Is Insulin Resistance Good Or Bad?

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This video describe what are reactive oxygen species (ROS) ,how they are generated and what could be the harmful effect of ROS on our body.

Reactive Oxygen Species And Insulin Resistance: The Good, The Bad And The Ugly - Sciencedirect

Volume 32, Issue 2 , February 2011, Pages 82-89 Reactive oxygen species and insulin resistance: the good, the bad and the ugly Author links open overlay panel TonyTiganis Get rights and content Reactive oxygen species (ROS) contribute to the progression of various human diseases, including type 2 diabetes mellitus (T2DM). ROS can suppress the insulin response and contribute to the development of insulin resistance, a key pathological feature of T2DM. Paradoxically, ROS generated by NADP(H) oxidases at the plasma membrane and endomembranes might also be required for normal intracellular signaling. Growth factors, cytokines and hormones such as insulin promote the generation of ROS for the coordinated inactivation of protein tyrosine phosphatases and the promotion of tyrosine phosphorylation-dependent signaling. A recent study has established the potential of H2O2 to enhance insulin sensitivity in vivo and attenuate the development of insulin resistance. Thus, ROS have the capacity to both promote and attenuate the insulin response. Here I review evidence indicating that ROS promote insulin sensitivity versus insulin resistance and discuss the potential complications associated with Continue reading >>

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  1. jagonmission

    Yesterday I had eaten roughly 70 g of complex carbs, roughly working out on treadmills 12min, cross trainer 15mins, rower 10 mins, cycle for 15 mins, 24 pushups and supported pull ups roughly 10(roughly 1:30 -45 hr). Before start of another round of pull ups i totally got tired and unconscious, i had to take some help in laying down.
    Its been my 4th Day of the start of keto Diet.
    Please let me know whats went wrong?
    Also if i had to do same workout tomorrow so if i increase my carbs up to 100g, considering the workout i do unmodified will it help me to move towards ketosis?

    Thanks in advance.

  2. richard

    Did you pass out, or just feel faint and have to sit down.
    If the former then that’s something you should discuss with your doctor. I’d suggest they look into your blood pressure under exercise load and look into electrolyte supplementation.
    If the latter, I had the same experience for the first couple of weeks. I used to cycle to the gym (15 min) and I’d be fine, and then about 10 mins in to a PT session (Cardio and light weight bearing like yours 2x a week, heavy lifting 2x a week) I would feel like someone had pulled my cord out of the socket and I had to sit down on a step for just 5 secs and then I was good to go for 5 mins before I’d get the sensation again.
    In my case I was hypertentive before keto and normotensive after - so the problem was likely that I was drawing through my limited reserves of energy in my muscles and my transports to get more in weren’t keeping pace with demand. That got gradually better until I became better adapted to using fat for energy.
    Here is Dr Phinney explaining this phenomena

    How Long Does Keto-adaptation Take?

  3. Shortstuff

    You do realise that under 20g of carbs is the recommended amount to get into ketosis? If you’re consuming as many as 70g - 100g a day then it unlikely any of your symptoms will be connected to keto as the chance of you being in ketosis are very small.

    Are you used to that amount of work in the gym? Is it possible you just pushed yourself too hard?

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Patient Comments: Insulin Resistance - Describe Your Experience

Please describe your experience with insulin resistance. Here are all my symptoms of insulin resistance. I have dark skin in my armpit area (very weird, I am fair skinned), and serious brain fog and short term memory issues that were scaring me to death as I make a living with my brain. I am 5 ft 6 inches, 207 pounds and an apple shape. I have tingling and numbness in my limbs especially at night, arms being the worst, and extreme tiredness always. My vision is deteriorating; worse at sometimes than others. I have skin tags, thinning hair at forehead, not sleeping well and low adrenals. I am so grateful to know what has been going on. At my age (62), I have been seriously wondering how much longer I could keep working in information technology when I know I must. I am now on a low carb diet, still in beginning phases, but these things have scared me enough that I am not likely to fall off the wagon. I really hope I can reverse this. Weight is coming down, I never have been able to lose since I put all this on 15 years ago. My son was diagnosed with insulin resistance about 4 weeks ago. For the last 2 years I knew there was a problem. No matter how little he ate or how much exercise Continue reading >>

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  1. iderpthereforeiherp

    Hi Keto-ers, i'm in ketosis, have been back in it for 3 weeks after a break for a vacation, and quite frankly i effing love this diet :)
    however today i slept in for work, and didn't have breakfast or make a lunch, yet i have had no hunger pains, been drinking my 500ml water per hour and just had a pepperami and a babybel.
    one of my friends is telling me how my metabolism must be overly slow for me not to have a hunger pang... and that this means if i have a kebab or anything like that it will show pretty quickly.
    how can i defend this diet of the gods??

  2. Casao

    General public perception of "slowing your metabolism" or "going into starvation mode" is bullshit, that is the #1 thing to keep in mind.
    In most people, the metabolism does not substantially change until around 1 week of fasting. You can skip meals, load up on meals, whatever you want - your metabolism will not slow down.
    What's happening here is you're solidly in ketosis. The current trend is to get your energy from carbohydrates, becoming glucose in the blood (blood sugar) and powering things that way. Glucose is short lived in a working body, which means that you'll get a burst of energy, and then it will go away. This is why you feel a sugar crash sometimes, and why people recommend eating 5 small meals instead of 3 big ones. As a result of this, your body will release horomones triggering hunger as your blood sugar drops.
    In a state of ketosis, your body is burning fat and releasing ketones. Once you've adapted to using ketones as your primary form of energy (I believe I've seen 2-3 weeks quoted for this), your body has a constant supply of ready energy, as it can burn fat as long as you have some. In this case, your body does not need to eat as much, and will release the hunger horomone less often. As long as you're getting the nutrients you need (which come from meats and vegetables much more easily than grains), you don't need to worry about forcing yourself to eat if you're not hungry.
    tl;dr: Your body is currently an efficient fat-burning machine, and that's why you're not hungry.

  3. iderpthereforeiherp

    thanks for the replies! my next question... the little amount i eat, is this dangerous in terms of slowing down weightloss? i always thought i should always have a breakfast? but i find myself forcing myself to eat it.

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What is INSULIN RESISTANCE? What does INSULIN RESISTANCE mean? INSULIN RESISTANCE meaning - INSULIN RESISTANCE definition - INSULIN RESISTANCE explanation. Source: Wikipedia.org article, adapted under https://creativecommons.org/licenses/... license. Insulin resistance (IR) is a pathological condition in which cells fail to respond normally to the hormone insulin. The body produces insulin when glucose starts to be released into the bloodstream from the digestion of carbohydrates in the diet. Normally this insulin response triggers glucose being taken into body cells, to be used for energy, and inhibits the body from using fat for energy. The concentration of glucose in the blood decreases as a result, staying within the normal range even when a large amount of carbohydrates is consumed. When the body produces insulin under conditions of insulin resistance, the cells are resistant to the insulin and are unable to use it as effectively, leading to high blood sugar. Beta cells in the pancreas subsequently increase their production of insulin, further contributing to a high blood insulin level. This often remains undetected and can contribute to a diagnosis of type 2 diabetes or laten

Why Insulin Resistance Is Good

We’re always told that insulin resistance is the root cause of diabetes type 2. But that may be wrong. Insulin resistance could be a GOOD thing. Dr. Fung explains it well in this insightful new post. Basically, insulin resistance is the way the cells protect themselves from excess insulin and glucose in the blood (the real problem): Dr. Fung: Insulin Resistance is Good? I love Dr. Fung’s take on inflammation in this post as well. It has bothered me for quite some time when people claim that inflammation is the cause of X (i.e. heart disease). Inflammation is usually a symptom of a problem, it’s the body’s default response to damage. The cause is something else. In the case of heart disease the cause is damage to the interior of the blood vessels. This damage results in inflammation – but that’s just a symptom. The cause of the damage? Many things. High blood sugar. High blood pressure. Toxic chemicals (e.g. from smoking). And probably oxidized small dense LDL particles. Excess bad carbs can be behind all these causes of heart disease, except perhaps smoking. The thing is that we can’t solve the problem by attacking a symptom of the problem. Diabetes type 2 can’t be Continue reading >>

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  1. LisaJA

    I'm 5 weeks in and for the past 2 weeks I've had truly repellent, revolting bad breath . My friends and family have rated it about a 7 or 8/10 . My teenager has to open the car windows , it's that bad ! It's ruining my social life - I wouldn't go to a party last weekend for fear of breathing on people :-( I've read up on it as much as I can find and checked - no, it's not down not drinking enough water. No, it's not down to eating too much protein. No, it's not down to oral health care - I brush, I floss, I mouthwash and tongue scrape .( And my mouth is actually loads fresher since removing sugar from my diet .) I read a reply somewhere to a similar question and the person enquired whether the post writer was in weeks 3-6 ..... so this leads me to ask, has anyone else had the bad breath ( possibly just between weeks 3-6 ) and then it gone away ? I really do want to stick to keto, I've lost over a stone already and have another 5 to go .... but this bad breath is a deal breaker ... Please tell me it gets better ........... please ....

  2. charlie_simms

    Strangely, I never got keto breath.

  3. pueve

    Me neither! At least I don't think that I've got kept breath! How do you know that you have it? What does it taste like?

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