Hyperglycemic Seizures

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Focal Seizures As A First Manifestation Of Nonketotic Hyperglycemia

I report two elderly females who developed repetitive focal seizures as their first manifestations of nonketotic hyperglycemia In the second patient, the seizures were constantly induced by active or passive movements of the involved arm. With a control of the hyperglycemia, the seizures stopped in both cases. Contrary to previous reports, the focal seizures of the second case seemed to respond to parenteral administration of phenytoin. Continue reading >>

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  1. RobinN

    Quote :

    The important new finding from Schwechter and colleagues is that hyperglycemia, itself, is proconvulsant. How can elevated glucose enhance seizure susceptibility? The answer to this crucial question regarding the mechanism of action awaits further research, as the mechanism per se is not addressed in this report. However, one clue to the answer might be gleaned from the authors's observation that hypoglycemia was associated with a higher seizure threshold. Other studies have indicated that restricting calories, thus inducing hypoglycemia, in the epilepsy-prone EL mouse also reduces seizure susceptibility (2). With any model that induces hypoglycemia, the role of ketosis must be excluded, as ketones themselves can affect seizure threshold (3). Moreover, multiple other mechanisms could explain hypoglycemia- and hyperglycemia-induced alterations of neuronal excitability. Furthermore, the effects of age on glucose balance and neuronal excitability must be delineated, as children with diabetes tend to develop seizures with hypoglycemia rather than with hyperglycemia. In addition to clarifying further the relation between hyperglycemia and seizures, Schwechter et al. highlight the link between metabolism and neuronal excitability and emphasize the need for further research on the long-term effects of hyperglycemia on various aspects of brain function.

  2. Nakamova

    I have the opposite experience -- for me, low blood sugar (hypoglycemia) is a seizure trigger, it lowers my seizure threshold....

  3. RobinN

    Yes I am doing some research on this, as the same seems to be true for my daughter as well.
    Her blood sugar is dropping before a seizure and then sometime spiking after.
    Though her last seizure when 911 was called it went down to 30. So we had a glucose tolerance test and it was at 50 on the last blood draw.
    I am reading conflicting information. Which only proves to me that they don't know much about this or why it really occurs.
    Can you tell me what you have done to try to remedy your situation. How do you manage it?
    Have you made nutritional changes?

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