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Is Ketoacidosis Metabolic Acidosis

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What Chemical Processes Or Reactions Contribute To Metabolic Acidosis?

There are three primary states metabolic acidosis. Their underlying physiological causes are from diabetes (ketoacidosis), normal anion gap acidosis from ailments such as kidney malfunction (renal tubular acidosis or more specifically hyperchloremic acidosis), and rare congenital mitochondrial disorders (lactic acidosis). More common causes of metabolic acidosis may come from liver disease or damage or from the ingestion of certain anti-retroviral drugs and poisons such as arsenic. In ketoacidosis, the body does not have enough insulin which allows glucose to be transported across the cell membranes. The body's response is to try to compensate for the supposed lack of energy source (starvation defense, even though there is plenty in the blood) by digesting fat which is converted by the liver into alternative energy sources, i.e. ketones such as acetoacetate and the carboxylic acid β-hydroxybutyrate. These byproducts are acidic and lower the pH of the blood. In renal tubular acidosis (RTA) the kidneys are not acidifying the urine as efficiently as they should which allows acid in the blood to accumulate. RTA is a normal anion gap acidosis during which the alpha intercalated cells f Continue reading >>

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Popular Questions

  1. Prem Prakash Gupta

    Human urine pH normally varies from 5.4-7.8; it may be acidic, neutral or alkaline.

    Under normal physiological conditions, an alkaline (high pH) urine is observed after consumptionof diet rich in vegetables and citrus fruits. However, in pathological conditions like metabolic alkalosis or respiratory alkalosis, urine becames alkaline. In urinary tract infections caused by pseudomonas or proteus (urease containing bacteria), urine also becomes alkaline.

    Under normal physiological conditions, an acidic (low pH) urine is observed after consumption of diet rich in proteins. However, in pathological conditions like metabolic acidosis, respiratory acidosis or diabetic ketoacidosis, urine becames acidosis.

  2. Mahesh Mahi

    Urine is an aqueous solution of greater than 95% water, with the remaining constituents, in order of decreasing concentration urea, sodium chloride, sodium, potassium, creatinine and other dissolved ions, inorganic and organic compounds (proteins, hormones, metabolites).

  3. Prince Horlortu

    The pH of human urine ranges from weakly acidic to weak alkaline depending on what we ingest predominantly. Human urine is weakly acidic in a healthy human based on our diet as omnivores. However the urine can be alkaline for vegetarians and in the event of a urinary tract infection.

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