How Does Acetazolamide Cause Metabolic Acidosis

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Nikita on Acute Mountain Sickness Presented at Parker Toastmasters Parker, Colorado http://www.parkertoastmasters.com

Mechanisms Of Action Of Acetazolamide In Prophylaxis And Treatment Of Acute Mountain Sickness

What are the 3 major classes of high altitude disease? 1)Acute mountain sickness (10% at 3500m, 75% at 4500) What are the multitude of systemic effects that make acteozolamide effective besides inducing metabolic acidosis (inducing chemoreceptors to respond more to hypoxic stimuli at high altitude? -Improvements in ventilation through, tissue respiratory acidosis -improvements in sleep quality from carotid body CA inhibition What are the two hypothesis that causes of AMS? ;What is the problem with these hypothesis?What is the agreement of symptoms caused by? 1) Hypoxia-mediated mild cerebral edema and increased cranial pressure; brain morphological changes don't correlate with symptoms of AMS 2)Vasogenic Edema: rupture of blood brain barrier, Free radical damage barrier function under hypoxic conditions don't support pathophysiology of AMS -HYPOXIA not hypobaria. Oxygen therapy also effective treatment Ambiguity of causes of AMS,but what is the relative agreement of symptoms? What txt is consistent with this? caused predominantly by hypoxia and not hypobaria --oxygen therapy is an effective treatment for AMS How did acetazolamide significantly increased minute ventilation by 50%? Continue reading >>

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  1. ski

    Ketogenic diets

    After reading about ketogenic diets and many saying how hunger was no longer there after being in ketosis for a while, and not even thinking about food sweets etc, at first i thought doubt it but OK being a food addict myself and obese, but after being in ketosis for about 5-6 weeks where my diet was 5% carbs 10-15 protein and 80-85% fat i finally realized what they said was right, the hunger went away and the thought of food sweets carbs and overeating was not there anymore.
    Another thing i read was complaints of hair loss while in a ketosis, some saying they didn't have hair loss while others saying they did especially thinning of the hair.
    3 months later and 60 lbs weight lose i noticed thinning if the hair and losing hair so i stopped being in ketosis thinking i try just adding some carbs via vegetables.
    So i did and the thinning stopped as did the hair loss 5 month later still adding vegetables and other little carb foods.
    But the diet is much harder to control not being in ketosis the extra carbs keep bringing me back to the old way of binging and always being hungry.
    Now some will say add more fat, i did but i never lost weight eating extra fat and need to count my calories if i don't count them i simply don't lose weight, even after 5-6 months on High fat 10-15 protein i still don't lose weight unless i counted calories.
    So i'm thinking of cutting back the carbs again and being in ketosis but at the same time thinking will it go back to losing hair :-(
    any comments?

  2. foxl

    Yeah if that is what caused my hair loss, I will sacrifice my hair! (I noted it at diagnosis, was not low carb at first, but also starting menopause then). I also have seen people blame hair loss on metformin. Who knows .... ?

  3. smorgan

    Adding some carbs stopped hair loss? It just doesn't sound right. What could be the relationship between glucose and hair? Hair is made of protein, as is the scalp and what connects them. Before resorting to glucose from carbs, I would have tried upping the protein slightly first. In any case, if that protein added was above the actual immediate need for it, it would mostly be turned into glucose, anyway, but in a safer manner than the carbs. I just can't imagine any relationship between hair and glucose.

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Get Dr. Berg's New Electrolyte Powder: http://bit.ly/Electrolyte-Powder-1 (use this code: IK7H05 to get 10% off) Take Dr. Berg's Advanced Evaluation Quiz: http://bit.ly/EvalQuiz Your report will then be sent via email analyzing 104 potential symptoms, giving you a much deeper insight into the cause-effect relationship of your body issues. It's free and very enlightening. Dr. Berg talks about acidosis. This is a state where they are too acid. Here are the symptoms 1. Irritable 2. Dehydrated 3. Hard to breath, signing frequently 4. Light sensitivity or sound sensitivity 5. Lump in throat 6. Feeling stuff in rooms 7. Uncomfortable in high altitudes 8. Uncomfortable with even a small amount of pain Too much lactic acid can create this effect, or uric acid from excess protein. Ketosis can also produce too much acid. If this happens, add more vegetable - calcium magnesium or potassium citrate can be added to the diet. Dr. Eric Berg DC Bio: Dr. Berg, 51 years of age is a chiropractor who specializes in weight loss through nutritional and natural methods. His private practice is located in Alexandria, Virginia. His clients include senior officials in the U.S. government and the Justice Department, ambassadors, medical doctors, high-level executives of prominent corporations, scientists, engineers, professors, and other clients from all walks of life. He is the author of The 7 Principles of Fat Burning, published by KB Publishing in January 2011. Dr. Berg trains chiropractors, physicians and allied healthcare practitioners in his methods, and to date he has trained over 2,500 healthcare professionals. He has been an active member of the Endocrinology Society, and has worked as a past part-time adjunct professor at Howard University. DR. BERG'S VIDEO BLOG: http://www.drberg.com/blog FACEBOOK: http://www.facebook.com/DrEricBerg TWITTER: http://twitter.com/DrBergDC YOUTUBE: https://www.youtube.com/user/drericbe... ABOUT DR. BERG: http://www.drberg.com/dr-eric-berg/bio DR. BERG'S SEMINARS: http://www.drberg.com/seminars DR. BERG'S STORY: http://www.drberg.com/dr-eric-berg/story DR. BERG'S CLINIC: https://www.drberg.com/dr-eric-berg/c... DR. BERG'S HEALTH COACHING TRAINING: http://www.drberg.com/weight-loss-coach DR. BERG'S SHOP: http://shop.drberg.com/ DR. BERG'S REVIEWS: http://www.drberg.com/reviews The Health & Wellness Center 4709 D Pinecrest Office Park Drive Alexandria, VA 22312 703-354-7336 Disclaimer: Dr. Eric Berg received his Doctor of Chiropractic degree from Palmer College of Chiropractic in 1988. His use of doctor or Dr. in relation to himself solely refers to that degree. Dr. Berg is a licensed chiropractor in Virginia, California, and Louisiana, but he no longer practices chiropractic in any state and does not see patients. This video is for general informational purposes only. It should not be used to self-diagnose and it is not a substitute for a medical exam, cure, treatment, diagnosis, and prescription or recommendation. It does not create a doctor-patient relationship between Dr. Berg and you. You should not make any change in your health regimen or diet before first consulting a physician and obtaining a medical exam, diagnosis, and recommendation. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. The Health & Wellness, Dr. Berg Nutritionals and Dr. Eric Berg, D.C. are not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this video or site.

Diuretic_pharm [tusom | Pharmwiki]

Diuretics are among the most commonly prescribed drugs, and play an important role in the treatment of heart failure and hypertension. They exert most of their therapeutic effects through inhibiting the reabsorption of sodium at different sites along the nephron of the kidney. Diminished reabsorption of sodium results in increased urinary loss of both sodium and water, leading to a reduction in plasma volume, and a reduction of blood pressure. Thiazide diuretics also exert an additional vasodilator effect on arterial smooth muscle by a still poorly understood mechanism. Figure 1. Overview of the transport systems in the renal nephron, and major sites of action of diuretics. ADH: antidiuretic hormone; ENaC: epithelial Na channel. Acetazolamide is the most commonly used carbonic anhydrase inhibitor (taken systemically) that affects the kidney. Figure 2. Mechanism of action of carbonic anhydrase inhibitor diuretics. Bicarbonate absorption by the proximal tubule is dependent on the activity of carbonic anhydrase (CA) which converts bicarbonate (HCO3-) to CO2 and H2O. CO2 rapidly diffuses across the cell membrane of proximal tubule cells where it is rehydrated back to H2CO3 by carbonic Continue reading >>

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Popular Questions

  1. Nikos Konstas

    I have been on low carb/keto for several years. It’s doable but its not easy as almost everything these days is full of carbs & low in fat. My advice would be:
    know your macros, use a keto calculator, like this one: KetoDiet Buddy - Easy Way to Calculate Your Macros on a Ketogenic Diet | The KetoDiet Blog
    Make sure your get enough electrolytes. You can make your own electrolyte drinks.
    In the long run, unless you’re treating a condition, you don’t want to go “zero carb”.
    Don’t be afraid to eat fats but know what fats to eat - not all fats are the same.
    People new to keto seem to think all you need is cheese and bacon - don’t make the same mistake - you need to have a balanced low-carb diet.

    Avoid low carb supplements/ meal replacements / ketone drinks at any cost. Know what you eat and learn to cook :)
    I run a Keto Blog with my partner - you can find guides and info on it.

    Best of luck!

  2. Peter Weintraub

    Hello - Thanks for reaching out!
    I personally have used a ketogenic diet long-term, and I have all of my clients follow one on their weight loss programs.
    In terms of tips, you want to keep your macros in this order: Fat (60–70%), Protein (20–30%) and Carbs (0–10%).
    There are no cheat days, and it will take cutting out fruits and starchy veggies for most people.
    I’ve yet to find any convincing evidence that you need to be careful following this type of nutrition long-term. So long as you’re not consuming too much protein, you’re not at risk for ketoacidosis, which many people often confuse for ketosis.
    My partner Evan and I recently did a podcast episode on this. Feel free to check it out at https://itunes.apple.com/us/podc...
    Hope this helps! If you have any further questions, feel free to email me at the address below.

    Peter Weintraub
    Founder and Permanent Weight Loss Expert at Fitness Retriever

    [email protected]itnessretriever.com

  3. Ron Hunter

    The precaution is to try to avoid cheating. The combination of refined carbohydrates and fat is something that should be avoided by all people. It’s not that fat is bad, it’s the combination.

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Metabolic Acidosis And Hyperventilation Induced By Acetazolamide In Patients With Central Nervous System Pathology

ACETAZOLAMIDE, a carbonic anhydrase inhibitor, is used in patients with meningeal inflammation, mild intracranial hypertension, and basal skull fractures to decrease the formation of cerebrospinal fluid (CSF). It causes mild metabolic acidosis by inhibiting the reabsorption of bicarbonate (HCO−3) ions from renal tubules. This effect has been used successfully in the treatment of patients with chronic respiratory acidosis with superimposed metabolic alkalosis 1 and central sleep apnea syndrome. 2 Life-threatening metabolic acidosis during acetazolamide therapy has been observed only in patients with renal impairment or 3 diabetes 4 and in elderly patients. 5 Severe metabolic acidosis, associated with acetazolamide, in the absence of other predisposing factors has not been reported in patients with central nervous system disease. We report three cases of severe metabolic acidosis and hyperventilation during acetazolamide therapy in normal doses in adult patients without renal impairment. A 35-yr-old man with a head injury underwent craniotomy for evacuation of a traumatic left temporal extradural hematoma. Postoperatively, the patient underwent mechanical ventilation to maintain a Continue reading >>

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  1. Butter_Butt

    Are they to be used with first Morning Urine?Will the test be accurate if we use while Menstruating?

  2. Ruthxxx

    I have never used them so don't know. Why are you using them?

  3. Satine

    Butter butt - I have used them and I dont think it has to be done first thing in the morning, I just use them whenever ...also being on your period will not effect the ketones in your urine ( that I have ever heard of )

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