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How Does The Body Try To Compensate For Metabolic Acidosis?

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Disorders Of Acid-base Balance

Module 10: Fluid, Electrolyte, and Acid-Base Balance By the end of this section, you will be able to: Identify the three blood variables considered when making a diagnosis of acidosis or alkalosis Identify the source of compensation for blood pH problems of a respiratory origin Identify the source of compensation for blood pH problems of a metabolic/renal origin Normal arterial blood pH is restricted to a very narrow range of 7.35 to 7.45. A person who has a blood pH below 7.35 is considered to be in acidosis (actually, physiological acidosis, because blood is not truly acidic until its pH drops below 7), and a continuous blood pH below 7.0 can be fatal. Acidosis has several symptoms, including headache and confusion, and the individual can become lethargic and easily fatigued. A person who has a blood pH above 7.45 is considered to be in alkalosis, and a pH above 7.8 is fatal. Some symptoms of alkalosis include cognitive impairment (which can progress to unconsciousness), tingling or numbness in the extremities, muscle twitching and spasm, and nausea and vomiting. Both acidosis and alkalosis can be caused by either metabolic or respiratory disorders. As discussed earlier in this Continue reading >>

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Popular Questions

  1. Autumn_B

    I've noticed that I've been losing a lot of hair, more than is normal, and I'm hungry every 3 hours or so with a general feeling of weakness. When I eat meals, I literally eat as much as I can, so I'm definitely pretty full when I'm done eating. Am I not eating enough calories (I haven't tracked them honestly), am I having too much Saturated fat for myself? What reasons could this be happening. It's been frustrating.

  2. Cassydowns

    I would start tracking EVERYTHING. That really helps to see where everything is and if you are getting an sneaky carbs or sugar

  3. Shortstuff

    You need to track as there's no way to even start figuring out what is wrong when you don't have any idea what you're actually doing... but for sure, the way you're feeling is not right and needs dealing with.

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Acid-base Disorders Flashcards | Quizlet

-accomplished by substances in blood buffering the pH (soaking up H+) *bicarbonate (5%, but most physiologically important) what are two ways to get acid out of the body? -pee it out through renal excretion as H+ *diabetic ketoacidosis, lactic acidosis (Increased AG) *diarrhea, renal failure (no change in AG( how does the body compensate for metabolic acidosis? *lungs compensate by increasing respiration (blowing off CO2) *kidneys compensate by excreting more H+ (minimal effect compared to the lungs) -the total concentration of positive molecules (Na+, K+) minus the total concentration of negative molecules (CL-, HCO3-) -many normal minor negative molecules are not counted, which collectively add up -many abnormal molecules have a negative charge (lactic acid, ketones), so there are more positive charges in the calculation and the anion gap increases how does the body compensate for respiratory alkalosis? -kidneys excrete HCO3- and decrease H+ excretion -compensatory abilities of the lung are 100 times greater than the kidney -compensation by both lungs and kidneys takes a while to kick in -in acute stages, you will see relatively large abnormalities of pH -as compensation occurs Continue reading >>

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  1. datums

    Unfortunately, biochemistry is not the kind of topic that can be easily researched online without formal training. There are a number of points you make that are incorrect. I keto myself, so don't think I am trying to attack your general position here.
    Starvation and the keto diet are actually nearly identical from a biochemical perspective. The key pathway is fat mobilization, where fatty acid chains are broken down two carbons at a time to produce energy. When this process starts to happen faster than your body can manage it, some of the chemical constituents of the process actually break down to become the ketones that can be detected in the urine and breath. In other words, ketones are a side effect, rather than a major player.
    The idea that a calorie deficit, ie starvation, is somehow bad, is incorrect. Anybody who is using diet and exercise to become more lean is doing the same thing. There is no magic method to lose weight without some form of starvation. The reason why the keto diet does not cause significant lean tissue loss is that the starvation involved is not sufficiently severe.
    An important point that you bring up is the idea that the keto diet stabilizes insulin levels. This is basically correct. Insulin signals cells to take up glucose from the blood, and also tells the liver to begin glycogenesis - the process of packing glucose into glycogen. High blood sugar triggers this. These effects are basically reversed by adrenaline, which tells the liver to start breaking glycogen down to make glucose.
    Part of the difficulty with this is that with a normal diet, blood sugar spikes after meals. This leads to cyclic variance in levels of glucose, insulin and adrenaline. As the cycle progresses toward the adrenaline end, you start to get cravings for foods that will once again spike your blood glucose.
    However, when you are relying on fat mobilization to make glucose, these spikes are greatly reduced. Fat mobilization is not efficient, and is not able to provide sudden bursts of glucose. It is more constant. This makes athletic activity much more difficult aswell.
    But this is the real reason why the keto diet works - it mitigates the cycle of spiking and lowering blood sugar, providing a more level and constant supply. This reduces the propensity for craving food.
    In essence, the keto diet is not unique in terms of the basic biochemistry of metabolism. It simply makes 'starvation' more tolerable, and easier to manage. For many of us, that is exactly what we need.
    Edit - swapped 'gluconeogenesis' with 'glycogenesis'.

  2. gogge

    Insulin signals cells to take up glucose from the blood, and also tells the liver to begin gluconeogenesis - the process of packing glucose into glycogen. High blood sugar triggers this. These effects are basically reversed by adrenaline, which tells the liver to start breaking glycogen down to make glucose.
    Insulin inhibits gluconeogenesis (creation of new glucose), you probably meant glycogenesis (conversion of glucose to glycogen)?

  3. datums

    You are right on that one. The word I was looking for was glycogenesis. It can be a little tricky to remember that between glycolysis, glucogenesis, and gluconeogenesis, one means glycogen synthesis, and the other two mean glycogen breakdown.

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Free Nursing Flashcards About Acid-base/fluid-elec

How does the body compensate for Respiratory Acidosis? Kidneys retain bicarb & release H+ to increase ph How does the body compensate for Respiratory Alkalosis? The kidneys retain H+ and excretee bicarb to decrease pH How does the body compensate for Metabolic Acidosis? Respiration increase to decrease the CO2 which lowers carbonic acid, which increases bicarb and pH How does the body compensate for Metabolic Alkalosis? Respirations decrease which increases CO2, causing carbonic acid to increase and pH to decrease What actions in the body causes Respiratory Acidosis? decreased respiration causes increase in CO2 and carbonic acid, which decreases bicarb and pH... What actions in the body causes Respiratory Alkalosis? Increased respiration causes a decrease in CO2 and carbonic acid, which increases bicarb and pH... What actions in the body causes Metabolic Acidosis? Decreased bicarb (from diarrhea, DKA or renal failure) causes increased carbonic acid and decreased pH... What actions in the body causes Metabolic Alkalosis? Increased bicarb (from prolonged vomiting, diuretics, antacids) causes a decrease in carbonic acid and increased pH... What is the normal range for HCO3 (bicarb)? Continue reading >>

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Popular Questions

  1. someguy008

    I'm a 48 year old male. 240 pounds, 6' 1", between 20 and 25% body fat.
    I'm somewhat active, no health issues, big frame, decent muscle development. I've always watched my carbs and generally eat lower amounts of carbs compared to a regular diet.
    My goal is to reach 200 pounds, 10% bf.
    Last week I started a semi serious keto diet. I'm not counting my calories or carbs, I just eliminated as many carbs as was convenient. I was consuming way more than 20grms a day. Probably 50-60 grams.
    I don't know whether it was the diet change or it would have happened otherwise, but I developed a sore inflamed throat and fever (keto flu ?) that persisted for 5 days. I'm just getting over it now.
    I also developed a terrible metallic taste in my mouth. So bad that I lost my appetite entirely. The metallic taste was so bad that I couldn't eat anything. Normally I like a beer with my dinner as a treat, but I could barely tolerate even a sip.
    I also developed severe cotton mouth. My mouth was severely dry at night and drinking water frequently didn't seem to help. I think this is how I developed the sore throat.
    I was also peeing excessively. Like every hour, though sometimes the volume wasn't large.
    After a few days of these symptoms I had no choice but to increase my carbs. It has been 2 days now since I increased my carbs. I feel better but the metallic taste still lingers. My throat is now much better, though I seem to have some swelling on the lymph glands in my neck.
    So... is the keto diet the cause of any of this ? Am I doing something wrong ? Is there a way to get rid of the metallic taste ? Is there a way to prevent the cotton mouth ?
    Thanks

  2. topherkeey

    I don't know if you already knew about this, but this sub has a Wiki page:
    Metallic Taste/Breath
    https://www.reddit.com/r/keto/wiki/acetone_breath
    Keto Flu and Electrolytes
    https://www.reddit.com/r/keto/wiki/faq#wikiwhat_is.201Cketo_flu.201D_and_how_long_will_i_have_it.3F
    Everything you're describing is normal if you're not tracking your macro- and micro-nutrients. I'd recommend tracking your intake and supplementing electrolytes as necessary.

  3. bidnow

    Did you read the FAQ before you started the diet?

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