How Do The Kidneys Compensate For Metabolic Acidosis?

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Renal Compensation - An Overview | Sciencedirect Topics

Rebecca A. Johnson, Helio Autran de Morais, in Fluid, Electrolyte, and Acid-Base Disorders in Small Animal Practice (Fourth Edition) , 2012 If hypercapnia persists, renal compensation occurs to stabilize plasma at a higher concentration within 5 days.34,62,69,79, Chronic hypercapnia causes intracellular H+ to increase in the renal tubular cells. Upregulation of the Na+-H+ antiporter of the renal brush border occurs,76 and hydrogen ions are exchanged for sodium and then excreted as is reabsorbed and exchanged for Cl, resulting in an increase in plasma SID, chloruresis, and negative chloride balance.20 The chloride lost in the urine decreases urine SID because the chloride is accompanied by rather than sodium ions. A new steady state is reached when the increased filtered load of resulting from the increased plasma concentration of is balanced by increased renal reabsorption of . The net effect is buffering of the respiratory acidosis and hypochloremic hyperbicarbonatemia caused by chronic hypercapnia. For each 1-mm Hg increase in Pco2, will increase 0.35mEq/L in dogs.15 (see Box 11-2). The renal response to chronic hypercapnia is not altered by moderate hypoxemia, dietary sodium or Continue reading >>

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Popular Questions

  1. cosmikdebris

    I started the PB 3 weeks ago and ever since I've been having weird heart sensations like my heart is not beating properly and pounding out of my chest. I was diagnosed with mitral valve prolapse many years ago and will get the occasional chest pain here and there but nothing like this. I'm curious if anyone else has experienced this? Also it seems like my anxiety has come back the 2nd week eating primally. I wonder if its my body adjusting to the change? before this i used to eat alot of carbs like white potatoes and pasta....

  2. Herbwifemama

    Years ago, when I first went on Atkins induction, I got heart palpitations. It was never formally diagnosed, I just researched it and figured it was potassium deficiency. I went back to eating the carbs, and it got better. Then I actually READ THE BOOK, lol, and I went on induction again with no issues. Anyway, I'm going to assume you've actually read the PB. If you're doing VLC, maybe add in some more carbs. Have a banana. And if it doesn't get better, go to your dr. Heart issues are nothing to mess around with.

  3. NutMeg

    I was diagnosed with an 'apparent MVP" (same symptoms you are complaining of) what they meant was that my body thought it was dehydrated because of an electrolyte imbalance. At the time I was eating CW healthy and trying very hard to lose weight. My diet was very 'healthy', and thus very low in salt/sodium. They encouraged me to drink Gatorade to fix the problem, which was not acceptable to me...too many calories. After doing some research I discovered that using sea salt might help, so I started adding it to my meals, and it worked like a charm.

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