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High Fat Diet Induced Insulin Resistance

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P24sucrose- And High Fat-induced Insulin Resistance Leads To Endothelial Dysfunction And Is Associated With Ketohexokinase Activation | Heart

P24 Sucrose- and high fat-induced insulin resistance leads to endothelial dysfunction and is associated with ketohexokinase activation P24 Sucrose- and high fat-induced insulin resistance leads to endothelial dysfunction and is associated with ketohexokinase activation 1Division of Cardiovascular and Diabetes Research, Leeds Institute for Cardiovascular and Metabolic Medicine, LIGHT Laboratories, University of Leeds, Clarendon Way, Leeds, UK 2Leeds Institute of Biomedical and Clinical Sciences, Wellcome Trust Brenner Building (level 9), St Jamess University Hospital, Beckett Street, Leeds, UK Introduction Cardiovascular diseases affect an increasing number of people and are one of the major causes of mortality. Over-consumption of fructose, widely used in soft drinks, compromises normal insulin transduction pathways, leading to impaired insulin signalling. Fructose is mainly metabolised by the enzyme ketohexokinase (KHK) in the liver. However, the mechanism underlying fructose-induced insulin resistance and endothelial dysfunction remains unknown. We aimed to investigate the role of KHK in mediating these effects. Methods C57/BL6 mice were fed with three different diets for 20 wee Continue reading >>

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Popular Questions

  1. airforcewife72

    Check out /r/xxketo! I wasn't on Keto while nursing because I already had low supply but I am now and have lost 25lbs so far. /r/ketobabies doesn't have a whole lot of activity as of yet.

  2. [deleted]

    I've been on a strict paleo diet (I am only lenient on cheese and some fruits) since 1 week PP and if anything I have an oversupply! I've also lost 20 pounds in the 6 weeks I've been doing it

  3. Mashiara

    Would love some insight on this. Also lost a lot of weight doing keto prior to pregnancy and /r/ketobabies doesn't really have enough activity.

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