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How Does Ketoacidosis Affect The Brain

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Neurological Consequences Of Diabetic Ketoacidosis At Initial Presentation Of Type 1 Diabetes In A Prospective Cohort Study Of Children

Go to: To investigate the impact of new-onset diabetic ketoacidosis (DKA) during childhood on brain morphology and function. Patients aged 6–18 years with and without DKA at diagnosis were studied at four time points: <48 h, 5 days, 28 days, and 6 months postdiagnosis. Patients underwent magnetic resonance imaging (MRI) and spectroscopy with cognitive assessment at each time point. Relationships between clinical characteristics at presentation and MRI and neurologic outcomes were examined using multiple linear regression, repeated-measures, and ANCOVA analyses. Thirty-six DKA and 59 non-DKA patients were recruited between 2004 and 2009. With DKA, cerebral white matter showed the greatest alterations with increased total white matter volume and higher mean diffusivity in the frontal, temporal, and parietal white matter. Total white matter volume decreased over the first 6 months. For gray matter in DKA patients, total volume was lower at baseline and increased over 6 months. Lower levels of N-acetylaspartate were noted at baseline in the frontal gray matter and basal ganglia. Mental state scores were lower at baseline and at 5 days. Of note, although changes in total and regional Continue reading >>

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Popular Questions

  1. Ibex3D

    I've been on keto for about 4 days now. I havent really been experiencing any of the keto flu symptoms(nor did I the first time I tried this diet a year ago) until this morning. I kept waking up with stomach pain, the shakes, and cold sweat. It felt like I was going through withdrawal. I attributed it to the keto flu but then I started vomiting. A lot. I've never read anything about people vomiting from keto so I'm wondering if this is the keto flu or if I'm actually sick.

  2. NotSureMyself

    That sounds like sick. Make sure to get some electrolytes in you and drink plenty fluids (you definitely don't want to get yourself any more dehydrated!).

  3. lecirca

    Uhm - no. You're probably actually sick.

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