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How Do The Kidneys Compensate For Metabolic Acidosis?

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Renal Compensation - An Overview | Sciencedirect Topics

Rebecca A. Johnson, Helio Autran de Morais, in Fluid, Electrolyte, and Acid-Base Disorders in Small Animal Practice (Fourth Edition) , 2012 If hypercapnia persists, renal compensation occurs to stabilize plasma at a higher concentration within 5 days.34,62,69,79, Chronic hypercapnia causes intracellular H+ to increase in the renal tubular cells. Upregulation of the Na+-H+ antiporter of the renal brush border occurs,76 and hydrogen ions are exchanged for sodium and then excreted as is reabsorbed and exchanged for Cl, resulting in an increase in plasma SID, chloruresis, and negative chloride balance.20 The chloride lost in the urine decreases urine SID because the chloride is accompanied by rather than sodium ions. A new steady state is reached when the increased filtered load of resulting from the increased plasma concentration of is balanced by increased renal reabsorption of . The net effect is buffering of the respiratory acidosis and hypochloremic hyperbicarbonatemia caused by chronic hypercapnia. For each 1-mm Hg increase in Pco2, will increase 0.35mEq/L in dogs.15 (see Box 11-2). The renal response to chronic hypercapnia is not altered by moderate hypoxemia, dietary sodium or Continue reading >>

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Popular Questions

  1. sammerb

    I understand ketosis is achieved when staying between 0-50g of carbs, upwards to 100g for some people.
    But I was wondering where sugar fits in to this?
    The reason I'm asking is there's a full fat greek yogurt that I LOVE. But it's got 15g of carbs and 10g of sugar.
    Will eating that likely to kick me out of ketosis?

  2. Egoldstein

    thinking about being IN ketosis or not is somewhat misleading. What you want is to be fully keto-adapted, meaning your body will seamlessly move from carb burning, fat burning, maybe protein burning back and forth. The carb flu period is when you are not fully adapted and feel a bit out of sorts when transitioning. For someone fully adapted, having a high carb meal or day should not impair longer-term fat burning and fatloss.

  3. OnTheBayou

    Sugar and carbs in yogurt is misleading. Carbs in all foods are not determined directly, but presumed to be what is left over after subtracting proteins and fats. Most, but not all, of the milk's lactose is converted to acids (acidolphilus, any one?) which while still carbs are no longer sugars.
    Just stay away from sugar added yogurts and don't eat it too often. It is dairy.

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Respiratory acidosis #sign and symptoms of Respiratory acidosis Respiratory acidosis ABGs Analyse https://youtu.be/L5MWy1iHacI Plz share n subscribe my chanel is a condition that occurs when the lungs cant remove enough of the Suctioning https://youtu.be/hMJGkxvXTW0 carbon dioxide (CO2) produced by the body. Excess CO2 causes the pH of blood and other bodily fluids to decrease, making them too acidic. Normally, the body is able to balance the ions that control acidity. This balance is measured on a pH scale from 0 to 14. Acidosis occurs when the pH of the blood falls below 7.35 (normal blood pH is between 7.35 and 7.45).Rinku Chaudhary NSG officer AMU ALIGARH https://www.facebook.com/rinkutch/ Respiratory acidosis is typically caused by an underlying disease or condition. This is also called respiratory failure or ventilatory failure. Suctioning https://youtu.be/hMJGkxvXTW0 Normally, the lungs take in oxygen and exhale CO2. Oxygen passes from the lungs into the blood. CO2 passes from the blood into the lungs. However, sometimes the lungs cant remove enough CO2. This may be due to a decrease in respiratory rate or decrease in air movement due to an underlying condition such as: asth

Respiratory Acidosis

Respiratory acidosis is an acid-base balance disturbance due to alveolar hypoventilation. Production of carbon dioxide occurs rapidly and failure of ventilation promptly increases the partial pressure of arterial carbon dioxide (PaCO2). [ 1 ] The normal reference range for PaCO2 is 35-45 mm Hg. Alveolar hypoventilation leads to an increased PaCO2 (ie, hypercapnia). The increase in PaCO2, in turn, decreases the bicarbonate (HCO3)/PaCO2 ratio, thereby decreasing the pH. Hypercapnia and respiratory acidosis ensue when impairment in ventilation occurs and the removal of carbon dioxide by the respiratory system is less than the production of carbon dioxide in the tissues. Lung diseases that cause abnormalities in alveolar gas exchange do not typically result in alveolar hypoventilation. Often these diseases stimulate ventilation and hypocapnia due to reflex receptors and hypoxia. Hypercapnia typically occurs late in the disease process with severe pulmonary disease or when respiratory muscles fatigue. (See also Pediatric Respiratory Acidosis , Metabolic Acidosis , and Pediatric Metabolic Acidosis .) Respiratory acidosis can be acute or chronic. In acute respiratory acidosis, the PaCO2 Continue reading >>

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  1. MarkM

    Originally Posted by 10xdiabetic
    ... the units of insulin I am having to take seem excessive. I feel my body is no longer sensitive to the insulin. ... Getting most calories from fat can be expected to reduce insulin sensitivity. There is a whole lot of science behind this, but the bottom line is that when in ketosis (eating low carb, high fat), we need a lot more insulin than the consumed carbs suggests. So you will have to adjust insulin dosing accordingly. Once you have done that, maintaining good control should get a lot easier.
    I gave up on the ketogenic diet because sticking to it was just too hard. Especially in China, where I have been living for a while. After switching back to a 'normal' diet, my control became somewhat more difficult, but my insulin requirements went down. I have become more insulin sensitive, and my TDD is now lower than it has ever been. Using a pump also helps with that, but I suspect that much of the difference is because of less fat in the diet.

  2. hughman

    The only thing constant about insulin dosing for me over the last 40+ years is change. At one point I was taking at least a total of 120 units a day, but that was with massive aspartame consumption. Once I stopped diet pop (soda), I now take a total of around 60 units, and take it totally differently amounts at different times than I used to. I could take less insulin if I ate less carbs, but we all make our decisions on our lifestyle.
    Everyone is different, and our environment and what we consume effects us all differently. And women have it even tougher with those pesky hormones.

  3. 10xdiabetic

    Thank you for that insight. This is what my feeling was also. I tried to find science to confirm my hypothesis. Could you share an article / source where you read about that so I can explore this further?

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Anion gap usmle - anion gap metabolic acidosis normal anion gap metabolic acidosis

Metabolic Acidosis: Practice Essentials, Background, Etiology

Metabolic acidosis is a clinical disturbance characterized by an increase in plasma acidity. Metabolic acidosis should be considered a sign of an underlying disease process. Identification of this underlying condition is essential to initiate appropriate therapy. (See Etiology, DDx, Workup, and Treatment.) Understanding the regulation of acid-base balance requires appreciation of the fundamental definitions and principles underlying this complex physiologic process. Go to Pediatric Metabolic Acidosis and Emergent Management of Metabolic Acidosis for complete information on those topics. An acid is a substance that can donate hydrogen ions (H+). A base is a substance that can accept H+ ions. The ion exchange occurs regardless of the substance's charge. Strong acids are those that are completely ionized in body fluids, and weak acids are those that are incompletely ionized in body fluids. Hydrochloric acid (HCl) is considered a strong acid because it is present only in a completely ionized form in the body, whereas carbonic acid (H2 CO3) is a weak acid because it is ionized incompletely, and, at equilibrium, all three reactants are present in body fluids. See the reactions below. Th Continue reading >>

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  1. leslieo

    I am on day 21 of the keto diet and I must say I did extremely well until very recently. I am now in full blown ketosis (blood ketones at 3.4 today) and I don't want to stop, but I suddenly have an aversion to fat. In fact, last night a tablespoon of coconut oil was determined to come back up. I won the fight but now I can't stomach the thought of ever eating coconut oil by itself again. Then, this morning, the bacon I was eating didn't want to stay down. I had to swallow it whole and chase it with water! For lunch, my salad and ranch dressing smelled and tasted horrible so I couldn't eat more than one bite of it! Then I literally choked down a fat bomb. I am literally in disbelief that after 21 days, I may have to throw in the towel! Wondering if anyone else has experienced this and if the solution is as easy as a few tweaks to my food choices? At the moment, I've decided not to eat at all which is not a solution, so this is an urgent issue.

    A point to note: I was unable to reach ketosis until I increased my fat proportions. Just a week ago, my blood ketones were 0.3 but after I increased the fat, I bounced up to 2.4 and today 3.4. With that said, I've had A LOT of fat for the past few days and not much variety: bacon, coconut oil, fat bombs and meat balls. Maybe I need to eat something different? But what? Help!

  2. thebobber

    leslieo,
    How do you test your blood ketone level? I have a blood glucose testing machine. I assume that I need a different device and different test strips to test blood ketones. Any recommendations?
    Bobber

  3. dargy

    I think most of us go through this stage, just some more than others. Stick at it as you will adapt. If you're like me you have probably eaten carbs for a long time and your body is not enjoying the fact that you have changed your fuel source. I still can't stomach coconut oil though. My body doesn't like it and it is maybe because I have candida issues. Adapting is not easy and may you go in out anyway but stick at it. Try watching that crazy lady Stephanie Person. She seems to be very knowledgable on the topic.
    What are your bowel movements like? This is often a good indication of what is going on inside your stomach.
    I would also add more of a variety in your diet as well. If you eat oranges all the time your body will reject it and want to puke.

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