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Ketone Esters

Incredible Fuel Could Treat Countless Diseases, If Only It Was Funded

Incredible Fuel Could Treat Countless Diseases, If Only It Was Funded

This could be as impactful as the discovery of penicillin That’s the first thing that comes to mind when learning about the history-altering work of NIH scientist (for over 45 years) Dr. Richard Veech, a man the general public has probably never heard of. Why haven’t you heard of him? Because he’s dedicated to science, not sales. So, what do scientists and entrepreneurs have in common? They both dedicate their lives to making a difference, discovering ways to make the world operate more effectively. But there’s an important cultural distinction between the two: Entrepreneurs’ success is tied to dollars, while scientists’ success is tied to discovery. Remember how penicillin altered history? We might be at that moment in history again, but with a “ketone ester” drink invented by Dr. Veech, that has insanely widespread uses. Imagine a drink that could treat Alzheimer’s, Parkinson’s, diabetes, epilepsy, concussions, heart failure, all while helping elite endurance athletes break world records. Then, imagine that it’s a formula perfected over decades, but only now ready in an era where genetics is sexiest of sciences, so this liquid goes underfunded and underproduced. It seems too good to be true, but it’s not. It’s real. Add to the issue of funding is an overly modest old scientist who said he would literally run if someone called him a hero for his work. Next, toss in imitation products that use salt-filled caffeinated versions of Dr. Veech’s decades old, already discarded work and you might be left very confused. If a breakthrough sports drink and patient treatment exists, would anyone even believe it? So what is this ketone ester? Ketones are human’s back up fuel system that kicks in when humans starve, or at least run out of sugar. The bod Continue reading >>

Of The Keto Diet?

Of The Keto Diet?

There are many awesome benefits that come with adopting a low-carb ketogenic diet, such as weight loss, decreased cravings and even possibly reduce disease risks. With that being said, it’s also good to talk about possible ketosis side-effects when ingesting these specific ketone supplements, so you know fully what to expect when you get started on this mission. If you’ve already heard about some of the side-effects that come with this special diet and are starting to freak out, don’t panic. We’re going to break down everything you need to know when it comes to what your body will experience when using these supplements for the first time. It’s important to remember, not everyone experiences side-effects when starting a ketogenic diet and thankfully, the symptoms are all very temporary and it can pass very quickly. It varies with the individual, but just to make sure all your bases are covered, we’re going to break down each possible side effect that you could possibly experience. 1. Flu Symptoms Within the first 2-4 days of beginning this diet, a common side-effect is known as the “ketosis flu” or “induction flu” because it mimics the symptoms of the actual flu. This means you might experience: Headaches Lethargy Lack of motivation Brain fog or confusion Irritability​ Although these symptoms typically go away completely within a few days, they are also completely avoidable if you stay very hydrated and increase your salt intake and like always, be sure you're eating enough fat. 2. Dizzyness & Drowsiness​ As you start dumping water, you'll lose minerals such as salt, potassium and magnesium. Having lower levels of these minerals will make you tired, lightheaded or dizzy. You may also experience muscle cramps, headaches and skin itchiness. Fatigue Continue reading >>

The Startup Behind Chewable Coffee Is Launching A Performance-enhancing 'superhuman Fuel' — We Gave It A Try

The Startup Behind Chewable Coffee Is Launching A Performance-enhancing 'superhuman Fuel' — We Gave It A Try

One of the world's first commercial ketone esters, a drink that could improve energy and athletic performance, is coming to market. HVMN is a startup based in San Francisco that wants to usher in a new era of human enhancement through technologies like the ketone ester. We tried the drink before its public launch. About 13 years ago, the Defense Advanced Research Projects Agency (DARPA) asked the scientific community to create a food that soldiers could take onto the battlefield. The agency, which has been tasked with building breakthrough technologies for the US military, wanted to improve troops' physical and mental performance, turning war fighters into super-soldiers. Researchers at University of Oxford and National Institutes of Health answered the call. With $10 million in funding from DARPA, a team of biochemists invented the ketone ester, a drink that generates energy from ketones — molecules formed by the breakdown of fat — rather than carbs, fat, or protein. It is, effectively, a fourth type of fuel for humans. On November 6, HVMN, a startup out of San Francisco, revealed that it is bringing one of the first commercial ketone esters to market. HVMN Ketone is an FDA-reviewed drink that promises increased athletic ability, heightened focus, and energy. The company is leveraging more than a decade and $60 million-worth of research from Oxford through an exclusive partnership. Starting today, anyone will be able to buy the product for $99 online. It ships in December. HVMN, an Andreessen Horowitz-backed startup whose other products include chewable coffee and "smart drugs," will market the product to competitive athletes to start. (Most clinical trials on the drink studied its effects on elite athletes.) But the company expects "biohackers" — people interest Continue reading >>

Ketone Ester Effects On Metabolism And Transcription

Ketone Ester Effects On Metabolism And Transcription

Go to: PRODUCTION OF KETONE BODIES Ketone bodies are formed in the liver from free fatty acids released from adipose tissue. As the blood concentration of free fatty acids increases, concentration of blood ketone bodies is correspondingly increased (1, 2). Ketone bodies serve as a physiological respiratory substrate and are the physiological response to prolonged starvation in man (3, 4), where the blood level of ketones reaches 5–7 mM (5). If the release of free fatty acids from adipose tissue exceeds the capacity of tissue to metabolize them, as occurs during insulin deficiency of type I diabetes or less commonly in the insulin resistance of type II diabetes, severe and potentially fatal diabetic ketoacidosis can occur, where blood ketone body levels can reach 20 mM or higher (2) resulting in a decrease in blood bicarbonate to almost 0 mM and blood pH to 6.9. Diabetic ketoacidosis, which is a pathological state, differs from the ketosis of prolonged starvation, which is a normal physiological state without known medical consequences. Elevation of blood ketones can however lead to elevation of blood uric acid, which can produce a gouty crisis. This can be prevented by feeding oral potassium citrate (6) Ketosis occurs during starvation in man. It occurs only with difficulty in species other than lactating cows where ketosis can occur due to the large requirement for lactose production in milk production. This form of ketosis can be treated by the administration of glucose. In this situation, ketosis occurs because of the competition for oxaloacetate, required for gluconeogenesis, where its shortage prevents acetyl-CoA in the liver from entering the Krebs cycle with a resultant increase in ketone body production (1). In vitro, ketone body production has been observed d Continue reading >>

Which Ketone Supplement Works Best: Ketone Salts Vs. Ketone Esters With Dr. Dominic D’agostino.

Which Ketone Supplement Works Best: Ketone Salts Vs. Ketone Esters With Dr. Dominic D’agostino.

Click here for the full written transcript of this podcast episode. A few months ago, I recorded a highly controversial ketosis interview with Dr. Richard Veech, in which Dr. Veech claimed that the form of ketones most people take to get into ketosis (ketone salts) are actually quite dangerous. Dr. Veech’s solution was something called “ketone esters“, which are extremely expensive, but, according to him, a far more natural, safe and healthy way to quickly get the body into ketosis – for anything from managing medical conditions, to improving cognition, to increasing endurance and beyond. In the video below, I actually experimented with these spendy ketone esters myself and, as you can see, the results were astounding… After shooting this video, I took another bottle of ketone esters to a Tough Mudder event and recorded a crazy video on Snapchat during which I elevated both blood glucose by drinking 75 grams of pure glucose and elevated blood ketones by drinking a bottle of the ketone esters, and the results were equally as astounding, resulting in one of the fastest races of my life. But the question remains: are these fancy, expensive ketone esters actually far better than ketone salts? Are ketone salts, which is what most people use, actually going to result in long term health issues? In today’s podcast, I bring on ketosis expert Dr. Dominic D’Agostino to get his opinion. Dominic is an Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine. He is also a Visiting Senior Research Scientist at the Institute for Human and Machine Cognition (IHMC). His laboratory develops and tests nutritional strategies and metabolic-based supplements for neurological disorders, cancer i Continue reading >>

The Perks Of Fasting, With None Of The Work

The Perks Of Fasting, With None Of The Work

“If there’s a downside, it is kind of crazy tasting,” said Geoff Woo, the founder of HVMN, a Silicon Valley company that makes nootropics, or performance-enhancing supplements. We were in a conference room in The Atlantic’s office building, and he was bracing me for my trial run of his latest product. It was a small, clear vial labeled “Ketone,” a new type of energy drink his company is releasing this week. Its nutrition label says it contains 120 calories, but no carbs, no fat, and no protein. Instead, it’s all ketones, the chemical that Woo and his company are calling a “fourth food group.” He hopes the drink will allow people to reap the benefits of occasional fasting—high ketone levels inside the body—without actually having to not eat. I unscrewed the top and, college-days muscle memory kicking in, chugged it like a shot of Captain Morgan. It tasted like cough syrup that had been poured into a garbage bag and left in the sun. “Augh!” I cried. “I compare it to a combination of a liquor shot with nail-polish remover,” Woo said. Woo’s coworker, Brianna Stubbs, went to fetch me a glass of water. “We’ve done a lot of work to make it better,” she said. Within an hour, the drink was supposed to help improve my athletic performance by changing how my body burned energy during exercise. Some people also say it helps them feel more energetic and focused on their work. About 25 minutes after I drank Ketone, Woo and Stubbs pricked my finger to see if it was working. My blood sugar, which had verged on diabetic levels from some pineapple I had eaten that morning, was down to near-normal levels. Meanwhile, my ketones, which had been practically nonexistent before imbibing—measuring just 0.2 millimolar—had soared to 4.9. “It would have Continue reading >>

Exogenous Ketone Supplements: Review Of Current Products And Future Developments

Exogenous Ketone Supplements: Review Of Current Products And Future Developments

Exogenous ketone supplements hold promise for individuals looking to lose weight, improve their health and longevity, and enhance cognitive performance. In this article, we will dive into the history of exogenous ketone supplementation, the different forms of exogenous ketones that are available and what to look out for when choosing a supplement. The first installment of this two-part series, which can be found here, takes an in-depth look at what exactly exogenous ketones are and how they work. If you haven’t had a chance to read that yet, it is highly recommended you do so before continuing on with this installment. Before moving on, it’s necessary to clarify that beta-hydroxybutyrate (BHB) is the predominant ketone found in exogenous ketone supplements. Therefore, “BHB” supplement (i.e. beta-hydroxybutyrate supplements) is just another name for exogenous ketone supplement. The State of Exogenous Ketone Supplements Exogenous ketone supplements are somewhat new on the scene, with a select few companies manufacturing them for dietary use. The exogenous ketone products currently available on the market are BHB mineral salts (BHB with sodium and potassium to improve absorption). The term “BHB mineral salts” is synonymous with beta-hydroxybutyrate salts and ketone salts. There are also combination BHB supplements that include MCT (or other) oils. Exogenous ketone products come in either liquid or powder form. Timeline of Introduction of Ketone Supplements Exogenous ketone supplements have been in research & development since the early 2000s, but didn’t start making their way to the general public until late 2014. Ketoforce by Prototype Nutrition was the first to launch, followed up shortly thereafter by Pruvit’s Keto OS (and Keto OS Charged, a caffeinated Continue reading >>

Want To Accomplish More? Drink Ketoneaid’s Ketone Esters

Want To Accomplish More? Drink Ketoneaid’s Ketone Esters

Want to accomplish more? Drink KetoneAid’s ketone esters A few weeks ago I received an email from Frank Llosa, founder of Ketone Aid, asking me if I wanted to try his new ketone esters. He’d found me after I posted a recent article on drinking ketones for productivity, so he knew I was a fan of this industry already… But even though I’ve been on a ketogenic diet for years and experimented with various ketone products, I’d never heard of ketone esters before, so that made me reasonably skeptical. I thought about just telling him no and sticking with products that I knew, but I was curious to see what a ketone ester even was… So I decided to look into it a little more, and after researching this product for 15 minutes, I quickly realized why I’d never heard of this before… BECAUSE IN THE PAST, IT COST $6,000 PER BOTTLE! This quickly changed my mind and made me very excited to give it a shot, so I responded to Frank and within 3 days I’d received a brand new bottle of ketone esters. I thought about drinking the bottle right away, but I was about ready to start writing a book and knew that if these were anything like ketone salts… Then they’d skyrocket my productivity and be helpful for writing, so I decided to wait until then. Fast forward 3 weeks and I was now ready to start writing my book…. And I wanted to start things off right, so on day 1 I quickly slammed the ketone esters and within 15 minutes, I can honestly say I’d entered the most productive time of my life. The Benefits I know some people take ketones to help with weight loss, and it does help, but I’ve always been a fan of ketones for the mental aspect of it. It just seems like ketones make me smarter, as I have a significant increase in mental clarity and a noticeable difference in Continue reading >>

A Startup Has Created A Performance-enhancing Bottled 'superfuel' — Here's What It's Like To Drink

A Startup Has Created A Performance-enhancing Bottled 'superfuel' — Here's What It's Like To Drink

HVMN Ketones could supercharge the body in a way unlike any other fuel source. HVMN, a startup based in San Francisco, is bringing to market a drink made of pure ketone ester that it says has performance-boosting qualities. We tried the drink before its public launch. HVMN, a startup building "human enhancement" technologies out of San Francisco, recently revealed that it is bringing one of the first commercial ketone esters to market. HVMN Ketone is an FDA-reviewed drink that claims to improve athletic ability, focus, and energy. The drink contains 120 calories, but it has no fat, protein, or carbohydrates. Those calories instead come from ketones — molecules formed by the breakdown of fat. Geoff Woo, cofounder and CEO of HVMN (pronounced "human"), likes to call ketones "the fourth macronutrient." "It's not a fat, it's not a protein, it's not a carb, but your body gets fuel from it," Woo told Business Insider. To make the product, HVMN leveraged more than a decade and $60 million worth of scientific research through an exclusive partnership with the University of Oxford. Brianna Stubbs, lead researcher at HVMN, joined a study on the effects of ketone esters in competitive rowers while a student-athlete at Oxford. The experienced inspired her to change her course of study from medicine to physiology. Stubbs remembered how the ketone ester made her feel during practice rowing sessions: "When you take it, you get to the red line and feel like you can go further. It's as you get to the end, when normally you'd run out of energy, it's as if you have this extra gear at the end." Stubbs holds a PhD around the science of ketones and two gold medals from the 2013 and 2016 World Rowing Championships. She resigned from the 2020 Tokyo Olympics to join HVMN. HVMN Ketone is availa Continue reading >>

Ketone Body Therapy: From Ketogenic Diet To Oral Administration Of Ketone Ester.

Ketone Body Therapy: From Ketogenic Diet To Oral Administration Of Ketone Ester.

Abstract Abstract Ketone bodies (KB), acetoacetate and β-hyroxybutyrate, were considered harmful metabolic by-products when discovered in the mid-nineteenth century in urine of patients with diabetic ketoacidosis. It took physicians many years to realize KB are normal metabolites synthesized by the liver and exported into the systemic circulation to serve as an energy source for most extrahepatic tissues. Studies have shown that the brain (which normally uses glucose for energy) can readily utilize KB as an alternative fuel. Even when there is diminished glucose utilization in cognition-critical brain areas, as may occur early in Alzheimer disease, there is preliminary evidence that these same areas remain capable of metabolizing KB. Because the ketogenic diet (KD) is difficult to prepare and follow, and effectiveness of KB treatment in certain patients may be enhanced by raising plasma levels to 4-8 mM, KB esters, such as 1,3-butanediol monoester of β-hydroxybutyrate and glyceryl-tris-3-hydroxybutyrate, have been devised. When administered orally in controlled dosages, these esters can produce plasma KB levels comparable to those achieved by the most rigorous KD, thus providing a safe, convenient, and versatile new approach to the study and potential treatment of a variety of diseases, including epilepsy, Alzheimer diesease, and Parkinson disease. Continue reading >>

Exogenous Ketones: What They Are, Benefits Of Use And How They Work

Exogenous Ketones: What They Are, Benefits Of Use And How They Work

Exogenous ketones have become a popular nutritional supplement since their introduction in 2014. Like with any new supplement, though, there tends to be a lot of misinformation that you have to sift your way through to find the reliable data. So, this article does the hard work for you and gets right to what the true benefits and drawbacks of exogenous ketones are. We also cover what forms of ketones to consider, how they function in the body, and their role in future research. What Are Ketones? Our bodies use ketones via our mitochondria to generate energy. They are an alternative fuel source to glucose. Ketones are simple compounds because of their small molecular structure and weight. Specifically, they are organic (carbon-based) compounds that contain a central carbon atom double-bonded to an oxygen atom and two carbon-containing substituents, denoted by “R” (see chemical structure below). In humans, there are 3 different ketones produced by the mitochondria of the liver. These are also often referred to as ketone bodies. The three ketones are: Acetone Acetoacetic Acid Beta-Hydroxybutyric Acid (also known Beta Hydroxybuyrate or BHB). Other chemical names include 3-hydroxybutyric acid or 3-hydroxybutyrate. BHB is not technically a ketone since it contains a reactive OH-group in place of where a double-bonded oxygen normally would be as you can see in the diagram below. Yet, BHB still functions like a ketone in the body and converts into energy much like acetoacetate and acetone. This happens via the acetoacetate and acetyl-CoA pathway. Note that acetone conversion to acetyl-CoA is not efficient due to the need to convert acetone to acetoacetate via decarboxylation. However, BHB still functions like a ketone in the body and can be converted to energy (via acetoace Continue reading >>

The Ketogenic Diet, Ketosis And Ketone Esters

The Ketogenic Diet, Ketosis And Ketone Esters

Please note: I was NOT paid to write this article NOR was I given the product in exchange for a review. I also have NO financial interest in this company NOR do I stand to benefit financially from sales of this product. In other words, I am in NO WAY affiliated with this company. There are NO affiliate links in this article. I received the product to sample at my own request. I am sharing my results here in hopes that others may benefit in some way. I Tried a Ketone Ester for the Very First Time and It Was Pretty Mind Blowing Even though I’m experienced at the ketogenic way of eating as well as extended fasting, I wondered what it would be like to be “instantly” transported to that magical level of deep ketosis without the lengthy process it normally takes to get there. Enter "ketone esters". But before I get into what ketone esters are and my experience sampling KetoneAid (a ketone ester), www.ketoneaid.com, let me back up just a bit and set the stage. What is Ketosis Dr. Joseph Mercola, www.mercola.com, defines ketosis as “a metabolic state in which your body burns fat rather than glucose as its primary fuel”. While some may define "ketosis" slightly differently, I believe Dr. Mercola hits the nail on the head, which would be further defined as endogenously creating ketones, meaning your body is producing them naturally through means of your dietary choices. What are Some Possible Benefits of Ketosis via Your Diet (Endogenous Ketones) Managing and preventing diabetes, healing insulin resistance and improving fatty liver disease Epilepsy treatment to control seizures May help with Alzheimers, Parkinsons and Cancer prevention Better hormone regulation Weight loss/weight management Increased mental focus Increased energy Decreased hunger and cravings These are Continue reading >>

All About Ketone Supplements!

All About Ketone Supplements!

Something new and emerging has finally hit the market. Something that is going to be a real game changer, that we have never seen before and, for a great amount of people, something that actually works. This supplement goes beyond assisting weight loss, that's merely a side effect to what therapeutic advantages it can offer. From slowing the progression of Alzheimer's, to decreasing inflammation and even controlling seizures and treating cancer patients. What if I told you it was possible to detect ketones in the blood and urine just 1 hour after ingesting a ketone supplement? Well, if you're like me you would probably dismiss it as too good to be true, like I initially did. But you would also be open minded and curious enough to read a little more about it before dismissing it entirely.... Right? Right. So real talk. You came here to find out what the deal is with this product I've been taking and thats just what I'm going to tell you. ​So lets get to it. This ketone product is whats referred to as an exogenous ketone. Exogenous meaning coming from an outside source as opposed what we're use to talking about, which are endogenous ketones that are formed by the body when diet is manipulated. These exogenous ketones are made up from β-hydroxybutyrate (aka BHB) and are often paired with sodium to act as a buffer since ketones are naturally acidic on their own. BHB Salt is a product of β-hydroxybutyrate, an organic compound that is extracted via acid hydrolysis, and then bonded with salt to create the base of the product you actually take. Once a little MCT oil (and flavor to mask the terrible taste) is added, it is packaged and shipped to you in a powder form to simply add to water and drink. Here's the long version of what BHB is: Beta-Hydroxybutyric acid (also known Continue reading >>

The Ketogenic Diet Now Comes In A Tiny Bottle, But Dietitians Are Skeptical

The Ketogenic Diet Now Comes In A Tiny Bottle, But Dietitians Are Skeptical

HVMN Don’t want to fast to try the ultra-trendy, high-fat, low-carb ketogenic diet? A San Francisco startup thinks you should take a shot of its elixir instead — even though the science behind it is dubious, experts say. The supplement company HVMN (that’s Silicon Valley-shorthand for “human”) unveiled its newest product on Monday: HVMN Ketone, a 2.3-ounce vial of a substance called ketone ester. It’s supposed to almost immediately put you in ketosis, a metabolic state where the body is forced to burn fats instead of carbohydrates. By loading the body with “an ultra-efficient form of fuel,” as the company says, it’s supposed to help you perform better in workouts and think more clearly. But even though HVMN says the drink is “proven to improve athletic performance and recovery,” nutrition experts say it is highly unlikely that a ketone supplement can single-handedly put you in ketosis. They also say there is little evidence that being in ketosis helps athletes. The public won’t get its first taste of it until next month. But registered dietitian Ben Sit is skeptical. “I have not yet found one ketone ester supplement that has been able to successfully put someone into the state of ketosis, no matter what dosage they take,” Sit, president of Evolved Sport and Nutrition, told BuzzFeed News. HVMN, formerly known as Nootrobox, is among a handful of consumer product startups that bill themselves as part of the loosely defined biohacking movement. Backed by tech venture capitalists, these companies, which include Bulletproof Coffee and Soylent, hawk food and supplements to busy, health-conscious people who have a quantify-everything mindset. HVMN, which raised $2 million in 2015 from Andreessen Horowitz (also a BuzzFeed investor), is best-known for Continue reading >>

To Ketone Or Not To Ketone: Mineral Salts

To Ketone Or Not To Ketone: Mineral Salts

Let me preface this article by stating that I am not affiliated, do not know any of these companies directly, and haven’t tested them in any way. Rather, due to the recent explosion of ketone supplements on the market, I wanted to cover the importance of considering mineral salt content of these supplements. Exogenous ketones are becoming more popular than ever as advancements in scientific research continue to show how they work to improve both health and performance. At first, the only options for delivering exogenous ketones were unpalatable ketone esters; however, now exogenous ketones can be taken in the form of ketone mineral salts that are easily blended and palatable in water. Making ketone mineral salts involves combining beta hydroxybutyrate (BHB) with mineral salts such as sodium, calcium, magnesium, or potassium. Before considering whether ketone supplements are a good option, most people immediately look at the salt load, and rightfully so. It is important to take into account the nutritional and health impact of not only the BHB, but to consider the minerals that are used to make the product. Although there is more current evidence on the effectiveness of ketone esters , ketone salt supplementation has the potential to provide additional benefits through the extra electrolytes/nutrients that are required to make the ketones. While ketone esters are expensive due to the manufacturing process involved in making them, ketone salts might be a more convenient option for both inducing a state of ketosis and elevating blood ketone levels for various reasons we will discuss separately. Let’s take a look at some of the facts and misconceptions about three of the minerals used to make ketone mineral salts: sodium, calcium, and magnesium. (Potassium is very hygro Continue reading >>

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