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Glucose Ketone Index Pdf

Ketosis

Ketosis

Not to be confused with Ketoacidosis. Ketosis is a metabolic state in which some of the body's energy supply comes from ketone bodies in the blood, in contrast to a state of glycolysis in which blood glucose provides energy. Ketosis is a result of metabolizing fat to provide energy. Ketosis is a nutritional process characterised by serum concentrations of ketone bodies over 0.5 mM, with low and stable levels of insulin and blood glucose.[1][2] It is almost always generalized with hyperketonemia, that is, an elevated level of ketone bodies in the blood throughout the body. Ketone bodies are formed by ketogenesis when liver glycogen stores are depleted (or from metabolising medium-chain triglycerides[3]). The main ketone bodies used for energy are acetoacetate and β-hydroxybutyrate,[4] and the levels of ketone bodies are regulated mainly by insulin and glucagon.[5] Most cells in the body can use both glucose and ketone bodies for fuel, and during ketosis, free fatty acids and glucose synthesis (gluconeogenesis) fuel the remainder. Longer-term ketosis may result from fasting or staying on a low-carbohydrate diet (ketogenic diet), and deliberately induced ketosis serves as a medical intervention for various conditions, such as intractable epilepsy, and the various types of diabetes.[6] In glycolysis, higher levels of insulin promote storage of body fat and block release of fat from adipose tissues, while in ketosis, fat reserves are readily released and consumed.[5][7] For this reason, ketosis is sometimes referred to as the body's "fat burning" mode.[8] Ketosis and ketoacidosis are similar, but ketoacidosis is an acute life-threatening state requiring prompt medical intervention while ketosis can be physiological. However, there are situations (such as treatment-resistant Continue reading >>

Glucose Ketone Index (gki) – What Ratio Do I Need For Nutritional Ketosis Benefits?

Glucose Ketone Index (gki) – What Ratio Do I Need For Nutritional Ketosis Benefits?

Generally these blog posts are a result of scratching my own itch (answering my own question), and this post is no different. At the time of writing this, I’m doing a 5-day fast, and wanted to understand the readings I’m getting for my blood glucose and blood ketone levels. Initially I thought that blood ketones were all that mattered, and certainly a lot of people only talk about that reading. But looking at Dr Thomas Seyfried’s paper on treating brain cancer (glioblastomas). It suggests that its important to take into account blood glucose also. In their study, they acheieved optimal results when their patients maintained what they called ‘nutritional ketosis’. And as part of the paper, they included a formula for what this means. The chart below describes visually what they mean by nutritional ketosis, and how it affected the tumour growth. The red is an increase in ketones as a fictional patient goes deeper into ketosis. The black line represents blood glucose, that decreases to a plateau, as carbohydrate sources are removed from the diet, and glycogen stores decrease. So that sweet spot they reach at the end is an optimum level of nutritional ketosis. Now… obviously in our case we are (hopefully) not trying to slow the growth of a glioblastoma. But by getting into ketosis we’re hoping to achieve a number of benefits including: Reduced IGF-1 Immune system rejuvenation (perhaps mainly lymphocytes) Increased cellular autophagy Reduced inflammation (often measured by improved C-reactive protein levels) The extent of these benefits will depend if you’re eating a keto diet, or doing a water fast/fast mimicking diet. But all 3 should improve the biomarkers such that you have a reduced risk of major diseases such as diabetes, cancer and cardiovascular disea Continue reading >>

Glucose Ketone Index Calculator For Cancer Management

Glucose Ketone Index Calculator For Cancer Management

Glucose Ketone Index Calculator For Cancer Management This is a fantastic article statingthe incredible benefits of using ketogenic diet for the metabolic management of cancer. To calculate your index you will need to have a blood glucose monitor and a blood ketone monitor to obtain your Glucose Ketone Index (GKI). Paying attention to the optimal ratio of your glucose and ketones has been scientifically proven to be a powerful tool for the metabolic management of brain tumors (and other aggressive and inoperable cancers). Mary Beauchamp is a Registered Nurse, Therapeutic Nutritionist and Mind Body Specialist. She is a world traveler, food alchemist, and student of ancient healing traditions. She has four beautiful children and two grandchildren. With her knowledge of nutritional science, medical research, plant medicines, ancient super foods and indigenous healing rituals, she formulates food products for the natural foods industry and is a private health coach, specializing in healing the metabolism. Mary works with a team of Naturopathic doctors at Auburn Naturopathic Medicine in northern California. She alsooffers private and group online coaching programs. You can learn more about her work by visiting her website, www.ketogenicdietcoach.com . Mary is passionate about re-educating people about nutrition. She invites you to experience your body as a master communication system and facilitates this sacred encounter within to unlock the bodys innate intelligence to heal and thrive! Continue reading >>

Us20160078782a1 - Glucose Ketone Index For Metabolictherapy - Google Patents

Us20160078782a1 - Glucose Ketone Index For Metabolictherapy - Google Patents

US20160078782A1 - Glucose Ketone Index for MetabolicTherapy - Google Patents Glucose Ketone Index for MetabolicTherapy US20160078782A1 US14854713 US201514854713A US2016078782A1 US 20160078782 A1 US20160078782 A1 US 20160078782A1 US 14854713 US14854713 US 14854713 US 201514854713 A US201514854713 A US 201514854713A US 2016078782 A1 US2016078782 A1 US 2016078782A1 Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.) Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.) G09EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS G09BEDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS G09B19/00Teaching not covered by other main groups of this subclass A61MEDICAL OR VETERINARY SCIENCE; HYGIENE A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue A61B5/14532Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement A61MEDICAL OR VETERINARY SCIENCE; H

Cancer As A Metabolic Disease – What You Need To Know: Professor Thomas Seyfried

Cancer As A Metabolic Disease – What You Need To Know: Professor Thomas Seyfried

My Kid Cures Cancer Podcast Episode 006 Have you heard about the metabolic theory of cancer but still need some clarification on exactly what it is and what it means for your path to wellness and healing cancer? If so you are most certainly in the right place as today on the show we have the scientist, professor and dare I say Godfather of the modern day understanding of cancer as a metabolic disease, Dr. Thomas Seyfried, who has revived this simple truth that was first laid out in the middle of the last century. Subscribe to our mailing list In This Episode: Professor Seyfried explains how there is no consistency in genetic mutations across cancer types or even much across individual cancers but the one hallmark trait that ALL cancer cells share is that they ferment glucose and glutamine to produce energy and why this is so important to our understanding of cancer. How genetic mutations and negative epigenetic changes in gene expression like oncogenes turning on and tumor suppressor genes turning off are not the main drivers of cancer but really the byproducts of damaged cellular respiration along with defective mitochondria, and the many experiments and studies Professor Seyfried has gathered that have been done over the years to prove this. From an implementation perspective Dr. Seyfried got into how lowering blood glucose and raising ketones along with other metabolic therapies will kill many cancer cells outright and leave the rest much more vulnerable to other therapies and how one would get started on this approach through fasting and the ketogenic diet. Professor Seyfried also explained two terms that every cancer patient and preventer alike need to know, autophagy and mitochondrial biogenesis which are the cleaning out of defective mitochondria and the growth o Continue reading >>

Glucose, Free Fatty Acid And Ketone Body Metabolism In Duchenne Muscular Dystrophy

Glucose, Free Fatty Acid And Ketone Body Metabolism In Duchenne Muscular Dystrophy

Glucose, free fatty acid and ketone body metabolism in duchenne muscular dystrophy Author links open overlay panel HisahideNishioMD13 Get rights and content We examined how the substances, especially glucose, free fatty acids (FFA) and ketone bodies, and hormones associated with energy metabolism change with the disease progress in Duchenne muscular dystrophy (DMD). Serum creatine kinase (CK) activity was used as an index of the stage of DMD, because this activity is exponentially decreases with the progress of the disease. The glucose concentration in DMD patients with CK activity of less than 1,000 U/l (low CK) was significantly lower than that in controls, although there was no significant difference between that in DMD patients with CK activity of more than 1,000 U/l (high CK) and that in controls. The FFA concentration in both high CK and low CK patients was significantly higher than that in controls. The FFA concentration in low CK patients tended to be higher than that in high CK patients. The ketone body concentration in low CK patients was significantly higher than that in controls and that in high CK patients. The [glucagon]: [insulin] ratio in low CK patients was significantly higher than that in controls and that in high CK patients. It was also observed in a correlational study that the glucose concentration decreased with the age and the decrease in CK activity, i.e., with the progress of DMD. The FFA and ketone body concentrations increased with the decrease in the glucose concentration. The decrease in the glucose concentration may be due to a caloric shortage and/or degenerated muscle, which cannot supply enough gluconeogenic substrates, such as alanine. The kinetics of insulin and glucagon in DMD may help to maintain the glucose metabolism. Increased Continue reading >>

Tracking The Glucose Ketone Index

Tracking The Glucose Ketone Index

In this post we will examine the “glucose ketone index” as a biomarker for tracking metabolic health. We will also explore some of the primary use cases for tracking the glucose ketone index including cancer treatment, weight loss, metabolic disease management and athletic performance. Lastly, we will demonstrate how you can use Heads Up Health to track the glucose ketone index along with all of your other important health data. If you want to skip ahead, click the button below to create an account with Heads Up and start tracking the glucose-ketone index alongside all of your other health metrics. Or, read on for more information on tracking the glucose ketone index. What is the Glucose Ketone Index? The glucose ketone index is simply a way to measure the relationship between your ketone levels and your glucose levels at any moment in time. It is measured by dividing your blood glucose level (mmol/L) by your blood ketone level (mmol/L). The result is a single number we can use an indicator of one’s metabolic state. The index has its roots in brain cancer treatment, where researchers using metabolic therapy found best results when glucose and ketones maintained a very precise relationship in the patient [1]. Since there are many aspects of daily life (stress, exercise, nutrition etc.) that can upset glucose or ketone levels in the body, thereby throwing off the optimal glucose-ketone ratio, the index was developed to ensure both metrics (glucose and ketones) are maintaining the ideal ratio for optimal treatment outcomes. Example: If my fasting blood sugar first thing in the morning is 4.6 mmol/L (82 mg/dL) and my ketone reading is 0.8 mmol/L, I would record a glucose ketone index of 5.75 (4.6 / 0.8). Despite its roots in cancer treatment, the index can also be ver Continue reading >>

Cancer As A Metabolic Disease – An Interview With Dr. Thomas Seyfried

Cancer As A Metabolic Disease – An Interview With Dr. Thomas Seyfried

In episode 94 of Cellular Healing TV, I had the privilege of interviewing Dr. Thomas Seyfried, the author of “Cancer as a Metabolic Disease.” A professor of biology at Boston College, his research delves deeply into the subject of cancer as a mitochondrial metabolic disease. In addition, he has taught neurogenetics and neurochemistry as it relates to cancer treatment at Yale University and Boston College for the past 25 years. He has also written numerous peer-reviewed science articles and book chapters, as well as authoring his groundbreaking book. Cancer as a Metabolic Disease Read Dr. Pompa’s full article below the video… Cancer as a Metabolic Disease During our interview, Dr. Thomas Seyfried started out by clarifying that he is not claiming to treat cancer or any disease; rather, he feels that current medical treatments are taking the wrong approach. He points out that billions of dollars are being spent on cancer research, and yet, the number of cancer deaths is not changing. In the last 25 years, there has been approximately a 37% increase in new cases and a 3.5 to 4% increase in the number of deaths per year. If the current treatments were successful, you would expect those numbers to drop. Also, in recent years, cancer genomic research has skyrocketed. In fact, it is estimated that there are at least 700 targeted cancer gene therapies… yet none have been shown to reduce tumors. Cancer Drugs and Theories The theory of what drives cancer is unbridled cell proliferation (an increase in the number of bad cells), and most of the therapies being used are focusing on halting the proliferation of those cells. The toxic chemicals (chemotherapy) and radiation are used to stop this cycle. Their treatment goal is to damage tumor cell DNA and stop the uncontrolled Continue reading >>

Optimal Ketone And Blood Sugar Levels For Ketosis

Optimal Ketone And Blood Sugar Levels For Ketosis

A low carb helps reduce blood sugars and insulin levels and helps with the management of many of the diseases of modern civilisation (e.g. diabetes, heart disease, stroke, cancer, Parkinson’s and Alzheimer’s). We become insulin resistant when our body fat can’t store any more energy. Excess energy is then stored in the liver, pancreas, heart, brain and other organs that are more insulin sensitive. We also see increased levels of energy in our blood in the form of glucose, fat and elevated ketone. Endogenous ketosis occurs when we eat less food than we need. Our insulin and blood sugar levels decrease and ketones rise to supply the energy we need. Exogenous ketosis occurs when we eat lots fat and/or take exogenous ketones. Blood ketones rise, but our insulin levels will also rise because we have an excess of energy coming from our diet. Most of the good things associated with ketosis occur due to endogenous ketosis. Most people following a ketogenic diet over the long term have ketone values lower than what some people consider to be “optimal ketosis”. If your goal is blood sugar control, longevity or weight loss then endogenous ketosis with lower blood sugars and lower ketones is likely a better place to be than chasing higher blood ketones. I have seen a lot of interest and confusion recently from people following a ketogenic about ideal ketone and blood sugar levels. In an effort to try to clear this up, this article reviews blood ketone (BHB), breath ketone (acetone) and blood sugar data from a large number of people who are following a low carb or ketogenic diet to understand what “normal” and “optimal” look like. Many people initiate a low carb diet to manage their blood glucose levels, insulin resistance or diabetes. As shown in the chart below, Continue reading >>

[science] The Glucose Ketone Index Calculator: A Simple Tool To Monitor Therapeutic Efficacy For Metabolic Management Of Brain Cancer - Nutrition & Metabolism : Keto

[science] The Glucose Ketone Index Calculator: A Simple Tool To Monitor Therapeutic Efficacy For Metabolic Management Of Brain Cancer - Nutrition & Metabolism : Keto

by dominoconsultant m 51 188cm/6'2" SW:100kg/220lbs GW:75kg/165lbs achieved!!!!!!!!! Metabolic therapy using ketogenic diets (KD) is emerging as an alternative or complementary approach to the current standard of care for brain cancer management. This therapeutic strategy targets the aerobic fermentation of glucose (Warburg effect), which is the common metabolic malady of most cancers including brain tumors. TheKD targets tumor energy metabolism by lowering blood glucose and elevating blood ketones (-hydroxybutyrate). Brain tumor cells, unlike normal brain cells, cannot use ketone bodies effectively for energy when glucose becomes limiting. Although plasma levels of glucose and ketone bodies have been used separately to predict the therapeutic success of metabolic therapy, daily glucose levels can fluctuate widely in brain cancer patients. This can create difficulty in linking changes in blood glucose and ketones to efficacy of metabolic therapy. LINK ==> PDF Warning Continue reading >>

Blood Ketone Level Clarification

Blood Ketone Level Clarification

This is somewhat normal. How long have you been on a ketogenic diet? Are you diabetic? Ketone numbers tend to be lowest in the morning for those of us on a ketogenic dietand diabetics tend to have an even more pronounced variance between morning and evening levels. I do find it depends on what I ate the night before. If I am very strict on carbs, almost none, then it can go higher. But As long as Im below 30ish carbs Im good. Do you ever have a dry martini? I have for several nights and am wondering if vodka is affecting these numbers. and Volek finished their companys clinical trial and they closely managed 235 participant for intake etc. for Ketogenisis. And here is their Ketone level: Daily BOHB level averaged over 10 weeks of the program was 0.6 (SD 0.6) mmolL1 (see Figure 1). This range is indicative of a modest state of nutritional ketosis in most of the subjects, with highest value similar to levels observed during fasting. There were no cases of diabetic ketoacidosis (ie, hyperglycemia concurrent with serum BOHB level >6 mmolL1)" I am new on this forum. Ive been doing the low carb thing off and on for years. I just bought a blood glucose monitoring system. Im trying to keep my carbs under 20 net carbs . The strips are reading .5. I am confused what is the optimal level for me. I am a woman 54 light activity. I drink a lot of coffee and artificial sweetened beverages. Could someone please give me some advice. PaulL (Always take time to stop and eat the bacon) How long have you been on a well-formulated ketogenic diet? I dont test, myself, but from what Ive picked up, ketone levels are highest when one first enters nutritional ketosis, because the body is not yet fully adapted to using them. Later on, levels tend to drop as the body becomes more efficient at burn Continue reading >>

Glucose : Ketone Index

Glucose : Ketone Index

Can fasting improve blood glucose levels and reduce the need for diabetes medications? Antonio Martinez was eager to find out, so he set out on his own n = 1 experiment. Antonio is an Attorney at Law (Martindale Hubbard Distinguished Rating and in The Legal Network Top Lawyers in New York) and businessman who worked for the late Dr Robert C. Atkins MD in government relations and appeared on his radio show in the 90s. Antonio was one of the principal lobbyists and strategists involved in the passage of the Dietary Supplement Health and Education Act of 1994 (DSHEA) and has been involved in health care issues in law and policy throughout his career. Back in the 90s Antonio adopted a low carb approach to lose weight for a time but says he then resumed a more moderate diet. It wasnt until Antonio started to have his own health issues, including type 2 diabetes and a heart attack, that he realised he needed to intensify his efforts. Antonio has a family history of Type 2 Diabetes, with both his mother and father suffering from the condition. Diagnosed with Type 2 Diabetes in 2002, Antonio was initially put on Metformin and eventually Janumet in 2008. With the help of anti diabetic medications Antonio maintained a HbA1c in the 6s and was commended for his great blood glucose control. However even though he kept his blood glucose under the American Diabetes Association recommended maximum HbA1c of 7% Antonio was still at risk for cardiovascular disease. As shown in the chart below, people with a HbA1c of less than 5.0% have the lowestrisk of cardiovascular disease and stroke, however it doesnt seem to count if you are using anti-diabetes medications to reduce blood glucose levelsas they simply drive the excess energy back into storage as fat. While anti-diabetic medications h Continue reading >>

The Glucose Ketone Index Calculator: A Simple Tool To Monitor Therapeutic Efficacy For Metabolic Management Of Brain Cancer

The Glucose Ketone Index Calculator: A Simple Tool To Monitor Therapeutic Efficacy For Metabolic Management Of Brain Cancer

The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic Joshua J Meidenbauer, Purna Mukherjee and Thomas N Seyfried Background: Metabolic therapy using ketogenic diets (KD) is emerging as an alternative or complementary approach to the current standard of care for brain cancer management. This therapeutic strategy targets the aerobic fermentation of glucose (Warburg effect), w hich i s the common metabolic malady of most cancers including brain tumors. The KD targets tumor energy metabolism by lowering blood glucose and elevating blood ketones (-hydroxybutyrate). Brain tumor cells, unlike normal brain cells, cannot use ketone bodies effectively for energy when glucose becomes limiting. Although plasma levels of glucose and ketone bodies have been used separately to predict the therapeutic success of metabolic therapy, daily glucose levels can fluctuate widely in brain cancer patients. This can create difficulty in linking changes in blood glucose and ketones to efficacy of metabolic therapy. Methods: A program was developed (Glucose Ketone Index Calculator, GKIC) that tracks the ratio of blood glucose to ketones as a single value. We have termed this ratio the Glucose Ketone Index (GKI). Results: The GKIC was used to compute the GKI for data published on blood glucose and ketone levels in humans and mice with brain tumors. The results showed a clear relationship between the GKI and therapeutic efficacy using Conclusions: The GKIC is a simple tool that can help monitor the efficacy of metabolic therapy in preclinical animal models and in clinical trials for malignant brain cancer and possibly other cancers that express aerobic fermentation. Keywords: Glucose, Beta-hydroxybutyrate, Calorie restriction, Metabolic therapy, Glioblast Continue reading >>

Dom Dagostino On Disease Prevention, Cancer, And Living Longer

Dom Dagostino On Disease Prevention, Cancer, And Living Longer

The FDA decides what is safe, but Anything is toxic at a high dosage. DL beta-Hydroxybutyric has many health benefits. Dangerous side effects have never been reported. Richard Veech has said that DL beta-Hydroxybutyric salts is dangerous because its a racemic compound. This podcast is brought to you by Vimeo Business . Vimeo Business has all of the prior benefits of Vimeo Pro, including VIP support. Whether you make videos for a living, run your own company, or simply want to amp up your video marketing, Vimeo Business is here to help. It has more than 280 million creators and viewers worldwide and makes it easier to share your videos with a global audience and connect with professional video makers to bring your stories to life. Vimeo Business allows you to upload up to five terabytes and store your videos in one secure place, add up to 10 team members to your account for easy collaboration, and gather feedback with seamless review tools. You can even add clickable calls to action and capture email addresses directly in the player, which can help you generate leads and drive conversion for whatever youre trying to optimize such as a newsletter or a sales page. Check out vimeo.com/tim10 to save 10 percent on Vimeo Business . This podcast is also brought to you by Wealthfront . Wealthfront is a massively disruptive (in a good way) set-it-and-forget-it investing service led by technologists from places like Apple. It has exploded in popularity in the last two years and now has more than $2.5B under management. Why? Because you can get services previously limited to the ultra-wealthy and only pay pennies on the dollar for them, and its all through smarter software instead of retail locations and bloated sales teams. Check out wealthfront.com/tim , take their risk assessme Continue reading >>

How To Easily Track Your Glucose Ketone Index (gki) On Your Ketogenic Diet

How To Easily Track Your Glucose Ketone Index (gki) On Your Ketogenic Diet

Tracking ketone levels is a large part of success on the ketogenic diet. It helps you know how far you are into ketosis and where we might need to make changes. But did you know that there’s an even better way to step it up a notch? The glucose ketone index is a simple calculation that allows you to find out how ketosis works best for you individually. Without it, you could be in full, high-level ketosis yet still not getting the full benefits. In this post, we’ll be looking at how to easily track your glucose ketone index for different aspects of health along with your ketogenic diet. Basics of the Glucose Ketone Index Here’s what you need to know about the glucose ketone index (GKI): Researchers have used the index in studies on the ketogenic diet, fasting, and more. Additionally, it has been used for tracking changes and progress regarding weight loss, athletic performance, management of metabolic diseases like type 2 diabetes, and even cancer treatment. Now that we’ve covered the basics of what the GKI does, let’s talk about how you can use tracking it to your advantage. Tracking Your Glucose Ketone Index What’s so special about the glucose ketone index is that it lets you track both glucose and ketones at the same time, taking into account how they work together. It’s a way to know your optimal state for addressing all sorts of health conditions. Tracking this number benefits you over simply measuring ketone levels. That’s because even if you’re deeply in ketosis, you could still have high blood glucose levels that throw things off and affect your health. Essentially, it gives you a more full picture of your metabolic health. The numbers you can expect to target depend on your intentions for being in ketosis. Is your goal weight loss, better overa Continue reading >>

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