nally, DO from DocMuscles.com – Jimmy Moore on Periscope Continue reading >>

Gout Patients: Dinner Cancelled

Gout Patients: Dinner Cancelled

A recent study by Yale University also shows that altering the diet could also be a possible therapeutic approach to use against gout: the ketone bod β-yhydroxybutyrate, which can specifically inhibit the NLRP3 inflammasome, is the basis for this. The scientists’ rat feeding experiments suggest that a particular diet could also help people with gout – without weakening the defence function of the immune system to bacterial infections at all. Rats with gout which received a ketogenic diet, in other words one especially high in fat and low in carbohydrate, formed elevated levels of β-hydroxybutyrate, which largely protected joints in the rats against swelling. What’s more, tissue damage and systemic inflammatory reactions occurred with this diet only in a weakened form. Once a “privilege” of rich old men, it is now a widespread disease Gout was once considered a “privilege” of wealthy, older men with a debauched lifestyle. Today, it affects a broad spectrum of the population – including women as well. Uric acid – the end product of purine metabolism – is considered to be the trigger for gout. Should the uric acid concentration in the blood reach its physiological solubility limit, precipitation of sodium urate occurs in the tissue. Attacking the urate crystals often backfires Gout occurs when urate crystals accumulate in the joints. There they continually stimulate the immune system, which responds through the activation of neutrophils. This process is controlled by a protein complex which is called the NLRP3 inflammasome. Gout manifests itself as strong joint pain, inflammation and fever. The treatment of gout patients aims to, among other things, reduce the concentration of uric acid in the body of patients. Yet paradoxically, general urate-reducin Continue reading >>

Ketogenic Diet May Protect Against Gout

Ketogenic Diet May Protect Against Gout

New research examines the effects of a high-fat, low-carb ketogenic diet on both rodents and humans, and suggests that it can alleviate the symptoms of gout. Gout is a rheumatic disease that affects more than 8 million people in the United States. It is caused by either an excessive production or insufficient excretion of uric acid. In gout, the uric acid crystals sediment in tissues and fluids, triggering the body's immune cells. This results in disabling pain, inflammation, and fever. These episodes of immune cell reactivation, also known as flares, are triggered by a protein complex called the NLRP3 inflammasome. New research from the laboratory of Vishwa Deep Dixit - professor of comparative medicine and immunobiology at Yale School of Medicine in New Haven, CT - suggests that the so-called ketogenic diet may help to relieve the symptoms of gout. A ketogenic diet is low in carbohydrates and typically used to lose weight. Ketogenic diets work by inducing "physiological ketosis" in the body - a state of the metabolism where the body's reserves of glucose are no longer enough for the body's central nervous system. The central nervous system then needs an alternative source of energy, so it makes the liver turn fats into fatty acids and ketone bodies. The new study - published in the journal Cell Reports - suggests that one of these ketone bodies, the beta-hydroxybutyrate (BHB), may alleviate urate crystal-induced gout. Ketogenic diet increases BHB, protects against gout-related inflammation The research team developed a new model of gout flares in rodents. As the researchers explain, these flares are triggered by the NLRP3 inflammasome. With the help of neutrophils - the most common type of white blood cell - NLRP3 activates the IL-1B pro-inflammatory cytokine, leading Continue reading >>

Could A Ketogenic Diet Alleviate Gout?

Could A Ketogenic Diet Alleviate Gout?

More than 8 million individuals in the United States have gout, a disease that can cause intense recurrent episodes of debilitating pain, inflammation, and fever. The cause of gout is the accumulation of urate crystals in joints, which continuously reactivate the immune system, leading to activation of the most common type of immune cell in the blood, neutrophils. These periods of immune reactivation are known as flares, and are driven by a protein complex called the NLRP3 inflammasome. Recent work from the laboratory of Vishwa Deep Dixit, Professor of Comparative Medicine and Immunobiology, has shown that the ketone body β-hydroxybutyrate can specifically inhibit the NLRP3 inflammasome. Ketones are byproducts of fat break down in the liver that can serve as alternative metabolic fuels for the brain and heart during periods of low carbohydrate intake, such as fasting, or ketogenic diet. To test if elevating ketones protected against inflammation during gout, a Postdoctoral Fellow in Dixit's lab, Emily Goldberg, and Associate Research Scientist and Clinical Veterinarian in Comparative Medicine, Jennifer Asher, and their colleagues collaborated to develop a novel model of gout flares in rats. They found that feeding rats a high-fat, low-carbohydrate ketogenic diet increased β-hydroxybutyrate levels and protected rats from joint swelling, tissue damage, and systemic inflammation normally seen during gout. "In isolated neutrophils, β-hydroxybutyrate completely blocked NLRP3 inflammasome activation, even when provided at low concentrations that are physiologically achievable through dietary modification," said Goldberg. She speculated that specifically targeting the NLRP3 inflammasome to reduce inflammation during a flare could improve gout patients' outcomes, but more st Continue reading >>

Acidosis — The Deciding Factor

Acidosis — The Deciding Factor

Most doctors (and websites) will tell you that gout attacks are caused by having too much uric acid in your blood. That often is true, but there is more to the story because: You can have low blood uric acid levels and still have gout attacks; and You can have high blood uric acid levels and not have gout attacks! Uric acid is only one of many types of acid that can accumulate in body tissues. The combination of all of these can lead to an overall body condition known as Acidosis. With acidosis, body chemistry as a whole has become too acidic, making it more prone to gout attacks. Kidneys and pH Testing The kidneys are responsible for keeping blood uric acid levels within the normal range. But they can be overwhelmed and unable to keep up when you have acidosis — leading to gout attacks. Thus, keeping overall body acidity low should be the primary goal in a natural gout treatment plan. . . . Bert, I know all about sleep apnea having been diagnosed in 1998. I have used a CPAP since then, its a nuisance but very effective. Thank God I haven’t had a gout attack for a very long time, since we were first in touch. Keep up the good work. Best regards, Colm . . . Managing and Monitoring Body pH Several lifestyle choices can affect overall body acidity level, which I outline in my seven-day video program “Kill Your Gout FOR GOOD.” The best way to monitor your gout-killing progress is to perform a simple daily pH test at home, using an inexpensive test strip to measure the pH of either your saliva or urine. pH Testing Procedure Testing should be done first thing in the morning. For saliva testing, do not eat or drink anything, or brush your teeth beforehand. For urine testing, use your first urine of the morning. Collect your saliva or urine in a clean cup, dip the test Continue reading >>

Will Eating A Paleo Diet Cause Gout?

Will Eating A Paleo Diet Cause Gout?

This article is part of a special report on Red Meat. To see the other articles in this series, click here. A common question I get from readers is whether a Paleo-type diet will increase their risk for gout. Gout is a type of inflammatory arthritis caused by elevated levels of uric acid in the blood, forming crystal deposits in the joints, tendons, and surrounding tissue. Gout typically affects the feet in general and big toe joint specifically, and causes severe pain and swelling. In the past, gout was referred to as a “rich man’s disease”, as it typically affected the upper class and royalty who could afford “rich” foods like meat, sugar, and alcohol. Uric acid is a byproduct of the metabolism of purines, one of two types of nitrogenous bases that form the basic structure of DNA and RNA. While purines are present in all foods, they are typically higher in many of the foods emphasized on a nutrient-dense Paleo diet, such as red meat, turkey, organ meats, and certain types of fish and seafood. Patients with gout are often advised to reduce or eliminate these purine-rich foods with the goal of preventing excess uric acid production, thereby reducing the symptoms of gout. And research has confirmed the association between high purine intakes and acute gout attacks, suggesting that those diagnosed with gout would benefit from a reduction in purine-rich foods. (1, 2) So, do we need reconsider recommendations to eat foods like liver, sardines, red meat, mussels, and other traditional foods? Do these nutrient-dense, purine-rich foods really cause gout? Are those of us following a Paleo-style diet putting ourselves at greater risk for this painful, debilitating condition? Does eating meat and fish increase your risk for gout? Inflammation as a cause of gout attacks Continue reading >>

Ketogenic Diet May Alleviate Gout

Ketogenic Diet May Alleviate Gout

Gout sufferers may be able to find relief of painful symptoms by switching to a high-fat, low carbohydrate ketogenic diet. Gout affects over 8 million Americans and is characterized by pain, inflammation, and even fevers during flare-ups, all symptoms that are caused by the continuous reactivation of the immune system. When urate crystals build up in the joints, your body’s immune system triggers the activation of neutrophils—the most common immune cell, resulting in inflammation. These immune system flare-ups are driven by a protein complex known as NLRP3 inflammasome. Recent research has discovered that a component of ketones—the byproducts of fat breakdown in the liver—may work to inhibit the NLRP3 inflammasome and in turn, reduce flare-ups. Ketones also serve as an alternative metabolic fuel for the brain and heart during periods of fasting. To test whether elevating ketone levels within individuals affected by gout could help prevent flare-ups, researchers used rat models with the disease and fed them different diets. Rats who were fed a ketogenic diet composed of low-carbohydrate and high-fat meals saw an increase in ketone levels which in turn protected them from side effects of flare-ups such as joint swelling, tissue damage, and systematic inflammation. The authors of the study commented on these findings, stating: “In isolated neutrophils, [ketones] completely blocked NLRP3 inflammasome activation, even when provided at low concentrations that are physiologically achievable through dietary modification.” The diet has yet to be tested on humans with gout, but if these results translate across species, then switching to a ketogenic diet may be a viable treatment option for many with the disease to reduce flare-ups and the severity of associated sympt Continue reading >>

Everything You Need To Do Right Now To Effectively Relieve Gout Pain

Everything You Need To Do Right Now To Effectively Relieve Gout Pain

Gout is an excruciatingly painful form of arthritis that often affects the feet. Dietary factors, such as red meat and alcohol, can trigger gout pain, however, medications and medical conditions can be a problem too. A gout attack happens when higher than normal levels of uric acid in the body build-up over time around a joint. This causes uric crystals to form, which causes a painful gout flare. Many things, including alcohol, certain foods, stress, and some medications, can cause your uric acid level to rise, leaving you open to a gout attack. Warning Signs of a Gout Flare-Up A gout attack can begin with a few subtle clues like burning, itching, or tingling feeling in a joint maybe an hour or two before the flare-up starts. The joint may feel a little stiff or sore, then not long after these warning signals, the telltale signs of gout begins. If you get repeated gout attacks, you'll learn your body's signals that a flare-up is about to happen. However, some people with gout have no warning signs, and wake up in the middle of the night with a very painful joint. When the gout flare starts, most people have redness, swelling, and severe pain usually in one joint. One of the most common places for a flare is the big toe, but it can occur in other joints such as the elbow, knee, wrist, ankle, and instep. The pain is often so strong that it hurts to have anything touch the area at all. Many people with gout say that just the feel of the bed sheet touching the inflamed joint is very painful. "Fix Gout Pain Faster" See the Fast Way to Kill Uric Acid Warning: This works extremely fast uricel.com Causes Of Gout Gout has been associated for centuries with overindulgence in meats, seafood and alcohol. The condition was considered a disease the wealthiest people who could afford Continue reading >>

Study Identifies Natural Gout Remedy With This Diet

Study Identifies Natural Gout Remedy With This Diet

A new study published in the journal Cell Reports suggests that a ketogenic (high fat, low carb) diet may be helpful in treating the symptoms of gout. What is Gout? Gout is a form of inflammatory arthritis that results from an imbalance in the production and secretion of uric acid. Uric acid, a normal byproduct of metabolic processes, is typically dissolved in the blood and then excreted from the body through the urine. However, when the body is unable to properly break down uric acid, blood levels rise, and the excess is deposited in bodily tissues. The “needle-like” uric acid crystals irritate the area where they are deposited, triggering inflammation, swelling, and severe pain. When uric acid accumulates around the joints it is known as “tophi,” and can manifest as jelly like lumps under the skin. When uric acid crystals collect in the kidneys, it can result in kidney stones. The Role Of Ketosis Recent research out of the laboratory of Vishwa Deep Dixit, professor of comparative medicine and immunobiology at Yale School of Medicine in New Haven, CT, suggests that symptoms of gout may be managed with a ketogenic diet. Ketogenic diets are typically implemented for weight loss, or to treat childhood epilepsy. The diet involves a significant reduction of carbohydrate intake favoring moderate protein and high fat foods. This starves the central nervous system of glucose and prompts the liver to metabolise fats producing fatty acids and ketone bodies. This is referred to as the physiologic state of ketosis. The new study focuses on one of these ketone bodies in particular called beta-hydroxybutyrate, or BHB. The researchers suggest that BHB may be responsible for the noticeable effect of ketosis on the symptoms of gout. BHB, Inflammation, and Gout Episodes of immun Continue reading >>

Exclusive: Interview With Ketone Expert Dr. Richard Veech – #299

Exclusive: Interview With Ketone Expert Dr. Richard Veech – #299

Why you should listen – For this special episode of Bulletproof Radio, we have an exclusive interview with Dr. Richard Veech. Dr. Veech is one of the world’s foremost experts on ketosis, and this is the first time he has EVER been on a podcast. He’s the Senior Researcher and Laboratory Chief at The National Institutes of Health and has worked for the last 47 years to understand the mechanics behind cellular energy and homeostasis. Dr. Veech is also the inventor of the ketone ester. On today’s episode, you’ll hear Dave and Dr. Veech discuss his ongoing research of ketones, including their potential dangers, the three different kinds, how to test for and raise them and how to use them as a vegan. Dr. Veech also talks to Dave about his work with George Cahill, General David Petraeus and several other significant figures over the course of his career. Enjoy the show! Follow Along with Interactive Transcripts! Speaker: Bulletproof Radio, a state of high performance. Dave: Hey, Dave Asprey with Bulletproof Radio. Today’s cool fact of the day is about Ketosis. Did you know that your alcohol tolerance is severely lower while you’re in Ketosis? There are a couple of reasons for that. The first is that the alcohol you drink when you’re in Ketosis will get metabolized immediately before your body keeps burning ketones for energy. The carbs in your system that are normally used to “soak up alcohol in the stomach” and slow down the intoxication process probably won’t be there if you are drinking while you’re in Ketosis. Not to mention, it’s difficult to stay in Ketosis while you’re drinking. You got to ask yourself, “Is it really worth it to have beer which is going to take you out of Ketosis or red wine which is going to take you out of Ketosis or vodk Continue reading >>

Steve Phinney And Richard Johnson: Ketones, Uric Acid, High Fat And Health

Steve Phinney And Richard Johnson: Ketones, Uric Acid, High Fat And Health

Note from Steve Phinney: What this shows is that uric acid goes up promptly in the same time frame that ketones go up, but after 4-6 weeks, despite ketones staying up, uric acid starts to come back down. Based on these data and my clinical observations in thousands of patients, uric acid returns to or below pre-diet baseline within 6-12 weeks despite the person remaining is a state of nutritional ketosis. Thus, when I’m asked how long ketoadaptation aks, I generally respond that some aspects of it take 6 weeks or more. This graph, by the way, shows blood uric acid levels from the untrained subjects (VT) and bicycle racers (MIT) at various times over 4-6 weeks of sustained carbohydrate restriction (aka keto-adaptation). LISTEN (50 Minutes) EDITOR’S NOTE: Sometimes, the divide between experts who advise against a high-fat, low-carb diet and those who recommend it seems larger than the Grand Canyon. But occasionally, top thinkers from both sides break through to discover common ground, along with new paths for exploration. With that in mind, here’s a discussion between two nationally recognized health researchers which refers to the uric data in this chart . . . and more. To see the charts in larger format, click on them, and they should enlarge. Before going to the transcripts of this interview, here’s more background: Dr. Steve Phinney is emeritus professor of medicine at UC-Davis and a world-renowned expert on high fat diets, including how they affect uric acid levels. Dr. RIck Johnson is a professor of medicine at the University of Colorado who’s an expert on fructose metabolism (fructose accounts for much of the sweetness in table sugar and in high fructose corn syrup). Johnson’s expertise on fructose ties him back to uric acid. Johnson writes: “Our work Continue reading >>

Raspberry Ketones

Raspberry Ketones

Maybe you've heard the claim that raspberry ketone supplements can melt away fat and prevent weight gain -- even if your diet is high in fat. But what are they, and can they really do that? Raspberry ketones are natural chemicals that give raspberries their enticing aroma. When ketones are taken from raspberries, they can be used to add fragrance and flavor to things such as colas, ice cream, and cosmetics. Experts say that investing in a bottle of raspberry ketone supplements amounts to little more than wishful thinking. And it may or may not be harmful. In one small study, people who took 200 milligrams of raspberry ketones combined with 1,200 mg of vitamin C daily for 4 weeks lost weight and body fat. But the study did not follow good scientific methods. It doesn't show whether any benefit was from either the vitamin C or the raspberry ketones or from the combination. Until more is known, experts say you're better off holding onto your money. Instead, stick to a healthy, balanced diet and regular exercise. Both of those have been shown to be effective ways to manage weight. Raspberry ketones in food and cosmetics are generally considered safe. But no one knows what short- or long-term effect raspberry ketone supplements could have on your overall health. No study has been done to document potential side effects. There are also no studies that look at potential drug or food interactions. The fact that raspberry ketones chemically resemble other stimulants suggests the potential for certain side effects. And there are anecdotal reports of jitteriness, increased blood pressure, and rapid heartbeat among people taking raspberry ketone supplements. Without scientific evidence, no one can say what dosage of raspberry ketone supplements, if any, might be safe to take. Talk Continue reading >>

Gout And Low Carb

Gout And Low Carb

It’s occasionally claimed that low-carb or keto diets high in meat often cause gout. This does not appear to be true (nor does a low-carb diet have to be high in meat). However, there may possibly be a temporary increase in risk of gout during the first six weeks on a strict low-carb diet. After this initial time period, a low-carb diet is likely neutral, or even protective, when it comes to gout. Keep reading to find out what gout is and how to avoid it. What gout is Gout is a sudden and painful inflammation of a joint, most often at the base of the big toe (see image). It may also affect other joints, like heels, knees, wrists and finger joints. The cause of gout is elevated levels of uric acid in the blood, resulting in crystals depositing in the affected joint. Gout is more common in people who are overweight and have metabolic syndrome, and have thus become more common in recent decades, affecting about 6% of adult men and 2% of women (it’s even more common in older people). 1 Historically, it was known as “the disease of kings” or a “rich man’s disease”, but now everyone can afford… sugar. Meat and gout Gout has often been blamed on excessive consumption of meat. This is because the uric acid that causes gout is a breakdown product of purines, a building block of protein, that is highly concentrated in meat. However, avoiding meat seems to have little effect on the risk of gout, and even vegetarians get gout much more often than would be expected if this was the main cause. Eating more protein (like meat) seems to increase the excretion of uric acid from the kidneys, through the urine, thus not having much of an effect on the blood uric acid levels… or the risk of gout. Sugar and gout As there is a very strong connection between gout, obesity, ty Continue reading >>

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