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Jardiance Dka

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Europe Agrees: Learn The Signs Of Atypical Dka In Patients Using Sglt-2s

European committee affirms benefits of SGLT-2s while urging healthcare providers to be vigilant and educate patients for signs and symptoms of atypical DKA. The FDA issued a warning back in 2015 about the risk of developing atypical diabetic ketoacidosis (DKA) in patients taking SGLT-2 inhibitors. Now, the European Commission has stepped in, as it has requested to have this class of medications reviewed by Pharmacovigilance Risk Assessment Committee (PRAC). PRAC is a European committee responsible for the safety of human medicine and makes recommendations for providing harmless and effective healthcare in Europe. In February of 2016, PRAC issued a review of sodium-glucose cotransporter 2 inhibitors, commonly known as SGLT-2 inhibitors. PRAC warns healthcare professionals about cases of DKA in patients who are on SGLT-2 inhibitor therapy. Patients could experience symptoms of DKA, but their glucose level might not be as high as usually seen in DKA, which would cause a delay in appropriate treatment of this life-threatening condition. However, PRAC did not state what would be the number that would indicate a possible case of atypical DKA. SGLT-2 inhibitors are approved only for type Continue reading >>

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  1. successful_great_guy

    I hear the experts say in interviews that a ketogenic diet is not for everyone. I recall D'Agostino saying 70-75% of people thrive on a ketogenic diet, but 25-30% do not. Do we have evidence-based examples of where keto does not work, is unhealthy, or is dangerous to one's health? There are clearly a multitude of anecdotal examples, but there are also a multitude of people who love eating sugar and won't make it past keto flu or who think they are doing keto when they're not (ex. low carb low fat) or eat the wrong things. Is there evidence either way on this?

  2. ShadedSpaces

    Well, I mean, I have no idea how one would create a PKU-friendly keto diet when everything like eggs, meat, fish, cheese, nuts, and dairy are best avoided.
    I can't imagine how someone with fat-intolerant IBS would be able to eat keto either. Or someone with one of the diseases that results in fat malabsorption.
    I don't think that conditions like these amount to a quarter of the population though. But we certainly have evidenced-based examples of people who are better off eating carbs. Feeding a traditional ketogenic diet to a kid with PKU would literally cause irreversible brain damage.

  3. saralt

    Dr. Noakes mentioned a number in the 10% range. The truth is that we just don't know yet how many people don't do well.

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Dr. Christopher Cannon discusses using JARDIANCE to Reduce Cardiovascular Death Risks in Adults with Type 2 Diabetes Guest Bio: Dr. Christopher Paul Cannon is a cardiovascular medicine specialist at Brigham and Womens Hospital (BWH) and a professor of medicine at Harvard Medical School (HMS). Dr. Cannon is the executive director of cardiometabolic trials at the Harvard Clinical Research Institute. Dr. Cannon earned his medical degree from Columbia University College of Physicians and Surgeons. He completed an internal medicine residency at New York-Presbyterian Hospital and a cardiology fellowship at BWH. Dr. Cannon is board certified in internal medicine. Segment overview: Dr. Christopher Cannon, discusses JARDIANCE, a treatment that can help reduce the risk of cardiovascular death in adults with type 2 diabetes and known cardiovascular disease. For more information about this interview, visit this link: http://healthprofessionalradio.com.au...

Will You Have Dka With Jardiance - From Fda Reports - Ehealthme

A study for a 48 year old woman who takes Botox NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk. You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088). If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. Continue reading >>

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  1. minnat3

    The IDEAL DIET Newsletter - April 2004
    http://www.theidealdiet.com/newslet...04WWZ/Apr04.htm
    (I don't know how many subscribe to this newsletter but it's free and often has good insights. There are a couple more articles at this link.)
    Hair Loss with Low Carb Diet
    "I started doing Atkins about 2 weeks ago. Why is my hair starting to fall out?"
    I received this question on the form at low-carb-diet-physician.com. My initial response was that a lack of vitamins can cause hair loss.
    Many people forget that Dr. Atkins recommends a variety of supplements to go along with his diet, because the vitamins you would normally get in fruits, vegetables and other foods are severely restricted. Whether you use the Atkins diet or not, I recommend a good multivitamin with minerals for everyone. An additional B-complex supplement can be helpful for the hair.
    After posting this response I had some emails from a few people who disagree, and they bring up a good point. Here is what one person had to say:
    "I strongly believe that low-carb (MEAT & FAT) is the way humans are designed to eat and would gladly eat nothing but protein with plenty of natural fat if it wouldn't slow my metabolism down. I have found in the past that eating unlimited amounts of protein tends to bring on hypothyroid symptoms. I think this is why many Atkins & Protein Power dieters complain of hair loss -- it's not because carbs are too low. Rather, it's because protein (unlimited) is too high.
    Broda Barnes MD who also advocates low-carb for hypothyroids states in his book that he had to quadruple his own thyroid meds when eating unlimited amounts of protein (mostly veal, hence also likely too lean). He then adapted the diet to limit protein to no more than 1 gram per kilogram of bodyweight. He also states that a study in the medical literature indicates that excessive amounts of protein use up thyroid hormone very quickly -- unfortunately, there was no foot-note reference. However, it's the only reasonable explanation for this hair-loss side-effect in connection with low-carbing that I've ever heard.
    The notion that it's the stress of losing weight is silly unless someone has lost 100 pounds; the notion that it's a vitamin deficiency is also silly because it's happened to low-carbers who take copious amounts of vitamin supplements; the notion that it's because of ketosis is also silly because obese people have plenty of stored body fat to use for fuel. Therefore, I believe that Broda Barnes is onto something when he mentions the unlimited protein as potentially creating metabolic problems. Also, given that so much meat in the US is trimmed down and skinless chicken breasts abound, it is very easy to eat tons of protein without sufficient fat".
    I have not seen any studies indicating that excess amounts of protein lower thyroid levels, but studies have shown that carbohydrate restriction does have this effect. Studies on dieters who stopped losing weight showed that a carbohydrate-free diet produced a 21 percent decline in RMR (resting metabolic rate), as well as a decrease in circulating T3 (the active thyroid hormone) and insulin. When carbohydrate was added, keeping the same caloric intake, RMR rose toward baseline, and weight loss continued. This was accompanied by a rise in serum T3, but not insulin.
    This study shows that you cannot discount the effect of carbohydrate restriction on thyroid function and weight loss plateau. I have noted this with many of my patients, and find that weight loss is more consistent when carbs are not eliminated from the diet. This is why I designed the Metabolic Switch diet, which uses carbs to "stimulate the metabolism" while still allowing the low-carb aspect of the diet to encourage fat burning. This carb intake apparently keeps the T3 levels from dropping.
    My patients have not complained of hair loss or other symptoms consistent with low thyroid levels, and I did not realize it was a common complaint with the Atkins and Protein Power diets.
    As for high protein intakes being responsible for decreased T3 levels, I have not seen any studies on this. The recommended intake of protein on a typical diet is 0.8 grams per kilogram of body weight (pounds divided by 2.2 equals kilograms). When using a low carb diet, the body converts some protein to glucose for its essential needs, so additional protein should be consumed to provide for this, in order to avoid losing muscle mass.
    The chart in DIET TRUTHS REVEALED indicates the minimum daily protein intake based on weight in pounds, while using a low carb diet. In some weight ranges this will calculate at up to 1.2 grams per kilogram. In the IDEAL DIET I do not place a maximum limit on protein, so more than this amount can be consumed.
    Based on Dr. Barnes' observations, if you are stalled in your weight loss you should calculate your protein intake and keep it in the range given in the chart for your corresponding weight. Remember that as you lose weight your protein needs will be less, so check the chart frequently during weight loss. Replacing excess protein in your diet with fat is reasonable.
    It really is not silly that the metabolism would decrease while a person is in ketosis. Even when a lot of body fat remains for fuel, the body does not want to keep burning it. It is very common that persons on very low carb diets stop losing weight and even have trouble staying in ketosis because the metabolism decreases, probably due to decreased T3 levels. People who have lost weight and then regained it may have this occur quite rapidly when they diet again.
    My recommendation to eat carbs does not mean that carbohydrate intake is necessary for humans. Carbs are not necessary but glucose is, and the body converts protein to glucose for its essential needs. However, this requires energy input, while carbs give the body easy and rapid fuel. The body's response to losing energy - both in weight loss and in converting protein to glucose - is to decrease its metabolic rate in order to save its fat stores.

  2. Kristine

    Interesting, but I strongly disagree that hair loss is common. At most, I'd say it's occasional. I wonder if this person inquired about the soy content in her patients' menus. Between protein shakes, Atkins bars, etc; it can add up really fast. Soy is a known thyroid "mucker-upper".

  3. DianaO

    I disagree about the hairloss though. This can happen with an drastic change in a diet, whether dropping calories or carbs.

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TORT LAW TEAM ... www.tortlawteam.com helps you to get financial compensation you deserve! This video about invokana, invokamet diabetes medicine side effects and lawsuit. If you or your loved one taken invokana, canagliflozin, diabetes medicine and faced side effect, ketoacidosis, oversee glucose, kidney failure, unsaturated fats, You may eligible to get the financial compensation. Learn More at: http://www.tortlawteam.com/ an antidiabetic drug for treatment of Type 2 diabetes. It is an individual from the new SGLT2 class of antidiabetic solution that additionally incorporates empagloflozin (Jardiance) and dapagliflozin (Farxiga). Canagliflozin is additionally sold in mix with metformin under the brand name Invokamet. invokana and Invokamet are made and advertised in the U.S. by Janssen pharmaceuticals which is a backup of Johnson and Johnson, one of the biggest pharmaceutical organizations on the planet with income of over $74 billion every year. invokana was affirmed in 2013 as the first SGLT2 (sort 2 sodium-glucose co-transporter) inhibitor. As it works uniquely in contrast to other hostile to diabetes pharmaceuticals available, it was wanted to be helpful for patients who did not react well to other drug. Sadly, numerous drugs for Type 2 diabetes have created genuine medicinal harm. The SGLT2 class rooftop solutions has been embroiled in a higher-than-ordinary advancement of diabetic ketoacidosis, an existence undermining condition. Learn More at: http://www.tortlawteam.com/ How to Dangerous of Using invokana, diabetes medicine invokana works by setting off the kidneys to discharge overabundance blood glucose through the urine. It is demonstrated for treatment of patients with Type 2 diabetes, which cant be controlled through eating regimen and activity. It is not to be endorsed to those with Type 1 diabetes or for treatment of diabetic ketoacidosis. Diabetic ketoacidosis happens when the body does not have enough insulin to oversee glucose levels. The body starts smoldering unsaturated fats, which brings about a waste item called acidic ketone bodies. These ketones are what trigger the indications of ketoacidosis. Those side effects incorporate spewing, parchedness, disarray, weakness, and stomach torment. In uncommon cases, untreated ketoacidosis can bring about trance state and even passing. While no passings have been accounted for with the utilization of invokana or Invokamet, the risk exists. Learn More at: http://www.tortlawteam.com/ About Invokana Lawsuits A conceivably deadly reaction of Invokana may prompt claims against a modest bunch of medication producers. The pharmaceutical treats Type 2 diabetes yet triggers hazardous levels of blood acids, which drove the FDA to sound an alert about the medications. Dont forget to fill the Medicine Healthcare Survey 2017 Nationwide USA at survey.tortlawteam.com Thank you and Have a nice day. www.tortlawteam.com .....................!

Jardiance, Invokana, And Farxiga Double Risk Of Diabetic Ketoacidosis

Jardiance, Invokana, And Farxiga Double Risk Of Diabetic Ketoacidosis The June 8, 2017 edition of The New England Journal of Medicine (NEJM) has a To the Editor letter, titled Risk of Diabetic Ketoacidosis after Initiation of an SGLT2 Inhibitor, which is likely causing some concerns among doctors and type 2 diabetes (T2D) patients. It is about the safety of Jardiance, Invokana, Farxiga, and other diabetes medicines in the SGLT2 inhibitor class of diabetes drugs. A June 7, 2017 MedPage Today article, Study Warns of Diabetic Ketoacidosis With SGLT2 Inhibitors in T2D, provides a summary and some commentary about the recent medical study which is described in this June 2017 NEJM letter to the editor: The newest class of drugs for treating type 2 diabetes carries a greater risk for diabetic ketoacidosis compared to other classes of drugs, a new study suggests. Newly initiated use of an SGLT2 inhibitor was associated with a roughly twofold greater risk of diabetic ketoacidosis versus new initiation of a DPP4 inhibitor (HR 2.2, 95% CI 1.4 to 3.6), according to Michael Fralick, MD, of Brigham and Womens Hospital, and colleagues. It is important to know that if diabetic ketoacidosis (DKA) Continue reading >>

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  1. m

    I talked with a friend about some symptoms of pre-eclampsia and she recommended that I test protein in my urine with ketostix. You just hold them under the stream while you pee and it shows up or doesn't. Well, I got a "small" amount positive, which is the second level (first is "trace") so I called my dr. and they want me to come in and do some tests at the local hospital tomorrow.

    Please send good vibes, if you can. I'm supposed to go visit my family out-of-state on Monday, and I don't want the dr. to tell me I can't go. (Even though I will do what dr. says to keep the baby safe.)

    Has anyone else gotten a small positive and been fine???

  2. ashtinbraedy

    I don't know what ketostix has to do with it. My friend used them to help lose weight..? Lol.

    Hope you're ok! I'd love to know more about how they relate if you're aware! Keep us updated xx

  3. mpls_rw

    Ketostix measures protein output in the urine. It's used by dieters to see if they're burning lots of fat (protein) especially if they're on a low-carb diet. But for pregnant mamas with high blood pressure, if there's too much protein in the urine it's a sign that our kidneys/other organs aren't doing well so it can be a tip-off to pre-eclampsia. I'm definitely not on a diet! LOL

    Thank you for your response, and I will let you know how it goes! :)

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