Hyperchloremic Metabolic Acidosis Uptodate

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Whether due to bicarbonate loss or volume repletion with normal saline, the primary problems is in hyperchloremic metabolic acidosis hcl ammonium chloride loading, reabsorption proximal tubule reduced, part, because of hyperchloraemic acidosis, anion gap (in most cases). Administration of ns will decrease the plasma sid causing an acidosis this patient also had a normal anion gap hyperchloremic metabolic (hcma). Googleusercontent search. Normal anion gap (hyperchloremic) acidosis semantic scholar. Hyperchloremic metabolic acidosis is it clinically relevant? (pdf hyperchloremic in diabetes mellitus. Hyperchloremic acidosis wikipedia. Treatment of acute non anion gap metabolic acidosis ncbi nih. Aug 4, 2016 a normal ag acidosis is characterized by lowered bicarbonate concentration, which counterbalanced an equivalent increase in plasma chloride concentration. Acid base physiology 8. Hyperchloraemic metabolic acidosisdepartment of medicine. Mechanism of hyperchloremic metabolic acidosis. Hyperchloremic acidosis background, etiology, patient education emedicine. Respiratory acidosis alkalosis as with the hyperchloremic may result from chloride replacing lost bicarbonate. Although it ca

Hyperchloremic Metabolic Acidosis Management | The

Link: Description: Abstract We evaluated the use of the urinary anion gap (sodium plus potassium minus chloride) in assessing hyperchloremic metabolic acidosis in 38 patients with altered distal urinary acidification and in 8 patients with diarrhea. Link: Description: Metabolic acidosis happens when a problem in your cells throws off the chemical balance in your blood, making it more acidic. Your treatment depends on what's causing it. 3. Metabolic Acidosis in the Newborn | Obgyn Key Link: Description: Metabolic Acidosis in the Newborn Kristina Cusmano-Ozog and Kimberly Chapman INTRODUCTION Metabolic acidosis in the neonate can be caused by several reasons, including increased acid intake from exogenous sources; increased endogenous production of an acid, such as seen in an inborn error of metabolism (IEM); inadequate 4. Metabolic acidosis | definition of metabolic acidosis Link: Description: Metabolic Acidosis Definition Metabolic acidosis is a pH imbalance in which the body has accumulated too much acid and does not have enough bicarbonate to effectively ... 5. Bicarbonate Therapy in Severe Metabolic Acidosis Link: Description: The utility of bicarbonate administration to patien Continue reading >>

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  1. c_washington

    Anyone have to use these? my MFM doc told me to get them but the pharmacy ordered glucose and protein... these don't test for ketones. I am going to return them tomorrow. Anyone have any suggestions for which brand to get and where to get them for not too much money? I see some on Amazon that are cheap and some that are expensive. What do you think?

  2. memali26

    I just check ketones, no proteins. I get my strips at any pharmacy - Walgreens, even Target has them. I think I paid about $11 for 50.

  3. c_washington


    I just check ketones, no proteins. I get my strips at any pharmacy - Walgreens, even Target has them. I think I paid about $11 for 50.
    yea, I have been checking ketones the whole pregnancy and I know those strips are widely available. Since I have type 1, our MFM doc is worried about pre-e so he wants me to test for protein and ketones everyday. I am looking for a combined strip.

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Respiratory acidosis #sign and symptoms of Respiratory acidosis Respiratory acidosis ABGs Analyse https://youtu.be/L5MWy1iHacI Plz share n subscribe my chanel is a condition that occurs when the lungs cant remove enough of the Suctioning https://youtu.be/hMJGkxvXTW0 carbon dioxide (CO2) produced by the body. Excess CO2 causes the pH of blood and other bodily fluids to decrease, making them too acidic. Normally, the body is able to balance the ions that control acidity. This balance is measured on a pH scale from 0 to 14. Acidosis occurs when the pH of the blood falls below 7.35 (normal blood pH is between 7.35 and 7.45).Rinku Chaudhary NSG officer AMU ALIGARH https://www.facebook.com/rinkutch/ Respiratory acidosis is typically caused by an underlying disease or condition. This is also called respiratory failure or ventilatory failure. Suctioning https://youtu.be/hMJGkxvXTW0 Normally, the lungs take in oxygen and exhale CO2. Oxygen passes from the lungs into the blood. CO2 passes from the blood into the lungs. However, sometimes the lungs cant remove enough CO2. This may be due to a decrease in respiratory rate or decrease in air movement due to an underlying condition such as: asth

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  1. Elizabeth6

    This is going to be a long blog post… but I woke up today feeling like I had to write it because I see so many people not understand the subject. And it’s important for people with diabetes — and parents of children with type 1 diabetes especially — to know what’s going on when ketones are present.
    I see a lot of parents saying that high blood sugars and ketones go hand in hand, and that if you let your child’s blood sugar get high, they will have ketones. This is actually not true. So what I want to accomplish with this post is to clear up a few misunderstandings when it comes to what’s happening when your child (or you, if the person with diabetes = the person in the mirror) shows ketones. You’ll have to forgive me for saying “your child” a lot in this post because I’m a parent of a CWD and I’m going to talk as if this is about parenting, but it goes for people who are caring for their own diabetes as well, naturally.
    First, some background on me: I’m a science/medical editor, and I review and research a wide range of topics. Diabetes, of course, is required reading, but I do a lot in cardiology, renal medicine (kidneys), oncology (cancer medicine), and pediatrics. So I know a great deal more than your average Joe or Jane, but I wouldn’t call myself an expert. An advanced beginner, maybe. I have, however, worked with a lot of experts — the most notable being my son’s endocrinologist, who heads a clinic that treats not only kids with type 1 diabetes but kids with adrenal disorders and cystic fibrosis. He and I, plus a Nurse Practitioner/CDE on his clinic’s staff, wrote this book
    5 together … and it was in the course of this project that I learned what I know about ketones.
    A mini lesson in metabolism and physiology
    Some of this may be familiar territory, but please take a minute to read through it anyway so we’re on the same page.
    We all know (hopefully) that insulin’s job is to open the door to a cell to let glucose inside so the glucose can be used to fuel the cell. And of course, we all know that type 1 diabetes = no insulin (or not enough) to accomplish this task — don’t feel left out, type 2s, I’ll get to you in a minute! What I sense many of us don’t know is where the ketones come from, and that’s key to understanding what’s happening and how to fix it.
    In diabetes, we're conditioned to think "ketones = bad" but they actually are part of a normal bodily function. (It's just that, in diabetes, many normal functions are off kilter because good old insulin is central to everything!) In a person without diabetes who is burning glucose in their cells the usual way, there are times they need more glucose than is circulating currently in their blood to keep up the level of activity or energy use they have going on. So they eat food with carbohydrates (or fats), their pancreas pumps out insulin, the food is broken down into glucose, the insulin transfers that glucose into the cells, and viola, cells have glucose to use for energy.
    But if the person doesn’t eat — they're too sick to eat, they're sleeping, or they just don't have the ability to eat right now — they can still get glucose one of two ways. First, their liver can release glycogen, which is stored sugar, directly into the blood — quick, but limited; it’s usually used by the body to keep blood glucose levels consistent while we’re sleeping. The other method is (and I’m going to gloss over a lot of the details here), the liver releases chemical signals that tell the body to convert fats into glucose. And the conversion of fatty acids into glucose is what produces ketone bodies or ketones. They are basically a waste product of the “fat burning” conversion process.
    The thing is, this process exists for a reason. When food is available, you don’t need to break down body fat for glucose unless you’re doing a lot more work than the glucose in the food you eat can support. But when food isn’t available, “burning fats” is a great backup to keep your body, and especially your brain, supplied with energy. This is why ketones are considered a sign of “starvation” — they only appear when the body lacks energy from food. And in small amounts, they’re harmless. It’s normal, for instance, for a person to produce ketones if they're on a weight loss program that is based around exercise and calorie restrictions, because that’s kind of the whole goal — to induce your body to use up the glucose stored in fat because you need more energy (glucose) than you take in via food.
    This is where the "acid" part comes in
    The one drawback is that ketones are acids, and we humans have a fairly limited tolerance of acidity in our blood and tissues. If ketones accumulate in the body to a point of reducing our bodily pH past the minimum tolerated level of 7.35, we get sick — metabolic acidosis develops, which, if it’s caused by diabetes-related ketones, is known as diabetic ketoacidosis or DKA. When this happens, we have to start using up all sorts of stored minerals (calcium, potassium) to “buffer” the acids and get us back into the range our body likes (pH over 7.35 but below 7.45), and we also use up a lot of fluids because the only way to remove the excess acids is to process them through the urine. Dehydration and electrolyte imbalance are the immediate result; if it’s not corrected quickly, many other serious and life-threatening problems happen down the line.
    Luckily for those of us without diabetes, and for the most part for those with type 2 diabetes, the body has a solution to prevent ketone/acid accumulation, too: the glucose released into the blood by “fat burning” triggers a release of insulin, and insulin in even small amounts stops the signal to convert fat to glucose because it enables the cells to have the fuel they need. The ketones produced by the temporary period of starvation get peed out, and off we go on our way.
    But, as you know, people with type 1 diabetes can’t produce adequate insulin to meet their needs. Even people with type 2 diabetes who are capable of producing insulin may not be able to produce enough insulin to halt ketone production, because there has to be enough insulin present so that most of the body's cells get glucose and stop yelling to the liver that they're starving — and if you're very insulin-resistant, the amount needed may be more than your pancreas can put out (particularly since stress hormones increase insulin resistance). This is why a type 2 diabetic who is under severe physical stress, like an illness, can develop DKA, contrary to popular wisdom that DKA only happens in T1s.
    In either case, T1 or stressed/sick T2, without putting artificial insulin into the system, there is no way to stop the “burn fats” signal — and thus, ketones accumulate and produce ketoacidosis.
    The connection between ketones and high blood sugar
    Now, obviously, if the body is burning fatty acids and producing ketones, it’s also producing glucose. That’s kind of the point, right? And if there’s no insulin, the glucose isn’t getting used, and the cells are still “starving” even though there’s glucose coming out your eyeballs at this point — that’s only a slight exaggeration, by the way — you get accumulation of glucose along with the accumulation of ketones. High ketones = high glucose, in this situation.
    But that’s not always the case. If you’ve ever had a T1 child or other PWD with a stomach virus, you know what I mean — the blood sugar is low because no food is going in, so you have to cut back the insulin to prevent catastrophe because the kid can’t eat anything, but the ketones are high because, obviously, body still needs energy to fight off the illness and so it’s burning fats — yet the three things needed to cushion against DKA (fluids, electrolytes, insulin) can’t be used without making the kid yack and/or go low.
    As I mentioned earlier, it takes a very small amount of insulin to put a stop to ketone production — a lot less than it takes to move high concentrations of glucose out of the blood and into the cells. And ketones start up when cells can't get enough glucose from the blood — which can be either not enough insulin or not enough glucose present, or both at the same time. That means that you can have ketones without high blood sugar or vice versa. In other words: high blood sugar doesn’t cause ketones or DKA. You can have ketone production leading to DKA with either high or low blood sugar, depending on the situation. Remember, ketones come about because cells aren't getting glucose, not because the glucose is missing but because the insulin isn't there. Ketones are produced because of a lack of insulin to move the glucose into cells, not because of the excess of blood glucose.
    This means that if your type 1 diabetic is getting some insulin — my endo said the amount is equivalent to 10% of what the body actually needs — he or she won’t start or keep burning fats and generating ketones, but may still have high blood sugar.
    High blood sugar can happen even when there’s insulin available for a lot of reasons with nothing to do with ketones:
    If you eat more carbs than you bolused for, then obviously your BG will be high; you’ve taken in more glucose than you have insulin to move it, but you still have enough glucose moving into cells to prevent a starvation response.
    Stress hormones produce insulin resistance, which means even a correctly bolused meal makes your BG go high — and stress can be physical (you’re catching a cold and your body is fighting it off, for instance) or mental (tests at school, a fight with your spouse, parent, friend, or sibling, even a mass attack of Creepers in Minecraft… and YES, I HAVE SEEN THAT ONE.)
    Growth hormone in children also produces insulin resistance; a major cause of consistent highs in kids is growth spurts, and it’s why you get consistent highs at night in elementary-age kids and in early morning in teens.
    I’ve seen this in action before many times: my son will have sky-high BG because I’ve under-dosed or because the insulin flow from his pump is occluded (but not stopped completely), yet he has no ketones because he’s gotten/getting enough insulin to prevent the starvation response. This is also why type 2 diabetics don’t get DKA very often, because even when their blood sugars are sky high, they usually have enough insulin present to move enough glucose into cells to prevent fat burning, but not enough to overcome insulin resistance completely (but that’s a different metabolic issue altogether from what T1s have).
    Bottom line:
    So if you’re a parent whose child is showing high blood sugar and ketones, you’re looking at two problems resulting from one cause: You have ketone production because cells are still starving, regardless of how much glucose there is in the blood; and you have high blood sugar because there’s not enough insulin to move the glucose into cells to give them the energy they need. These problems have the same solution: give more insulin so the glucose goes where it's needed and the perceived need to provide more glucose by breaking down fats goes away.
    The reason I think it’s important to recognize this distinction is that I worry that parents may resist letting blood sugar get “too high” in a sick child who is showing ketones, thinking that keeping blood sugar lower will help avoid DKA, when in fact, when children are ill, it’s better to maintain blood sugar at higher levels so you can give enough insulin to avoid ketones and DKA. Given the two possibilities, working to avoid ketones is a much higher priority than striving for lower blood sugar.

    I hope this has been helpful.

  2. shoshana27

    I,ve learned a lot, thank you.

  3. Mari5

    Thanks for your explanation! I'm sure it can help many. The idea of 10% insulin being enough to keep from producing ketones is quite incredible. Of course, all depends on your diabetes, sickness, etc I understand that a person should look at the overall situation not just the fixed number.
    In YOUR experience, what level of ketones should a person feel concerned?

    I see your book was published in 2012 I'm sure lots of newly diagnosed parents would be interested in reading it. Is it mentioned on the site as a reference for newcomers? I don't know if that possible..... Congratulations on the book anyway!

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Metabolic Acidosis - Bi Cardiology Fellows

ELEVATED GAP ("MUDPILES") (or " PLUM SEEDS ") Diabetic ketoacidosis (ketoacids also in alcoholism and starvation) Lacticacidosis (circulatory or resp failure, sepsis, ischemic bowel/limb,seizure, malignancy, hepatic failure, DM, CO or cyanide poisoning,metformin, inborn errors of metabolism) OG = [serum osm] - [(Nax2) + (BUN/2.8) + (Glucose/18) + (Ethanol/4.3)] OG > 15 implies: Ethylene glycol, Methanol, Sorbitol, Mannitol, Isopropanol (delta Anion Gap)/ (delta Bicarb) Ratio Method If <1, there is an Elevated-AG and concurrent normal-AG acidoses If >2, there is an Elevated-AG acidosis and concurrent metabolic alkalosis "corrected bicarb" = delta gap + HCO3 [Remember: delta gap=AG - 12] If "corrected bicarb" is too high (>28), there is a coexistent metabolic alkalosis If "corrected bicarb" is too low (<22), there is a coexistent metabolic non-AG acidosis (hyperchloremic metabolic acidosis) Bicarb Gap = Na - Cl - 39 ( derivation of formula , Wrenn et al. ) If Bicarb Gap >6, there is an additional metabolic alkalosis If Bicarb Gap <-6, there is an additional non-AG acidosis Lactate (gray top tube on ice) and Ketones (gold top/SST tube); review the significance of lactate Miscellaneou

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  1. HellenicViking

    I know GNG is a demand driven process and nothing to be scared of, also not to fear protein. On the other hand, it's also encouraged here that you don't really need that much protein, that 0.8g per lbs of LBM is more than enough.
    Now the thing is, I'm currently bulking, and I find it EXTREMELY HARD to not eat a shit load of protein. I eat pretty much only whole foods, and everyday I end up eating around 1.5g of protein per lbs of bodyweight (not even LBM), even though I focus only on fatty cuts of meat and everything as fatty as possible.
    Should I be concerned or just keep gorging on my protein? I'm insulin resistant btw if that changes anything (apparently it does to a degree when it comes to protein).

  2. rickamore

    Protein just makes a poor fuel, may make you sluggish and smell like ammonia working out. Otherwise don't really worry about it.
    This article written by /u/causalcorrelation just for you: http://ketogains.com/2016/05/protein-over-consumption-ketosis/

  3. HellenicViking

    I do actually feel more sluggish when I eat really high protein, and extremely energetic when I manage to go higher on the fat side than the protein one.
    Thanks for the link! I still struggle to keep protein lower, I eat pretty much only stuff like eggs, the fattest ground beef I can find, fat fish like mackerel, sardines, salmon, chicken thigh with skin, fat cheeses, avocados and nuts, and still, I always end up eating soooo much protein.

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