Do Microbes Live Also In Human Brain?
There was an established dogma that the brain is normally a sterile site. It was long thought to be a kind of fortress, separated from the body by a virtually impenetrable barrier of specialized cells. Now, that view is beginning to shift, with increasing evidence that intruders can, and do, sneak in. Mechanisms used by microbes to enter the CNS are usually divided according to the cellular route involved and whether the organisms breach endothelial cells of blood-brain barrier or specialized epithelial cells of blood-choroid barriers. These routes of entry are commonly referred to as (i) intercellular, i.e., passing between cells, (ii) transcellular, i.e., passing through cells, (iii) leukocyte facilitated, i.e., a Trojan horse-like mechanism, or (iv) nonhematogenous. The most common routes of entry for extracellular bacteria are the intercellular and transcellular routes. Viruses: Unlike other organs such as liver where the specific location within the liver infected by the virus does not substantively alter the symptoms, the precise region in the brain that is infected plays a key role in the type of resulting dysfunction. Limbic infections will manifest a completely different s Continue reading >>