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Ketoacidosis Pathophysiology

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Ketoacidosis Pathophysiology

Introduction Diabetic ketoacidosis Diabetic ketoacidosis is a serious, life threatening condition - successful treatment requires attention to metabolic consequences. Ketone production In the normal animal free fatty acids (FFA) are released from adipose tissue in the process of lipolysis and are used as fuel or assimilated by the liver in the presence of reduced insulin concentrations and increased glucagon concentrations. They are used to build triglycerides, metabolized in the tricarboxylic acid cycle or converted to ketone bodies. In the face of a relative or absolute insulin deficiency the cells are unable to uptake and utilize glucose. Ketone bodies can be used by peripheral tissues and the liver as an alternative source of energy and are therefore life-saving in the short-term. Production is normally carefully controlled by a homeostatic mechanism. If this balance is disturbed a number of processes are activated which together produce a decompensated state which inevitably progresses towards death unless averting action is taken. As the rate of ketone body production begins to exceed the rate at which they can be used, ketonemia develops with associated acidosis. Once the co Continue reading >>

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Popular Questions

  1. 2ndChance

    It's hard for me to describe the way I feel... I can feel the fat draining from my face, I become really aware of my thyroid's existence, I sort of feel like my body is attempting to figure out what bare minimum things it needs to survive, and then it starts burning everything else for fuel. This seems like a very good thing in the prevention of disease to me--when I think of cancer cells, I think of things that shouldn't exist. Cells in our bodies that shouldn't be there. Hopefully with a ketogenic diet, malicious extra cells will be the first to be burned? I can definitely tell that the primal way of life is better for me than any other eating/lifestyle plan I have ever followed. I haven't eaten since breakfast, and yeah, food sounds nice right now, but at the same time I'm mentally stable. I feel very aware of the realities being ignored by those around me, who eat SAD foods unquestioningly and never have the thought, "I am my body." Each time I fast I believe I become a more efficient beast, reduced to my essential self, my "essence," and free of unnecessary things. It's very meditative for me.
    What does it feel like to you?

  2. Paleobird

    To me it feels exceptionally awake and aware. I can feel my heart beating and hear my breath. I feel like I could chase down a woolly mammoth for dinner or run like hell to avoid being dinner for a saber toothed tiger.
    Keto-land has been my permanent home for a while now so this feeling has become the new normal. I wouldn't want to go back to life without it. This is why I wonder at all the people saying how the cookies at the office are such a "temptation", etc. I am not in the least tempted. Why would I want to leave this awesome place even temporarily? For a cookie? Why?
    Also being in ketosis for me means perfect seizure control on 25% less medication than before and I plan to cut that back further gradually. The medication I'm cutting back is a barbiturate so getting some of that out of my system is an added bonus.
    And I hope what you said about cancer cells is true as well. Five and a half years cancer free and planning to stay that way.

  3. Derpamix

    While I was in ketosis I felt like I was going to die. I was in more pain in ketosis than I was when I was stabbed in the stomach. Not even exaggerating.

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