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Glucose Ketone Index Formula

The Glucose Ketone Index Calculator: A Simple Tool To Monitor Therapeutic Efficacy For Metabolic Management Of Brain Cancer

The Glucose Ketone Index Calculator: A Simple Tool To Monitor Therapeutic Efficacy For Metabolic Management Of Brain Cancer

The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic Joshua J Meidenbauer, Purna Mukherjee and Thomas N Seyfried Background: Metabolic therapy using ketogenic diets (KD) is emerging as an alternative or complementary approach to the current standard of care for brain cancer management. This therapeutic strategy targets the aerobic fermentation of glucose (Warburg effect), w hich i s the common metabolic malady of most cancers including brain tumors. The KD targets tumor energy metabolism by lowering blood glucose and elevating blood ketones (-hydroxybutyrate). Brain tumor cells, unlike normal brain cells, cannot use ketone bodies effectively for energy when glucose becomes limiting. Although plasma levels of glucose and ketone bodies have been used separately to predict the therapeutic success of metabolic therapy, daily glucose levels can fluctuate widely in brain cancer patients. This can create difficulty in linking changes in blood glucose and ketones to efficacy of metabolic therapy. Methods: A program was developed (Glucose Ketone Index Calculator, GKIC) that tracks the ratio of blood glucose to ketones as a single value. We have termed this ratio the Glucose Ketone Index (GKI). Results: The GKIC was used to compute the GKI for data published on blood glucose and ketone levels in humans and mice with brain tumors. The results showed a clear relationship between the GKI and therapeutic efficacy using Conclusions: The GKIC is a simple tool that can help monitor the efficacy of metabolic therapy in preclinical animal models and in clinical trials for malignant brain cancer and possibly other cancers that express aerobic fermentation. Keywords: Glucose, Beta-hydroxybutyrate, Calorie restriction, Metabolic therapy, Glioblast Continue reading >>

Biohacking: Using The Glucose Ketone Index

Biohacking: Using The Glucose Ketone Index

Looking for a way to measure metabolic health? One technique is to look at the ratio of blood glucose to blood ketones. The idea is to reduce carbohydrate intake which will result in lower blood sugar and higher ketone levels. The chart below explains the ideal ratios. The glucose ketone index is simply a way to measure the relationship between your ketone levels and your glucose levels at any moment in time. It is measured by dividing your blood glucose level (mmol/L) by your blood ketone level (mmol/L). The result is a single number we can use an indicator of one’s metabolic state. The index has its roots in brain cancer treatment, where researchers using metabolic therapy found best results when glucose and ketones maintained a very precise relationship in the patient [1]. Since there are many aspects of daily life (stress, exercise, nutrition etc.) that can upset glucose or ketone levels in the body, thereby throwing off the optimal glucose-ketone ratio, the index was developed to ensure both metrics (glucose and ketones) are maintaining the ideal ratio for optimal treatment outcomes. [ … Read More … ] I tend to stay in a solid level of ketosis most of the day and cycle out for just two hours. Using my numbers from the photo above look like: Convert Blood Glucose – 85 mg/dL / 18 = 4.72 mmol/L Divide Glucose by Ketones – 4.72 mmol/L / 1.6 mmol/L = 2.95 GKI No Comments No comments yet. Sorry, the comment form is closed at this time. Continue reading >>

Glucose Ketone Index (gki) – What Ratio Do I Need For Nutritional Ketosis Benefits?

Glucose Ketone Index (gki) – What Ratio Do I Need For Nutritional Ketosis Benefits?

Generally these blog posts are a result of scratching my own itch (answering my own question), and this post is no different. At the time of writing this, I’m doing a 5-day fast, and wanted to understand the readings I’m getting for my blood glucose and blood ketone levels. Initially I thought that blood ketones were all that mattered, and certainly a lot of people only talk about that reading. But looking at Dr Thomas Seyfried’s paper on treating brain cancer (glioblastomas). It suggests that its important to take into account blood glucose also. In their study, they acheieved optimal results when their patients maintained what they called ‘nutritional ketosis’. And as part of the paper, they included a formula for what this means. The chart below describes visually what they mean by nutritional ketosis, and how it affected the tumour growth. The red is an increase in ketones as a fictional patient goes deeper into ketosis. The black line represents blood glucose, that decreases to a plateau, as carbohydrate sources are removed from the diet, and glycogen stores decrease. So that sweet spot they reach at the end is an optimum level of nutritional ketosis. Now… obviously in our case we are (hopefully) not trying to slow the growth of a glioblastoma. But by getting into ketosis we’re hoping to achieve a number of benefits including: Reduced IGF-1 Immune system rejuvenation (perhaps mainly lymphocytes) Increased cellular autophagy Reduced inflammation (often measured by improved C-reactive protein levels) The extent of these benefits will depend if you’re eating a keto diet, or doing a water fast/fast mimicking diet. But all 3 should improve the biomarkers such that you have a reduced risk of major diseases such as diabetes, cancer and cardiovascular disea Continue reading >>

How To Easily Track Your Glucose Ketone Index (gki) On Your Ketogenic Diet

How To Easily Track Your Glucose Ketone Index (gki) On Your Ketogenic Diet

Tracking ketone levels is a large part of success on the ketogenic diet. It helps you know how far you are into ketosis and where we might need to make changes. But did you know that there’s an even better way to step it up a notch? The glucose ketone index is a simple calculation that allows you to find out how ketosis works best for you individually. Without it, you could be in full, high-level ketosis yet still not getting the full benefits. In this post, we’ll be looking at how to easily track your glucose ketone index for different aspects of health along with your ketogenic diet. Basics of the Glucose Ketone Index Here’s what you need to know about the glucose ketone index (GKI): Researchers have used the index in studies on the ketogenic diet, fasting, and more. Additionally, it has been used for tracking changes and progress regarding weight loss, athletic performance, management of metabolic diseases like type 2 diabetes, and even cancer treatment. Now that we’ve covered the basics of what the GKI does, let’s talk about how you can use tracking it to your advantage. Tracking Your Glucose Ketone Index What’s so special about the glucose ketone index is that it lets you track both glucose and ketones at the same time, taking into account how they work together. It’s a way to know your optimal state for addressing all sorts of health conditions. Tracking this number benefits you over simply measuring ketone levels. That’s because even if you’re deeply in ketosis, you could still have high blood glucose levels that throw things off and affect your health. Essentially, it gives you a more full picture of your metabolic health. The numbers you can expect to target depend on your intentions for being in ketosis. Is your goal weight loss, better overa Continue reading >>

Glucose Ketone Index Calculator For Cancer Management

Glucose Ketone Index Calculator For Cancer Management

Glucose Ketone Index Calculator For Cancer Management This is a fantastic article statingthe incredible benefits of using ketogenic diet for the metabolic management of cancer. To calculate your index you will need to have a blood glucose monitor and a blood ketone monitor to obtain your Glucose Ketone Index (GKI). Paying attention to the optimal ratio of your glucose and ketones has been scientifically proven to be a powerful tool for the metabolic management of brain tumors (and other aggressive and inoperable cancers). Mary Beauchamp is a Registered Nurse, Therapeutic Nutritionist and Mind Body Specialist. She is a world traveler, food alchemist, and student of ancient healing traditions. She has four beautiful children and two grandchildren. With her knowledge of nutritional science, medical research, plant medicines, ancient super foods and indigenous healing rituals, she formulates food products for the natural foods industry and is a private health coach, specializing in healing the metabolism. Mary works with a team of Naturopathic doctors at Auburn Naturopathic Medicine in northern California. She alsooffers private and group online coaching programs. You can learn more about her work by visiting her website, www.ketogenicdietcoach.com . Mary is passionate about re-educating people about nutrition. She invites you to experience your body as a master communication system and facilitates this sacred encounter within to unlock the bodys innate intelligence to heal and thrive! Continue reading >>

Glucose Ketone Index Calculator | Optimising Nutrition

Glucose Ketone Index Calculator | Optimising Nutrition

A low carb helps reduce blood sugars and insulin levels. Blood glucose control and improved metabolic health will help to reduce your risk of many of the diseases of modern civilisation such as diabetes, heart disease, stroke, cancer, Parkinsons and Alzheimers. We become insulin resistant when our body fat cant store more energy. Once our adipose tissue becomes insulin resistant, excess energy is stored in theliver, pancreas, heart, brain, eyes and other organs that are more insulin sensitive. Once our body fat cant hold the excess, we see increased levels of energy in our blood in the form of glucose, ketones and triglycerides. Endogenous ketosis occurs when weeat less food than we need. Our insulin and blood sugar levels decrease and ketones rise to supply the energy we need. Exogenous ketosis occurs when we eat lots fat and/or take exogenous ketones. Blood ketones rise, but our insulin levels will also increase because we have an excess of energy coming from our diet. While a low carb or ketogenic diet helps to stabilise blood sugars, most of the good things associated with ketosis occur due to endogenous ketosis, that is, when we drive lower levels of energy in our system. If your goal isblood sugarcontrol, longevity orweight loss then endogenous ketosis with lower blood sugars and lower ketones is likely a better place to be than higher blood ketones. There has been a lot of interest and confusion recently from people following a ketogenic about ideal ketone and blood sugar levels. In an effort to try to clear this up, this article reviews blood ketone (BHB), breath ketone (acetone) and blood sugar data from a large number of people who are following a low carb or ketogenic diet to understand what normal and optimal look like. low carb diets reduce blood glucose l Continue reading >>

The Glucose-ketone Index Approach To Cancer Therapy Some Early Insights

The Glucose-ketone Index Approach To Cancer Therapy Some Early Insights

The Glucose-Ketone Index Approach to Cancer Therapy Some Early Insights Written by Chris on June 01, 2015 No comments This recent article appeared in March 2015. Thomas Seyfried and colleagues came up with a way to monitor the therapeutic efficacy for managing brain cancer by introducing the glucose ketone index. This tool measures the ratio of blood glucose to ketones (BOHB) and its helpful because it outputs a single number that would tell if a patient is predominantly burning ketones or glucose. It would assess whether the patient is successful into implementing a ketogenic dietary approach (or a fasting approach) to managing different pathological conditions. The Glucose Ketone Index (GKI) was created to track the zone of metabolic management for brain tumor management. The GKI is a biomarker that refers to the molar ratio of circulating glucose over -OHB, which is the major circulating ketone body. A mathematical tool called the Glucose Ketone Index Calculator was developed that can calculate the GKI and monitor changes in this parameter on a daily basis. The GKIC generates a single value that can assess the relationship of the major fermentable tumor fuel (glucose) to the non-fermentable fuel (ketone bodies). The formula is quite comprehensive and it can be used with different unit systems and devices: The graphics above show you how you can switch between mg/dL and mM (millimolar). So, far theyve used the calculator to estimate the GKI for mice and humans with brain tumors that were treated with either calorie restriction or ketogenic diets from five previously published reports.[1] They noticed that the optimal results in terms of the efficacy of the treatment would be when GKI was around 1, or lower. I suspect that lower than 1 would be even better. This would Continue reading >>

Keto Katie All Things Ketones

Keto Katie All Things Ketones

The glucose ketone index is a ratiototrack your metabolic state. Dr. Thomas Seyfried suggests in his book, Cancer as a Metabolic Disease ,that you aim for a GKI between 0.7 to 2.o with a goal of 1. Today, Todd hit 1! When fighting cancer with the Ketogenic Diet, the goal is to depletethe supply of sugar/glucoseto thecancer cells and elevate the blood ketone level between 2-5 mmol depending on who you ask. Elevated ketone bodies have a very promising effect on shrinking tumors in lab & case studies. Getting your blood glucose down & ketones elevated can be a challenging task for some. What works for some may not for others. Through trial & error, Todd found out that tomatoes, almonds & too much dairy will kick him out of ketosis . There are many factors that play into the equation of raisingglucose including too much protein to any type of stress on the body. Heres how we got to 1. Precision Xtra monitor measure blood glucose in mg/dl and ketones in mmol so the glucose needs to be converted into mmol. Continue reading >>

Gki (glucose To Ketone Index)

Gki (glucose To Ketone Index)

Diabetes Forum The Global Diabetes Community Find support, ask questions and share your experiences. Join the community I posted this in the prediabetes forum and someone there suggested I try my posting in this forum as well. So...here it is; Michael here from Tasmania in Australia. Just briefly, I was obese and prediabetic for an excess of 15 years until I discovered intermittent and longer term fasting. I have now lost in excess of 20 kg and whilst I haven't tested my HbA1c for a while am probably no longer prediabetic. I will test my bloods again soon. When doing longer fasts (up to 21 days) I would regularly test my BSL and ketones. I learned that dividing BSL by ketones gives an index called GKI (glucose to ketone index). This is apparently an accurate way of assessing insulin levels in the blood. A GKI of 1 or less is optimal. This morning (my 7th and last day of my current modified water fast), my BSL was 3.1 and my ketones were 3.4. This gives me a GKI of less than 1. I'm happy with that, have lost just under 5 kg in 7 days (though I'm aware I will regain a couple of kilo in water), have absolutely no signs of hypoglycaemia and I feel good. My question is, does anyone else use GKI? Anyone got any research on the reliability and/or validity of using GKI to assess insulin levels in the blood. What a great forum. Very happy to have come across it. Well so much for my theory @Tassiemike ......... Perhaps you'd have more luck over at reddit or maybe the 2 keto dudes forums? I posted this in the prediabetes forum and someone there suggested I try my posting in this forum as well. So...here it is; Michael here from Tasmania in Australia. Just briefly, I was obese and prediabetic for an excess of 15 years until I discovered intermittent and longer term fasting. I have Continue reading >>

Us20160078782a1 - Glucose Ketone Index For Metabolictherapy - Google Patents

Us20160078782a1 - Glucose Ketone Index For Metabolictherapy - Google Patents

US20160078782A1 - Glucose Ketone Index for MetabolicTherapy - Google Patents Glucose Ketone Index for MetabolicTherapy US20160078782A1 US14854713 US201514854713A US2016078782A1 US 20160078782 A1 US20160078782 A1 US 20160078782A1 US 14854713 US14854713 US 14854713 US 201514854713 A US201514854713 A US 201514854713A US 2016078782 A1 US2016078782 A1 US 2016078782A1 Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.) Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.) G09EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS G09BEDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS G09B19/00Teaching not covered by other main groups of this subclass A61MEDICAL OR VETERINARY SCIENCE; HYGIENE A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue A61B5/14532Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement A61MEDICAL OR VETERINARY SCIENCE; H

What Is A Glucose Ketone Index And Why You Should Care

What Is A Glucose Ketone Index And Why You Should Care

Having high levels of ketones doesn’t mean you’re automatically getting all of the benefits. Luckily, research shows us that there’s an easy way to know if you’re in prime therapeutic mode so you can be confident you’re getting the best results. Ketosis can already be complicated if you don’t test and figure out what kicks you out. Once you start getting serious about ketosis and tracking ketone levels, you can usually step things up a notch with a simple calculation. You can become more specific with what works for you as an individual. How you do that is by calculating your glucose ketone index. The Glucose Ketone Index, or the GKI, is a ratio that researcher Dr. Thomas Seyfried has been using in his studies relating to both fasting and the ketogenic diet. There’s nothing fancy to this index, it is just a ratio of blood glucose levels to blood ketone levels. Having high level of ketones are great and all, but if you also have a super high level of blood glucose, you’re really just spinning your wheels and not getting any benefits of ketosis. And the real key here is to make sure that the ratio between glucose and ketone levels is as low as possible. If you’ve been following along, you’ll note I was pretty big on this glucose ketone index on my recent my four day fast and it actually dictated the time spent in the fast. But why did I care about this ratio, and why should you care? Why Should You Care? Dr. Seyfried does a lot of his research in the realm of cancer treatment and has noticed increasingly impressive therapeutic outcomes with the lower the glucose ketone index ratio gets. Dr. Seyfried claims that a GKI of lower than 1.0 is prime therapy for patients with cancer, and he has plenty of data to back this up. The graph above shows how tumor g Continue reading >>

The Glucose Ketone Index Calculator: A Simple Tool To Monitor Therapeutic Efficacy For Metabolic Management Of Brain Cancer

The Glucose Ketone Index Calculator: A Simple Tool To Monitor Therapeutic Efficacy For Metabolic Management Of Brain Cancer

The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic management of brain cancer Meidenbauer et al.; licensee BioMed Central.2015 Metabolic therapy using ketogenic diets (KD) is emerging as an alternative or complementary approach to the current standard of care for brain cancer management. This therapeutic strategy targets the aerobic fermentation of glucose (Warburg effect), which is the common metabolic malady of most cancers including brain tumors. The KD targets tumor energy metabolism by lowering blood glucose and elevating blood ketones (-hydroxybutyrate). Brain tumor cells, unlike normal brain cells, cannot use ketone bodies effectively for energy when glucose becomes limiting. Although plasma levels of glucose and ketone bodies have been used separately to predict the therapeutic success of metabolic therapy, daily glucose levels can fluctuate widely in brain cancer patients. This can create difficulty in linking changes in blood glucose and ketones to efficacy of metabolic therapy. A program was developed (Glucose Ketone Index Calculator, GKIC) that tracks the ratio of blood glucose to ketones as a single value. We have termed this ratio the Glucose Ketone Index (GKI). The GKIC was used to compute the GKI for data published on blood glucose and ketone levels in humans and mice with brain tumors. The results showed a clear relationship between the GKI and therapeutic efficacy using ketogenic diets and calorie restriction. The GKIC is a simple tool that can help monitor the efficacy of metabolic therapy in preclinical animal models and in clinical trials for malignant brain cancer and possibly other cancers that express aerobic fermentation. GlucoseBeta-hydroxybutyrateCalorie restrictionMetabolic therapyGlioblastomaWar Continue reading >>

High Ketosis, Low Ketosis; Does It Matter?

High Ketosis, Low Ketosis; Does It Matter?

There are various degrees of ketosis depending on your needs. According to the chart below a Glucose:Ketone Index (GKI) below 3 is “Therapeutic ketosis” that the medical profession uses to treat epilepsy and cancer. A range between 3 and 6 would be “Moderate/functional ketosis” and desirable for obesity, type 2 diabetes and insulin resistance. Lower on the index, between 6 and 9, is “low ketosis” and used for maintenance, optimal health and weight loss. Any thing above 9 there is no ketosis. From Wikipedia we learn that “Ketosis is a metabolic state in which some of the body’s energy supply comes from ketone bodies in the blood, in contrast to a state of glycolysis in which blood glucose provides most of the energy. Ketosis is a nutritional process characterized by serum concentrations of ketone bodies over 0.5 m/mol, with low and stable levels of insulin and blood glucose. It is almost always generalized with hyperketonemia, that is, an elevated level of ketone bodies in the blood throughout the body. Ketone bodies are formed by ketogenesis when liver glycogen stores are depleted (or from metabolising medium-chain triglycerides). The main ketone bodies used for energy are acetoacetate and β-hydroxybutyrate, and the levels of ketone bodies are regulated mainly by insulin and glucagon. Most cells in the body can use both glucose and ketone bodies for fuel, and during ketosis, free fatty acids and glucose synthesis (gluconeogenesis) fuel the remainder. Longer-term ketosis may result from fasting or staying on a low-carbohydrate diet (ketogenic diet), and deliberately induced ketosis serves as a medical intervention for various conditions, such as intractable epilepsy, and the various types of diabetes. In glycolysis, higher levels of insulin promote stora Continue reading >>

What Is The Glucose Ketone Index And Why Does It Matter?

What Is The Glucose Ketone Index And Why Does It Matter?

We’re all for using tools to improve our health and meet personal goals for our body. If you’ve never heard of or used the glucose ketone index (GKI), now’s the time to learn more about this useful tool. This article will fully explain what the glucose ketone index is and why it matters that we all use it. What is the Glucose Ketone Index? The glucose ketone index (GKI) is a single number that gives you a way to monitor the state of your metabolic health. Tracking your ketone levels lets you know how far you are into ketosis, and the GKI gives you a picture of the relationship between your ketone levels and your glucose levels. It’s simply an even more efficient way to see where you stand with your health. Let’s take a second to talk about what metabolic health means, as this needs to be clarified for two reasons: Many people who hear the term think of “metabolism,” which has been watered down a lot in recent times and is often misunderstood (such as the myth that intermittent fasting kills your metabolism, etc), and it’s not the same as an overall picture of metabolic health. Metabolic health has been defined in many different ways by researchers depending on what’s being measured: triglycerides, blood pressure, cholesterol, etc. Perhaps most commonly, we see it used in tandem with research on type 2 diabetes patients. This can get confusing if we’re not sure what type of metabolic health someone is referencing. Even experts haven’t completely agreed on a set definition of metabolic health, but the GKI index can help show the bigger picture. When we talk about metabolic health in the context of the GKI, we mean: the level of function in every cell of your body. This is important because proper cell function means everything is working in harmony ( Continue reading >>

The Glucose Ketone Index Calculator: A Simple Tool To Monitor Therapeutic Efficacy For Metabolic Management Of Brain Cancer

The Glucose Ketone Index Calculator: A Simple Tool To Monitor Therapeutic Efficacy For Metabolic Management Of Brain Cancer

The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic management of brain cancer Joshua J Meidenbauer - Boston College Purna Mukherjee - Boston College Thomas N Seyfried - Boston College BACKGROUND: Metabolic therapy using ketogenic diets (KD) is emerging as an alternative or complementary approach to the current standard of care for brain cancer management. This therapeutic strategy targets the aerobic fermentation of glucose (Warburg effect), which is the common metabolic malady of most cancers including brain tumors. The KD targets tumor energy metabolism by lowering blood glucose and elevating blood ketones (-hydroxybutyrate). Brain tumor cells, unlike normal brain cells, cannot use ketone bodies effectively for energy when glucose becomes limiting. Although plasma levels of glucose and ketone bodies have been used separately to predict the therapeutic success of metabolic therapy, daily glucose levels can fluctuate widely in brain cancer patients. This can create difficulty in linking changes in blood glucose and ketones to efficacy of metabolic therapy. METHODS: A program was developed (Glucose Ketone Index Calculator, GKIC) that tracks the ratio of blood glucose to ketones as a single value. We have termed this ratio the Glucose Ketone Index (GKI). RESULTS: The GKIC was used to compute the GKI for data published on blood glucose and ketone levels in humans and mice with brain tumors. The results showed a clear relationship between the GKI and therapeutic efficacy using ketogenic diets and calorie restriction. CONCLUSIONS: The GKIC is a simple tool that can help monitor the efficacy of metabolic therapy in preclinical animal models and in clinical trials for malignant brain cancer and possibly other cancers that express Continue reading >>

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