Keto Physiological Insulin Resistance

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What is INSULIN RESISTANCE? What does INSULIN RESISTANCE mean? INSULIN RESISTANCE meaning - INSULIN RESISTANCE definition - INSULIN RESISTANCE explanation. Source: Wikipedia.org article, adapted under https://creativecommons.org/licenses/... license. Insulin resistance (IR) is a pathological condition in which cells fail to respond normally to the hormone insulin. The body produces insulin when glucose starts to be released into the bloodstream from the digestion of carbohydrates in the diet. Normally this insulin response triggers glucose being taken into body cells, to be used for energy, and inhibits the body from using fat for energy. The concentration of glucose in the blood decreases as a result, staying within the normal range even when a large amount of carbohydrates is consumed. When the body produces insulin under conditions of insulin resistance, the cells are resistant to the insulin and are unable to use it as effectively, leading to high blood sugar. Beta cells in the pancreas subsequently increase their production of insulin, further contributing to a high blood insulin level. This often remains undetected and can contribute to a diagnosis of type 2 diabetes or latent autoimmune diabetes of adults. Although this type of chronic insulin resistance is harmful, during acute illness it is actually a well-evolved protective mechanism. Recent investigations have revealed that insulin resistance helps to conserve the brain's glucose supply by preventing muscles from taking up excessive glucose. Insulin resistance should even be strengthened under harsh metabolic conditions such as pregnancy, during which the expanding fetal brain demands more glucose. People who develop type 2 diabetes usually pass through earlier stages of insulin resistance and prediabetes, although those often go undiagnosed. Insulin resistance is a syndrome (a set of signs and symptoms) resulting from reduced insulin action; it is also part of a larger constellation of symptoms called the metabolic syndrome. Insulin resistance may also develop in patients who have recently experienced abdominal or bariatric procedures. This acute form of insulin resistance that may result post-operatively tends to increase over the short-term with sensitivity to insulin typically returning to patients after about five days.

Physiological Insulin Resistance

I have been trying to find an answer to why my FBG levels have been increasing over the last couple of weeks. It is very frustrating and as a diabetic trying to reverse the disease it is scary (will this WOE work? Are the consequences of out of control diabetes, I am trying to escape, going to happen anyways?). I ran across a blog post that seems to describe what may be happening in my case. It is a possible phenomenon called Physiological Insulin Resistance. The High Blood Glucose Dilemma on Low Carb (LC) Diets If you are on a ketogenic or very low carb (VLC) diet (e.g. with 50-100gr carb/day and/or eating ketone producing MCT oils such as coconut oil), you m Low insulin levels activate hormone sensitive lipase. Fatty tissue breaks down and releases non-esterified fatty acids (NEFA). These are mostly taken up by muscle cells as fuel and automatically induce insulin resistance in those muscles. Palmitic acid is the primary NEFA released from human adipose tissue during fasting. Think of palmitic as a signal molecule to tell the muscles that inhibition of glucose uptake is needed and to tell the liver that increased gluconeogenesis is required because there is no food coming in. Th Continue reading >>

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  1. Gl0riousGr0uch

    Hello all, as i write this my arms are all jittery and i am very squirrely because i had a full cup of coffee. Is this normal after going on Keto? Before i would drink 2-3 cups a day and never once did i get all hyped up. Just enough to wake up and that about it. Now i drink a cup and i'm set for about 9 hours, until i get home and crash.
    I will adjust my drinking habits, but i was wondering if this was common with the rest of us Ketoers or if its just me.

  2. d00derman

    I actually call it "finally caffeine is doing its job". With carbs, the coffee would just be ineffective since the carbs would counter me with sluggishness. I'd enjoy the taste but never woke me up. Now I drink more, and I kick into high gear. To me it's great.

  3. MitsyMowler

    I agree with this 100%, I feel as though coffee serves me a purpose now.

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Ketoadaptation And Physiological Insulin Resistance

This is where the magic happens. Rat pups, fed a flaxseed oil-based ketogenic diet from weaning onward – note the drop-off in ketones after 2 weeks (Likhodii et al., 2002): Patient history: these rats have been “low carb” their whole lives. Side note: flaxseed oil is very ketogenic! (Likhodii et al., 2000): Flaxseed oil-based ketogenic diet produced higher ketones than 48h fasting; the same can’t be said for butter or lard. PUFAs in general are more ketogenic than saturated fats in humans, too (eg, Fuehrlein et al., 2004): Crisco keto (adult rats) (Rho et al., 1999): At this point, please just note the stunning consistency in the drop-off of ketones. Experiment 1 & 2 (above) are adult rats; they went through a period of high carb chow dieting, unlike experiment 3 and the rats in the first study, who were weaned onto ketogenic diets. Still same phenomenon: ~few weeks after initiation of ketogenic diet = breakpoint; ketones decline. Ketoadaptation: why do ketone levels decline? This happened in both rat studies above, Phinney 1983, and in many “n=1” practitioners. Possible explanation 1 (ketoadaptation): rat milk is kind of like a low carb diet; high in fat, but not low e Continue reading >>

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  1. Mark Simpson

    (edit: it's worth pointing out that "Ketosis " on it's own is not a bad thing, but Diabetic ketoacidosis is. I assume this is the point of the question)
    Diabetic Ketoacidosis comes from High (hyper) Blood Sugar not Low (Hypo). They could happen together, if you had high blood sugar for too long, the Ketoacidosis happened then you over treated the high and it went low. In this case you'd have 2 separate problems. Hypoglaycemia and Ketoacidosis. Low blood sugar will make you pass out and go into a coma eventually. Ketoacidosis is very painful and horrible to be part of. But I wouldn't say they increase each others danger very much.
    (i am a diabetic, not a medical professional)


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  2. Dennis Kitainik

    I'm not a doctor, but from what I know of diabetic conditions, both of these can be dangerous, and especially if they occur together (especially since ketosis would probably indicate serious hypoglycemia).

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Low Carbing And Physiological Insulin Resistance

Diabetes Forum The Global Diabetes Community Find support, ask questions and share your experiences. Join the community Low Carbing and Physiological Insulin Resistance On a T1 thread ( ), @azure , in past #35, you post: "I agree @Garr Eating a moderate level of carbs can give you a great HbA1C as long as you apply yourself. That way you also avoid the physiological insulin resistance that so,often comes with cutting out carbs and ketosis. You also usually don't need to bolus for protein when you have carbs with it. It's a total fallacy to say that LCHF is the only way to get good results. Controlling carbs, yes, but that doesn't mean you have to cut them out completely." I would be interested to learn what percentage of low carbers you believe develop physiological insulin resistance (PIR), as a result of the LC approach, and at what point they develop it? I started a new thread to prevent derailing the source thread, and think others could be interested too. For those reading who are T2 (or other non-insulin dependant members) who have not fully read the source thread, please note it is a T1 thread, so please do not post on there, unless you have something both relevant and on-t Continue reading >>

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  1. kattykat243

    I find it interesting to know benefits of specific diets. Everyone seems to argue about their diets. Keto is bad for you, go vegan. Vegan is bad for you etc. So I'm interested to know how has being on a Keto diet changed your life?

  2. anbeav

    11 years, I feel better than ever, honestly it's hard to describe in words, it's just part of the way I live and makes all the puzzle pieces fit together - sustained energy/concentration/focus, improved exercise performance, stable mood, stable hunger/satiety, fewer IBS symptoms, improved sleep, reduced sleep needs, "better health than any of my patients" - my doctor
    IMO - don't listen to what other people have to say and learn what works for you, you can be healthy eating many different "diets" but at the end of the day it's about what keeps you healthy (health metrics, sustainability, etc) not someone else

  3. zraii

    I always enjoy hearing your outlook.
    at the end of the day it's about what keeps you healthy
    Thanks for being such a great contributor to this community.

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