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How Does Infection Trigger Dka?

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How Do Mi & Infection Trigger Dka? - Medicine

Myocardial infarction is a known trigger for diabetic ketoacidosis. I am having trouble finding a comprehensive mechanism for how this works. From what I have read, it seems like it would be a combination of: ischemia of the myocardium triggers SNS to dump catecholamines, which induce hyperglycemia and suppress insulin production (epinephrine) and induce lipolysis (norepinephrine), combined with the MI inducing a state of acidosis by way of reduced cardiac output + arterial hypoxemia + excess hydronium formation during rapid ATP hydrolysis + lactate accumulation. Am I missing parts or off the mark with anything? Also wondering about infection as a trigger for DKA. Is this effect attributed to elevated catecholamines in early sepsis (leading to the metabolic effects above?) Catecholamine release during times of stress cause insulin resistance. This leads to increased ketone formation. The 2 main ketones, Acetoacetate and b-hydroxybutyrate have low pKa's, and thus cause an anion gap acidosis. In MI/infection, you may have a Lactic acidosis, but this is usually a consequence of impaired oxygen delivery (decreased cardiac output/hypovolemia), not imparied glucose uptake. Continue reading >>

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What is DIABETIC KETOACIDOSIS? What does DIABETIC KETOACIDOSIS mean? DIABETIC KETOACIDOSIS meaning - DIABETIC KETOACIDOSIS definition - DIABETIC KETOACIDOSIS explanation. Source: Wikipedia.org article, adapted under https://creativecommons.org/licenses/... license. SUBSCRIBE to our Google Earth flights channel - https://www.youtube.com/channel/UC6Uu... Diabetic ketoacidosis (DKA) is a potentially life-threatening complication of diabetes mellitus. Signs and symptoms may include vomiting, abdominal pain, deep gasping breathing, increased urination, weakness, confusion, and occasionally loss of consciousness. A person's breath may develop a specific smell. Onset of symptoms is usually rapid. In some cases people may not realize they previously had diabetes. DKA happens most often in those with type 1 diabetes, but can also occur in those with other types of diabetes under certain circumstances. Triggers may include infection, not taking insulin correctly, stroke, and certain medications such as steroids. DKA results from a shortage of insulin; in response the body switches to burning fatty acids which produces acidic ketone bodies. DKA is typically diagnosed when testing finds high b

Diabetic Ketoacidosis

Author: Osama Hamdy, MD, PhD; Chief Editor: Romesh Khardori, MD, PhD, FACP more... Diabetic ketoacidosis (DKA) is an acute, major, life-threatening complication of diabetes that mainly occurs in patients with type 1 diabetes, but it is not uncommon in some patients with type 2 diabetes. This condition is a complex disordered metabolic state characterized by hyperglycemia, ketoacidosis, and ketonuria. The most common early symptoms of DKA are the insidious increase in polydipsia and polyuria. The following are other signs and symptoms of DKA: Malaise, generalized weakness, and fatigability Nausea and vomiting; may be associated with diffuse abdominal pain, decreased appetite, and anorexia Rapid weight loss in patients newly diagnosed with type 1 diabetes History of failure to comply with insulin therapy or missed insulin injections due to vomiting or psychological reasons or history of mechanical failure of insulin infusion pump Altered consciousness (eg, mild disorientation, confusion); frank coma is uncommon but may occur when the condition is neglected or with severe dehydration/acidosis Signs and symptoms of DKA associated with possible intercurrent infection are as follows: Gl Continue reading >>

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Popular Questions

  1. dasviech

    Fastest way to get back into Ketosis after carb-up?

    Hi, I was wondering what is the best (fastest) way to get into ketosis after a 24 hour carb-up on CKD?
    Thanks in advance

  2. Atavis

    Originally Posted by dasviech
    Hi, I was wondering what is the best (fastest) way to get into ketosis after a 24 hour carb-up on CKD?
    Thanks in advance

    Do a depletion style workout.

  3. Rodenward

    H.I.I.T is the best way

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Epidemiology Of Infection As A Precipitating Factor For Diabetic Ketoacidosis At Tanta University Hospital Hamed Zs, Gawaly Am, Abbas Km, El Ahwal Lm - Tanta Med J

Infection is the main precipitating factor of DKA in patients of Tanta University Hospital. Keywords:diabetes mellitus, diabetic ketoacidosis, infection Hamed ZS, Gawaly AM, Abbas KM, El Ahwal LM. Epidemiology of infection as a precipitating factor for diabetic ketoacidosis at Tanta University Hospital. Tanta Med J 2017;45:68-72 Hamed ZS, Gawaly AM, Abbas KM, El Ahwal LM. Epidemiology of infection as a precipitating factor for diabetic ketoacidosis at Tanta University Hospital. Tanta Med J [serial online] 2017 [cited2018 Mar 28];45:68-72. Available from: Diabetic ketoacidosis (DKA) is a metabolic derangement with three main presentations, hyperglycemia, ketosis, and acidosis, which occurs in the presence of low effective insulin. It is one of the common emergencies in patients with diabetes mellitus (DM) [1] . DKA affects more than 8 per 1000 diabetics annually. It is associated with significant morbidity and mortality, with a worldwide mortality rate of 210% [1] . DKA frequently occurs in type 1 diabetes as this type of diabetes is presented with an absolute lack of insulin production by the Islets of Langerhans More Details . In type 2 diabetes, the production of insulin is insu Continue reading >>

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  1. fatslayermcgee

    So I had my labs done last week and got the results back:
    http://imgur.com/a/AEv1h
    Obligatory: "OMG! OMG! High cholesterol the sky is falling!"
    Just kidding, I'm actually not worried. For one thing, while I don't know what my numbers looked like pre-keto, I know that I had a history of high cholesterol.
    After some thought on the matter and some research I've decided to stick with keto and retest in another 3+ months.
    High cholesterol, don't even care, KCKO.

  2. 186394

    I think what you meant to say was "I ate a terrible diet for the first couple decades of my life, but it's the last 90 days of keto that has ruined my health. Worst diet ever!"
    Just kidding. Great attitude. Keep it up!

  3. fatslayermcgee

    I realize you're being facetious, but there's probably some truth to that. Oh well, at least I will die with bacon and almonds falling out of my mouth.

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    Practice Essentials Diabetic ketoacidosis (DKA) is an acute, major, life-threatening complication of diabetes that mainly occurs in patients with type 1 diabetes, but it is not uncommon in some patients with type 2 diabetes. This condition is a complex disordered metabolic state characterized by hyperglycemia, ketoacidosis, and ketonuria. Signs and symptoms The most common early symptoms of DKA are the insidious increase in polydipsia and polyuri ...

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