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High Frequency Of Diabetic Ketoacidosis At Diagnosis Of Type 1 Diabetes In Italian Children: A Nationwide Longitudinal Study, 2004–2013

This longitudinal population-based study analyses the frequency of diabetic ketoacidosis (DKA) at type 1 diabetes diagnosis in Italian children under 15 years of age, during 2004–2013. DKA was defined as absent (pH ≥ 7.30), mild/moderate (7.1 ≤ pH < 7.30) and severe (pH < 7.1). Two multiple logistic regression models were used to evaluate the time trend of DKA frequency considered as present versus absent and severe versus absent, adjusted for gender, age group and geographical area of residence at diagnosis. Overall, 9,040 cases were ascertained. DKA frequency was 40.3% (95%CI: 39.3–41.4%), with 29.1% and 11.2% for mild/moderate and severe DKA, respectively. Severe DKA increased significantly during the period (OR = 1.03, 95%CI: 1.003–1.05). Younger-age children and children living in Southern Italy compared to Central Italy were at significantly higher risk of DKA and severe DKA. Family history of type 1 diabetes and residence in Sardinia compared to Central Italy were significantly associated with a lower probability of DKA and severe DKA. The high frequency of ketoacidosis in Italy over time and high variability among age groups and geographical area of residence, str Continue reading >>

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Popular Questions

  1. Kalisiin

    Ketosis Versus Ketoacidosis

    Since much discussion has come up lately concerning Dr. Fung, Intermittent Fasting, and ketosis…I thought it would be timely to share this article I found explaining the difference between ketosis and ketoacidosis.
    New diabetics and even a few old hands seem to sometimes confuse these two things…even some doctors do!!
    Ketosis is safe, ketoacidosis can be a life-threatening condition. I might add that DKA, diabetic ketoacidosis happens much more frequently in Type 1 rather than Type 2 diabetics. Usually, you also need to have high BG readings to develop ketoacidosis, as I understand it.
    Anyway, my clinical knowledge is limited, and I certainly am not qualified to give medical advice, so I will just present the article as is.

  2. Gabby

    This really does help explain things a good bit. Once again, when we try to get things into any extreme, we end up out of balance.

  3. kidsclubkryse

    I tried to do ketosis because a friend mines father does it and it's work wonders, but it's very restrictive most things I can leave behind but I really really like oatmeal!! I'm still looking into it and I do find it promising lol!

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