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Is Glucose Stored As Fat?

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Nih Study Shows How Insulin Stimulates Fat Cells To Take In Glucose

Findings could aid in understanding diabetes, related conditions. Using high-resolution microscopy, researchers at the National Institutes of Health have shown how insulin prompts fat cells to take in glucose in a rat model. The findings were reported in the Sept. 8 issue of the journal Cell Metabolism. By studying the surface of healthy, live fat cells in rats, researchers were able to understand the process by which cells take in glucose. Next, they plan to observe the fat cells of people with varying degrees of insulin sensitivity, including insulin resistance — considered a precursor to type 2 diabetes (These observations may help identify the interval when someone becomes at risk for developing diabetes. "What we're doing here is actually trying to understand how glucose transporter proteins called GLUT4 work in normal, insulin-sensitive cells," said Karin G. Stenkula, Ph.D., a researcher at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and a lead author of the paper. "With an understanding of how these transporters in fat cells respond to insulin, we could detect the differences between an insulin-sensitive cell and an insulin-resistant cell, Continue reading >>

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  1. SoxGirl02

    Its been a interesting 1.5 weeks. Last Last Frday 3/27, I thought I might have a kidney stone. I am prone to stones, so I know the sympoms etc. Friday it bothered me, Saturday it bothered me, Monday it bothered me. I went to the Urologist on this past Friday 4/3. He said there were large blood cells in my urine blah blah and I was to get a CT scan on Monday (yesterday). I get this call yesterday morning from the nurse in his office stating that I need to start Cipro immediatly becuase I deffinatly have a bladder infection, and a slight kidney infection (slight? its either infected or not infected!).
    I was exhausted yesterday, had the CT scan, came home and just crashed. 8pm woke up ate..something in my brain had me check the ketones about 9:30 last night. LARGE ketones. I start freaking because ive never had large ones....I call the doc on call and she tells me not to worry about it, its dehydration keep drinking and check in 2 hours. 2 hours it was fine.
    Today..they are back again! Am I over reacting to think that the 2 are related?

  2. gsmama

    Ketones and infection, yes!
    Are these urine ketones or blood ketones?
    Yes, you can get them from dehydration too. Very possible.
    Leslie

  3. andrea

    I agree that these can definately be related... hope you feel better soon.

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Don't forget to do the questions that accompany this video, at http://www.macrophage.co -- it's free and only takes 1 second to sign up! Macrophage is the most cutting edge platform for medical education. We use machine learning to adapt our courses to your specific strengths and weaknesses. Make a free account now! http://www.macrophage.co

How Is Glucose Stored In The Liver?

The liver is large and in charge. The dark reddish-brown organ sits in the upper right abdomen and, at about 3 pounds, is the largest one inside the body (the skin is the largest organ overall). The liver manages a dizzying array of tasks, including digesting fats, making and storing glucose, and serving as the body's detox center. Glucose Warehouse The liver is an insulin-guided organ: Its behavior changes depending on the level of the hormone insulin in the body and how sensitive the liver is to that insulin. After eating, blood glucose levels rise, which in people without diabetes triggers the pancreas to release insulin into the blood. Insulin is the signal for the body to absorb glucose from the blood. Most cells just use the glucose to supply them with energy. But the liver has a special job when it comes to glucose. When levels of glucose (and consequently insulin) are high in the blood, the liver responds to the insulin by absorbing glucose. It packages the sugar into bundles called glycogen. These glucose granules fill up liver cells, so the liver is like a warehouse for excess glucose. When glucose levels drop, insulin production falls, too. The shortage of insulin in the Continue reading >>

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  1. Aine

    I just called Boots in Cambridge for Ketone testing strips and was interrogated like a criminal. They wanted to know why I wanted them, and I said I was testing for ketones, and then further questioning, so Isaid I was on a diet. She abruptly said, "Okay, right..I'm sorry, we're not allowed to sell them. Goodbye," and hung up. :confused:
    What am I missing? :rolleyes: I thought they were easily available and didn't know I was trying to purchase some restricted item. I know they are really for diabetics, but didn't want to be dishonest or rather, didn't think I had to be dishonest to purchase them.
    Are there restrictions on their sale in the UK? (I hav only been here a few months) Maybe I can do without them, but I was curious to know if I am in ketosis.
    Now I feel stupid for calling, and like I called to ask for ganja (marijauana). :(
    Bye for now :wave:

  2. daisy

    Boots refused to sell my boyfriend Ketostix (that's the brand name) when he admitted he wasn't a diabetic, & they refused to give a reason. :mad: From what I've heard there aren't official restrictions on them, so I'm assuming Boots are just fascists. I don't have my boyfriend's scruples, so I went to Superdrug & lied- I said they were for my mum!:rolleyes: - but they had run out.
    Finally we got them from a company called Pharmacy4U, which I'm sure has a website (try Pharmacy4U.co.uk). After all that, though, we never use them any more! Maybe I will once I'm on maintenance. So don't worry too much about them :)
    Take care, Daisy
    :daizy:

  3. Aine

    Thanks Daisy, I think I'll just do without them or try the website you suggested.
    Cheers :wave:

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In a global first, Australian scientists have figured out the way to reprogram adult bone or fats cells to form stem cells that could doubtlessly regenerate any damaged tissue within the frame. The researchers were stimulated by the manner salamanders are able to update lost limbs, and advanced a technique that gives grownup cells the capacity to lose their person characteristics, multiply and regenerate more than one cell types - what is called multipotency. which means the brand new stem cells can hypothetically repair any injury within the body, from severed spinal cords to joint and muscle degeneration. And its a pretty big deal, because there are currently no person stem cells that certainly regenerate a couple of tissue kinds. "This approach is a massive strengthen on most of the modern-day unproven stem mobile treatment options, that have shown little or no goal evidence they make contributions immediately to new tissue formation," stated lead researcher John Pimanda from the university of recent South Wales, faculty of medication (united states remedy). "we're presently assessing whether or not grownup human fat cells reprogrammed into [induced multipotent stem cells (iMS cells)] can accurately restore broken tissue in mice, with human trials anticipated to begin in past due 2017." proper now, even though its an exciting and plenty-hyped field of look at, stem mobile therapy still has some of boundaries, in general due to the fact the maximum beneficial cells are embryonic stem cells, which can be taken from growing embryos and have the potential to become any cell type within the frame. however in addition they have the tendency to shape tumours and can't be transplanted immediately to regenerate person cells. as a substitute, researchers are able to use tissue-unique person cells, that may simplest change into the cellular types in their vicinity of the body as an instance, lung stem cells can best differentiate into lung tissue, so that theyre now not as versatile as scientists want. Scientists have additionally labored out a way to reprogram ordinary grownup stem cells into caused pluripotent stem cells (iPS) a form of stem cell thats even extra bendy than multipotent stem cells, but requires the usage of viruses in order for the cells to be reset, which isnt perfect to help deal with patients. Thats why the new studies is so interesting. "Embryonic stem cells can't be used to deal with damaged tissues because of their tumour forming capacity," stated one of the researchers, Vashe Chandrakanthan. "the alternative hassle whilst generating stem cells is the requirement to use viruses to transform cells into stem cells, which is clinically unacceptable." "We accept as true with weve overcome these problems with this new method." To create the brand new type of stem cells, the researchers collected grownup human bone and fats cells and treated them with compounds: five-Azacytidine (AZA); and platelet-derived boom component-AB (PDGF-AB) for two days. This kick-started the method of dedifferentiation which basically way it started out to revert them to a multipotent stem cell nation. The cells were then kept in PDGF-AB for a few weeks while they slowly changed into stem cells, subsequently turning into tissue-regenerative iMS cells which basically method they could repair any form of tissue within the body. ; Source: https://www.sciencealert.com/

How Are Carbohydrates Converted Into Fat Deposits?

How are carbohydrates converted into fat deposits? There are two ways that carbohydrates and body fat interact. One is directly by turning into body fat, and the other is via insulin. Turning into body fat is like adding fat into the fat cells, whereas carbohydrates spiking insulin does not add anything to fat cells per se, but hinders the release. The former is like a + equation, where the latter is a double negative which results in something that seems positive. There is a process called de novo lipogenesis (literally: Creation of fat from non-fat sources) that can occur in the body. This process turns glucose into lipids, which are then stored as body fat. This process is normally quite inefficient in the body [1] , which suggests that carbohydrates cannot be stored as fat to a high degree. The process can be upregulated (enhanced) if dietary fat comprised almost none of the diet (lesser than 10%, as a rough estimate), if carbohydrate intake is excessively high for a period of a few days, or if one follows an obesogenic diet (diet that is likely to make you fat) for a prolonged period of time. [1] [2] [3] Carbohydrates spike insulin , which is a hormone that mediates glucose m Continue reading >>

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  1. MarvinW

    Prediabetic Fasting Blood Glucose Level on Keto Diet

    Anyone ever take a fasting blood glucose test and get disappointing results?
    My wife had a kit leftover from her last pregnancy and struggle with gestational diabetes. Out of curiosity I decided to try it. I was disappointed to see that it showed me 113 mg/dL. In the past I've had results in the upper 90s before, but never over 100. I later found out that it is the result of a very low carb diet and that physiological insulin resistance starts as a method to preserve what little glucose is in the body for the brain by preventing your muscles from absorbing it. What sucks is that you could potentially be branded "diabetic" by a doctor because of these results even though the number shouldn't really apply because it is based on a reaction of those with a higher-carb diet. This could affect you should you ever try to get on an individual insurance plan.

  2. lawrencep93

    If your body is doing that, it means you are still burning sugar not ketones for brain fuel, look at your keto diet and get it correct.
    Buy a ketone meter and get yourself into the 1-3 millimolar range to be in proper keto.

  3. MarvinW

    Originally Posted by lawrencep93
    If your body is doing that, it means you are still burning sugar not ketones for brain fuel, look at your keto diet and get it correct.
    Buy a ketone meter and get yourself into the 1-3 millimolar range to be in proper keto.

    Perhaps, but I am not inclined to agree. I've been keeping net carbs <20 and protein at a level just enough to maintain my lean mass. Whether you are in ketosis or not you will still have glucose in your system- whether it is from protein synthesis (dietary or taken from lean mass) or from net carbs that you consume. And some glucose is
    still required by your brain, though it can operate primarily on ketones. Having a slightly higher fasting blood glucose level does not necessarily mean that I am burning sugar primarily rather than ketones for brain fuel. The effect of physiological insulin resistance is documented as having an association with VLC diets and fasting. Here are a few references you might find interesting:
    jpet.aspetjournals.org/content/304/3/994.long
    high-fat-nutrition.blogspot.com/2007/10/physiological-insulin-resistance.html
    high-fat-nutrition.blogspot.com/2008/05/physiological-insulin-resistance-2-dawn.html
    ketojenic.com/post/47273188840/does-eating-a-low-carb-diet-cause-insulin-resistance
    To get an accurate read not affected by hydration levels the blood glucose measurement would be best, but I'm not going to spend $2-5 a test strip to make that happen. Unless you have a good source of cheap strips? I'd definitely be interested there.

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