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Ketone Supplements

The Perks Of Fasting, With None Of The Work

The Perks Of Fasting, With None Of The Work

“If there’s a downside, it is kind of crazy tasting,” said Geoff Woo, the founder of HVMN, a Silicon Valley company that makes nootropics, or performance-enhancing supplements. We were in a conference room in The Atlantic’s office building, and he was bracing me for my trial run of his latest product. It was a small, clear vial labeled “Ketone,” a new type of energy drink his company is releasing this week. Its nutrition label says it contains 120 calories, but no carbs, no fat, and no protein. Instead, it’s all ketones, the chemical that Woo and his company are calling a “fourth food group.” He hopes the drink will allow people to reap the benefits of occasional fasting—high ketone levels inside the body—without actually having to not eat. I unscrewed the top and, college-days muscle memory kicking in, chugged it like a shot of Captain Morgan. It tasted like cough syrup that had been poured into a garbage bag and left in the sun. “Augh!” I cried. “I compare it to a combination of a liquor shot with nail-polish remover,” Woo said. Woo’s coworker, Brianna Stubbs, went to fetch me a glass of water. “We’ve done a lot of work to make it better,” she said. Within an hour, the drink was supposed to help improve my athletic performance by changing how my body burned energy during exercise. Some people also say it helps them feel more energetic and focused on their work. About 25 minutes after I drank Ketone, Woo and Stubbs pricked my finger to see if it was working. My blood sugar, which had verged on diabetic levels from some pineapple I had eaten that morning, was down to near-normal levels. Meanwhile, my ketones, which had been practically nonexistent before imbibing—measuring just 0.2 millimolar—had soared to 4.9. “It would have Continue reading >>

Top 8 Keto Supplements And 5 Functional Foods

Top 8 Keto Supplements And 5 Functional Foods

So you’ve decided to go keto and you’ve done all of your research on which foods you’ll be eating on the keto diet. But before you do your next big grocery run, you may want to consider these keto supplements too. While supplements aren’t 100% necessary on the keto diet, certain keto supplements can maximize your results by accelerating weight and fat loss and boosting your energy levels. Some keto supplements are also helpful for reducing symptoms of the keto flu and can help make the transition to a high-fat/low-carb diet much easier, especially in the early stages when you may want to give up. In addition to keto supplements, we’ll also let you know which superfoods — or ‘functional foods’ as we call them — can also be helpful on the keto diet. These foods are concentrated in essential nutrients and can further improve how you feel on the keto diet. Let’s take a look at the most popular keto supplements and the keto-approved functional foods you may also want to try. Top 8 Keto Supplements 1. Perfect Keto Perfect Keto is a powdered drink mix and keto supplement that provides your body with exogenous ketones (whereas your body produces endogenous ketones). Taking exogenous ketones provides ketone bodies for you to burn as fuel right away, whether or not you’re in ketosis. This is why some people who aren’t following a keto diet will still take ketone supplements for energy. Being made from exogenous ketones, Perfect Keto provides the same benefits that endogenous ketones naturally offer your body: long-lasting energy, improved cognitive function, athletic performance, and mental focus, fat burning, and accelerated weight loss. To be clear, exogenous ketones aren’t a replacement for the keto diet. While exogenous ketone supplements will raise Continue reading >>

Why I’m Using Exogenous Ketone Supplements

Why I’m Using Exogenous Ketone Supplements

Exogenous ketone supplements have gotten extremely popular lately with high performers like Tim Ferriss posting non-stop about all the benefits they offer, so I decided to give it a try as a self-experiment. Man I am glad I did. I was a bit skeptical at first because of all the hype, but I really felt the difference it made for me. As with most guys in my generation, I’ve take tons of different supplements trying to find the perfect shortcut, putting all kinds of weird stuff into my body. Then I realized how ridiculous that was and stopped taking most supplements. Needless to say I was a little hesitant to try this stuff because I have pretty much only been taking protein, greens, and pre-workout sometimes (pretty basic and well-established supplements). But with a bunch of my friends and people I follow talking about the benefits of a ketogenic diet (or ketosis) I thought it would be worth giving it a shot. The reason I wasn’t turned off by exogenous ketones (and the reason for taking it actually makes sense to me) is that ketosis is a completely natural metabolic state your body goes into in the absence of carbohydrates. Instead of burning sugar for primary energy, your body starts burning the breakdown of fat (or ketones) as your primary energy source. The reason I really wanted to try them is that ketones are a far preferred energy source to your brain than glucose or carbs, but getting into ketosis can be miserable and I want to continue to eat carbs for the working out I do. Exogenous ketones are basically supplemental ketones. When you take them, your body immediately starts using ketones for energy just like you would if you were in a deep state of ketosis. This means no crash diets, no low carb craziness; I can just have the benefits of ketosis whenever I w Continue reading >>

Ketone Supplement

Ketone Supplement

What are Ketone Supplements? Ketone supplements are products that can be taken that will increase ketone production. There are supplements such as coconut oil that contain Medium Chain Triglyceride (MCT) that convert to ketones (Beta-Hydroxybutyrate) in the body. Often times consuming Coconut / MCT oil can cause some GI discomfort until the body is efficient at processing the fats. A new technology has recently been made available to the public that allows us to drink ketones / Beta-Hydroxybutyrate (BHB) that within 30 mins will increase ketone levels to a therapeutic level with little if any GI discomfort. These supplements are exogenous ketones, meaning we are putting ketones into our body instead of relying on our bodies to create its own ketones. Both of these ketone supplements have been found to be beneficial. I currently consume both and recommend them both highly. I’m extremely excited and passionate about the advancements in the exogenous ketone supplementation. Continue reading >>

Exogenous Ketones: The Best Supplements, Benefits And Side Effects

Exogenous Ketones: The Best Supplements, Benefits And Side Effects

It’s amazing how much of an effect ketosis can have on weight loss. However, modern lifestyle is intertwined with the heavy intake of carbs, and for many people – it’s very hard to go full keto. Enter exogenous ketones. Ketones are extremely beneficial when it comes to our health. By following a ketogenic die t, you will reach ketosis, which is a state of our body producing a lot of ketones, and they are very good if you have high blood sugar. Another great “feature” of ketones is that, if they are consumed too much, leading to an excess amount – you probably won’t gain fat through it. The reason for this is that excess ketones are eliminated from our body very quickly, especially by the help of the kidneys; they throw them out with urine, instead of sending them into tissues. Of course, if you take incredibly high amounts of ketones – you risk gaining weight, but the chances for that are much, much lower, which is what makes ketones amazing nutrients. But first of all... What are ketones? And what are exogenous ketones? Ketones are organic compounds which are used by our body to generate energy. There are three different types of ketones which are produced in the liver: acetone acetoacetic acid and beta-hydroxybutyric acid. When we’re on a low-carb diet, then our body uses stored fat as its primary source of energy, and it doesn’t rely on glucose at all. The direct result of this is fat burning i.e. weight loss. Ketones are produced naturally in our body, but the term exogenous refers to those ketones which are taken through supplements. Here’s a good word of advice: don’t get confused if you end up looking at BHB products (beta-hydroxybutyrate), because the supplements of today are mostly distributed as BHB salts. The reason for this lies in th Continue reading >>

Exogenous Ketone Supplements Reduce Anxiety-related Behavior In Sprague-dawley And Wistar Albino Glaxo/rijswijk Rats

Exogenous Ketone Supplements Reduce Anxiety-related Behavior In Sprague-dawley And Wistar Albino Glaxo/rijswijk Rats

1Department of Molecular Pharmacology and Physiology, Hyperbaric Biomedical Research Laboratory, Morsani College of Medicine, University of South Florida, Tampa, FL, USA 2Department of Zoology, University of West Hungary, Szombathely, Hungary 3Proteomics Laboratory, Eotvos Lorand University, Budapest, Hungary Nutritional ketosis has been proven effective for seizure disorders and other neurological disorders. The focus of this study was to determine the effects of ketone supplementation on anxiety-related behavior in Sprague-Dawley (SPD) and Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. We tested exogenous ketone supplements added to food and fed chronically for 83 days in SPD rats and administered sub-chronically for 7 days in both rat models by daily intragastric gavage bolus followed by assessment of anxiety measures on elevated plus maze (EPM). The groups included standard diet (SD) or SD + ketone supplementation. Low-dose ketone ester (LKE; 1,3-butanediol-acetoacetate diester, ~10 g/kg/day, LKE), high dose ketone ester (HKE; ~25 g/kg/day, HKE), beta-hydroxybutyrate-mineral salt (βHB-S; ~25 g/kg/day, KS) and βHB-S + medium chain triglyceride (MCT; ~25 g/kg/day, KSMCT) were used as ketone supplementation for chronic administration. To extend our results, exogenous ketone supplements were also tested sub-chronically on SPD rats (KE, KS and KSMCT; 5 g/kg/day) and on WAG/Rij rats (KE, KS and KSMCT; 2.5 g/kg/day). At the end of treatments behavioral data collection was conducted manually by a blinded observer and with a video-tracking system, after which blood βHB and glucose levels were measured. Ketone supplementation reduced anxiety on EPM as measured by less entries to closed arms (sub-chronic KE and KS: SPD rats and KSMCT: WAG/Rij rats), more time spent in open ar Continue reading >>

Are Exogenous Ketones Right For You?

Are Exogenous Ketones Right For You?

I’ve spent a lot of time lately analysing three thousand ketone vs. glucose data points trying to determine the optimal ketone and blood sugar levels for weight loss, diabetes management, athletic performance and longevity. In this article, I share my insights and learnings on the benefits, side effects and risks of endogenous and endogenous ketosis. But first, I think it’s important to understand the difference between exogenous and endogenous ketosis: Endogenous ketosis occurs when we go without food for a significant period. Our insulin levels drop, and we transition to burning body fat and ketones in our blood rise. Exogenous ketosis occurs when we drink exogenous ketones or consume a ketogenic diet. Ketones are important. As blood glucose decreases, the ketones in your blood increase to keep our energy levels stable. The chart below shows three thousand blood glucose vs ketone values measured at the same time from a range of people following a low carbohydrate or ketogenic diet. While there is generally a linear relationship between glucose and ketones, each person has a unique relationship between their blood glucose and ketone values that provide a unique insight into a particular person’s metabolic health. Hyperinsulinemia has been called as the “unifying theory of chronic disease” [1] [2] [3] [4] [5]. It’s beneficial to understand where you stand on the spectrum of metabolic health and insulin sensitivity. The chart below shows the typical relationship between blood glucose and blood ketone for a range of different degrees of insulin resistance/sensitivity. If your blood glucose levels are consistently high it’s likely you are not metabolising carbohydrate well. When you go without food, endogenous ketones are slow to kick in because your insulin Continue reading >>

What Are Exogenous Ketones: When And How To Supplement With Ketones

What Are Exogenous Ketones: When And How To Supplement With Ketones

You can’t deny it. Exogenous ketones are one of the hottest products on the market right now, especially for those interested in ketosis and the ketogenic diet. But what exactly are exogenous ketones, and what do they offer? We’ll dive into that in this in-depth guide about how to benefit from supplementing with exogenous ketones. Exogenous ketones come in different forms and even more importantly can be used for several different applications. Fat burning, reducing ketosis symptoms, enhancing physical performance and mental performance are some of the ways that ketones can be used. WHAT IS KETOSIS? If you are new to ketosis and don’t know much about it, it is a metabolic state, where your body preferentially uses ketones (instead of glucose) for energy. This can lead to a host of different health benefits. If you’d like to learn more about ketosis, what ketones are, and how to benefit from these, feel free to read through our guides: What is Ketosis? What is the Ketogenic Diet? What Are Ketones? TYPES OF EXOGENOUS KETONES If you’ve read our guide, What Are Ketones, you’ll know that there are three different types of ketones your body can make in the absence of carbohydrates, typically from stored fat. However, there are ways to get ketones easily from exogenous (outside of your body) sources. There are three different types of “ketones” that your body runs on: Acetoacetate, beta-hydroxybutyrate, and acetone. Beta-hydroxybutyrate is the active form that can flow freely in the blood and be used by your tissues, so that is the one that most exogenous ketone supplements are based off. Ketone Esters Ketone esters are the raw ketone (in this case, beta-hydroxybutryate) that is not bound to any other compound. These exogenous ketones can be utilized a little q Continue reading >>

Exogenous Ketones: What They Are, Benefits Of Use And How They Work

Exogenous Ketones: What They Are, Benefits Of Use And How They Work

Exogenous ketones have become a popular nutritional supplement since their introduction in 2014. Like with any new supplement, though, there tends to be a lot of misinformation that you have to sift your way through to find the reliable data. So, this article does the hard work for you and gets right to what the true benefits and drawbacks of exogenous ketones are. We also cover what forms of ketones to consider, how they function in the body, and their role in future research. What Are Ketones? Our bodies use ketones via our mitochondria to generate energy. They are an alternative fuel source to glucose. Ketones are simple compounds because of their small molecular structure and weight. Specifically, they are organic (carbon-based) compounds that contain a central carbon atom double-bonded to an oxygen atom and two carbon-containing substituents, denoted by “R” (see chemical structure below). In humans, there are 3 different ketones produced by the mitochondria of the liver. These are also often referred to as ketone bodies. The three ketones are: Acetone Acetoacetic Acid Beta-Hydroxybutyric Acid (also known Beta Hydroxybuyrate or BHB). Other chemical names include 3-hydroxybutyric acid or 3-hydroxybutyrate. BHB is not technically a ketone since it contains a reactive OH-group in place of where a double-bonded oxygen normally would be as you can see in the diagram below. Yet, BHB still functions like a ketone in the body and converts into energy much like acetoacetate and acetone. This happens via the acetoacetate and acetyl-CoA pathway. Note that acetone conversion to acetyl-CoA is not efficient due to the need to convert acetone to acetoacetate via decarboxylation. However, BHB still functions like a ketone in the body and can be converted to energy (via acetoace Continue reading >>

My Experience With Exogenous Ketones

My Experience With Exogenous Ketones

Last year I wrote a couple of posts on the nuances and complexities of ketosis, with an emphasis on nutritional ketosis (but some discussion of other states of ketosis—starvation ketosis and diabetic ketoacidosis, or DKA). To understand this post, you’ll want to at least be familiar with the ideas in those posts, which can be found here and here. In the second of these posts I discuss the Delta G implications of the body using ketones (specifically, beta-hydroxybutyrate, or BHB, and acetoacetate, or AcAc) for ATP generation, instead of glucose and free fatty acid (FFA). At the time I wrote that post I was particularly (read: personally) interested in the Delta G arbitrage. Stated simply, per unit of carbon, utilization of BHB offers more ATP for the same amount of oxygen consumption (as corollary, generation of the same amount of ATP requires less oxygen consumption, when compared to glucose or FFA). I also concluded that post by discussing the possibility of testing this (theoretical) idea in a real person, with the help of exogenous (i.e., synthetic) ketones. I have seen this effect in (unpublished) data in world class athletes not on a ketogenic diet who have supplemented with exogenous ketones (more on that, below). Case after case showed a small, but significant increase in sub-threshold performance (as an example, efforts longer than about 4 minutes all-out). So I decided to find out for myself if ketones could, indeed, offer up the same amount of usable energy with less oxygen consumption. Some housekeeping issues before getting into it. This is a self-experiment, not real “data”—“N of 1” stuff is suggestive, but it prevents the use of nifty little things likes error bars and p-values. Please don’t over interpret these results. My reason for shari Continue reading >>

10 Best Exogenous Ketones: Weight Loss Using Ketone Supplements

10 Best Exogenous Ketones: Weight Loss Using Ketone Supplements

The benefits of ketosis for weight loss are explosive. However, going keto is not exactly a walk in the park. The modern diet is ridiculously high carb, and many people find it difficult to make the transition. This is where exogenous ketones for weight loss could come in handy. What Are Ketones? Going Keto is especially important if you suffer from chronically high sugar levels. With the ketogenic diet, your goal is to achieve ketosis, a state where your body produces an increased number of ketones. The body uses ketones to generate energy. When you have a low carb diet, your body tends to use up stored fat as energy, instead of relying on glucose. As a result, you get to manage your sugar levels, AND burn fat.​ What Are Exogenous Ketones Supplements? The body naturally produces ketones. Exogenous ketones are merely in reference to ketone bodies that are ingested by taking supplements. The supplements on the market these days are usually in the form of beta-hydroxybutyrate (BHB). That’s why when you look up exogenous ketones, you’d probably end up seeing beta-hydroxybutyrate supplements, or BHB salts. Sodium and potassium are added to the formula to make the substances easier to absorb. Some supplements come with MCT oil (medium-chain triglycerides or medium-chain fatty acids. MCT are saturated fats that can be easily digested by the liver. They help boost metabolism and are used up for energy instead of being stored as fat.​ A diet high in fat is also beneficial for boosting testosterone levels. A Quick Look at The Best Exogenous Ketones Supplements There are many types of exogenous ketone supplements out on the market, and if you’re new to going keto, you’ll need all the help you can get to choose the best one. We did the legwork and came up with this lis Continue reading >>

My Big, Fat, N=1 Exogenous Ketones Supplementation Experiment (while Eating A Keto Diet)

My Big, Fat, N=1 Exogenous Ketones Supplementation Experiment (while Eating A Keto Diet)

My Big, Fat, n=1 Exogenous Ketones Supplementation Experiment (while Eating a Keto Diet) Here we go. I’ve been slightly apprehensive about sharing this latest experiment with you, because up until recently I was where I’m sure many of you are right now in my belief that exogenous ketones were a mother flippin’ ripoff. After all, all good keto kids know that ketone bodies are the RESULT of putting our bodies successfully in ketosis, so why in the hell would we want to pay to put ketones from outside ourselves into our system? Well, I got my reasons, which I’ll share with you in a bit. First, my purpose: to do an n=1 experiment in order to see if using exogenous ketones can help me lose weight while on a ketogenic diet — that is, a diet that already puts my body in ketosis. ***HUGE DISCLAIMER: I used my own hard-earned money to pay for the exogenous ketones. I was not approached by any company, and I am not doing this experiment on behalf of anybody but myself.*** Now for some background info on me: I’ve been following a keto diet for 20 months now I am approximately 75lbs overweight Aside from an initial fluid loss of 10lb, I have never lost any weight on keto Over these last 20 months I have experimented with altering my macros, intermittent fasting (IF), extended fasting, egg fasting, and meat fasting, and nothing to date has had any measurable, lasting impact on my weight I have PCOS I have low cortisol levels due to chronic Lyme disease that was finally treated in December 2016 and January 2017 I still do consider keto to be a success for me! I used it along with the protocol in the book The Mood Cure to finally get off antidepressants and anti-anxiety medication that I was previously unsuccessful in transitioning off of for 10 years (Note: Don’t ever a Continue reading >>

Do Raspberry Ketones Really Work? A Detailed Review

Do Raspberry Ketones Really Work? A Detailed Review

If you need to lose weight, you are not alone. More than a third of Americans are overweight, and another third are obese (1). Only 30% of people are now at a healthy weight... being overweight has become the new "normal." The problem is, conventional weight loss methods are so difficult that 85% of people fail in the long run (2). However... there are many products out there that are claimed to make things easier. These are herbs, shakes and pills that are supposed to help you burn fat or reduce your appetite. Among the most popular ones is a supplement called Raspberry ketones. Raspberry ketones are claimed to cause the fat within cells to be broken down more effectively, helping the body burn fat faster. They are also claimed to increase levels of adiponectin, a hormone that helps to regulate metabolism. This article reviews the current scientific research behind raspberry ketone supplements and whether they are actually worth considering. Raspberry ketone is a natural substance that gives red raspberries their powerful aroma. This substance is also found in small amounts in blackberries, cranberries and kiwis. It has a long history of use in cosmetics and has been added to soft drinks, ice cream and other processed foods as a flavorant. Actually... most people are already eating small amounts of raspberry ketones, either from the fruits themselves or because of their popularity as a flavorant (3). Only recently did they became popular as a weight loss supplement. Even though the word "raspberry" may appeal to people, the supplement is actually NOT derived from raspberries. Extracting raspberry ketones from raspberries is insanely expensive, because you need 90 pounds (41 kg) of raspberries to get the amount needed for a single dose! In fact, a kilogram (2.2 pounds) Continue reading >>

Cupcakes And Ketones; Do Ketone Supplements Really Work?

Cupcakes And Ketones; Do Ketone Supplements Really Work?

I’ve heard several questions about ketone supplementation for fat loss… they seem to be the next big weight-loss fad. But what are they, and do they really work? Ketones are a natural fuel source produced by your body when glucose (sugar) is not available to use as fuel. This is called nutritional ketosis and it happens when you’re on a very low carb diet, or have fasted for an extended period of time. Once you burn through your glucose stores, your body digs into your stored fat for fuel. Fatty acids are released from your fat cells, and your liver uses those fatty acids to create ketones, which are then burned as fuel. Exogenous (from an external source) ketones have recently hit the market and have been hailed by some as the next great magic fat loss pill. Instead of fasting or cutting carb intake so that your body produces ketones, you’re drinking ketones so you body can then use them as fuel. Sounds great, right? Keep eating carbs and receive the fat burning benefits of NOT eating carbs! If something sounds too good to be true, then it probably is. Remember that to create ketones, your liver uses fatty acids from your fat cells to produce them. If you’re drinking the ketones, then you don’t actually have to dig into your own fat stores to create them. Creating the ketones, not burning them, is what causes your body to use fat. And if you’re now using ketones as fuel, but haven’t even used up your glucose stores first (which is how it happens naturally), then what happens to the glucose? You now have 2 fuel sources, and you can’t burn them both at the same time. Well, studies of ketone supplement use do show that as blood ketones increase, blood sugar (glucose) decreases, but it isn’t because you are burning that glucose; it’s because your insu Continue reading >>

Can Ketone Supplements Really Enhance Athletic Performance?

Can Ketone Supplements Really Enhance Athletic Performance?

Some scientists, athletes and nutritionists have started promoting ketone supplements, suggesting they greatly enhance performance and focus, while also helping the body burn fat more rapidly. "It's not like caffeine or anything — it's not a stimulant," Kieran Clarke, a professor of physiological biochemistry at Oxford University in the United Kingdom, who has studied ketone supplements and their effects, told Business Insider. "If you're not watching what you're doing, you think, 'Oh, I'm doing all right, everything feels normal,' but then you look down, and all of a sudden you see, 'Oh, wow, I've gone a lot further than usual!' You'll find on a rowing machine, for example, you're going a lot faster, and you didn't even realize it," she said. However, while Clarke has conducted research that points to ketones’ positive effects on athletes, another recent study showed very different results. Such conflicting and minimal data has left many dietitians and scientists skeptical about what some are already marketing as "the fourth macronutrient." What is ketone? Ketones are naturally produced in the liver when humans are fasting, starving, consuming low carbohydrate diets or exercising for a prolonged period of time. Our bodies' muscles and brain use them for fuel when carbohydrates are lacking. Essentially, ketones burn our stores of fat while also powering the body, a state called ketosis. This has led some athletes and nutritionists to believe that increasing ketones can not only burn fat more efficiently, but also enhance athletic performance by allowing us to continue longer with greater intensity. "It's not a fat, it's not a protein, it's not a carb, but your body gets fuel from it," Geoff Woo, the co-founder and CEO of a San Francisco-based human-performance start Continue reading >>

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