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Fig. 6. Ketolysis Pathway. Β -ohb: Β -hydroxybutyrate

Cognitive decline related to advancing age includes many sub-categories of diseases, some more or less well defined and understood. First, there is “normal” cognitive decline, which is gradual and progressive during aging and seems inevitable. When cognitive decline is large enough to disrupt the activities of daily life, a state of dementia is diagnosed. There are several types of dementia according to the etiology of cognitive decline: vascular dementia, which results from a circulatory disorder causing an obstruction of cerebral blood vessels which leads to the progressive degeneration of brain cells due to a lack of oxygen. Vascular dementia represents 20% of all cases of dementia. Lewis body dementia is an accumulation of α -synuclein protein within the cell and it represents 5 to 15% of neurodegenerative diseases. Frontotemporal dementia as the name suggests, is a degeneration of the region of the frontal and temporal anterior cortex. The reasons for this degeneration are not fully understood. Alzheimer's disease (AD) represents the majority of cases of dementia (65%) although its etiology is not known exactly, or rather multi-factorial. The most accepted theory in the m Continue reading >>

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Popular Questions

  1. _pickleliquor_

    A bit over a year ago I started noticing difficulties with speaking, occasionally. I'd often completely blank on a word and stop talking midsentence, and kept using one tense of a word when I meant to use another. I wasn't having any issues thinking or writing, just talking. I was being screened for some other neurological issues at the time and came back with a clean bill of health, so I just assumed this was the dreaded "brain fog" that was a consequence of living too many years as a diabetic or just my age catching up with me (I'm 27).
    I've been on keto about six months, and it recently occurred to me that my tense misuse had virtually disappeared. Went off of keto for a few days last week, and just like magic, it was back.
    Just thought it was an interesting anecdote, and I'm curious if anyone else has noticed similar effects. I never really got the noticeable sustained energy boost or mental clarity that a lot of people feel on keto, but it's clearly still doing something for me.

  2. IllConceivedIdeas

    The cells in your brain quite literally work using different systems when you're in ketosis to such an extent that it's being actively researched for possible use in combating alzheimers, bpd and autism disorders.
    It's incredible just how many things it changes and how little we truly know about what exactly is going on.

  3. IllConceivedIdeas

    btw, just how far off did you go? Was it a lot of carbs or just a few more than your limit? Was a lot of sugar involved? You don't have to answer, but I'd be curious to know if you think there was any more to it than simply not being in ketosis.

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