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How Do Ketone Bodies Causes Metabolic Acidosis?

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Chronic disease has one cause and mechanism: nutritional deficiency lactic acidosis. There are three components and you can break the cycle by addressing these. Please Like, Share, and Subscribe! -Dr. Schmidt You have already taken the first step to better your health by watching my video! Next, I recommend that you join our Long Distance Patient Program so that you can get diet modification and supplement recommendations designed specifically for you by me or one of my fellow practitioners in our Ann Arbor, Michigan office. You have to be a patient of our office in order to receive supplements, per our distribution agreement with the producer of the Standard Process brand supplements. Becoming a Long Distance Patient as outlined below allows you that access. In order to be part of our online patient program, you would purchase an annual membership for $200. This membership includes an initial 30 minute phone appointment with me or one of our practitioners. At that time, the practitioner will make a recommendation to you for diet modifications, supplements and the quantities that you should take. After the phone call, you are able to order supplements for a year, as needed, directly from our website and our app. We will then promptly ship the supplements out to you. Follow up phone calls with your practitioner are $125 for a 20 minute phone/SKYPE appointment. If you would like to move forward and take advantage of this opportunity, please call: (734) 302-7575 or email [email protected] to schedule your phone appointment, and make the $200 payment. You can reach us by phone Monday through Saturday 9am-5pm EST. To learn more about our office and clinical practice, go to: http://thenutritionalhealingcenter.com Since not everyone is fortunate enough to live within driving distance of Ann Arbor, Michigan, and many feel that an telephone/online consultation is not enough to meet their clinical needs, I am happy to offer you our Long Distance Patient Travel Package. The package is comprised of a series of appointments with myself or another practitioner that are time sensitive, and a time allowance of 48-72 hours in our beautiful city is required. Not only are your health issues of concern thoroughly evaluated, but you receive a comprehensive full body evaluation, two different computerized cardiac health tests, a great deal of teaching and health education, and leave with a program of diet modification and supplement support that the practitioner is confident will improve your health and quality of life. This program can initiate your relationship with our clinic, and be followed up with telephone/online consultations, or it can be incorporated into your already existing program with our clinic to further enhance the program you already have in place. The cost for the Long Distance Travel Package is $560 and includes everything mentioned above. We also have a relationship with a lovely landmark hotel conveniently located less than 2 miles from our office, that offers a reduced nightly rate to our patients. In the meantime, if you are truly interested in what we have to offer, please watch these 5 important videos of mine: https://www.youtube.com/playlist?list... We look forward to helping you feel your best! If you find my info helpful, please visit my Patreon page. https://www.patreon.com/drdarrenschmi... This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. UCC 1-308 without prejudice.

Metabolic Effects Of The Very-low-carbohydrate Diets: Misunderstood "villains" Of Human Metabolism

Go to: The Ketone Bodies are an Important Fuel The hormonal changes associated with a low carbohydrate diet include a reduction in the circulating levels of insulin along with increased levels of glucagon. This activates phosphoenolpyruvate carboxykinase, fructose 1,6-biphosphatase, and glucose 6-phosphatase and also inhibits pyruvate kinase, 6-phosphofructo-1-kinase, and glucokinase. These changes indeed favor gluconeogenesis. However, the body limits glucose utilization to reduce the need for gluconeogenesis. In the liver in the well-fed state, acetyl CoA formed during the β-oxidation of fatty acids is oxidized to CO2 and H2O in the citric acid cycle. However, when the rate of mobilization of fatty acids from adipose tissue is accelerated, as, for example, during very low carbohydrate intake, the liver converts acetyl CoA into ketone bodies: Acetoacetate and 3-hydroxybutyrate. The liver cannot utilize ketone bodies because it lacks the mitochondrial enzyme succinyl CoA:3-ketoacid CoA transferase required for activation of acetoacetate to acetoacetyl CoA [3]. Therefore, ketone bodies flow from the liver to extra-hepatic tissues (e.g., brain) for use as a fuel; this spares glucose Continue reading >>

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  1. Hatzil

    hi everyone,
    I am looking to plan a meal - the current situation is kidneys issues ( not much time left before i will need dialysis), and autoimmunity disease and inflammation, yeah it's bad.
    however, after reading the whole30 & robbwolf articles i came down to that:
    I need ketogenic diet including 80% fat, 10-15% carbohydrate and 10% proteins.
    AND
    Need to avoid: all the whole30 stuff(dairy,grains,legumes..etc) AND- nightshades & fructose.
    nightshades because of autoimmunity and fructose because of kidneys issues.
    What i eat right now: a lot of fruits,proteins,nightshades,sugar and the bad stuff.. not very good.
    What's your opinions about that ketogenic plan?, is anyone been there?
    please don't be afraid to give out your opinion, of course I'm going to ask for medical advice as well. but i want to start the change with food too, and NOW. it seems like doctors don't find the true solution for years, so i will give it a chance.

  2. Karen_Suep

    It's not gonna hurt anything to avoid high FODMAP foods and I have a friend who discovered she had a nightshade sensitivity and still is able to enjoy a lot of delicious foods (I made her a nightshade free Thai curry that she devoured! It was surprisingly still really flavorful, despite the lack of chilies!)
    As you look for recipes for nightshade free stuff, you can look for AIP recipes (autoimmune protocol... It eliminates a lot more than just nightshades, but it's guaranteed nightshade free) and make sure they're compliant with the keto/w30.
    Hopefully you can prolong the life of your kidneys a little longer by some dietary choices:)

  3. jmcbn

    Whole30 is not designed to be a ketogenic diet and the template reflects this. Melissa has also stated in quite clear terms that if you are not familiar with a ketogenic diet, and have never done a Whole30 that it would not be wise to combine the two.
    It's easy enough to avoid both high FODMAPs & nightshades on Whole30, although it can be quite restrictive in terms of both variety and nutrients, but it would also naturally lower your carb intake - which may be low enough carb & high enough fat for you (particularly if you grasp that fat is your friend here and eat to the high end of the template in terms of fat intake) to see marked improvement in your symptoms.
    Bear in mind that FODMAPs fall into three categories - fructose, fructans and polyols - if it's just the fructose you need to eliminate then you're in a much better place as far as variety is concerned.
    Keto is not something to be embarked on lightly and without proper research, knowledge, and self experimentation - especially when it's being done for medical purposes.
    I get that you want to make changes NOW, and I respect & appreciate that you want to take steps to improve your health - which is a great thing - but I'd suggest you complete a Whole30 BY THE BOOK before you start trying to further hack the program.

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Moof's Medical Biochemistry Video Course: http://moof-university.thinkific.com/... In this video, I describe how Ketone Bodies are oxidized for energy. The liver makes ketone bodies that travel through the blood to extrahepatic tissues, where they are oxidized in the mitochondrial matrix to give energy. The pathway begins with D--Hydroxybutyrate, as it is oxidized to Acetoacetate by the same D--Hydroxybutyrate Dehydrogenase reaction (except in reverse). The Acetoacetate is then activated to Acetoacetyl-CoA by -Ketoacyl-CoA Transferase (also known as Thiophorase); this second step takes a Coenzyme A from Succinyl-CoA (an intermediate of the Krebs Cycle). The Acetoacetyl-CoA is then cleaved into two Acetyl-CoA molecules that can go through the Krebs Cycle to be oxidized, resulting in energy that cell can use. Ultimately, the liver is basically sending Acetyl-CoA that it isnt metabolizing to other tissues (by way of Ketone Bodies in the blood) so that those other tissues can utilize the Acetyl-CoA. However, sometimes, the extrahepatic tissues do not oxidize the ketone bodies rapidly enough to keep up with the pace at which they are arriving from the blood. This is a problem described in more detail in the next video in the series. For a suggested viewing order of the videos, information on tutoring, personalized video solutions, and an opportunity to support Moof University financially, visit MoofUniversity.com, and follow Moof University on the different social media platforms. Don't forget to LIKE, COMMENT, and SUBSCRIBE: http://www.youtube.com/subscription_c...

Metabolism Of Ketone Bodies

What is the main precusor for ketogenesis? -Acetyl CoA to be used for Ketone body synthesis is derived mainly from beta- oxidation of fatty acids and to some extent from ketogenic amino acids WHere is acetoacetate and beta hydroxybuterate produced, and where is it taken? WHat is the MAJOR KB circulating in the palsma? Once produced in liver, Acetoacetate and beta-hydroxybutyrate are transported to different extra hepatic tissues through blood. Beta-hydroxybutyrate is the major ketone body circulating in the plasma In extra hepatic tissues these two ketone bodies undergo utilization to yield energy. Again utilization of ketone bodies occurs only in the cells that contain mitochondria However, liver is incapable of utilizing these ketone bodies. Why? bcz the liver doesnt have the enzyme Thiophorase They dont need any tranporter like FFA, they are clearly soluble in the plasma Ketone bodies are water soluble compounds and do not need any proteins in plasma for their transportation Heart, SK muscle...Brain? no, only in prolonged starvation only wants glucose unless starving. Most glucose is taken by brain, bcz the brain cannot utilize the FFA bcz of the BBB To utilize KBs, i must gain Continue reading >>

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  1. DustinX

    Fasting to get into ketosis... faster?

    The other day I remembered that when I was young I had to get a physical. Well to keep the story short, I hadn't eaten much the day before and didn't eat breakfast before I went. After he looked at the urine results I remember him asking if I ate breakfast, he said he asked because I had alot of ketones in my urine.
    I was thinking, would it be possible to do a 24 hour fast to enter ketosis and then the next day continue a keto diet (I'm saying for when you're first starting a keto diet). Maybe 12 hours of fasting would get you into ketosis? I'm not sure, but I figured this could be a quick way to get into ketosis without having to wait 3 or even 4 days when you first begin.

  2. Eileen

    If you are young and active, then you'll get into ketosis quickly. Someone who is older or less active will take longer the first time.
    Fasting will get out into ketosis, but so will eating high fat meals. Don't know about you, but I get very crabby if I miss my breakfast.

  3. jg_girl088

    yeah it sure will. I remember reading in Good Calories Bad Calories that the original recommendation for the ketogenic diet was to start with a 48 hour fast, however, atkins was the one who changed it to a 2 week induction period of minimal carbs.

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Is Keto Healthy? Ketosis Vs Ketoacidosis

Is Keto Healthy? Ketosis vs Ketoacidosis When looking at a ketogenic diet and ketosis, it’s common for some people to confuse the process with a harmful, more extreme version of this state known as diabetic ketoacidosis. But there are a lot of misconceptions out there about ketosis vs ketoacidosis, and it’s time to shed some light on the subject by looking at the (very big) differences between the two. An Overview of Ketosis A ketogenic, or keto, diet is centered around the process of ketosis, so it’s important to understand exactly what ketosis is first before we get into whether or not it’s safe (spoiler: it is): Ketosis is a metabolic state where the body is primarily using fat for energy instead of carbohydrates. Burning carbohydrates (glucose) for energy is the default function of the body, so if glucose is available, the body will use that first. But during ketosis, the body is using ketones instead of glucose. This is an amazing survival adaptation by the body for handling periods of famine or fasting, extreme exercise, or anything else that leaves the body without enough glucose for fuel. Those eating a ketogenic diet purposely limit their carb intake (usually betwe Continue reading >>

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  1. Laurie R Zawiskie, RHIT

    Has anyone tried to code DKA in a patient with DM 2? The 3M encoder takes you to the code for secondary/other diabetes and then when you try to code other diabetic manifestations you get an excludes 1 notes saying they can't be coded with other diabetes. My code book is a 2014 draft, so I don't know if this has been corrected in the 2015 version, but there is not an entry for DM 2 with DKA. I think the 3M encoder is wrong to code it as secondary/other diabetes, but I can't find another way to code it.

  2. Lynn M Farnung

    Laurie,
    There is a Coding Clinic that addresses the type of DM with DKA. I have pasted it below.
    Diabetes mellitus with diabetic ketoacidosis
    Coding Clinic, First Quarter 2013 Page: 26-27 Effective with discharges: March 27, 2013
    Related Information
    Question:
    What is the correct code assignment for type 2 diabetes mellitus with diabetic ketoacidosis?
    Answer:
    Assign code E13.10, Other specified diabetes mellitus with ketoacidosis without coma, for a patient with type 2 diabetes with ketoacidosis. Given the less than perfect limited choices, it was felt that it would be clinically important to identify the fact that the patient has ketoacidosis. The National Center for Health Statistics (NCHS), who has oversight for volumes I and II of ICD-10-CM, has agreed to consider a future ICD-10-CM Coordination and Maintenance Committee meeting proposal.
    © Copyright 1984-2015, American Hospital Association ("AHA"), Chicago, Illinois. Reproduced with permission. No portion of this publication may be copied without the express, written consent of AHA. ------------------------------
    Lynn Farnung
    Inpatient/Outpatient coder, AHIMA Approved ICD-10 Trainer
    Original Message

  3. Laurie R Zawiskie, RHIT

    Thanks, Lynn. If a patient also has DM 2 w/nephropathy (E11.21), I guess we will have to ignore the Excludes 1 note that says E13.10 can't be coded with Type 2 DM (E11.-).
    ------------------------------
    Laurie Zawiskie
    Coder III
    Original Message

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