Diabetes With Ketone Bodies In Dogs
Diabetes Mellitus with Ketoacidosis in Dogs Diabetes is a medical condition in which the body cannot absorb sufficient glucose, thus causing a rise the blood sugar levels. The term “ketoacidosis,” meanwhile, refers to a condition in which levels of acid abnormally increased in the blood due to presence of “ketone bodies”. In diabetes with ketoacidosis, ketoacidosis immediately follows diabetes. It should be considered a dire emergency, one in which immediate treatment is required to save the life of the animal. This condition typically affects older dogs as well as females. In addition, miniature poodles and dachshunds are predisposed to diabetes with ketoacidosis. Symptoms and Types Weakness Lethargy Depression Lack of appetite (anorexia) Muscle wasting Rough hair coat Dehydration Dandruff Sweet breath odor Causes Although the ketoacidosis is ultimately brought on by the dog's insulin dependency due to diabetes mellitus, underlying factors include stress, surgery, and infections of the skin, respiratory, and urinary tract systems. Concurrent diseases such as heart failure, kidney failure, asthma, cancer may also lead to this type of condition. Diagnosis You will need to give a thorough history of your dog’s health, including the onset and nature of the symptoms, to your veterinarian. He or she will then perform a complete physical examination, as well as a biochemistry profile and complete blood count (CBC). The most consistent finding in patients with diabetes is higher than normal levels of glucose in the blood. If infection is present, white blood cell count will also high. Other findings may include: high liver enzymes, high blood cholesterol levels, accumulation in the blood of nitrogenous waste products (urea) that are usually excreted in the urine (azo Continue reading >>
How To Spot And Treat Diabetic Ketoacidosis (dka)
Even if you work hard at your diabetes management and use technology to help keep your numbers in range, you can still experience high blood glucose, which can escalate to diabetic ketoacidosis (DKA). While DKA can be scary if left untreated, it is preventable if you know what to look for and what to do. Senior District Clinical Manager, Melinda Turenne, BSN, RN, CDE, has more than 15 years of diabetes clinical experience. Today she shares some valuable DKA risk factors and prevention tips. Living with diabetes involves a lot of duties. You are checking your blood glucose (BG), counting your carbohydrates, exercising, and keeping doctors’ appointments. I am sure you remember your doctor or diabetes educator telling you to check for ketones too, right? Checking my what? One more thing to add to my to-do list! Yes, and here is WHY. What are ketones? Ketones are acid molecules produced when we burn fat for energy or fuel. As fat is broken down, ketones build up in the blood and urine. In high levels, ketones are toxic and can make you very sick. When combined with dehydration, it can lead to Diabetic Ketoacidosis (DKA), a life threatening condition. Why would DKA happen? DKA occurs when there is not enough insulin present in the body. Without enough insulin, glucose builds up in the blood, causing high BG levels. Since the body is unable to use glucose without insulin for energy, it breaks down fat instead. This can occur for several reasons: Infection, injury, or serious illness A lack of insulin in the body due to missed injections, spoiled insulin, poor absorption Severe dehydration Combination of these things What are the signs of DKA? High BG levels Ketones (in blood and urine) Nausea, vomiting, and abdominal pain (cramps) Confusion Tired, sluggish, or weak Flushed, Continue reading >>
Diabetic ketoacidosis is a potentially life-threatening complication of diabetes caused by a lack of insulin in the body. It's important to seek medical advice quickly if you think that you or your child is experiencing the condition. Causes of diabetic ketoacidosis Diabetic ketoacidosis is a complication of diabetes that can occur if the body starts to run out of insulin. It's common in people with type 1 diabetes and can very occasionally affect those with type 2 diabetes. It sometimes develops in people who were previously unaware they had diabetes. Children and young adults are most at risk. Insulin enables the body to use blood sugar (glucose). If there is a lack of insulin, or if it can't be used properly, the body will break down fat instead. The breakdown of fat releases harmful, acidic substances called ketones.The lack of insulin in your body leads to high blood glucose levels (hyperglycaemia). The combination of high ketone and blood sugar levels can cause a number of symptoms that can be very serious if the levels aren't corrected quickly. Symptoms of diabetic ketoacidosis The initial symptoms of diabetic ketoacidosis can develop quite suddenly. They will continue to get worse if not treated. Early symptoms In the early stages, the main signs of diabetic ketoacidosis include: passing large amounts of urine severe thirst weight loss feeling sick tiredness You may also develop other symptoms of dehydration, such as a dry mouth. If you have your own device or kit to measure your blood sugar and/or ketone levels, you may notice that the levels of both of these are higher than normal. Advanced symptoms Left untreated, more advanced symptoms can develop, including: rapid heartbeat (tachycardia) rapid breathing, where you breathe in more oxygen than your body actua Continue reading >>
Do You Believe That Pets Can Find Cancer And Other Diseases By Smell?
No belief, but have been proven to do so, see these scientific publications. From dogs sniffing out explosives, drugs, even peanuts to prevent an allergic child to ingest hidden peanuts in the food, it's not so a big step to sniffing out cancers from people's breath, urine and stool samples: Page on googlegroups.com "Diagnostic Accuracy of Canine Scent Detection in Early- and Late-Stage Lung and Breast Cancers" by Michael McCulloch et al found that Among lung cancer patients and controls, overall sensitivity of canine scent detection compared to biopsy-confirmed conventional diagnosis was 0.99 (95% confidence interval [CI], 0.99, 1.00) and overall specificity 0.99 (95% CI, 0.96, 1.00). Among breast cancer patients and controls, sensitivity was 0.88 (95% CI, 0.75, 1.00) and specificity 0.98 (95% CI, 0.90, 0.99). Sensitivity and specificity were remarkably similar across all 4 stages of both diseases. Conclusion: Training was efficient and cancer identification was accurate; in a matter of weeks, ordinary household dogs with only basic behavioral “puppy training” were trained to accurately distinguish breath samples of lung and breast cancer patients from those of controls. For canine lung cancer detection by sniffing exhaled breaths also see Canine scent detection in the diagnosis of lung cancer: revisiting a puzzling phenomenon For canine bladder cancer detection by sniffing urine please see: Olfactory detection of human bladder cancer by dogs: proof of principle study For canine prostate cancer detection by sniffing urine please see: Trained dogs can sniff out prostate cancer - Harvard Prostate Knowledge referring to Olfactory System of Highly Trained Dogs Detects Prostate Cancer in Urine Samples. looking at the urine samples of 362 prostate cancer patients and 540 Continue reading >>
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> Hyperglycemia And Diabetic Ketoacidosis
When blood glucose levels (also called blood sugar levels) are too high, it's called hyperglycemia. Glucose is a sugar that comes from foods, and is formed and stored inside the body. It's the main source of energy for the body's cells and is carried to each through the bloodstream. But even though we need glucose for energy, too much glucose in the blood can be unhealthy. Hyperglycemia is the hallmark of diabetes — it happens when the body either can't make insulin (type 1 diabetes) or can't respond to insulin properly (type 2 diabetes). The body needs insulin so glucose in the blood can enter the cells to be used for energy. In people who have developed diabetes, glucose builds up in the blood, resulting in hyperglycemia. If it's not treated, hyperglycemia can cause serious health problems. Too much sugar in the bloodstream for long periods of time can damage the vessels that supply blood to vital organs. And, too much sugar in the bloodstream can cause other types of damage to body tissues, which can increase the risk of heart disease and stroke, kidney disease, vision problems, and nerve problems in people with diabetes. These problems don't usually show up in kids or teens with diabetes who have had the disease for only a few years. However, they can happen in adulthood in some people, particularly if they haven't managed or controlled their diabetes properly. Blood sugar levels are considered high when they're above someone's target range. The diabetes health care team will let you know what your child's target blood sugar levels are, which will vary based on factors like your child's age. A major goal in controlling diabetes is to keep blood sugar levels as close to the desired range as possible. It's a three-way balancing act of: diabetes medicines (such as in Continue reading >>
What Are The Dangers Of Not Treating Your Diabetes?
The effects of diabetes manifest in nearly all organ systems of the body and it left untreated, diabetes can lead to heart disease, kidney failure, loss of vision, loss of foot etc. But what is cause of these effects of diabetes? As you know, diabetics have higher blood glucose levels than do normal people, the excess blood sugar starts getting deposited in the blood vessels of diabetics, which in turn leads to two sets of long-term complications both related to abnormalities in blood vessel Microvascular complications: these complications are due to abnormalities in small blood vessels. They are Diabetic retinopathy affecting the eyes/vision: can result in sudden/accelerated loss of vision Diabetic nephropathy affecting the kidneys: diabetes type 2 is a leading cause of renal failure in India Diabetic neuropathy including diabetic foot, erectile dysfunction, GI and urinary problems, gangrene of foot etc . Increased risk of infection and sepsis: due to diabetic angiopathy (injury to blood vessels) and immune compromise To read in detail about what % of diabetics get these and after how many years and how good control of blood sugar levels help: read Diabetes complications: what is the cause and how good control helps? Tight control of blood sugar (HbA1c levels less than 7% and less than 6.5%, if possible) results in lesser microvascular complications in all diabetics, whereas for CVD risk reduction, tight control in the initial years of diabetes is most beneficial To know more about what does tight control actually mean, read ‘What does good control of blood sugar mean in diabetes?’ Also, diabetes experts recommend frequent monitoring of diabetic patients by blood tests and physical examination to detect and treat early the complications of diabetes as well as to en Continue reading >>
How Can Diabetics Have Diabetic Emergencies? (see Details)
You evidently have no idea what diabetes is, and what complications can occur. Diabetes is much, much more than just a high blood sugar. Roughly speaking, type I diabetes is due to people developing auto-antibodies against their own pancreatic islet beta cells that produce insulin causing insulitis, thus destroying these islets, so after some time there is an absolute lack of insulin, without which no sugar can be metabolized to produce energy in the form of ATP. In the days before insulin was invented they all quickly died, Banting and Best first used a rough pancreas extract to save the life of a 14 yo boy in 1922 see The Discovery of Insulin and were awarded the Nobel Prize for that. It is hard to exactly dose the insulin right, giving too much in relationship to food intake (which will make blood sugar rise) and exertion (which will make blood sugar go down) will cause people to develop such a low blood sugar that the brain, which needs sugar in the form of glucose to function to lose consciousness, a hypoglycemic coma, which if very severe might rarely lead to death, this needs to be treated by giving glucose often by intravenous injection. If too little, blood sugar will rise, with no immediate adverse results, but in the longer term associated with all kinds for terrible complications like serious nerve damage, impotence, occluded arteries in the limbs leading to amputations, heart attacks, stroke, blindness, kidney failure leading to dialysis, etc. etc. If no insulin is taken at all after around 1,5 day no glucose can be metabolized, so blood sugar will rise, be excreted into the urine, taking lots of water with it leading to serious dehydration, acute kidney failure, circulatory shock, because fat metabolism needs insulin keto-acids will form so the body become Continue reading >>
What Are Symptoms Of Diabetic Ketoacidosis?
Diabetic ketoacidosis is a serious complication typically faced by people with type-1 diabetes, which occurs when body starts running out of insulin. This condition can leave the patient in coma or even death if not treated immediately. Diabetic ketoacidosis occurs when body is lacking lacking insulin to allow sufficient glucose to enter cells. Therefore the body absorbs energy by burning fatty acids and in turn produce acidic ketone bodies. Blood containing high levels of ketone bodies can cause serious illness. Diabetic ketoacidosis is itself a symptom of undiagnosed type-1 diabetes. Other symptoms of diabetic ketoacidosis include: 1. Dehydration 2. Vomiting 3. Nausea 4. Blurred vision 5. Fatigue & sleepiness 6. Frequent urination 7. Rapid heartbeat 8. Unusual smell on the breath (similar to that of pear drops) 9. Confusion and disorientation 10. Hyperventilation or deep laboured breathing 11. Coma The symptoms of diabetic ketoacidosis usually develop over a 24-hour period if blood glucose levels are and remain very high (hyperglycemia). Continue reading >>
Feline Diabetic Ketoacidosis
Fall 2008 Ketoacidosis is a metabolic imbalance that is most commonly seen as a sequel to unmanaged or poorly regulated diabetes mellitus. It is caused by the breakdown of fat and protein in a compensatory effort for the need of more metabolic energy. The excessive breakdown of these stored reserves creates a toxic by-product in the form of ketones. As ketones build up in the blood stream, pH and electrolyte imbalances proceed. This condition is a potentially life-threatening emergency that requires immediate medical attention. Diabetes mellitus is a common endocrine disease in geriatric felines. It is caused by a dysfunction in the beta cells of the exocrine pancreas resulting in an absolute or relative deficiency of insulin. Insulin has been called the cells' gatekeeper. It attaches to the surface of cells and permits glucose, the cells' primary energy source, to enter from the blood. A lack of insulin results in a build up of glucose in the blood, physiologically causing a state of cellular starvation. In response to this condition the body begins to increase the mobilization of protein and fat storage. Fatty acids are released from adipose tissue, which are then oxidized by the liver. Normally, these fatty acids are formed into triglycerides. However, without insulin, these fatty acids are converted into ketone bodies, which cannot be utilized by the body. Together with the increased production and decreased utilization an abnormally high concentration of ketone bodies develop. These fixed acids are buffered by bicarbonate; however, the excessive amounts overwhelm and deplete the bicarbonate leading to an increase in arterial hydrogen ion concentration and a decrease in serum bicarbonate. This increase in hydrogen ions lowers the body's pH, leading to a metabolic ac Continue reading >>
Diabetic Ketoacidosis Symptoms
What is diabetic ketoacidosis? Diabetic ketoacidosis, also referred to as simply ketoacidosis or DKA, is a serious and even life-threatening complication of type 1 diabetes. DKA is rare in people with type 2 diabetes. DKA is caused when insulin levels are low and not enough glucose can get into the body's cells. Without glucose for energy, the body starts to burn fat for energy. Ketones are products that are created when the body burns fat. The buildup of ketones causes the blood to become more acidic. The high levels of blood glucose in DKA cause the kidneys to excrete glucose and water, leading to dehydration and imbalances in body electrolyte levels. Diabetic ketoacidosis most commonly develops either due to an interruption in insulin treatment or a severe illness, including the flu. What are the symptoms and signs of diabetic ketoacidosis? The development of DKA is usually a slow process. However, if vomiting develops, the symptoms can progress more rapidly due to the more rapid loss of body fluid. Excessive urination, which occurs because the kidneys try to rid the body of excess glucose, and water is excreted along with the glucose High blood glucose (sugar) levels The presence of ketones in the urine Other signs and symptoms of ketoacidosis occur as the condition progresses: These include: Fatigue, which can be severe Flushing of the skin Fruity odor to the breath, caused by ketones Difficulty breathing Type 2 Diabetes Diagnosis, Treatment, Medication What should I do if I think I may have, or someone I know may diabetic ketoacidosis? You should test your urine for ketones if you suspect you have early symptoms or warning signs of ketoacidosis. Call your health-care professional if your urine shows high levels of ketones. High levels of ketones and high blood sug Continue reading >>
Ketones in the urine, as detected by urine testing stix or a blood ketone testing meter, may indicate the beginning of diabetic ketoacidosis (DKA), a dangerous and often quickly fatal condition caused by low insulin levels combined with certain other systemic stresses. DKA can be fixed if caught quickly. Diabetics of all species therefore need to be checked for ketones with urine testing stix, available at any pharmacy, whenever insulin level may be too low, and any of the following signs or triggers are present: Ketone Monitoring Needed: Little or no insulin in last 12 hours High blood sugar over 16 mmol/L or 300 mg/dL (though with low insulin, lower as well...) Dehydration (skin doesn't jump back after pulling a bit gums are tacky or dry) Not eating for over 12 hours due to Inappetance or Fasting Vomiting Lethargy Infection or illness High stress levels Breath smells like acetone (nail-polish remover) or fruit. Note that the triggers and signs are somewhat interchangeable because ketoacidosis is, once begun, a set of vicious circles which will make itself worse. So dehydration, hyperglycemia, fasting, and presence of ketones are not only signs, they're also sometimes triggers. In a diabetic, any urinary ketones above trace, or any increase in urinary ketone level, or trace urinary ketones plus some of the symptoms above, are cause to call an emergency vet immediately, at any hour of the day. Possible False Urine Ketone Test Results Drugs and Supplements Valproic Acid (brand names) Depakene, Depakote, Divalproex Sodium Positive. Common use: Treatment of epilepsy. Cefixime/Suprax Positive with nitroprusside-based urine testing. Common use: Antibiotic. Levadopa Metabolites Positive with high concentrations. Tricyclic Ring Compounds Positive. Commo Continue reading >>
Diabetic Ketoacidosis (dka)
Short-term high blood sugars are rarely lethal. However, for people with type 1 diabetes and some with type 2 who are not producing enough insulin, periods of high blood sugars can lead to diabetic ketoacidosis. The absence of insulin allows your blood to slowly become acidic. The body’s cells cannot survive under acidic conditions so the liver will try to help the cells that are starved for glucose and secrete glucose. When combined with dehydration, this process accelerates into a poisonous cocktail that undermines the heart, impairs the brain, and can lead to death in days. Prolonged high blood sugars can be caused by missing insulin doses, problems with an insulin pump, being sick with the flu or other illness, or eating more carbohydrates than your body has insulin to process. Who Can Develop Diabetic Ketoacidosis (DKA)? People with type 1 diabetes and type 2 diabetes can develop DKA. Most at risk however, are people with type 1 diabetes because they don’t make any insulin of their own and most people with type 2 diabetes do usually make some of their own insulin. Oftentimes DKA develops in people who have not yet been diagnosed with diabetes. Once diagnosed, people with diabetes can avoid DKA if they learn to recognize the beginning symptoms. How Do I Know If I Have Diabetic Ketoacidosis (DKA)? DKA can develop slowly or quickly. At first, it mimics the symptoms of high blood sugar: thirstiness dry mouth frequent urination You will likely have high blood sugars and ketones in your urine (more on this below). If your body still doesn’t get the insulin it needs, your blood becomes more acidic. you will likely feel tired your body might start to feel very achy like when you have a high fever. When any of the following symptoms occur, your condition has likely pr Continue reading >>
What Is It? Diabetic ketoacidosis is a potentially fatal complication of diabetes that occurs when you have much less insulin than your body needs. This problem causes the blood to become acidic and the body to become dangerously dehydrated. Diabetic ketoacidosis can occur when diabetes is not treated adequately, or it can occur during times of serious sickness. To understand this illness, you need to understand the way your body powers itself with sugar and other fuels. Foods we eat are broken down by the body, and much of what we eat becomes glucose (a type of sugar), which enters the bloodstream. Insulin helps glucose to pass from the bloodstream into body cells, where it is used for energy. Insulin normally is made by the pancreas, but people with type 1 diabetes (insulin-dependent diabetes) don't produce enough insulin and must inject it daily. Your body needs a constant source of energy. When you have plenty of insulin, your body cells can get all the energy they need from glucose. If you don't have enough insulin in your blood, your liver is programmed to manufacture emergency fuels. These fuels, made from fat, are called ketones (or keto acids). In a pinch, ketones can give you energy. However, if your body stays dependent on ketones for energy for too long, you soon will become ill. Ketones are acidic chemicals that are toxic at high concentrations. In diabetic ketoacidosis, ketones build up in the blood, seriously altering the normal chemistry of the blood and interfering with the function of multiple organs. They make the blood acidic, which causes vomiting and abdominal pain. If the acid level of the blood becomes extreme, ketoacidosis can cause falling blood pressure, coma and death. Ketoacidosis is always accompanied by dehydration, which is caused by high Continue reading >>
A Preventable Crisis People who have had diabetic ketoacidosis, or DKA, will tell you it’s worse than any flu they’ve ever had, describing an overwhelming feeling of lethargy, unquenchable thirst, and unrelenting vomiting. “It’s sort of like having molasses for blood,” says George. “Everything moves so slow, the mouth can feel so dry, and there is a cloud over your head. Just before diagnosis, when I was in high school, I would get out of a class and go to the bathroom to pee for about 10–12 minutes. Then I would head to the water fountain and begin drinking water for minutes at a time, usually until well after the next class had begun.” George, generally an upbeat person, said that while he has experienced varying degrees of DKA in his 40 years or so of having diabetes, “…at its worst, there is one reprieve from its ill feeling: Unfortunately, that is a coma.” But DKA can be more than a feeling of extreme discomfort, and it can result in more than a coma. “It has the potential to kill,” says Richard Hellman, MD, past president of the American Association of Clinical Endocrinologists. “DKA is a medical emergency. It’s the biggest medical emergency related to diabetes. It’s also the most likely time for a child with diabetes to die.” DKA occurs when there is not enough insulin in the body, resulting in high blood glucose; the person is dehydrated; and too many ketones are present in the bloodstream, making it acidic. The initial insulin deficit is most often caused by the onset of diabetes, by an illness or infection, or by not taking insulin when it is needed. Ketones are your brain’s “second-best fuel,” Hellman says, with glucose being number one. If you don’t have enough glucose in your cells to supply energy to your brain, yo Continue reading >>
Ketosis Vs. Ketoacidosis: What You Should Know
Despite the similarity in name, ketosis and ketoacidosis are two different things. Ketoacidosis refers to diabetic ketoacidosis (DKA) and is a complication of type 1 diabetes mellitus. It’s a life-threatening condition resulting from dangerously high levels of ketones and blood sugar. This combination makes your blood too acidic, which can change the normal functioning of internal organs like your liver and kidneys. It’s critical that you get prompt treatment. DKA can occur very quickly. It may develop in less than 24 hours. It mostly occurs in people with type 1 diabetes whose bodies do not produce any insulin. Several things can lead to DKA, including illness, improper diet, or not taking an adequate dose of insulin. DKA can also occur in individuals with type 2 diabetes who have little or no insulin production. Ketosis is the presence of ketones. It’s not harmful. You can be in ketosis if you’re on a low-carbohydrate diet or fasting, or if you’ve consumed too much alcohol. If you have ketosis, you have a higher than usual level of ketones in your blood or urine, but not high enough to cause acidosis. Ketones are a chemical your body produces when it burns stored fat. Some people choose a low-carb diet to help with weight loss. While there is some controversy over their safety, low-carb diets are generally fine. Talk to your doctor before beginning any extreme diet plan. DKA is the leading cause of death in people under 24 years old who have diabetes. The overall death rate for ketoacidosis is 2 to 5 percent. People under the age of 30 make up 36 percent of DKA cases. Twenty-seven percent of people with DKA are between the ages of 30 and 50, 23 percent are between the ages of 51 and 70, and 14 percent are over the age of 70. Ketosis may cause bad breath. Ket Continue reading >>