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How Long Does Lactic Acidosis Last

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Lactic Acidosis

Patient professional reference Professional Reference articles are written by UK doctors and are based on research evidence, UK and European Guidelines. They are designed for health professionals to use. You may find one of our health articles more useful. Description Lactic acidosis is a form of metabolic acidosis due to the inadequate clearance of lactic acid from the blood. Lactate is a byproduct of anaerobic respiration and is normally cleared from the blood by the liver, kidney and skeletal muscle. Lactic acidosis occurs when the body's buffering systems are overloaded and tends to cause a pH of ≤7.25 with plasma lactate ≥5 mmol/L. It is usually caused by a state of tissue hypoperfusion and/or hypoxia. This causes pyruvic acid to be preferentially converted to lactate during anaerobic respiration. Hyperlactataemia is defined as plasma lactate >2 mmol/L. Classification Cohen and Woods devised the following system in 1976 and it is still widely used:[1] Type A: lactic acidosis occurs with clinical evidence of tissue hypoperfusion or hypoxia. Type B: lactic acidosis occurs without clinical evidence of tissue hypoperfusion or hypoxia. It is further subdivided into: Type B1: du Continue reading >>

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Popular Questions

  1. lorrained8

    Metformin and lactic acidosis

    Has anyone here had lactic acidosis because of taking metformin
    I have leg and muscular pain I feel tired and weak
    I've discontinued my met er
    I will talk to my dr tomorrow

  2. Sweetpoison

    Originally Posted by lorrained8
    I have leg and muscular pain I feel tired and weak
    I have leg pain and bad night cramps but I had that occasionally before I even started Met. I am sorry, Lorraine, this is happening to you!
    How long have you been on the Met ER before you realized this?

  3. Lynnw

    Originally Posted by lorrained8
    Has anyone here had lactic acidosis because of taking metformin
    I have leg and muscular pain I feel tired and weak
    I've discontinued my met er
    I will talk to my dr tomorrow Are you on any other medications that could cause that? How long have you been on the Metformin? Metformin made me incredibly fatigued, to the point where I couldn't do anything but drag myself from my bed to my chair (I'm normally a very active person). I never figured out if that was lactic acidosis, Vit B-12 deficiency (which Metformin can cause), or something else. Others have had the same experience.

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