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Insulin Resistance Keto

The Great Medical Disconnect

The Great Medical Disconnect

There is probably no greater disconnect in medicine than the root cause of obesity. Even if you think you already know the answer to this “obvious” question, it’s still worth reading on. The reason this question matters, of course, is clear to everyone. Obesity (and more broadly the syndrome we define as metabolic syndrome) predisposes us to virtually every disease afflicting us in the modern age. Above is a simple graphic from the journal Nature showing the linkage between obesity and all of its sequela. When you are obese, your risk of disease goes up. This is not disputed. Here is where the controversy starts…what actually makes us obese? Obesity is a disorder of fat accumulation – fat cells accumulate too much fat, relative to how much fat the body breaks down. Conventional wisdom, however, says obesity is a disorder of eating too much and/or exercising too little. These are not the same thing. Let’s turn to a well-respected source of medical information, Lehninger’s Principles of Biochemistry (the so-called “bible” of biochemistry). Go to the index and query, what makes fat cells fat? (the technical way of asking this question is, what causes adipose cells to accumulate triglycerides) and you’ll get the following response: “High blood glucose elicits the release of insulin, which speeds the uptake of glucose by tissues and favors the storage of fuels as glycogen and triacyglycerols, while inhibiting fatty acid mobilization in adipose tissue.” Let me translate this: Eating glucose (carbohydrates) increases insulin levels in our body. Insulin drives glucose into liver and muscle cells as glycogen (in small, finite amounts) and into fat cells as triglycerides (in unlimited amounts). Insulin also inhibits the breakdown and utilization of fat. Pa Continue reading >>

10 Graphs That Show The Power Of A Ketogenic Diet

10 Graphs That Show The Power Of A Ketogenic Diet

The low-carb, high-fat ketogenic diet is a proven way to lose weight (1). It also has powerful benefits against type 2 diabetes and metabolic syndrome, and may even help treat cancer (2, 3, 4). Additionally, it has been used to treat epilepsy since the 1920s (2). Here are 10 graphs that show the many powerful benefits of a ketogenic diet. Source: Johnstone AM, et al. Effects of a high-protein ketogenic diet on hunger, appetite, and weight loss in obese men feeding ad libitum. The American Journal of Clinical Nutrition, 2008. Over 20 studies have shown that a low-carb or ketogenic diet can help you lose weight. The weight loss is usually much greater than with a high-carb diet (5). In the graph above, the ketogenic group in the study lost more weight, despite the fact that their protein and calorie intake were equal to the non-ketogenic group (6). The ketogenic group was also less hungry and found it easier to stick to the diet. This suggests that a low-carb or ketogenic diet provides a distinct "metabolic advantage" over a high-carb diet, although this is still being debated (7, 8, 9, 10). The ketogenic diet is effective for weight loss. It is superior to a high-carb diet, and may even provide a metabolic advantage. Source: Volek JS, et al. Comparison of energy-restricted very low-carbohydrate and low-fat diets on weight loss and body composition in overweight men and women. Nutrition and Metabolism, 2004. Abdominal obesity, or excess belly fat, is a serious risk factor for all sorts of metabolic diseases (11, 12). This kind of stored fat can increase the risk of heart disease, type 2 diabetes and premature death (12). Interestingly, a ketogenic diet is a very effective way to lose belly fat. As shown in the graph above, a ketogenic diet reduced total weight, body fat a Continue reading >>

I Went On The Silicon Valley Diet Craze That Encourages Butter And Bacon For 2 Months — And It Vastly Improved My Life

I Went On The Silicon Valley Diet Craze That Encourages Butter And Bacon For 2 Months — And It Vastly Improved My Life

Bacon became my new best friend on the ketogenic diet.Business Insider A diet that goes against conventional wisdom on healthy eating is gaining momentum among Silicon Valley tech workers. And it involves eating a lot of fat. The ketogenic, or "keto," diet — which first became popular in the 1920s as a treatment for epilepsy and diabetes — limits carbohydrates to no more than 50 grams a day, which is the rough equivalent of a plain bagel or a cup of white rice. By comparison, dietary guidelines laid out by the US Department of Agriculture recommend consuming between 225 and 325 grams of carbs a day. On the keto diet, the body goes into starvation mode and taps its fat stores for fuel. Studies suggest the low-carb, high-fat diet may promote weight loss, dull hunger, and stave off age-related diseases. More research is needed on its long-term effects, especially in healthy people. An increasing number of health nuts — from the internet entrepreneur Kevin Rose to the podcaster Tim Ferriss — swear by the keto diet. I spent the past two months eating bacon, butter, and avocados to see why the keto movement is so popular. I am no stranger to diets. I've cut sugar, counted points on Weight Watchers, and swapped solid food for Soylent, a venture-capital-backed meal-replacement shake. Here's me eating a doughnut.Melia Robinson/Business Insider I gave up breakfast for a week and drank this caffeinated meal-replacement shake instead » But those usually don't last long. I love food. I'm a chronic snacker. Melia Robinson/Business Insider When I first learned about the keto diet, it caught my interest because dieters could eat seemingly unlimited amounts of healthy fats, like cheese, nuts, avocado, eggs, butter — foods that have high "point values" on Weight Watchers and a Continue reading >>

Are You Insulin Resistant?

Are You Insulin Resistant?

Finding out you are insulin resistant doesn't mean much unless you understand what that implies, and how it effects your health. Insulin resistance is an condition in which the body is not responding properly to the hormone insulin. If faulty insulin signaling is not treated, it can develop into worsening conditions of metabolic syndrome, pre diabetes, and finally type 2 diabetes. What Causes the Insulin Resistant Condition? The insulin resistant condition is rooted in the metabolic effects of a high carb diet in combination with a lack of exercise. Weight gain is a symptom of insulin resistance, rather than a cause. Carbohydrates are foods which contain either some form of sugar or starch, or both. For instance, orange juice is full of fructose, a type of sugar, and white potatoes contain large amounts of starch. Both types of carbohydrate are broken down in the body into glucose, a simple sugar, which your cells can use for energy to do all the things that cells do. Since too much glucose in your body can be toxic, your pancreas releases a powerful hormone called insulin. Insulin works to control the amount of glucose in your bloodstream. It acts to quickly move glucose from your bloodstream and push it into your cells where it can be burned or stored. But there's a catch. To get the glucose into the cells, the cell's glucose "storage tanks" have to be empty. This is logical when you think about it. Imagine what would happen if you tried to fill up your car's gas tank if it were already full. And just like running a car burns up gasoline, when a person exercises, the glucose which is already in the glucose tanks get used. Now there is room for insulin to push the glucose made from the last meal into the muscle cell for fuel. If a person exercises frequently, lots of c Continue reading >>

How Optimize Your Diet For Your Insulin Resistance

How Optimize Your Diet For Your Insulin Resistance

Lately, I’ve seen a number of common themes come up at low carb conferences and online. The contentious questions tend to run along the lines of: I did really well on a low carb diet initially, but my fat loss seems to have stalled. What gives? What should I do now? If protein is insulinogenic should I actively avoid protein as well as carbs if my goal is to reduce insulin because low insulin = weight loss? If eating more fat helped kick start my weight loss journey, then why does eating more fat seem to make me gain weight now? This article outlines some quantitative parameters around these contentious questions and helps you chose the most appropriate nutritional approach. Coming from a diabetes headspace, I’ve seen firsthand the power of a low carb diet in reducing blood glucose and insulin levels. As a Type 1 Diabetic, my wife Moni has been above to halve her insulin dose with a massive improvement in energy levels, body composition and mood. If your blood glucose levels are high, then chances are your insulin levels are also high. Insulin is the hormonal “switch” that causes us to store excess energy as body fat in times of plenty.[1] Lower levels of insulin in times of food scarcity then enable us to access to the stored energy on our body.[2] You can actively manage the fat storing potential of your diet by managing the insulin load of the food you eat. The chart below shows that our glucose response is fairly well predicted by the carbohydrates we eat. (note: The “glucose score” is the area under the curve of glucose response to various foods tested over the three hours relative to glucose which gets a score of 100%.) [3] [4] Having high blood glucose levels is bad news.[5] The chart below shows the correlation between HbA1c (a measure of your averag Continue reading >>

Ketogenic Diet And Insulin Resistance

Ketogenic Diet And Insulin Resistance

Ketogenic diets around the world have been known to be extremely effective in helping improve health and lose weight fast. The diet takes into account and addresses the underlying causes of your weight gain, which could include things such as hormonal imbalances. With the ketogenic diet, you are restricting your net carb intake to under 50 grams a day. With the number of restricted carbs, your body needs to reset its way of getting the fuel that it needs. See how a diet high in healthy fats can help improve insulin resistance by changing the bodies preferred fuel source from glucose to ketones. What is Insulin and Insulin Resistance Insulin is a fat storing hormone formed by the pancreas that enables your body to manage glucose and sugars from carbs within the food. It prevents blood sugar levels from hyperglycemia or reaching too high or hyperglycemia which is too low. Insulin resistance has many symptoms including sugar cravings, weight gain, high blood pressure, high cholesterol.(1) Insulin resistance is also linked to type 2 diabetes. Therefore, cutting out or reducing sugar in your meal planning will help prevent becoming diabetic. The worrying thing about insulin resistance is symptoms take a long time to appear. When symptoms surface such as weight gain, multiple other problems may creep up. Why You Gain Weight Insulin in your body helps to regulate your blood sugar levels. Blood sugar also referred to as glucose is the primary fuel in the body for energy and brain function. When blood sugar rises, the insulin your pancreas releases move the glucose into your bloodstream. If there is glucose in your system your body will burn it first for fuel. If your body is already filled with higher glucose levels, more cannot be broken down for fuel. So because of this, your Continue reading >>

The Link Between Cancer, Insulin Resistance And A Ketogenic Diet

The Link Between Cancer, Insulin Resistance And A Ketogenic Diet

Research done by Dr Dominic D’Agostino, Dr Thomas Seyfried and Dr Gary Fettke has revealed that cancer is predominantly a metabolic disease and not a genetic one as previously thought. “Most cancer scientists have historically thought that cancer was a genetic disease, but only 5-10% of cancer is hereditary,” says Dr D’Agostino. A metabolic disease is one that disrupts normal metabolism, the process of converting food to energy on a cellular level. The mitochondria generate the energy that our cells need to do their job – and are often referred to as the powerhouses of the cells. When carbs (made up of glucose) are ingested, they cause the blood glucose levels to rise. The hormone insulin, responsible for regulating energy usage – in particular our relationship to carbs – is secreted by the pancreas because a high blood glucose concentration is toxic for human tissues as it damages the structure of all proteins. According to Dr Fettke, we can only metabolise about one teaspoon (4 grams) of glucose at once and the rest is stored in the liver and muscles as glycogen, or if this cannot happen, it is stored as fat. The more carbs ingested, the more insulin is produced, the more our body becomes resistant. Insulin resistance occurs when the body does not respond to insulin correctly. This results in increased blood glucose levels, which can’t be stored in the liver or muscles, so must be stored as fat. This is discussed in great detail, by Prof Noakes, in the Beginner Banting Online Program. Insulin is therefore the fat storing hormone, which leads to an expanding waistline. If a high carb diet is followed, and if unchecked, it can lead to obesity, metabolic syndrome (a combination of obesity, hypertension and gout) and to type 2 Diabetes. The long-term damag Continue reading >>

Ketogenic Diet: Insulin, Sugar And Inflammation

Ketogenic Diet: Insulin, Sugar And Inflammation

You can view the first part of this series here: The Ketogenic Diet Part 1: What is Keto? Have you ever wondered about the link between sugar and inflammation? Do you know what you can do to reduce inflammation in the body? Let’s explore the relationship between insulin, sugar and inflammation, and weight gain, beginning with what we put in our mouth. How does sugar cause inflammation? After you eat excess carbohydrates (sugar) and/or too much protein, your blood glucose stays at a higher level longer because the glucose can’t make it into the cells of the muscles. This toxic glucose is like tar in the bloodstream, clogging arteries, binding with proteins to form damaging AGEs (advanced glycation end-products), and causing inflammation in the body. What happens when you have high levels of inflammation in the body? High inflammation is triggered by glucose, which sets off a chain reaction in your body. High levels of glucose causes triglycerides to go up, increasing your risk for coronary artery disease. Then, sugars (and starches) get stored as fat. Because the cells of the musculature basically have a crust over top of them (called glycation), the cells aren’t taking glycogen in from the bloodstream, and are therefore considered “resistant.” Additionally, you can’t even metabolize stored fat since insulin stops the production of the fat-burning enzyme lipase! You can exercise all you want, but if you continue to eat oatmeal before your workouts, you will never be a fat-burner: you will remain a sugar-burner and you will continue to become insulin resistant. If the above information isn’t bad enough, I have more bad news: when you’re insulin resistant, the pancreas begins to mistakenly believe, “if a little insulin isn’t working, I’ll just produce Continue reading >>

A High-fat, Ketogenic Diet Causes Hepatic Insulin Resistance In Mice, Despite Increasing Energy Expenditure And Preventing Weight Gain

A High-fat, Ketogenic Diet Causes Hepatic Insulin Resistance In Mice, Despite Increasing Energy Expenditure And Preventing Weight Gain

Go to: Low-carbohydrate, high-fat ketogenic diets (KD) have been suggested to be more effective in promoting weight loss than conventional caloric restriction, whereas their effect on hepatic glucose and lipid metabolism and the mechanisms by which they may promote weight loss remain controversial. The aim of this study was to explore the role of KD on liver and muscle insulin sensitivity, hepatic lipid metabolism, energy expenditure, and food intake. Using hyperinsulinemic-euglycemic clamps, we studied insulin action in mice fed a KD or regular chow (RC). Body composition was assessed by 1H magnetic resonance spectroscopy. Despite being 15% lighter (P < 0.001) than RC-fed mice because of a 17% increase in energy expenditure (P < 0.001), KD-fed mice manifested severe hepatic insulin resistance, as reflected by decreased suppression (0% vs. 100% in RC-fed mice, P < 0.01) of endogenous glucose production during the clamp. Hepatic insulin resistance could be attributed to a 350% increase in hepatic diacylglycerol content (P < 0.001), resulting in increased activation of PKCε (P < 0.05) and decreased insulin receptor substrate-2 tyrosine phosphorylation (P < 0.01). Food intake was 56% (P < 0.001) lower in KD-fed mice, despite similar caloric intake, and could partly be attributed to a more than threefold increase (P < 0.05) in plasma N-acylphosphatidylethanolamine concentrations. In conclusion, despite preventing weight gain in mice, KD induces hepatic insulin resistance secondary to increased hepatic diacylglycerol content. Given the key role of nonalcoholic fatty liver disease in the development of type 2 diabetes and the widespread use of KD for the treatment of obesity, these results may have potentially important clinical implications. Keywords: nonalcoholic fatty liv Continue reading >>

Insulin Resistance From The Ground Up With Ivor Cummins

Insulin Resistance From The Ground Up With Ivor Cummins

Carl Franklin and Richard Morris talk to Ivor Cummins about his work with Hungarian Biologist Gabor Erdosi based on research that paints a more detailed picture of how insulin resistance happens. It turns out that adipose tissue (fat cells) have a much bigger role to play in metabolic dysfunction than previously thought. This is a fascinating discussion. Ivor Cummins is a Chemical Engineer who spent 25 years in Engineering Lead and Engineering Manager positions. He has worked in the Medical Device, Special Purpose Equipment and Electronic Component industries, always gravitating towards the most complex interactions where the Physics comes alive. His specialty throughout has been leadership in Complex Problem Solving Methodology (Comparative Analysis, Mechanistic Analysis and Experimental/Statistical Inference) - the ultimate destination was always Root Cause Resolution in the minimum timeframe. Following less-than-ideal blood test results he went back to his Biochemical Engineering roots and intensively studied the mechanistic physics and primary drivers of Dyslipidemia, elevated GGT and Serum Ferritin. Ivor has analysed several hundred related papers and studies carried out over the past 5 decades, and a few prior to this period. He found the value of the technical expertise gained during his career to be of paramount, indeed crucial importance in this odyssey, realizing that to be successful in determining root cause and solution in this complex arena, required far more than a general medical background. Ketogenic Forums Richard's Tumor NIDDM and its metabolic control predict coronary heart disease in elderly subjects. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study Ivors prese Continue reading >>

Keto And Metabolism, Part 5

Keto And Metabolism, Part 5

Insulin resistance is a two-pronged problem closely and causally related to obesity and disease. Last week we discussed insulin, insulin resistance, and the first prong to why it’s so damaging to our bodies, oxidative stress. I encourage you to go back and refresh your memory on those points because this week we’re wrapping up our series on metabolism by talking about the second prong of the insulin resistance problem, and also the big kahuna for obese people everywhere: Fat Storage. One of the main reasons people turn to Ketogenic living is because they have body fat they want to lose, and keto is extremely efficient at burning it off during ketosis. How does all that fat get there anyway? Why is it that keto helps us not only burn fat but also reduce fat storage in the first place? When it comes to fat creation and storage, there are several factors involved, but the primary hormone that directs fat storage and accumulation is our old friend insulin. As discussed last week, insulin opens the door to our cells and forces excess glucose out of the blood and into the cells of our muscles and/or organs, and fat tissue. But that’s not all! It is also responsible for pushing any excess fatty acids floating around in our blood into the cells as well. So it not only puts extra sugar into our cells for storage (which can then be converted into fat molecules), it also puts fat into storage. A problem that the medical community is mildly baffled by is an inconsistency in our liver function caused by excessive insulin and insulin resistance. When insulin is released, it tells a normal liver to stop producing glucose from protein (via gluconeogenesis) and to also stop producing fat. In an insulin resistant liver, however, scientists have found that the presence of insulin do Continue reading >>

Insulin Resistance! ..... And Chocolate Brains

Insulin Resistance! ..... And Chocolate Brains

Okay, so not the sexiest topic but very timely... As we’ve got the sweetest holiday coming up in just one week, I’ve got to drop some knowledge regarding Insulin Resistance so you can keep yourself and your loved ones safe. Oh and read to the end where I give you an awesome recipe for Chocolate Brains! If you’re "meeting" me for the first time EVER, my name is Kate Jaramillo and I am a Ketogenic Lifestyle Expert, the Creator of Ketogenic Living 101, 102 and the Ketogenic Living Coach Certification, a Badass Wellness Advocate, and a #girlmom. Soooo Insulin Resistance: Insulin is a hormone produced by the pancreas. The role of insulin is to allow cells of the body to take in glucose to be used as fuel or stored as body fat. When blood sugar levels are elevated, the pancreas runs into overdrive to create enough insulin to remove that sugar from the bloodstream. What ends up happening is that the cells build up a tolerance to the insulin being produced, they stop responding, and blood sugar levels elevate. This is Insulin Resistance. Initially, insulin resistance shows no symptoms, but eventually someone who is insulin resistant may experience weight gain mostly in the midsection (belly fat), lethargy, hormonal imbalances like irregular periods and PCOS, sleep disturbances, brain fog, high blood pressure, High triglyceride levels, which leads to heart disease and a slew of other issues, and constant hunger. Insulin resistance may develop into pre-Diabetes and Type-2 Diabetes, which will cause many other health issues and symptoms. Think you are insulin resistant? You may want to test your fasting blood glucose levels. If they are above 100, consider what you ate the night before and if it was carb and/or sugar-heavy, cut those out and test again. If you’re still hig Continue reading >>

#125: Food Aversions, Keto “freedom”, & Low Carb Diets For Insulin Resistance

#125: Food Aversions, Keto “freedom”, & Low Carb Diets For Insulin Resistance

Here’s the notes for episode #125 of The Paleo Women Podcast. Be sure to check back every Tuesday for a new episode, and head over to iTunes or Stitcher to subscribe! To leave a review for the podcast (HORRAY!), go to: In this episode, Stefani and Noelle discuss food aversions, keto “freedom”, and low carb diets for insulin resistance. Got a question you’d like us to answer? Email us at [email protected] 10% of the funds we receive from our sponsors is donated directly to our partner charity, Thistle Farms, a place where women survivors of abuse, addiction, trafficking and prostitution receive help and support through residential programs, therapy, education, and employment opportunities. Because we get paid per download, you are actively supporting Thistle Farms by downloading our podcast each week. [17:05] Food Aversions and Keto “Freedom” [32:17] Low Carb Diets for Insulin Resistance Noelle’s website: Stefani’s website: Paleovalley We have a brand new offer from Paleovalley to share with you that we are incredibly excited about. Paleovalley not only offers Grass-Fed Organ Complex, a gently freeze-dried organ supplement in pill form that contains beef liver, heart, brain and kidney, they also high quality snacks and collagen supplements on their website. Now, when you use the promotion code paleowomen at check out, you’ll get 30% OFF your entire order. You can try their grass-fed beef sticks, which are made from 100% grass-fed beef preserved through a natural fermentation process that gives probiotics to the sticks, or their superfood bar, which is made with grass-fed collagen. To take advantage of this special deal, simply go to and use the code paleowomen at check out. Thanks for your support, and for listening! We absolutely love being Continue reading >>

When Not To Be On A Ketogenic Diet

When Not To Be On A Ketogenic Diet

When Not To Be on a Ketogenic Diet A ketogenic diet is a very low carbohydrate, moderate protein and high fat based nutrition plan. A ketogenic diet trains the individual’s metabolism to run off of fatty acids or ketone bodies. This is called fat adapted or keto adapted, when the body has adapted to run off of fatty acids/ketones at rest. This nutrition plan has been shown to improve insulin sensitivity and reduce inflammation. It also improves cellular healing and mitochondrial biogenesis which supports stronger and healthier cells. All of this leads to reduced risk of chronic disease as well as improved muscle development and fat metabolism (1, 2). Where Ketosis Can Be Extremely Beneficial There are certain cases, where I typically recommend a ketogenic diet as the research appears to support that ketosis significantly improves the functionality of these individuals. Overweight or Obese Neurodegenerative Conditions such as dementia, Alzheimer’s and Parkinson’s Most Cancers but especially those of the brain, nervous system and blood (leukemia) Chronic Pain Seizure Disorders Non-Elite athletes or individuals looking for higher mental & physical performance The final one is the area that I and many others who have pursued a state of ketosis fall into. At this point in my life, I have no chronic diseases, I feel great 99% of the time, but I am always looking to improve my productivity and performance. I have found being in mild-ketosis to be one of the best ways to improve my energy, mental acuity, creativity, physical strength and overall life performance. There is no one diet that works perfectly for everyone. Ketosis has the potential to benefit everyone, but under unique circumstances it would not be warranted. Here are a list of special cases where long-term st Continue reading >>

64: Keto Vs. Raw Vegan, Dry Eyes, Weaning Off Insulin, Rosacea, Mechanism Of Insulin Resistance

64: Keto Vs. Raw Vegan, Dry Eyes, Weaning Off Insulin, Rosacea, Mechanism Of Insulin Resistance

If you are interested in the low-carb, moderate protein, high-fat, ketogenic diet, then this is the podcast for you. We zero in exclusively on all the questions people have about how being in a state of nutritional ketosis and the effects it has on your health. There are a lot of myths about keto floating around out there and our two amazing cohosts are shooting them down one at a time. Keto Talk is cohosted by 10-year veteran health podcaster and international bestselling author Jimmy Moore from “Livin’ La Vida Low-Carb” and Arizona osteopath and certified bariatric physician Dr. Adam Nally from “Doc Muscles” who thoroughly share from their wealth of experience on the ketogenic lifestyle each and every Thursday. We love hearing from our fabulous Ketonian listeners with new questions–send an email to Jimmy at [email protected] And if you’re not already subscribed to the podcast on iTunes and listened to the past episodes, then you can do that and leave a review HERE. Listen in today as Jimmy and Adam tackle diet misconceptions and bring your weekly dose of good news on the low-carb, high-fat, ketogenic lifestyle in Episode 64. Here’s what Jimmy and Adam talked about in Episode 64: KETO COMFORT FOODS BY MARIA EMMERICK NOTICE OF DISCLOSURE: Paid sponsorship **Special THANK YOU to Ted, Becky, Timothy, Merril (G’day guys, Thank you both for your awesome hard work every week. I love your podcast – it is inspiring & makes me sound quite the expert when I pass on your knowledge to others. I love the pathophysiology content. Cheers! Merril Melbourne, Australia.), Jane from Denmark, Kate, Aisha, Pamela, Jana, Bruce, and Sarah (Hi guys!! Thank you so much for all your hard work and your informative and entertaining podcast! I’m a new listener and Continue reading >>

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