Ketoacidosis Word Breakdown

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Essay: Diabetic Ketoacidosis

Introduction: Diabetic ketoacidosis, or DKA, is one of the most serious metabolic disorders seen in both human and veterinary medicine. A severe complication of diabetes mellitus, DKA is characterized by a more concentration of blood sugar, the presence of substances called ketones in the urine, and decreased concentrations of bicarbonate in the blood. Some dogs with DKA will be less affected but the majority will be seriously ill and may have severe complications such as neurological problems due to brain swelling, acute kidney failure, pancreatitis, and anemia. DKA will lead to death in many cases, but aggressive diagnostics and treatment can be life saving. DKA often develops in diabetes that had previously been unrecognized or untreated. Thus, it is essential to identify diabetes mellitus or the development of additional symptoms in a dog that is known to be diabetic to prevent DKA from occurring. Clinical Signs: Clinical signs include weight loss, lethargy, anorexia, and vomiting. Complications may include anemia, electrolyte abnormalities, neurological disorders, and acute renal failure. Symptoms: Some of the symptoms related to this disease are as follows; ‘ Increased thir Continue reading >>

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  1. Diamattic

    This may be a weird questions but i was comparing some blood work i had done in January 2011 (back before i had T1D) and the blood work that was conducted a couple days after i was admitted to the hospital. I have nothing in between those dates.
    I was admitted to the Emergency room with Diabetic Ketoacidocis, and they drew blood everyday but only on the first day did they do a full work up which included my cholesterol levels.. when i compare these numbers to what i had come back from the lab in 2011 i find quite a difference. The May 2014 numbers are much lower across the board then the Jan 2011 numbers.
    My question is - Is this change because i likely spent so much time undiagnosed and in which case they will likely go back up? or does DKA not really affect these numbers and thats just an accurate look at my levels these days?

  2. Diamattic

    Well, i kept searching and found this research paper - http://pubs.niaaa.nih.gov/publications/arh22-3/211.pdf
    It talks mostly about Alcohol use in diabetics, BUT it mentions DKA can occur tom alcohol abuse and then goes on to explain how that DKA can alter lipid metabolism, which isn't exactly what i was looking for BUT it does say that it can lower your LDL, and raise your HDL for a short period in which it will return to normal afterwards.. So maybe my levels were abnormally low but returned to where they were afterwards...
    SIDENOTE - This paper also mentions that in non-habitual drinkers having 2.5-5 standard alcoholic drinks occasionally can be beneficial to BS levels haha However, habitual drinking (i.e. - daily drinks) is a no-no..
    Does anyone know anything conclusive though, I am still wondering how much i can trust these numbers?

  3. pavlosn

    Ketosis based diets are known too rely on burning triglycerides for fuel instead of glucose of fuel, as well as to reduce LDL and increase HDL.
    DKA is effectively ketosis but on a more problematic scale. This time it is brought about not by a restriction in carbs and lowering of glucose but by a lack of insulin to transfer the glucose to the blood, I would expect both to have a similar effect on lipids.
    Where triglycerides significantly reduced after DKA?
    Not that DKA would ever qualify as a treatment for high cholesterol!

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