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Severe Ketoacidosis Associated With Canagliflozin (invokana): A Safety Concern

Case Reports in Critical Care Volume 2016 (2016), Article ID 1656182, 3 pages 1Section of Pulmonary and Critical Care Medicine, Providence Hospital and Medical Center, 16001 W 9 Mile Road, Southfield, MI 48075, USA 2Department of Internal Medicine, Providence Hospital and Medical Center, 16001 W 9 Mile Road, Southfield, MI 48075, USA Academic Editor: Kurt Lenz Copyright © 2016 Alehegn Gelaye et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Canagliflozin (Invokana) is a selective sodium glucose cotransporter-2 (SGLT-2) inhibitor that was first introduced in 2013 for the treatment of type 2 diabetes mellitus (DM). Though not FDA approved yet, its use in type 1 DM has been justified by the fact that its mechanism of action is independent of insulin secretion or action. However, some serious side effects, including severe anion gap metabolic acidosis and euglycemic diabetic ketoacidosis (DKA), have been reported. Prompt identification of the causal association and initiation of appropriate therapy shoul Continue reading >>

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Popular Questions

  1. c_washington

    Anyone have to use these? my MFM doc told me to get them but the pharmacy ordered glucose and protein... these don't test for ketones. I am going to return them tomorrow. Anyone have any suggestions for which brand to get and where to get them for not too much money? I see some on Amazon that are cheap and some that are expensive. What do you think?

  2. memali26

    I just check ketones, no proteins. I get my strips at any pharmacy - Walgreens, even Target has them. I think I paid about $11 for 50.

  3. c_washington

    memali26:

    I just check ketones, no proteins. I get my strips at any pharmacy - Walgreens, even Target has them. I think I paid about $11 for 50.
    yea, I have been checking ketones the whole pregnancy and I know those strips are widely available. Since I have type 1, our MFM doc is worried about pre-e so he wants me to test for protein and ketones everyday. I am looking for a combined strip.

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