Metformin For Gestational Diabetes - What It Is And How It Works
In the UK it is common to use Metformin for gestational diabetes where dietary and lifestyle changes are not enough to lower and stabilise blood sugar levels. It is widely used to help lower fasting blood sugar levels as well as post meal levels. Metformin is an oral medication in tablet form. It is used in diabetics to help the body use insulin better by increasing how well the insulin works. In pregnancy it can be used in women who have diabetes before becoming pregnant (Type 2 diabetes) and in women who develop diabetes during pregnancy (gestational diabetes). Metformin is also used for other conditions too, commonly used in those that have PCOS (polycystic ovarian syndrome). Metformin is a slow release medication. Here are the most commonly asked Q&A on Metformin for gestational diabetes from our Facebook support group Why do I need to take Metformin? For many ladies with gestational or type 2 diabetes, if lower blood sugar levels cannot be reached through diet and exercise then medication will be required to assist. If blood sugar levels remain high, then the diabetes is not controlled and can cause major complications with the pregnancy and baby. Some consultants will prescribe Metformin on diagnosis of gestational diabetes on the basis of your GTT results. Others will let you try diet control first and when blood glucose levels rise out of target range, or close to the target range, they may prescribe Metformin as a way to help lower and control your levels. NICE guidelines regarding the timing and use of Metformin for gestational diabetes 1.2.19 Offer a trial of changes in diet and exercise to women with gestational diabetes who have a fasting plasma glucose level below 7 mmol/litre at diagnosis. [new 2015] 1.2.20 Offer metformin to women with gestational dia Continue reading >>
Fda Drug Safety Communication: Fda Revises Warnings Regarding Use Of The Diabetes Medicine Metformin In Certain Patients With Reduced Kidney Function
[ 4-8-2016 ] The U.S. Food and Drug Administration (FDA) is requiring labeling changes regarding the recommendations for metformin-containing medicines for diabetes to expand metformin’s use in certain patients with reduced kidney function. The current labeling strongly recommends against use of metformin in some patients whose kidneys do not work normally. We were asked1,2 to review numerous medical studies regarding the safety of metformin use in patients with mild to moderate impairment in kidney function,3-14 and to change the measure of kidney function in the metformin drug labeling that is used to determine whether a patient can receive metformin. We have concluded our review, and are requiring changes to the labeling of all metformin-containing medicines to reflect this new information. Health care professionals should follow the latest recommendations when prescribing metformin-containing medicines to patients with impaired kidney function. Patients should talk to their health care professionals if they have any questions or concerns about taking metformin. Metformin-containing medicines are available by prescription only and are used along with diet and exercise to lower blood sugar levels in patients with type 2 diabetes. When untreated, type 2 diabetes can lead to serious problems, including blindness, nerve and kidney damage, and heart disease. Metformin-containing medicines are available as single-ingredient products and also in combination with other drugs used to treat diabetes (see FDA Approved metformin-containing Medicines). The current drug labeling strongly recommends against metformin use in some patients whose kidneys do not work normally because use of metformin in these patients can increase the risk of developing a serious and potentially dead Continue reading >>
Can Metformin Help With Weight Loss?
Metformin is a drug prescribed to manage blood sugar levels in people with type 2 diabetes. You may have heard that metformin can also help you lose weight. But is it true? The answer is a resounding maybe. Here’s what you should know about what metformin can do for weight loss, as well as why your doctor may prescribe it for you. According to research, metformin can help some people lose weight. However, it’s not clear why metformin may cause weight loss. One theory is that it may prompt you to eat less by reducing your appetite. It may also change the way your body uses and stores fat. Although studies have shown that metformin may help with weight loss, the drug is not a quick-fix solution. According to one long-term study, the weight loss from metformin tends to occur gradually over one to two years. The amount of weight lost also varies from person to person. In the study, the average amount of weight lost after two or more years was four to seven pounds. Taking the drug without following other healthy habits may not lead to weight loss. Individuals who follow a healthy diet and exercise while taking metformin tend to lose the most weight. This may be because metformin is thought to boost how many calories you burn during exercise. If you don’t exercise, you likely won’t have this benefit. In addition, any weight loss you have may only last as long as you take the medication. That means if you stop taking metformin, there’s a good chance you will return to your original weight. And even while you’re still taking the drug, you may slowly gain back any weight you’ve lost. In other words, metformin may not be the magic diet pill some people have been waiting for. It has been shown to reduce weight in some, but not others. One of the benefits of metformin Continue reading >>
Diabetes: Metformin Still First Choice, With Redefined Cutoffs For Use
As the number of patients diagnosed with diabetes each year continues to rise, pharmacists are intervening in their care in monumental ways. Pharmacists are often asked by patients to help them navigate the numerous medication choices available, manage comorbidities, and determine a treatment plan that works for them financially. Recent publications and industry updates can help clinicians provide the best care for their patients with diabetes. The American College of Physicians (ACP) updated the 2012 guideline on the oral pharmacologic treatment of type 2 diabetes in adults. The authors compared different arrangements of monotherapies, monotherapy and combination therapy, and combination therapies of five drug classes: biguanide, thiazolidinediones, sulfonylureas, dipeptidyl peptidase-4 (DPP-4) inhibitors, and sodium–glucose cotransporter-2 (SGLT-2) inhibitors. “This guideline includes a place in therapy for the newer agents,” said Teresa H. Truong, PharmD, BCPS, CDE, assistant professor at University of Oklahoma College of Pharmacy in Oklahoma City, in an interview with Pharmacy Today. “Now, it gives you more second-line options.” Using meta-analysis outcomes, the guideline authors evaluated the comparative effectiveness of oral medications. The results provided evidence for two recommendations: Metformin should be prescribed to patients with type 2 diabetes when pharmacologic therapy is needed to improve glycemic control. Consider adding a sulfonylurea, thiazolidinedione, SGLT-2 inhibitor, or DPP-4 inhibitor to metformin to improve glycemic control when a second oral therapy is considered. The authors attempted to examine long-term all-cause mortality, microvascular, and macrovascular outcomes, but because of the short duration (≤ 1 year) or the low quali Continue reading >>
(sitagliptin And Metformin Hcl) Tablets Or
JANUMET tablets contain 2 prescription medicines: sitagliptin (JANUVIA®) and metformin. Once-daily prescription JANUMET XR tablets contain sitagliptin (the medicine in JANUVIA®) and extended-release metformin. JANUMET or JANUMET XR can be used along with diet and exercise to lower blood sugar in adults with type 2 diabetes. JANUMET or JANUMET XR should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had pancreatitis (inflammation of the pancreas), it is not known if you have a higher chance of getting it while taking JANUMET or JANUMET XR. Selected Risk Information About JANUMET and JANUMET XR Metformin, one of the medicines in JANUMET and JANUMET XR, can cause a rare but serious side effect called lactic acidosis (a buildup of lactic acid in the blood), which can cause death. Lactic acidosis is a medical emergency that must be treated in a hospital. Call your doctor right away if you get any of the following symptoms, which could be signs of lactic acidosis: feel cold in your hands or feet; feel dizzy or lightheaded; have a slow or irregular heartbeat; feel very weak or tired; have unusual (not normal) muscle pain; have trouble breathing; feel sleepy or drowsy; have stomach pains, nausea, or vomiting. Most people who have had lactic acidosis with metformin have other things that, combined with the metformin, led to the lactic acidosis. Tell your doctor if you have any of the following, because you have a higher chance of getting lactic acidosis with JANUMET or JANUMET XR if you: have severe kidney problems or your kidneys are affected by certain x-ray tests that use injectable dye; have liver problems; drink alcohol very often, or drink a lot of alcohol in short-term “binge” drinkin Continue reading >>
'can I Take Metformin If I Want To Lose Weight?'
Metformin is a drug designed to treat patients with Type 2 diabetes, but it comes with an interesting side effect: weight loss. And Reddit is filled with stories from people who have lost weight on the drug. “Was trying to lose weight for a long time with no success,” one person wrote of being prescribed metformin. “I’m on 1000 mg a day and am down 10 pounds.” “I saw weight loss at first with 500 mg twice per day,” another wrote. “The difference was almost immediate.” While some people say the drug didn’t do much for them, others swear by it—even those that don’t have Type 2 diabetes, says Fatima Cody Stanford, M.D., an instructor of medicine and pediatrics at Harvard Medical School and obesity medicine physician at Massachusetts General Hospital. In fact, Cody Stanford says that she often prescribes the medication to overweight or obese people who don't have Type 2 diabetes. Here’s what you need to know about the drug. (Hit the reset button—and burn fat like crazy with The Body Clock Diet!) How It Works Metformin causes a decrease in the release of glucose from a person’s liver. This helps to lower a person’s blood sugar when it’s too high and restore the way someone uses food to make energy, according to the Mayo Clinic. "Weight loss can occur because it decreases appetite in some people who take it," says women's health expert Jennifer Wider, M.D. In order for the prescription to work effectively, the amount of metformin you take must be balanced against your diet and exercise because it helps level out your blood sugar, the clinic says. For that reason, if you change your diet or exercise, you doctor may need to change the amount of metformin you take. Check out these moves that can help you light those calories up! Can It Help You Continue reading >>
What Is Metformin?
MORE Metformin is a prescription drug used primarily in the treatment of Type II diabetes. It can be used on its own or combined with other medications. In the United States, it is sold under the brand names Fortamet, Glucophage, Glumetza and Riomet. "Metformin is very often prescribed as the first step in a diabetic's regime," said Ken Sternfeld, a New York-based pharmacist. How it works "When you're diabetic you lose the ability to use the insulin you need to offset the food," Sternfeld explained. "If you eat a carb or sugar that can't be metabolized or offset by the insulin you produce, your sugar levels will be higher. Metformin and drugs in that category will help your body better metabolize that food so that insulin levels will be able to stay more in line." Metformin aims to decrease glucose production in the liver, consequently lowering the levels of glucose in the bloodstream. It also changes the way that your blood cells react to insulin. "It makes them more sensitive to insulin," said Dr. Stephen Neabore, a primary care doctor at the Barnard Medical Center in Washington, D.C. "It makes the same amount of insulin work better. It transports the insulin to the cells in a more effective way." Metformin may have a preventive health role, as well. New research presented at the American Diabetes Association 2017 Scientific Sessions showed that long-term use of metformin is particularly useful in preventing the onset of type II diabetes in women who have suffered from gestational diabetes. Because metformin changes the way the body uses insulin, it is not used to treat Type I diabetes, a condition in which the body does not produce insulin at all. Metformin & PCOS Metformin is sometimes prescribed to treat polycystic ovarian syndrome (PCOS), according to Neabore. "I Continue reading >>
Pcos: Insulin And Metformin
Young women with PCOS often have elevated insulin levels and are more likely to develop diabetes. Metformin is a medication often prescribed for women with PCOS to help prevent diabetes. A lifestyle that includes healthy nutrition and daily exercise is the most important part of a PCOS treatment plan. What is insulin? Insulin is a hormone made by an organ in the body called the pancreas. The food you eat is broken down into simple sugar (glucose) during digestion. Glucose is absorbed into the blood after you eat. Insulin helps glucose enter the cells of the body to be used as energy. If there’s not enough insulin in the body, or if the body can’t use the insulin, sugar levels in the blood become higher. What is insulin resistance? If your body is resistant to insulin, it means you need high levels of insulin to keep your blood sugar normal. Certain medical conditions such as being overweight or having PCOS can cause insulin resistance. Insulin resistance tends to run in families. What can insulin resistance do to me? High insulin levels can cause thickening and darkening of the skin (acanthosis nigricans) on the back of the neck, axilla (under the arms), and groin area. In young women with PCOS, high insulin levels can cause the ovaries to make more androgen hormones such as testosterone. This can cause increased body hair, acne, and irregular or few periods. Having insulin resistance can increase your risk of developing diabetes. How can I lower my insulin levels? You can help lower your insulin levels naturally by eating fewer starches and sugars, and more foods that are high in fiber and low in refined carbohydrates. Low glycemic foods, on the other hand, don’t raise your blood sugar or insulin levels as much as foods that are high in sugar or refined carbohydr Continue reading >>
Why Good Doctors No Longer Prescribe Metformin
Until recently, diabetics looking for doctor-approved, drug-free treatment options were out of luck. But a growing number of health experts believe those days are behind us. Dr. Marlene Merritt (LAc, DOM(NM), MS Nutrition), an Austin-based doctor who used to suffer high blood sugar herself, made a recent announcement that is sending shockwaves through the medical community. Dr. Merritt knew all too well that commonly-prescribed diabetes drugs like Metformin came with a host of unwanted side effects, and was determined to find a natural, drug-free solution that could actually eliminate the disease, not just treat its symptoms. After months of research, Dr. Merritt developed a simple diet and exercise regimen that had a profound success rate in treating and even reversing type II diabetes. Despite the regimen’s clear effectiveness, medical journals were slow to publish her findings, perhaps due in part, some have speculated, to financial ties to the pharmaceutical industry. In response, Dr. Merritt took matters in to her own hands and shocked the medical community by partnering with independent health publisher Primal Health to make her diabetes-reversing regimen available to everyone in the form of an online presentation. Several viewers have noted the simplicity of the regimen, along with how non-restrictive the diet sounds. Unsurprisingly, many in the pharmaceutical industry have taken issue with the presentation’s drug-free emphasis, but many doctors who have wished for a natural, drug-free treatment to share with their diabetic patients have been quick to embrace it. Dr. Merritt herself cautions viewers to exercise common sense and only go off your medication with the approval of your doctor. Never underestimate the influence you have on those around you. Your wo Continue reading >>
Metformin And Type 1 Diabetes – An Experiment
Metformin is not usually prescribed for Type 1 diabetes, but over the past couple years, inspired in part by Mike’s experience on it (see here, here, here and here), I’ve become interested in trying it. Not only has it been in widespread use as a treatment for Type 2 diabetes since its approval in 1994, but it’s currently being investigated for potential cognitive and anti-cancer benefits as well. As Mike has asked, “Could metformin be the new aspirin?” The typical explanation for why metformin is not prescribed to people with Type 1 diabetes is that metformin increases your insulin sensitivity — and given that, by definition, people with Type 1 don’t make any insulin, it won’t help them. But I see two obvious holes in that logic. First, people with Type 1 diabetes do have insulin in their bodies; it’s just administered in a different way (i.e. injected subcutaneously, rather than secreted by the pancreas). And as anyone who’s struggled with the dawn phenomenon knows, people with Type 1 diabetes experience insulin resistance, too. And second, metformin does more than just affect insulin sensitivity. It also appears to regulate the genes responsible for causing the liver to release glucose into your blood. As you may know, your pancreas and your liver work closely together to maintain a proper level of glucose in the blood. When you’ve got a lot of glucose in your blood, your pancreas secretes insulin to remove it (provided you don’t have Type 1 diabetes!). And when you don’t have sufficient external glucose – like when you’re sleeping — your liver releases some stored glucose so that your blood sugar does not drop too low. To put this a different way, insulin is what keeps a non-diabetic person’s blood glucose from getting too high; the Continue reading >>
Why Am I Taking Metformin?
I was controlling my blood sugar with regular insulin injections, so why did my doctor add metformin during my last visit? Conditions Expert Chief Medical Officer, American Cancer Society Type 2 diabetes mellitus is a disease that can initially show no symptoms. Eventually very high blood sugars cause symptoms of blurred vision, increased urination, and increased thirst. The long-term effects of diabetes, especially uncontrolled diabetes, can include cardiovascular disease, heart attack and stroke, peripheral vascular disease, and kidney disease. In type 2 diabetes, the cells of the muscles and organs of the body have difficulty bringing blood sugar, which is also called blood glucose, inside to use as fuel for metabolism. Insulin's normal function is to help bring sugar into the cell, and the problem is these cells have what is called insulin resistance. The body's response to insulin resistance is to increase the amount of insulin secreted by the pancreas. Over time, higher and higher amounts of insulin are secreted to overcome insulin resistance. Eventually the blood sugar levels rise higher than normal despite the high levels of circulating insulin. Type 1 diabetes differs from type 2 diabetes in that type 1 is a disease in which the pancreas stops producing insulin. The initial treatment of mild type 2 diabetes mellitus is lifestyle intervention. This usually consists of diet modification, exercise and weight loss. If this does not control blood sugars, metformin is usually the first drug prescribed. Metformin is an oral medication that is taken once or twice a day. It decreases sugar production in the liver and decreases blood sugar levels by increasing muscle and organ sensitivity to insulin. The dose of metformin can be increased over a period of weeks to months Continue reading >>
Do You Have A Good Doctor?
There is one often overlooked factor that can save you or someone you love from a future filled with amputations, failing vision, and dialysis: a family doctor who keeps up-to-date on diabetes treatment. Not all doctors do. In fact, quite a few doctors out there got their training in diabetes care in medical school decades ago, and the only "diabetes education" they've gotten since then has been provided by the drug companies. Drug company "education" is nothing more than promotion for whatever is the newest, most expensive drug available for treating diabetes--with the side effects unmentioned or dismissed as insignificant. Even those doctors who do attempt to keep up with the latest in diabetes treatments may do so by reading newsletters that summarize the most publicized recent research findings. But these, too, focus almost entirely on new drugs and often just summarize drug company press releases. That is why a major part of your diabetes self-care should include finding a doctor who will become a partner, not an obstacle, in your quest for normal health. While this whole site contains a lot of information that can help you assess the quality of the treatment you are getting what I've done here is put together a list of questions you can use to evaluate the care you are getting from the medical professionals you are paying for your care. Does your doctor support you in your desire to attain normal blood sugars? A major warning sign that a doctor's knowledge of diabetes is out of date is the doctor who dismisses your concern about an abnormal blood sugar test because it isn't, in his mind, abnormal enough. If your fasting blood sugar is over 110 mg/dl, or your post meal blood sugars are routinely going over 140 mg/dl at 2 hours, and your doctor tells you that this i Continue reading >>
Metformin controls the insulin resistance of people who have type 2 diabetes so well that, if possible, all of us should be taking it. That’s what Roderic Crist, M.D., told me at the annual convention of the American Society of Bariatric Physicians in Denver this weekend. Dr. Crist specializes in family medicine in Cape Girardeau, Missouri. “Not everybody can take every drug,” he added, when I followed up our conversation by calling him at his office after he returned home. “But most of the time people can take metformin if they take it carefully.” Doctors increasingly prescribe it not only for type 2 diabetes but also for insulin resistance, polycystic ovary syndrome, and non-alcoholic fatty liver disease. Roughly one-third of Dr. Crist’s patients have diabetes. Well over half, if not two-thirds of the people he sees are insulin resistant. “I treat insulin resistance with that drug even if they aren’t fully diabetic.” he says. “If they have high triglyceride levels and low HDL levels, particularly if they are centrally obese, they should probably be on metformin. It helps slow the progression of the disease from one thing to the next.” But he goes further. He prescribes metformin to almost all of his patients who have type 2 diabetes — no matter how low their A1C level is. And he tells his patients that their levels should be 5.0 or less — not the American Diabetes Association’s less stringent recommendation of 7.0 or less. “If their A1C is at 5, their diabetes is in complete remission. So I have that as a goal.” And he still prescribes metformin to them after they reach that goal. “The two important issues are that it will prevent progression and it should be used in the earliest phases of insulin resistance. We vastly underutilize me Continue reading >>
Pcos And Metformin – Is This Treatment Right For You?
Here at Flo Living headquarters I speak with many women suffering with PCOS who have either been offered Metformin and decided against it or have tried Metformin and it’s not worked for them. If you have a diagnosis of PCOS it’s very likely that at some point your doctor has suggested Metformin. I personally was what would be considered the “perfect” candidate for this treatment when I was in my 20s and suffering with PCOS – overweight, struggling with acne and a complete lack of periods. However, I never tried it myself – instead I created a protocol for myself that became Flo Living. I’ve since helped many women manage their PCOS successfully with this protocol, just as I did my own diagnosis. That said, I speak with women so often about the Metformin option that I want to share my perspective with you. Although I do not dismiss the option completely, I do have some caveats and concerns. What is Metformin? Metformin is a first-line medication for those suffering with type 2 diabetes. It is also presented as a treatment for PCOS sufferers who are also overweight or obese. Not all PCOS sufferers have weight gain as a symptom, it depends on the kind of PCOS. Women with the kind of PCOS that causes weight gain are usually insulin resistant. Metformin reduces overall insulin levels. Insulin resistance is when the cells of your body become resistant to the hormone insulin, preventing glucose from entering your cells to be used for energy, and instead causing soaring levels of sugar blood stream bringing about diabetes, pre-diabetes or insulin-resistant PCOS. The connection between insulin and PCOS is blood sugar regulation. We hear about this most commonly with diabetes, but it’s also very important with PCOS. An unstable, constantly spiking and crashing, bl Continue reading >>
The Effects Of Stopping Metformin
The medication metformin is a drug in the biguanide family that is used to treat type 2 or adult-onset diabetes mellitus. Drugs.com notes that metformin is often the first prescribed medication for individuals with type 2 diabetes and may also be used in combination with other diabetes medications or insulin. This medication is sold under the brand name Glucophage, Glucophage XR and Fortamet. Metformin helps to reduce glycemic or sugar levels in the blood in a number of ways. If an individual with type 2 diabetes stops taking metformin, they may experience serious immediate and long-term effects of uncontrolled high levels of blood glucose. Video of the Day A primary mode of action of metformin is increasing the sensitivity of the body’s muscles, tissues and cells to insulin--a hormone that is essential for transporting glucose from the blood to the body. Drugs.com notes that individuals with type 2 diabetes have insulin resistance. This causes the cells to ignore the effects of insulin and not allow glucose to be transported into the muscles and tissues where it is vital to produce energy. The body tries to compensate by secreting more insulin, which only leads to hyperinsulinemia in the blood. If a patient stops taking metformin, the type 2 diabetes effects occur due to insulin resistance causing symptoms such as severe thirst, hunger and urinary frequency. The chronic levels of hyperinsulinemia and hyperglycemia also contribute to diseases of the heart and vascular-blood vessel-system. Gluconeogenesis is the production of glucose by the liver. A storage supply of glucose is reserved in the liver and released into the bloodstream when the body requires energy due to stress or hunger. The MayoClinic.com notes that another one of the mechanisms of metformin to reduce Continue reading >>