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How Do Ketone Bodies Causes Metabolic Acidosis?

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Moof's Medical Biochemistry Video Course: http://moof-university.thinkific.com/... In this video, I describe how Ketone Bodies are oxidized for energy. The liver makes ketone bodies that travel through the blood to extrahepatic tissues, where they are oxidized in the mitochondrial matrix to give energy. The pathway begins with D--Hydroxybutyrate, as it is oxidized to Acetoacetate by the same D--Hydroxybutyrate Dehydrogenase reaction (except in reverse). The Acetoacetate is then activated to Acetoacetyl-CoA by -Ketoacyl-CoA Transferase (also known as Thiophorase); this second step takes a Coenzyme A from Succinyl-CoA (an intermediate of the Krebs Cycle). The Acetoacetyl-CoA is then cleaved into two Acetyl-CoA molecules that can go through the Krebs Cycle to be oxidized, resulting in energy that cell can use. Ultimately, the liver is basically sending Acetyl-CoA that it isnt metabolizing to other tissues (by way of Ketone Bodies in the blood) so that those other tissues can utilize the Acetyl-CoA. However, sometimes, the extrahepatic tissues do not oxidize the ketone bodies rapidly enough to keep up with the pace at which they are arriving from the blood. This is a problem described

Metabolism Of Ketone Bodies

What is the main precusor for ketogenesis? -Acetyl CoA to be used for Ketone body synthesis is derived mainly from beta- oxidation of fatty acids and to some extent from ketogenic amino acids WHere is acetoacetate and beta hydroxybuterate produced, and where is it taken? WHat is the MAJOR KB circulating in the palsma? Once produced in liver, Acetoacetate and beta-hydroxybutyrate are transported to different extra hepatic tissues through blood. Beta-hydroxybutyrate is the major ketone body circulating in the plasma In extra hepatic tissues these two ketone bodies undergo utilization to yield energy. Again utilization of ketone bodies occurs only in the cells that contain mitochondria However, liver is incapable of utilizing these ketone bodies. Why? bcz the liver doesnt have the enzyme Thiophorase They dont need any tranporter like FFA, they are clearly soluble in the plasma Ketone bodies are water soluble compounds and do not need any proteins in plasma for their transportation Heart, SK muscle...Brain? no, only in prolonged starvation only wants glucose unless starving. Most glucose is taken by brain, bcz the brain cannot utilize the FFA bcz of the BBB To utilize KBs, i must gain Continue reading >>

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  1. tturko

    So I have just started to follow a Keto plan, I have no problem with cutting carbs down to 20 gr per day, no problem with the protein, but my concern is the required amount of fat and what if I don't take in the recommended 70%.......will I still hit ketosis? I am very encouraged with the sharing of personal experiences sharing of the knowledge on this forum....thanks for that!!! CHEERS!

  2. Fiorella

    Protein is insulinogenic. The point of being in ketosis with high fat is to get control of insulin rollercoasting up and down with your blood sugar. Fat helps to buffer the effect and keep insulin low and blood sugar level stable.

  3. brownfat

    If you sufficiently restrict carbs and protein then for ketosis it doesn't much matter how much fat you eat. Eat an amount of fat appropriate to your goal for losing, sustaining or gaining weight.

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What is DIABETIC KETOACIDOSIS? What does DIABETIC KETOACIDOSIS mean? DIABETIC KETOACIDOSIS meaning - DIABETIC KETOACIDOSIS definition - DIABETIC KETOACIDOSIS explanation. Source: Wikipedia.org article, adapted under https://creativecommons.org/licenses/... license. SUBSCRIBE to our Google Earth flights channel - https://www.youtube.com/channel/UC6Uu... Diabetic ketoacidosis (DKA) is a potentially life-threatening complication of diabetes mellitus. Signs and symptoms may include vomiting, abdominal pain, deep gasping breathing, increased urination, weakness, confusion, and occasionally loss of consciousness. A person's breath may develop a specific smell. Onset of symptoms is usually rapid. In some cases people may not realize they previously had diabetes. DKA happens most often in those with type 1 diabetes, but can also occur in those with other types of diabetes under certain circumstances. Triggers may include infection, not taking insulin correctly, stroke, and certain medications such as steroids. DKA results from a shortage of insulin; in response the body switches to burning fatty acids which produces acidic ketone bodies. DKA is typically diagnosed when testing finds high b

Alcoholic Ketoacidosis

Author: George Ansstas, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP more... In 1940, Dillon and colleagues first described alcoholic ketoacidosis (AKA) as a distinct syndrome. AKA is characterized by metabolic acidosis with an elevated anion gap, elevated serum ketone levels, and a normal or low glucose concentration. [ 1 , 2 ] Although AKA most commonly occurs in adults with alcoholism, it has been reported in less-experienced drinkers of all ages. Patients typically have a recent history of binge drinking, little or no food intake, and persistent vomiting. [ 3 , 4 , 5 ] A concomitant metabolic alkalosis is common, secondary to vomiting and volume depletion (see Workup). [ 6 ] Treatment of AKA is directed toward reversing the 3 major pathophysiologic causes of the syndrome, which are: An elevated ratio of the reduced form of nicotinamide adenine dinucleotide (NADH) to nicotinamide adenine dinucleotide (NAD+) This goal can usually be achieved through the administration of dextrose and saline solutions (see Treatment). The pathogenesis of AKA is complex. [ 7 ] Although the general physiological factors and mechanisms leading to AKA are understood, the precise factors have not Continue reading >>

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  1. Monsieur-Anana

    DMAA, Caffeine, and Ketosis

    I'm currently taking 50mg of caffeine, 25mg of DMAA, and am also on a ketogenic diet. Has anyone else used a similar stack? Also I take piracetam, GABA, Ginkgo Biloba, vitamins, and amino acids supplements. Doesn't doing too dangerous I hope. Any thoughts on this?

  2. Insamity

    You might want to try asking this in /r/supplements.

  3. Poolstiksamurai

    Alternatively, there will be a thread on /r/fitness tomorrow all about supplements and someone very educated about supplements will likely respond.

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Anion gap usmle - anion gap metabolic acidosis normal anion gap metabolic acidosis

Renal Fellow Network: Starvation Ketosis: A Rare Cause Of Metabolic Acidosis

Starvation Ketosis: A Rare Cause of Metabolic Acidosis Asa child growing up in India, I have seen several family members performingritual fasting. Fasting is aubiquitous religio-cultural practice that is found, in varying forms, acrossthe world. The month-long Ramadan and Buddhist Lent fasts are examples ofreligious observances practiced by followers of Islam, and Buddhism,respectively. These fasts are characterized by a documented impact on metabolic health , which can be minimized by well-known management strategies .The practice of fastingis a major part of Hinduism and can range from light restriction toextreme abstention. Mahatma Gandhi was a fervent supporter of fasting byreligious convictionand as a way of freeingoneself of theconstraints of the body. He used fasting as a means of exerting politicalpressure and engaged in several hungerstrikesto protest withnon-violence. Inthe western countries, starvation ketosis or ketoacidosis has been reported inindividuals with strict dieting (e.g. carb-restricted, ketogenic diets or Atkins diet), extreme exercise, andrarely with malnutrition. Few cases of starvation-induced ketoacidosis during pregnancy and lactation , and during the Continue reading >>

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  1. Prairie-dawg

    So I went to the pharmacy yesterday to pick up a new scale and some Ketostix. The pharmacist (who works right next door to me and I've become friendly with) asked me if I was "starting some kind of crazy diet." I told him I've started a ketogenic diet and I'm just trying it out to see if it's right for me. He asked me a few questions about it, mostly about macro ratios and if it's been working so far. When I told him about the higher fat ratio (as opposed to high protein) he seemed somewhat intrigued, but still a little skeptical. The other pharmacist who was working with him chimed in at that point. He said apparently in some Scandinavian countries, they've found that a higher fat content and fewer simple carbs in a person's diet is ideal and actually recommended. However, they both agreed that ketosis for an extended period of time can be very hard on the kidneys. I did a little investigating on my own and there's very little info regarding the long-term effects of the high fat/moderate protein/low carb keto diet. So my question is, has anybody experienced any kidney issues on this diet? Has anyone received any similar warnings from their physician?
    TL;DR
    Pharmacist warned about kidney issues caused by long term ketosis. Seeking out facts/sources to prove or disprove this claim.

  2. cloudmind

    When I first started keto I ended up going to hospital because I had severe internal pain that wouldn't go away. Turns out I was eating far too much protein so my kidneys were giving me grief. Fixed it by upping the fat macros in my diet and I went back to being pain free. Hooray for butter and coconut oil!
    Given my experience, I can understand where the pharmacists are coming from since I think there might* have been a spate of people doing atkins-like diets with kidney problems in the past (too much protein, not enough fat).
    *rampant speculation on my part

  3. Prairie-dawg

    I don't blame them for that at all. In fact, before I really started doing my homework on keto, I used to internally roll my eyes when people would talk about low carb dieting. I think there's a lot of risidual negativity held over from the early days of Atkins regarding low carb diets. Fortunately, I'm always happy to have a teaching moment when the chance arises!

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