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Ketone Esters

Regular Article A Ketone Ester Diet Exhibits Anxiolytic And Cognition-sparing Properties, And Lessens Amyloid And Tau Pathologies In A Mouse Model Of Alzheimer's Disease

Regular Article A Ketone Ester Diet Exhibits Anxiolytic And Cognition-sparing Properties, And Lessens Amyloid And Tau Pathologies In A Mouse Model Of Alzheimer's Disease

Abstract Alzheimer's disease (AD) involves progressive accumulation of amyloid β-peptide (Aβ) and neurofibrillary pathologies, and glucose hypometabolism in brain regions critical for memory. The 3xTgAD mouse model was used to test the hypothesis that a ketone ester–based diet can ameliorate AD pathogenesis. Beginning at a presymptomatic age, 2 groups of male 3xTgAD mice were fed a diet containing a physiological enantiomeric precursor of ketone bodies (KET) or an isocaloric carbohydrate diet. The results of behavioral tests performed at 4 and 7 months after diet initiation revealed that KET-fed mice exhibited significantly less anxiety in 2 different tests. 3xTgAD mice on the KET diet also exhibited significant, albeit relatively subtle, improvements in performance on learning and memory tests. Immunohistochemical analyses revealed that KET-fed mice exhibited decreased Aβ deposition in the subiculum, CA1 and CA3 regions of the hippocampus, and the amygdala. KET-fed mice exhibited reduced levels of hyperphosphorylated tau deposition in the same regions of the hippocampus, amygdala, and cortex. Thus, a novel ketone ester can ameliorate proteopathic and behavioral deficits in a mouse AD model. Continue reading >>

Ketone Body Therapy: From Ketogenic Diet To Oral Administration Of Ketone Ester.

Ketone Body Therapy: From Ketogenic Diet To Oral Administration Of Ketone Ester.

Abstract Abstract Ketone bodies (KB), acetoacetate and β-hyroxybutyrate, were considered harmful metabolic by-products when discovered in the mid-nineteenth century in urine of patients with diabetic ketoacidosis. It took physicians many years to realize KB are normal metabolites synthesized by the liver and exported into the systemic circulation to serve as an energy source for most extrahepatic tissues. Studies have shown that the brain (which normally uses glucose for energy) can readily utilize KB as an alternative fuel. Even when there is diminished glucose utilization in cognition-critical brain areas, as may occur early in Alzheimer disease, there is preliminary evidence that these same areas remain capable of metabolizing KB. Because the ketogenic diet (KD) is difficult to prepare and follow, and effectiveness of KB treatment in certain patients may be enhanced by raising plasma levels to 4-8 mM, KB esters, such as 1,3-butanediol monoester of β-hydroxybutyrate and glyceryl-tris-3-hydroxybutyrate, have been devised. When administered orally in controlled dosages, these esters can produce plasma KB levels comparable to those achieved by the most rigorous KD, thus providing a safe, convenient, and versatile new approach to the study and potential treatment of a variety of diseases, including epilepsy, Alzheimer diesease, and Parkinson disease. Continue reading >>

Ketone Ester Review: What Are They, And Do They Work?

Ketone Ester Review: What Are They, And Do They Work?

It's an exciting day at the KetoConnect household! We finally got our hands on the first commercially available ketone ester! The only company currently making this stuff is KetoneAid and they were nice enough to send us a sample to try for ourselves. We have tried most of the exogenous ketone supplements on the market and have not been impressed, but this is something completely different. Exogenous Ketones - Salts VS Esters The difference is night and day. When supplementing with the current BHB Salts on the market the impact is negligible. Often I will feel absolutely nothing, where other times I will notice a small benefit in energy and focus. It turns out this is due to the small dose that all BHB Salts deliver. There is an upper limit to how much you can consume at a given time because the ketones are binded to a salt such as sodium, potassium or magnesium. Ketone Esters on the other hand have no limit. You can consume exponentially more at a given time, which leads to a dramatic increase in benefits. The difference is rather astonishing and has completely reversed my thoughts on supplementing ketones and the future of the ketone supplement market. The Taste - Yes...It's That Bad! While the taste is much improved from the original iteration of these ketone esters, it's still pretty terrible. I'd describe it as a mix between rubbing alcohol and what I imagine toilet cleaner would taste like, with a squeeze of lemon. I'm sure this will continue to improve over time, and while it is terrible I don't feel it makes the supplement too prohibitive. It's easy to justify a few minutes of discomfort for hours of increased productivity. We Monitored Our Ketone and Glucose Levels After choking down our respective drinks, we started monitoring our blood ketone and glucose leve Continue reading >>

013: Frank Llosa – Ketone Esters For Insane Ketosis

013: Frank Llosa – Ketone Esters For Insane Ketosis

[2:33] What are ketones and what can and should ketone supplements be used for? [4:01] What makes Ketone Aid different from other exogenous ketone supplements? What’s the difference between endogenous and exogenous ketones? [12:31] Why do we want to get into ketosis and even higher levels of ketosis? [13:50] With KetoneAid, since you’re not getting the SALT load so it allows you to intake more ketones [14:34] What does it mean to get into “deeper” or “increased levels” of ketosis [17:20] Why don’t we see many Ketone Ester products out there? Ketone Esters for $40,000!! [18:45] How do Ketone Esters taste? [20:34] My first experience with Ketone Aid [23:40] Why you should be following the instructions EXACTLY [24:02] The benefits I personally noted from Ketone Aid + results of my Ketone Levels! [28:45] How little it takes to notice a benefit cognitively. [28:57] Ketone Aid was actually NOT made for Keto people! Here’s why? [31:47] Can you get into ketosis without ketone supplements? [33:30] Who should be using ketone esters and what are they beneficial for? [36:53] The unreal benefits for athletic performance! [39:12] How much is it? Does it always work? Continue reading >>

The Startup Behind Chewable Coffee Is Launching A Performance-enhancing 'superhuman Fuel' — We Gave It A Try

The Startup Behind Chewable Coffee Is Launching A Performance-enhancing 'superhuman Fuel' — We Gave It A Try

One of the world's first commercial ketone esters, a drink that could improve energy and athletic performance, is coming to market. HVMN is a startup based in San Francisco that wants to usher in a new era of human enhancement through technologies like the ketone ester. We tried the drink before its public launch. About 13 years ago, the Defense Advanced Research Projects Agency (DARPA) asked the scientific community to create a food that soldiers could take onto the battlefield. The agency, which has been tasked with building breakthrough technologies for the US military, wanted to improve troops' physical and mental performance, turning war fighters into super-soldiers. Researchers at University of Oxford and National Institutes of Health answered the call. With $10 million in funding from DARPA, a team of biochemists invented the ketone ester, a drink that generates energy from ketones — molecules formed by the breakdown of fat — rather than carbs, fat, or protein. It is, effectively, a fourth type of fuel for humans. On November 6, HVMN, a startup out of San Francisco, revealed that it is bringing one of the first commercial ketone esters to market. HVMN Ketone is an FDA-reviewed drink that promises increased athletic ability, heightened focus, and energy. The company is leveraging more than a decade and $60 million-worth of research from Oxford through an exclusive partnership. Starting today, anyone will be able to buy the product for $99 online. It ships in December. HVMN, an Andreessen Horowitz-backed startup whose other products include chewable coffee and "smart drugs," will market the product to competitive athletes to start. (Most clinical trials on the drink studied its effects on elite athletes.) But the company expects "biohackers" — people interest Continue reading >>

The Ketogenic Diet Now Comes In A Tiny Bottle, But Dietitians Are Skeptical

The Ketogenic Diet Now Comes In A Tiny Bottle, But Dietitians Are Skeptical

HVMN Don’t want to fast to try the ultra-trendy, high-fat, low-carb ketogenic diet? A San Francisco startup thinks you should take a shot of its elixir instead — even though the science behind it is dubious, experts say. The supplement company HVMN (that’s Silicon Valley-shorthand for “human”) unveiled its newest product on Monday: HVMN Ketone, a 2.3-ounce vial of a substance called ketone ester. It’s supposed to almost immediately put you in ketosis, a metabolic state where the body is forced to burn fats instead of carbohydrates. By loading the body with “an ultra-efficient form of fuel,” as the company says, it’s supposed to help you perform better in workouts and think more clearly. But even though HVMN says the drink is “proven to improve athletic performance and recovery,” nutrition experts say it is highly unlikely that a ketone supplement can single-handedly put you in ketosis. They also say there is little evidence that being in ketosis helps athletes. The public won’t get its first taste of it until next month. But registered dietitian Ben Sit is skeptical. “I have not yet found one ketone ester supplement that has been able to successfully put someone into the state of ketosis, no matter what dosage they take,” Sit, president of Evolved Sport and Nutrition, told BuzzFeed News. HVMN, formerly known as Nootrobox, is among a handful of consumer product startups that bill themselves as part of the loosely defined biohacking movement. Backed by tech venture capitalists, these companies, which include Bulletproof Coffee and Soylent, hawk food and supplements to busy, health-conscious people who have a quantify-everything mindset. HVMN, which raised $2 million in 2015 from Andreessen Horowitz (also a BuzzFeed investor), is best-known for Continue reading >>

Ketone Esters Amazon

Ketone Esters Amazon

7 grams of the ketone body Beta-Hydroxybutyrate (BHB) per serving in a delicious orange flavored base; KetoCaNa is similar to our Ketoforce product in that it contains the endogenous ketone body 8 Aug 2016 Patrick Arnold, who worked with Dr Dominic D'Agostino to develop the first ketone esters and ketone salts, has noted that exogenous ketones may help alleviate the symptoms of the 'keto flu' during the transition from a high . com NOTICE OF DISCLOSURE: Paid sponsorship. . Snapchat: KetoConnect. D. Jan 18, 2017 Which Ketone Supplement Works Best: Ketone Salts vs. Ein Professor der Universität wollte wissen, ob es möglich sei, den Keto-Ester genannt “Beta Hydroxybuttersäure” (abgekürzt BHB) für Untersuchungszwecke produzieren zu Ketones as an alternative fuel are also under study at USF in the lab under the direction of Dominic D'Agostino, Ph. We Tried The Worlds First Ketone Ester | Full Review | KetoneAid. Citation data What you need to know on how to get into ketosis, keto diet tips, ketone supplements and keto meal plans! 1 Aug 2016 Supplementing your sports drink with ketone esters, which help your body produce ketones for energy, may help you ride harder and longer. Only problem is the huge dose of salt limits how much you can take without adverse effects… but these are the ones on the market. , 1970, 35 (1), pp 171–175. 23 Sep 2017 It's an exciting day at the KetoConnect household! We finally got our hands on the first commercially available ketone ester! The only company currently making this stuff is KetoneAid and they were nice enough to send us a sample to try for ourselves. Free Shipping, Cash on The LLVLC Show (Episode 1039): Brian Underwood From Pruvit Shares Benefits Of KETO//OS Ketone Esters. , Westerterp, K. org/action/display Abstract? from Continue reading >>

Incredible Fuel Could Treat Countless Diseases, If Only It Was Funded

Incredible Fuel Could Treat Countless Diseases, If Only It Was Funded

This could be as impactful as the discovery of penicillin That’s the first thing that comes to mind when learning about the history-altering work of NIH scientist (for over 45 years) Dr. Richard Veech, a man the general public has probably never heard of. Why haven’t you heard of him? Because he’s dedicated to science, not sales. So, what do scientists and entrepreneurs have in common? They both dedicate their lives to making a difference, discovering ways to make the world operate more effectively. But there’s an important cultural distinction between the two: Entrepreneurs’ success is tied to dollars, while scientists’ success is tied to discovery. Remember how penicillin altered history? We might be at that moment in history again, but with a “ketone ester” drink invented by Dr. Veech, that has insanely widespread uses. Imagine a drink that could treat Alzheimer’s, Parkinson’s, diabetes, epilepsy, concussions, heart failure, all while helping elite endurance athletes break world records. Then, imagine that it’s a formula perfected over decades, but only now ready in an era where genetics is sexiest of sciences, so this liquid goes underfunded and underproduced. It seems too good to be true, but it’s not. It’s real. Add to the issue of funding is an overly modest old scientist who said he would literally run if someone called him a hero for his work. Next, toss in imitation products that use salt-filled caffeinated versions of Dr. Veech’s decades old, already discarded work and you might be left very confused. If a breakthrough sports drink and patient treatment exists, would anyone even believe it? So what is this ketone ester? Ketones are human’s back up fuel system that kicks in when humans starve, or at least run out of sugar. The bod Continue reading >>

Which Ketone Supplement Works Best: Ketone Salts Vs. Ketone Esters With Dr. Dominic D’agostino.

Which Ketone Supplement Works Best: Ketone Salts Vs. Ketone Esters With Dr. Dominic D’agostino.

Click here for the full written transcript of this podcast episode. A few months ago, I recorded a highly controversial ketosis interview with Dr. Richard Veech, in which Dr. Veech claimed that the form of ketones most people take to get into ketosis (ketone salts) are actually quite dangerous. Dr. Veech’s solution was something called “ketone esters“, which are extremely expensive, but, according to him, a far more natural, safe and healthy way to quickly get the body into ketosis – for anything from managing medical conditions, to improving cognition, to increasing endurance and beyond. In the video below, I actually experimented with these spendy ketone esters myself and, as you can see, the results were astounding… After shooting this video, I took another bottle of ketone esters to a Tough Mudder event and recorded a crazy video on Snapchat during which I elevated both blood glucose by drinking 75 grams of pure glucose and elevated blood ketones by drinking a bottle of the ketone esters, and the results were equally as astounding, resulting in one of the fastest races of my life. But the question remains: are these fancy, expensive ketone esters actually far better than ketone salts? Are ketone salts, which is what most people use, actually going to result in long term health issues? In today’s podcast, I bring on ketosis expert Dr. Dominic D’Agostino to get his opinion. Dominic is an Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine. He is also a Visiting Senior Research Scientist at the Institute for Human and Machine Cognition (IHMC). His laboratory develops and tests nutritional strategies and metabolic-based supplements for neurological disorders, cancer i Continue reading >>

A Copd Patient’s Journey Into The World Of Ketone Esters!

A Copd Patient’s Journey Into The World Of Ketone Esters!

A few years ago, a movie came out called Limitless. This was a movie about a super pill that supercharged Bradley Cooper’s brain and made him superhuman. I remember watching that movie thinking, how far are we away from this movie being a reality? After my recent experience, I would say we’re almost there. Those of you who have followed my journey would know for the last 9 months I have been following a ketogenic diet, to see what effects being in a state of ketosis would have on my disease, COPD. Scientists have for some years been experimenting with producing supplements that will put you in a state of ketosis regardless of what your diet is. There is now a range of ketone supplements that can put you in a moderate range of ketosis. But what are the benefits of taking these supplements? Ketones are anti-inflammatory so the theory is being in ketosis lowers inflammation and can help treat many chronic diseases. It is also claimed being in ketosis improves cognitive function. So where is the science you ask? Scientists studying 23 elderly people with mild cognitive impairment showed a ketogenic diet improved verbal memory performance after 6 weeks compared to a standard high carbohydrate diet. In a double-blind, placebo-controlled study, 152 patients with mild- to moderate Alzheimer’s disease were given either a ketogenic agent or a placebo, while maintaining a normal diet. 90 days later, those receiving the ketogenic agent showed marked cognitive improvement compared to placebo, which was correlated with the level of ketones in the blood. The current range of ketone supplements I have tried put me in a moderate range of ketosis, between .5 – 1.5 millimolar (mM) depending on the dose. I do notice reduced symptoms for my disease when my blood ketones are over 1 m Continue reading >>

Of The Keto Diet?

Of The Keto Diet?

There are many awesome benefits that come with adopting a low-carb ketogenic diet, such as weight loss, decreased cravings and even possibly reduce disease risks. With that being said, it’s also good to talk about possible ketosis side-effects when ingesting these specific ketone supplements, so you know fully what to expect when you get started on this mission. If you’ve already heard about some of the side-effects that come with this special diet and are starting to freak out, don’t panic. We’re going to break down everything you need to know when it comes to what your body will experience when using these supplements for the first time. It’s important to remember, not everyone experiences side-effects when starting a ketogenic diet and thankfully, the symptoms are all very temporary and it can pass very quickly. It varies with the individual, but just to make sure all your bases are covered, we’re going to break down each possible side effect that you could possibly experience. 1. Flu Symptoms Within the first 2-4 days of beginning this diet, a common side-effect is known as the “ketosis flu” or “induction flu” because it mimics the symptoms of the actual flu. This means you might experience: Headaches Lethargy Lack of motivation Brain fog or confusion Irritability​ Although these symptoms typically go away completely within a few days, they are also completely avoidable if you stay very hydrated and increase your salt intake and like always, be sure you're eating enough fat. 2. Dizzyness & Drowsiness​ As you start dumping water, you'll lose minerals such as salt, potassium and magnesium. Having lower levels of these minerals will make you tired, lightheaded or dizzy. You may also experience muscle cramps, headaches and skin itchiness. Fatigue Continue reading >>

Quantified Bob’s Experience With Ketone Esters

Quantified Bob’s Experience With Ketone Esters

Quantified Bob has a writeup on his latest adventure which is reaching a deep therapeutic level of ketosis while avoiding the usual time consuming efforts of fasting, calorie restriction or very low carb diets. He drank 40g of a ketone monoester (KME) made by KetoneAid. Within 30 minutes his ketone readings were off the chart (>8.0 mmol/L) and blood sugar had dropped down to 72 mg/dL. Bob went on to test his cognitive performance using Lumosity which showed significant performance improvement across the board. Memory: working memory, spatial recall Attention: selective attention, divided attention Problem Solving: quantitative reasoning, logical reasoning Flexibility: task switching, response inhibition Speed: information processing, spatial orientation In a nutshell… WOW! The chart above shows each of the games/categories I played, showing my prior 5-day averages compared to the day I took the ketone esters. Compared to my baselines, my scores increased across the board, with the biggest improvements in spatial orientation (+32.2%), working memory (+23.7%), quantitative reasoning (21.5%), task switching (+14.9%), and information processing (+14.9%). [ … Read More @ QuantifiedBob …] No Comments No comments yet. Sorry, the comment form is closed at this time. Continue reading >>

A Ketone Ester Drink Increases Postexercise Muscle Glycogen Synthesis In Humans.

A Ketone Ester Drink Increases Postexercise Muscle Glycogen Synthesis In Humans.

Abstract INTRODUCTION: Physical endurance can be limited by muscle glycogen stores, in that glycogen depletion markedly reduces external work. During carbohydrate restriction, the liver synthesizes the ketone bodies, D-β-hydroxybutyrate, and acetoacetate from fatty acids. In animals and in the presence of glucose, D-β-hydroxybutyrate promotes insulin secretion and increases glycogen synthesis. Here we determined whether a dietary ketone ester, combined with plentiful glucose, can increase postexercise glycogen synthesis in human skeletal muscle. METHODS: After an interval-based glycogen depletion exercise protocol, 12 well-trained male athletes completed a randomized, three-arm, blinded crossover recovery study that consisted of consumption of either a taste-matched, zero-calorie control or a ketone monoester drink, followed by a 10-mM glucose clamp or saline infusion for 2 h. The three postexercise conditions were control drink then saline infusion, control drink then hyperglycemic clamp, or ketone ester drink then hyperglycemic clamp. Skeletal muscle glycogen content was determined in muscle biopsies of vastus lateralis taken before and after the 2-h clamps. RESULTS: The ketone ester drink increased blood D-β-hydroxybutyrate concentrations to a maximum of 5.3 versus 0.7 mM for the control drink (P < 0.0001). During the 2-h glucose clamps, insulin levels were twofold higher (31 vs 16 mU·L, P < 0.01) and glucose uptake 32% faster (1.66 vs 1.26 g·kg, P < 0.001). The ketone drink increased by 61 g, the total glucose infused for 2 h, from 197 to 258 g, and muscle glycogen was 50% higher (246 vs 164 mmol glycosyl units per kilogram dry weight, P < 0.05) than after the control drink. CONCLUSION: In the presence of constant high glucose concentrations, a ketone ester dri Continue reading >>

Ketone Ester Effects On Metabolism And Transcription

Ketone Ester Effects On Metabolism And Transcription

Go to: PRODUCTION OF KETONE BODIES Ketone bodies are formed in the liver from free fatty acids released from adipose tissue. As the blood concentration of free fatty acids increases, concentration of blood ketone bodies is correspondingly increased (1, 2). Ketone bodies serve as a physiological respiratory substrate and are the physiological response to prolonged starvation in man (3, 4), where the blood level of ketones reaches 5–7 mM (5). If the release of free fatty acids from adipose tissue exceeds the capacity of tissue to metabolize them, as occurs during insulin deficiency of type I diabetes or less commonly in the insulin resistance of type II diabetes, severe and potentially fatal diabetic ketoacidosis can occur, where blood ketone body levels can reach 20 mM or higher (2) resulting in a decrease in blood bicarbonate to almost 0 mM and blood pH to 6.9. Diabetic ketoacidosis, which is a pathological state, differs from the ketosis of prolonged starvation, which is a normal physiological state without known medical consequences. Elevation of blood ketones can however lead to elevation of blood uric acid, which can produce a gouty crisis. This can be prevented by feeding oral potassium citrate (6) Ketosis occurs during starvation in man. It occurs only with difficulty in species other than lactating cows where ketosis can occur due to the large requirement for lactose production in milk production. This form of ketosis can be treated by the administration of glucose. In this situation, ketosis occurs because of the competition for oxaloacetate, required for gluconeogenesis, where its shortage prevents acetyl-CoA in the liver from entering the Krebs cycle with a resultant increase in ketone body production (1). In vitro, ketone body production has been observed d Continue reading >>

Novel Ketone Drink May Boost Athletic Performance

Novel Ketone Drink May Boost Athletic Performance

This content requires a premium subscription. Please log in or subscribe to continue. Ben Greenfield Fitness: Diet, Fat Loss and Performance Could This Ketosis-Based Elixir Hold The Key To Weight Loss, World Record Performances, Brain Healing and More? 30 00:00:00 30 To skip Ads, please fast forward to 6:25 Download Interview Transcript Endogenous ketones are what your liver produces when it converts fat into energy, but you can also supply your body with ketones from an external source These externally sourced, or exogenous ketones, can mimic or replicate your body’s endogenous ketones, providing an energy boost. One good and readily available ketone supplement is medium-chain triglyceride (MCT) oil Other ketone supplements are either commercially available now or in development. One specially formulated ketone ester drink was given to competitive cyclists who were then able to cycle 2 percent faster, compared to their speed when given a drink high in carbohydrates or fat By Dr. Mercola For many years, carb-loading has been the go-to solution for building energy storage capacity in athletes. This is built on the premise that since glucose is a quick-burning form of energy, bolstering your capacity to store glucose will help boost athletic performance. However, nutritional science suggests this is far from an ideal strategy. Ketones are emerging as a far better fuel. For optimal health, I recommend eating a diet high in healthy fats and low in net carbs (total carbohydrates minus fiber), and this type of diet may be particularly beneficial for endurance athletes. Despite running counter to conventional sports nutrition advice, research has shown that high-fat, low-carb ketogenic diet may provide superior benefits. We all have to eat; we need fuel and other nutrients t Continue reading >>

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