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Ketone Esters

New Important Article On Ketone Ester From Dr. Richard Veech Nih

New Important Article On Ketone Ester From Dr. Richard Veech Nih

A groundbreaking research study of a ketone ester in an Alzheimer’s mouse model was released for publication January 4, 2012, in Neurobiology of Aging by Yoshira Kashiwaya, M.D. and others in the laboratory of Dr. Richard L. Veech at the NIH in Rockville, Maryland. This study showed that, compared to animals fed a normal control diet, the Alzheimer’s model mice who were fed the ketone ester (D-beta-hydroxybutyrate-(R)-1,3-butanediol) had significantly less amyloid and tau protein that form the plaques and tangles in the Alzheimer’s brain, and the animals showed reduced anxiety, and improved learning and memory compared to the mice fed the control diet. The Alzheimer brain in people becomes resistant to insulin beginning at least ten to twenty years before symptoms appear and this affects the ability of the brain cells to use glucose causing them to malfunction and die. It was discovered in the late 1960’s in the laboratory of George Cahill, M.D. (now deceased) that the brain easily switches over to using ketone bodies as an alternative fuel during starvation when glucose supplies are used up. This new research is the culmination of decades of research that followed, and, for the first time, shows that ketones could lessen the changes that occur in the brain and also improve cognitive function in this disease. In addition to acting as an alternative fuel, ketones mimic some of the effects of insulin and are also anti-inflammatory. Inflammation is another key feature affecting the Alzheimer’s brain. Toxicity studies have already been conducted of the ketone ester in people showing there are no adverse effects and it has been approved by the FDA as “Generally Regarded as Safe (GRAS)”. Funding is now urgently needed to mass produce this ketone ester and conduc Continue reading >>

Avoid This Ketogenic Rip-off

Avoid This Ketogenic Rip-off

The Truth About Exogenous Ketones Ketones are all the rage among low carbers. And like most things in nutrition and performance, we've found a way to get them in supplement form so we don't have to do any actual work. What are ketones? They're a byproduct of ketosis caused by the process of converting fat to fuel. Your body makes them when it's in a calorie or carb restricted state. What do they do? The body and brain can use them as fuel without the presence of glucose in the blood. And now, you can take ketone supplements (salts and esters), known as exogenous ketones, without actually restricting anything. According to those promoting this nasty-tasting supplement, that means you can have a brain and body fuelled by ketones, along with all of the supposed health benefits that come with running on fat. Well, don't fall for it. Exogenous Ketones = Endogenous Fat Storage? The problem with ketone supplementation (EXOgenous) is that it's not even close to the same thing as being in ketosis (ENDOgenous ketone production). And just like the butter-blended-into-coffee trend, it's a farce. Ketones may be depressing dieters' hunger and giving them a hit of energy and cognitive enhancement, but it's INHIBITING their ability to burn fat, providing zero nourishment, and doing nothing for their metabolic health. There's an assortment of evidence suggesting that it's probably making things worse. Think of exogenous ketones kind of like alcohol. When they're consumed, everything is stored and nothing else is burned. So any lipolysis (fat burning) that would be taking place is halted; any glucose and fatty acids in your blood that were circulating are stored; and the ingested ketones are burned until there aren't any left. More importantly, this clearance of alternative fuels (glucos Continue reading >>

To Ketone Or Not To Ketone: Mineral Salts

To Ketone Or Not To Ketone: Mineral Salts

Let me preface this article by stating that I am not affiliated, do not know any of these companies directly, and haven’t tested them in any way. Rather, due to the recent explosion of ketone supplements on the market, I wanted to cover the importance of considering mineral salt content of these supplements. Exogenous ketones are becoming more popular than ever as advancements in scientific research continue to show how they work to improve both health and performance. At first, the only options for delivering exogenous ketones were unpalatable ketone esters; however, now exogenous ketones can be taken in the form of ketone mineral salts that are easily blended and palatable in water. Making ketone mineral salts involves combining beta hydroxybutyrate (BHB) with mineral salts such as sodium, calcium, magnesium, or potassium. Before considering whether ketone supplements are a good option, most people immediately look at the salt load, and rightfully so. It is important to take into account the nutritional and health impact of not only the BHB, but to consider the minerals that are used to make the product. Although there is more current evidence on the effectiveness of ketone esters , ketone salt supplementation has the potential to provide additional benefits through the extra electrolytes/nutrients that are required to make the ketones. While ketone esters are expensive due to the manufacturing process involved in making them, ketone salts might be a more convenient option for both inducing a state of ketosis and elevating blood ketone levels for various reasons we will discuss separately. Let’s take a look at some of the facts and misconceptions about three of the minerals used to make ketone mineral salts: sodium, calcium, and magnesium. (Potassium is very hygro Continue reading >>

Ketone Salts Vs Ketone Esters With Dr. Dominic D’agostino

Ketone Salts Vs Ketone Esters With Dr. Dominic D’agostino

Full Transcript: [3:19] Introduction [7:02] About Dr. Dominic D’Agostino [9:25] The Difference Between Ketone Esters and Ketone Salts [18:08] How Do They Commercialize the Ketones From Their Labs? [23:55&25:00&27:01] Three Unique Compounds and Others You Can “mix” with Ketones [29:00] What Occurs on a Physiological Level That Would Allow the Consumption of Branched Chain Amino Acids to Maintain Ketosis or Elevate It? [37:44] Sun in your Pocket – The Human Charger [39:17] Four Sigmatic [41:07] Why Some People Including Dr. Veech Believe Ketone Esters to be Dangerous and That MCT Oil Blocks Beta-Hydroxybutyrate Absorption or Utilization [47:50] Are There Any Evidence of People Experiencing Medical Issues with Using Ketone Salts or Esters? [60:05] Why Ephedrine Can Be Safely Used for Fat Loss and Dom’s Own Experience With It [65:40 & 1:05:41] Can You Combine Glucose with Ketones to Enhance Performance? [72:15] Why Esters are More Expensive Than Salts? Are There Ways to Make Either More Cost Effective? [1:12:14] Why are Ketone Esters More Expensive Than Ketone Salts? [1:28:40] End of Podcast Ben: Hey, you smart cookie, it’s Ben Greenfield. You better be a smart cookie because we put our propeller hats on in today’s episode with Dominic D’Agostino we get into ketosis. And speaking of ketosis as a nutritional therapy, I’m headed down to Vancouver in March and you should join me. March 3rd through the 5th. I’m speaking at this thing called the NTA Conference. Do you think I should keep you hanging on the edge of your seat wondering what NTA stands for? It’s actually Nutritional Therapy Association, you guessed it. They do therapy practitioner and consultant certifications meaning they teach people how to be nutritionists but it’s not like run of the mil Continue reading >>

The Ketogenic Diet, Ketosis And Ketone Esters

The Ketogenic Diet, Ketosis And Ketone Esters

Please note: I was NOT paid to write this article NOR was I given the product in exchange for a review. I also have NO financial interest in this company NOR do I stand to benefit financially from sales of this product. In other words, I am in NO WAY affiliated with this company. There are NO affiliate links in this article. I received the product to sample at my own request. I am sharing my results here in hopes that others may benefit in some way. I Tried a Ketone Ester for the Very First Time and It Was Pretty Mind Blowing Even though I’m experienced at the ketogenic way of eating as well as extended fasting, I wondered what it would be like to be “instantly” transported to that magical level of deep ketosis without the lengthy process it normally takes to get there. Enter "ketone esters". But before I get into what ketone esters are and my experience sampling KetoneAid (a ketone ester), www.ketoneaid.com, let me back up just a bit and set the stage. What is Ketosis Dr. Joseph Mercola, www.mercola.com, defines ketosis as “a metabolic state in which your body burns fat rather than glucose as its primary fuel”. While some may define "ketosis" slightly differently, I believe Dr. Mercola hits the nail on the head, which would be further defined as endogenously creating ketones, meaning your body is producing them naturally through means of your dietary choices. What are Some Possible Benefits of Ketosis via Your Diet (Endogenous Ketones) Managing and preventing diabetes, healing insulin resistance and improving fatty liver disease Epilepsy treatment to control seizures May help with Alzheimers, Parkinsons and Cancer prevention Better hormone regulation Weight loss/weight management Increased mental focus Increased energy Decreased hunger and cravings These are Continue reading >>

The Race To Make A Ketone Supplement

The Race To Make A Ketone Supplement

Two brilliant scientists are racing to be the first to commercialise exogenous ketones. The applications include athletic performance and metabolic therapies for CNS oxygen toxicity, epilepsy, and neurodegenerative diseases. In the red corner, Dr. Richard Veech, one of the greatest living minds in basic biochemistry. In the blue corner, the also brilliant renegade chemist Patrick Arnold. Stuck somewhere in the middle is superhuman researcher Dominic D’Agostino, associate professor in the department of molecular pharmacology and physiology at the University of South Florida, and a visiting research scientist at the IHMC. Patrick clearly has the head start, and I’ve been supplementing with his KetoForce and KetoCaNa products for over two years for bike races. Imagine my horror then when Dr. Veech appeared on the Bulletproof and Ben Greenfield podcasts to claim that Patrick’s racemic ketone salts were “harmful and inhibitory” and “a dumb for convenience of manufacturing”. Caution is warranted. A racemic mixture is one that includes both the D and L enantiomers. The source of the D and L labels was the Latin words dexter (on the right) and laevus (on the left). You may also have seen the labels R and S. R comes from rectus (right-handed) and S from sinister (left-handed). The physiological form of beta-hydroxybutyrate (BHB) is the D form. This is the same reason why Tommy would never recommend synthetic vitamins (vitamin E is a good example), because you get a racemic mixture and the inactive form tends to inhibit the more active form. L-BHB is also metabolised. BHB is not like the synthetic vitamins. Through some elegant radiotracer studies, Dr. Veech’s colleague Dr. Henri Brunengraber showed that the L-form is neither harmful nor inhibitory, and is also me Continue reading >>

Ketone Ester Review: What Are They, And Do They Work?

Ketone Ester Review: What Are They, And Do They Work?

It's an exciting day at the KetoConnect household! We finally got our hands on the first commercially available ketone ester! The only company currently making this stuff is KetoneAid and they were nice enough to send us a sample to try for ourselves. We have tried most of the exogenous ketone supplements on the market and have not been impressed, but this is something completely different. Exogenous Ketones - Salts VS Esters The difference is night and day. When supplementing with the current BHB Salts on the market the impact is negligible. Often I will feel absolutely nothing, where other times I will notice a small benefit in energy and focus. It turns out this is due to the small dose that all BHB Salts deliver. There is an upper limit to how much you can consume at a given time because the ketones are binded to a salt such as sodium, potassium or magnesium. Ketone Esters on the other hand have no limit. You can consume exponentially more at a given time, which leads to a dramatic increase in benefits. The difference is rather astonishing and has completely reversed my thoughts on supplementing ketones and the future of the ketone supplement market. The Taste - Yes...It's That Bad! While the taste is much improved from the original iteration of these ketone esters, it's still pretty terrible. I'd describe it as a mix between rubbing alcohol and what I imagine toilet cleaner would taste like, with a squeeze of lemon. I'm sure this will continue to improve over time, and while it is terrible I don't feel it makes the supplement too prohibitive. It's easy to justify a few minutes of discomfort for hours of increased productivity. We Monitored Our Ketone and Glucose Levels After choking down our respective drinks, we started monitoring our blood ketone and glucose leve Continue reading >>

The Truth About Bleeding-edge Ketone Esters

The Truth About Bleeding-edge Ketone Esters

Ketones are the future of food, says science. Use them today to supercharge stamina Tweet Share In an athlete’s eternal search for supercharged endurance, ketones may provide the answer. A 50ml shot provides 120 calories but contains no protein, fats or carbohydrate. Despite having none of the three macros, your body draws in a huge fuel hit from it, with some endurance athletes citing levels of energy never felt before. Could ketones be the fourth macro? MH investigates. Searing lungs and leg muscles leaden with lactic acid — taking your fitness up a step often means elevating your pain threshold to new heights. But it’s no longer necessary to beast your body in search of superior stamina. Clinicians at the University of Cambridge have been harnessing a new fuel source to be taken as a supplement: ketone esters. In rat studies, these organic chemicals increased both time to fatigue and mental sharpness over a snack of fat or carbs. Usually it takes the physiological stress of starvation to kickstart ketone production — a process called ketosis, whereby your body goes into ‘survival mode’, breaking-down internal fat stores to provide fast energy to muscles and mind. But now that we’re no longer hunting wooly mammoths, scientists are looking for an easier way to tap into this state. Though human trials are in their infancy, Oxford University recently tested a ketone-based drink on 39 cyclists. They found their supplement — a simpler form of its ester cousin, similar to the ‘bulletproof’ oils beloved by wellness biohackers — helped the body to switch from burning glucose for energy to fat, boosting riders’ performance during an endurance test by 400m. This could prove invaluable when you crash into the wall with the finish line in sight. While you Continue reading >>

Ketone Esters Boost Endurance In Elite Athletes: Study

Ketone Esters Boost Endurance In Elite Athletes: Study

Ketone esters, normally made by the liver as a back-up energy source when someone is observing a low-carbohydrate diet or fasting (state of ketosis), were shown to boost athletic performance, with cyclists riding 400m further over 30 minutes compared to control in one of the five study arms. That was a 2% improvement, significant in elite cycling terms. “We have demonstrated the metabolic effects of elevated circulating ketone bodies as a fuel and biological signal to create a unique physiological condition,”​ the researchers concluded. “Ketosis may alter substrate competition for respiration, while improving oxidative energy transduction under certain conditions, such as endurance exercise.”​ The single-blind, cross-over, randomised trial​​ published in Cell Metabolism​ involved 39 injury and illness-free professional or semi-professional, 18-40 year old, British resident mostly male (except two) rowers, cyclists or triathletes. "The ketone itself is inhibiting glycolysis, so that with the same exercise you're preserving glycogen and producing much less lactic acid - this hasn't been seen before,”​ said researcher, professor Kieran Clarke, professor of physiological biochemistry at Oxford University Department of Physiology, Anatomy & Genetics and CEO of UK ketone-focused start-up, TdeltaS. Previous research has been animal-based or remained unpublished. The researchers suggested the introduction of ketone esters provoked the performance-enhancing physiological shift - altering the "hierarchy of fuel selection"​ - to a state of or like ketosis. Other research has shown the body must be in a state of ketosis for a long period of time - perhaps months - before it would respond to the introduction of ketone esters and switch or moderate glucose and Continue reading >>

Exogenous Ketone Supplements: Review Of Current Products And Future Developments

Exogenous Ketone Supplements: Review Of Current Products And Future Developments

Exogenous ketone supplements hold promise for individuals looking to lose weight, improve their health and longevity, and enhance cognitive performance. In this article, we will dive into the history of exogenous ketone supplementation, the different forms of exogenous ketones that are available and what to look out for when choosing a supplement. The first installment of this two-part series, which can be found here, takes an in-depth look at what exactly exogenous ketones are and how they work. If you haven’t had a chance to read that yet, it is highly recommended you do so before continuing on with this installment. Before moving on, it’s necessary to clarify that beta-hydroxybutyrate (BHB) is the predominant ketone found in exogenous ketone supplements. Therefore, “BHB” supplement (i.e. beta-hydroxybutyrate supplements) is just another name for exogenous ketone supplement. The State of Exogenous Ketone Supplements Exogenous ketone supplements are somewhat new on the scene, with a select few companies manufacturing them for dietary use. The exogenous ketone products currently available on the market are BHB mineral salts (BHB with sodium and potassium to improve absorption). The term “BHB mineral salts” is synonymous with beta-hydroxybutyrate salts and ketone salts. There are also combination BHB supplements that include MCT (or other) oils. Exogenous ketone products come in either liquid or powder form. Timeline of Introduction of Ketone Supplements Exogenous ketone supplements have been in research & development since the early 2000s, but didn’t start making their way to the general public until late 2014. Ketoforce by Prototype Nutrition was the first to launch, followed up shortly thereafter by Pruvit’s Keto OS (and Keto OS Charged, a caffeinated Continue reading >>

Ketones For Optimal Cognitive Performance And Deep Ketosis

Ketones For Optimal Cognitive Performance And Deep Ketosis

I’ve previously written about some experiments I’ve conducted involving ketosis, from intermittent fasting to longer five-day fasts and caloric restriction, to help my body kick-start production of ketones. However, in these cases getting into ketosis involved a lot of work so I was looking for ways to shortcut/“hack” the process. In recent years, exogenous ketone supplements have become very popular. They elevate blood-ketone levels without having to eat large amounts of fats, follow (excessively carbohydrate-restrictive) ketogenic diets, or fast constantly. These ketones (beta-hydroxybutyrate) come in two forms, ketone salts and ketone esters: Ketone Salts: While the body uses and makes BHB ketones salts naturally, in supplement form ketone salts are synthetically (lab) made compounds that combine sodium (and/or potassium, calcium, or magnesium) with BHB. The salt is used to raise the pH and make things less acidic. Currently, all ketone supplements on the market are made from ketone salts. While they raise ketone levels, most people will only experience mild nutritional ketosis (~0.6-1.0 mmol/L). Ketone Esters: These are not normally found in the body, but exogenous ketone esters convert into BHB once it is in the body. They are also synthetically (lab) made compounds that link an alcohol to a ketone body, which can then be metabolized by the liver into a ketone. They are like ketone salts on steroids as they have 5-10 time more BHB per serving/maximum daily intake than ketone salts. To date, pure ketone esters have been very expensive to produce and have only been available to researchers, elite athletes (Tour de France cyclists), and the US Department of Defense (people have spent more than $20,000 to have an independent lab produce a single serving!). A re Continue reading >>

Ketone Ester Effects On Metabolism And Transcription

Ketone Ester Effects On Metabolism And Transcription

Go to: PRODUCTION OF KETONE BODIES Ketone bodies are formed in the liver from free fatty acids released from adipose tissue. As the blood concentration of free fatty acids increases, concentration of blood ketone bodies is correspondingly increased (1, 2). Ketone bodies serve as a physiological respiratory substrate and are the physiological response to prolonged starvation in man (3, 4), where the blood level of ketones reaches 5–7 mM (5). If the release of free fatty acids from adipose tissue exceeds the capacity of tissue to metabolize them, as occurs during insulin deficiency of type I diabetes or less commonly in the insulin resistance of type II diabetes, severe and potentially fatal diabetic ketoacidosis can occur, where blood ketone body levels can reach 20 mM or higher (2) resulting in a decrease in blood bicarbonate to almost 0 mM and blood pH to 6.9. Diabetic ketoacidosis, which is a pathological state, differs from the ketosis of prolonged starvation, which is a normal physiological state without known medical consequences. Elevation of blood ketones can however lead to elevation of blood uric acid, which can produce a gouty crisis. This can be prevented by feeding oral potassium citrate (6) Ketosis occurs during starvation in man. It occurs only with difficulty in species other than lactating cows where ketosis can occur due to the large requirement for lactose production in milk production. This form of ketosis can be treated by the administration of glucose. In this situation, ketosis occurs because of the competition for oxaloacetate, required for gluconeogenesis, where its shortage prevents acetyl-CoA in the liver from entering the Krebs cycle with a resultant increase in ketone body production (1). In vitro, ketone body production has been observed d Continue reading >>

The Ketogenic Diet Now Comes In A Tiny Bottle, But Dietitians Are Skeptical

The Ketogenic Diet Now Comes In A Tiny Bottle, But Dietitians Are Skeptical

HVMN Don’t want to fast to try the ultra-trendy, high-fat, low-carb ketogenic diet? A San Francisco startup thinks you should take a shot of its elixir instead — even though the science behind it is dubious, experts say. The supplement company HVMN (that’s Silicon Valley-shorthand for “human”) unveiled its newest product on Monday: HVMN Ketone, a 2.3-ounce vial of a substance called ketone ester. It’s supposed to almost immediately put you in ketosis, a metabolic state where the body is forced to burn fats instead of carbohydrates. By loading the body with “an ultra-efficient form of fuel,” as the company says, it’s supposed to help you perform better in workouts and think more clearly. But even though HVMN says the drink is “proven to improve athletic performance and recovery,” nutrition experts say it is highly unlikely that a ketone supplement can single-handedly put you in ketosis. They also say there is little evidence that being in ketosis helps athletes. The public won’t get its first taste of it until next month. But registered dietitian Ben Sit is skeptical. “I have not yet found one ketone ester supplement that has been able to successfully put someone into the state of ketosis, no matter what dosage they take,” Sit, president of Evolved Sport and Nutrition, told BuzzFeed News. HVMN, formerly known as Nootrobox, is among a handful of consumer product startups that bill themselves as part of the loosely defined biohacking movement. Backed by tech venture capitalists, these companies, which include Bulletproof Coffee and Soylent, hawk food and supplements to busy, health-conscious people who have a quantify-everything mindset. HVMN, which raised $2 million in 2015 from Andreessen Horowitz (also a BuzzFeed investor), is best-known for Continue reading >>

Incredible Fuel Could Treat Countless Diseases, If Only It Was Funded

Incredible Fuel Could Treat Countless Diseases, If Only It Was Funded

This could be as impactful as the discovery of penicillin That’s the first thing that comes to mind when learning about the history-altering work of NIH scientist (for over 45 years) Dr. Richard Veech, a man the general public has probably never heard of. Why haven’t you heard of him? Because he’s dedicated to science, not sales. So, what do scientists and entrepreneurs have in common? They both dedicate their lives to making a difference, discovering ways to make the world operate more effectively. But there’s an important cultural distinction between the two: Entrepreneurs’ success is tied to dollars, while scientists’ success is tied to discovery. Remember how penicillin altered history? We might be at that moment in history again, but with a “ketone ester” drink invented by Dr. Veech, that has insanely widespread uses. Imagine a drink that could treat Alzheimer’s, Parkinson’s, diabetes, epilepsy, concussions, heart failure, all while helping elite endurance athletes break world records. Then, imagine that it’s a formula perfected over decades, but only now ready in an era where genetics is sexiest of sciences, so this liquid goes underfunded and underproduced. It seems too good to be true, but it’s not. It’s real. Add to the issue of funding is an overly modest old scientist who said he would literally run if someone called him a hero for his work. Next, toss in imitation products that use salt-filled caffeinated versions of Dr. Veech’s decades old, already discarded work and you might be left very confused. If a breakthrough sports drink and patient treatment exists, would anyone even believe it? So what is this ketone ester? Ketones are human’s back up fuel system that kicks in when humans starve, or at least run out of sugar. The bod Continue reading >>

A Copd Patient’s Journey Into The World Of Ketone Esters!

A Copd Patient’s Journey Into The World Of Ketone Esters!

A few years ago, a movie came out called Limitless. This was a movie about a super pill that supercharged Bradley Cooper’s brain and made him superhuman. I remember watching that movie thinking, how far are we away from this movie being a reality? After my recent experience, I would say we’re almost there. Those of you who have followed my journey would know for the last 9 months I have been following a ketogenic diet, to see what effects being in a state of ketosis would have on my disease, COPD. Scientists have for some years been experimenting with producing supplements that will put you in a state of ketosis regardless of what your diet is. There is now a range of ketone supplements that can put you in a moderate range of ketosis. But what are the benefits of taking these supplements? Ketones are anti-inflammatory so the theory is being in ketosis lowers inflammation and can help treat many chronic diseases. It is also claimed being in ketosis improves cognitive function. So where is the science you ask? Scientists studying 23 elderly people with mild cognitive impairment showed a ketogenic diet improved verbal memory performance after 6 weeks compared to a standard high carbohydrate diet. In a double-blind, placebo-controlled study, 152 patients with mild- to moderate Alzheimer’s disease were given either a ketogenic agent or a placebo, while maintaining a normal diet. 90 days later, those receiving the ketogenic agent showed marked cognitive improvement compared to placebo, which was correlated with the level of ketones in the blood. The current range of ketone supplements I have tried put me in a moderate range of ketosis, between .5 – 1.5 millimolar (mM) depending on the dose. I do notice reduced symptoms for my disease when my blood ketones are over 1 m Continue reading >>

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