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How Does Acetazolamide Cause Metabolic Acidosis

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Carbonic Anhydrase Inhibitor

Carbonic anhydrase inhibitors are a class of pharmaceuticals that suppress the activity of carbonic anhydrase . Their clinical use has been established as anti- glaucoma agents, diuretics , antiepileptics , in the management of mountain sickness , gastric and duodenal ulcers , idiopathic intracranial hypertension , neurological disorders , or osteoporosis . [1] [2] [3] Carbonic anhydrase inhibitors are primarily used for the treatment of glaucoma. They may also be used to treat seizure disorder and acute mountain sickness . Because they encourage solubilization and excretion of uric acid, they can be used in the treatment of gout. [4] Acetazolamide is an inhibitor of carbonic anhydrase . It is used for glaucoma, epilepsy (rarely), idiopathic intracranial hypertension , and altitude sickness . For the reduction of intraocular pressure (IOP), acetazolamide inactivates carbonic anhydrase and interferes with the sodium pump, which decreases aqueous humor formation and thus lowers IOP. Systemic effects include increased loss of sodium, potassium, and water in the urine, secondary to the drugs effects on the renal tubules , where valuable components of filtered blood are re-absorbed in Continue reading >>

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  1. LanceWackerle

    As of today, I've been on keto for 1 month. My experience was typical, so I tried to avoid making typical posts. There is always a steady stream about keto flu, initial water weight loss, and the 2-3 week stall after that. I experienced all these things.
    I haven't seen too much info on what to expect the 2nd month though. Do plateaus usually go away around week 5 or 6? What's a good amount of weight I can expect to lose per month going forward? (currently 238 lbs, 6 ft).
    I get about a 1,000 calorie deficit per day, so simple math suggests 2 pounds a week. Is that about right?
    When do I need to start trying stuff like IF? I'd like to lose weight as effortlessly as possible but I'd also like to know when I need to step up my game a bit.
    Thanks!

  2. ConsistentSauce

    Don't get down if you do not see the same results as the Ketoers below. The reason you hear less bout month 2 is because sadly a lot of people quit after the plateau becomes too much. Although different ages, I have a very similar starting weight and height as you. I lost 17 pounds in the first 3 weeks and then plateaued for 3 weeks before slowly dropping 4.5 more lbs over the last 2.5 weeks. Depending on your lean body mass, you may not see 10-15 lbs this month. But that is nothing to worry about. As long as you don't give up and keep losing, every pound is a victory. Things I did when the plateau didn't break, introduce more Potassium, Magnesium, Psyllium and Vitamin D to my diet (mainly through vitamins), tried IF (not going to work for me), and replaced breakfast with Bulletproof coffee (saves me 100-200 calories at breakfast while still getting the macros I need). And last but not least, if you plan to keep the muscle you have built up from carrying the extra weight all these years, make sure you are eating minimum .8 grams of protein for every pound of lean mass you have.

  3. LanceWackerle

    Thanks for the reality check.
    I was kind of wondering about that. You see tons of 1st week, 1st month posts, and people struggling with plateaus who simultaneously get told "don't worry it's normal" along with "but you should try xxx and xxx and xxx". Then the big victories get super upvoted so it looks like that's what's normal.
    Happily, it seems like that the truth is somewhere in between, and that if we keep ketoing on we'll get there one way or another.
    I told myself I'd do keto for at least a year, so even 2-4 pounds a month will still add up.

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Basic home exercise plan for seniors or individuals living with chronic disease such as cardiovascular disease, diabetes, COPD and metabolic disease. The exercises were performed by Nick Pratap who is a ACSM Certified Clinical Exercise Physiologist and Kinesiologist who prescribes exercise to patients who have chronic disease. Website: www.nextgenrehab.ca

Use Of Acetazolamide In Copd Patients

I'm a doctor in Ho Chi Minh City, Vietnam. In my department (Pulmonology), some doctors prescribe acetazolamide for the patients with COPD who have edema and chronic respiratory failure. What is the role of acetazolamide in these patients? Response from Christine Campbell Reardon, MD Some patients with chronic obstructive pulmonary disease (COPD) develop carbon dioxide (CO2) retention and hypoxemia. There are multiple factors that lead to the development of CO2 retention. One of the major factors is an alteration of ventilation and perfusion matching leading to an increase in dead space. The diaphragm may function at an anatomical disadvantage in patients with COPD. In the setting of hyperinflation caused by airflow obstruction, the diaphragm is flattened and generates less pressure than what would occur under normal circumstances. In addition, hypercapnic patients demonstrate a breathing pattern characterized by a lower tidal volume and higher respiratory rate, which increases dead space. The lower tidal volume is caused by a shorter inspiratory time rather than a decrease in respiratory drive. It had previously been thought that hypercapnic COPD patients had a blunted central re Continue reading >>

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  1. K-Jay

    Best Keto Calculator

    Hey guys, where can I find the best calculator to give me my macronutrient ratios for a keto diet for a 200lb man with 20%BF?

  2. philip41

    Originally Posted by K-Jay
    Hey guys, where can I find the best calculator to give me my macronutrient ratios for a keto diet for a 200lb man with 20%BF?

    Hi there, have you tried Fitday.com that is what i used.

  3. rtmiii

    I dont remember who posted this the other day, but here it is based on a Lean Body Mass of 176 (220 * .2)
    LBM of 176
    ----------------------------------------------
    180 * 4 / 0.3 = 2346 (total calorie intake for Keto)
    2436 * .3 = 704 calories of protein
    2436 * .65 = 1583 calories of fat
    2436 *.05 = 122 calories of carbs

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Acute Mountain Sickness is a serious issue. You either pop in a Diamox and take preventive measures, or you nip it in the bud when you see symptoms. Arjun Majumdar, who has seen several cases of Acute Mountain Sickness, right from the 1980's when he first started trekking. He has seen it go from AMS to HAPE (High Altitude Pulmonary Edema) and he has managed to rescue trekkers. Having been affected by it himself, he sure knows how to avoid it now. This video will give you some tips to avoid the illness. "For more information check this quick article explaining AMS - http://indiahikes.in/lack-oxygen-affe... How does Diamox help avoid AMS - http://indiahikes.in/benefits-of-usin... How I dealt with Acute Mountain Sickness on my 28th high altitude trek - http://indiahikes.in/how-i-dealt-with..."

Mechanisms Of Action Of Acetazolamide In Prophylaxis And Treatment Of Acute Mountain Sickness

What are the 3 major classes of high altitude disease? 1)Acute mountain sickness (10% at 3500m, 75% at 4500) What are the multitude of systemic effects that make acteozolamide effective besides inducing metabolic acidosis (inducing chemoreceptors to respond more to hypoxic stimuli at high altitude? -Improvements in ventilation through, tissue respiratory acidosis -improvements in sleep quality from carotid body CA inhibition What are the two hypothesis that causes of AMS? ;What is the problem with these hypothesis?What is the agreement of symptoms caused by? 1) Hypoxia-mediated mild cerebral edema and increased cranial pressure; brain morphological changes don't correlate with symptoms of AMS 2)Vasogenic Edema: rupture of blood brain barrier, Free radical damage barrier function under hypoxic conditions don't support pathophysiology of AMS -HYPOXIA not hypobaria. Oxygen therapy also effective treatment Ambiguity of causes of AMS,but what is the relative agreement of symptoms? What txt is consistent with this? caused predominantly by hypoxia and not hypobaria --oxygen therapy is an effective treatment for AMS How did acetazolamide significantly increased minute ventilation by 50%? Continue reading >>

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  1. Betty2003

    Not a very lady-like subject, but need to ask anyway. I notice during induction (probably in week 2) that my urine started to have a horrible smell. I thought I read somewhere that that is a sign of ketosis--is it? I've looked for test sticks at Meijer, K-mart, and the grocery store but can't find them anywhere. I do notice that I drop pounds when the smell is there--what do you think? Is that my indicator of ketosis? Thanks!

  2. pokey one

    I've noticed the same thing. And that constant metallic taste in my mouth lets me know I'm in ketosis, too.
    The strips are usually back with the pharmacist, not out on the shelves. So you just have to ask for ketone testing strips. (I guess they're expensive enough and the box is small enough that they could easily be shoplifted.)
    If you do get the strips, don't worry about the shade of pink to purple--even the slightest pink signals ketosis. I was very happy to see mine change from being beige for a few days to pink .
    HTH

  3. tofi

    In Canada, the stix are with the supplies for diabetics. They used to be behind the pharmacy counter but are now out on the shelves in Shoppers' Drug Marts. They cost about $7.50 Canandian. I hear that Wal-Mart in the US has them. The most common brand name is Ketostix by Bayer.
    And the interesting odour is less expensive. If you are losing, why bother with the stix?

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