The Glucose Ketone Index Calculator: A Simple Tool To Monitor Therapeutic Efficacy For Metabolic Management Of Brain Cancer
The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic management of brain cancer Meidenbauer, J.J.; Mukherjee, P.; Seyfried, T.N., 2015: The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic management of brain cancer. Nutrition & Metabolism 12(): 12-12 Metabolic therapy using ketogenic diets (KD) is emerging as an alternative or complementary approach to the current standard of care for brain cancer management. This therapeutic strategy targets the aerobic fermentation of glucose (Warburg effect), which is the common metabolic malady of most cancers including brain tumors. The KD targets tumor energy metabolism by lowering blood glucose and elevating blood ketones (-hydroxybutyrate). Brain tumor cells, unlike normal brain cells, cannot use ketone bodies effectively for energy when glucose becomes limiting. Although plasma levels of glucose and ketone bodies have been used separately to predict the therapeutic success of metabolic therapy, daily glucose levels can fluctuate widely in brain cancer patients. This can create difficulty in linking changes in blood glucose and ketones to efficacy of metabolic therapy. A program was developed (Glucose Ketone Index Calculator, GKIC) that tracks the ratio of blood glucose to ketones as a single value. We have termed this ratio the Glucose Ketone Index (GKI). The GKIC was used to compute the GKI for data published on blood glucose and ketone levels in humans and mice with brain tumors. The results showed a clear relationship between the GKI and therapeutic efficacy using ketogenic diets and calorie restriction. The GKIC is a simple tool that can help monitor the efficacy of metabolic therapy in preclinical animal models and in clinical trials Continue reading >>
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Nutr Metab (Lond) 2015 11;12:12. Epub 2015 Mar 11. Biology Department, Boston College, Chestnut Hill, MA 02467 USA. Background: Metabolic therapy using ketogenic diets (KD) is emerging as an alternative or complementary approach to the current standard of care for brain cancer management. This therapeutic strategy targets the aerobic fermentation of glucose (Warburg effect), which is the common metabolic malady of most cancers including brain tumors. The KD targets tumor energy metabolism by lowering blood glucose and elevating blood ketones (-hydroxybutyrate). Brain tumor cells, unlike normal brain cells, cannot use ketone bodies effectively for energy when glucose becomes limiting. Although plasma levels of glucose and ketone bodies have been used separately to predict the therapeutic success of metabolic therapy, daily glucose levels can fluctuate widely in brain cancer patients. This can create difficulty in linking changes in blood glucose and ketones to efficacy of metabolic therapy. Methods: A program was developed (Glucose Ketone Index Calculator, GKIC) that tracks the ratio of blood glucose to ketones as a single value. We have termed this ratio the Glucose Ketone Index (GKI). Results: The GKIC was used to compute the GKI for data published on blood glucose and ketone levels in humans and mice with brain tumors. The results showed a clear relationship between the GKI and therapeutic efficacy using ketogenic diets and calorie restriction. Conclusions: The GKIC is a simple tool that can help monitor the efficacy of metabolic therapy in preclinical animal models and in clinical trials for malignant brain cancer and possibly other cancers that express aerobic fermentation. ( Please be advised that this article is hosted on an external website not affiliated with P Continue reading >>
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- Diabetes And Your Brain: Understand The Connection & Safeguard Your Brain
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Tracking The Glucose Ketone Index
In this post we will examine the “glucose ketone index” as a biomarker for tracking metabolic health. We will also explore some of the primary use cases for tracking the glucose ketone index including cancer treatment, weight loss, metabolic disease management and athletic performance. Lastly, we will demonstrate how you can use Heads Up Health to track the glucose ketone index along with all of your other important health data. If you want to skip ahead, click the button below to create an account with Heads Up and start tracking the glucose-ketone index alongside all of your other health metrics. Or, read on for more information on tracking the glucose ketone index. What is the Glucose Ketone Index? The glucose ketone index is simply a way to measure the relationship between your ketone levels and your glucose levels at any moment in time. It is measured by dividing your blood glucose level (mmol/L) by your blood ketone level (mmol/L). The result is a single number we can use an indicator of one’s metabolic state. The index has its roots in brain cancer treatment, where researchers using metabolic therapy found best results when glucose and ketones maintained a very precise relationship in the patient [1]. Since there are many aspects of daily life (stress, exercise, nutrition etc.) that can upset glucose or ketone levels in the body, thereby throwing off the optimal glucose-ketone ratio, the index was developed to ensure both metrics (glucose and ketones) are maintaining the ideal ratio for optimal treatment outcomes. Example: If my fasting blood sugar first thing in the morning is 4.6 mmol/L (82 mg/dL) and my ketone reading is 0.8 mmol/L, I would record a glucose ketone index of 5.75 (4.6 / 0.8). Despite its roots in cancer treatment, the index can also be ver Continue reading >>
Maxximumforum Poglej Temo - Fasting For Three Days Can Regenerate Entire Immune System
Fasting for three days can regenerate entire immune system ivila in sestavine, pogovori o zdravi in nezdravi hrani Fasting for three days can regenerate entire immune system Fasting for three days can regenerate entire immune system, study finds A person's entire immune system can be rejuvenated by fasting for as little as three days as it triggers the body to start producing new white blood cells, a study suggests Fasting for as little as three days can regenerate the entire immune system, even in the elderly, scientists have found in a breakthrough described as "remarkable". Although fasting diets have been criticised by nutritionists for being unhealthy, new research suggests starving the body kick-starts stem cells into producing new white blood cells, which fight off infection. Scientists at the University of Southern California say the discovery could be particularly beneficial for people suffering from damaged immune systems, such as cancer patients on chemotherapy. It could also help the elderly whose immune system becomes less effective as they age, making it harder for them to fight off even common diseases. Vabljeni na moje spletne strani: www.gaspergrom.com 07. jan 2016 10:10 Napisal/-a blackflag86 Velja ta asovni okvir (3 dni) tudi pri nas na keto ali pride e prej v to regenerativno stanje? Kolikor se spomnim je bilo enkrat reeno, da dalji post od 18 ur ne prinaa dodatnih koristi (na keto adaptiranih seveda) My metabolism switched from glucose to ketones (and fatty acids) by the end of the 3rd day, which fits with what is generally expected based on the standard biochemistry literature. On typical non-fasting days Ill hit between 1 and 2 mmol/L ketones (see my baseline data in appendix here) because I eat a reasonably high fat diet. It wasnt till day 3 til Continue reading >>
What Is A Glucose Ketone Index And Why You Should Care
Having high levels of ketones doesn’t mean you’re automatically getting all of the benefits. Luckily, research shows us that there’s an easy way to know if you’re in prime therapeutic mode so you can be confident you’re getting the best results. Ketosis can already be complicated if you don’t test and figure out what kicks you out. Once you start getting serious about ketosis and tracking ketone levels, you can usually step things up a notch with a simple calculation. You can become more specific with what works for you as an individual. How you do that is by calculating your glucose ketone index. The Glucose Ketone Index, or the GKI, is a ratio that researcher Dr. Thomas Seyfried has been using in his studies relating to both fasting and the ketogenic diet. There’s nothing fancy to this index, it is just a ratio of blood glucose levels to blood ketone levels. Having high level of ketones are great and all, but if you also have a super high level of blood glucose, you’re really just spinning your wheels and not getting any benefits of ketosis. And the real key here is to make sure that the ratio between glucose and ketone levels is as low as possible. If you’ve been following along, you’ll note I was pretty big on this glucose ketone index on my recent my four day fast and it actually dictated the time spent in the fast. But why did I care about this ratio, and why should you care? Why Should You Care? Dr. Seyfried does a lot of his research in the realm of cancer treatment and has noticed increasingly impressive therapeutic outcomes with the lower the glucose ketone index ratio gets. Dr. Seyfried claims that a GKI of lower than 1.0 is prime therapy for patients with cancer, and he has plenty of data to back this up. The graph above shows how tumor g Continue reading >>
Cancer As A Metabolic Disease A New Look At An Old Foe
Cancer is a metabolic disease, not a genetic one. The genetic mutations observed in some cancers are a downstream effect of defective energy metabolism in the mitochondria (the energy stations inside your cells) As long as your mitochondria remain healthy and functional, your chances of developing cancer are slim Ketogenic therapy calls for restricting net carbs to 50 grams per day and limiting protein; I recommend a limit of 1 gram of protein per kilogram of lean body mass. Fasting glucose needs to be below 70 mg/dL Each year during the anniversary week of Mercola.com, we recognize a Game Changer; someone whose work stands as a great service to humanity by making a significant contribution to improving people's health. This year, we present the Game Changer Award to Thomas Seyfried, Ph.D., 1 a professor of biology at Boston College and a leading expert and researcher in the field of cancer metabolism and nutritional ketosis. His book, " Cancer as a Metabolic Disease " is an important contribution to the field of how cancer starts and can be treated. Seyfried's work is also heavily featured in Travis Christofferson's excellent book, "Tripping Over the Truth: The Metabolic Theory of Cancer." Each day, some 1,600 people die from cancer in the United States alone. Worldwide, we're looking at a death toll of about 21,000 people daily. So many of these deaths are unnecessary they're preventable and treatable. Seyfried is one of the pioneers in the application of nutritional ketosis for cancer; a therapy that stems from the work of Dr. Otto Warburg, who was undoubtedly one of the most brilliant biochemists of the 20th century. He received the Nobel Prize in Physiology or Medicine in 1931 for the discovery of metabolism of malignant cells. Warburg also held a doctorate in che Continue reading >>
How To Easily Track Your Glucose Ketone Index (gki) On Your Ketogenic Diet
Tracking ketone levels is a large part of success on the ketogenic diet. It helps you know how far you are into ketosis and where we might need to make changes. But did you know that there’s an even better way to step it up a notch? The glucose ketone index is a simple calculation that allows you to find out how ketosis works best for you individually. Without it, you could be in full, high-level ketosis yet still not getting the full benefits. In this post, we’ll be looking at how to easily track your glucose ketone index for different aspects of health along with your ketogenic diet. Basics of the Glucose Ketone Index Here’s what you need to know about the glucose ketone index (GKI): Researchers have used the index in studies on the ketogenic diet, fasting, and more. Additionally, it has been used for tracking changes and progress regarding weight loss, athletic performance, management of metabolic diseases like type 2 diabetes, and even cancer treatment. Now that we’ve covered the basics of what the GKI does, let’s talk about how you can use tracking it to your advantage. Tracking Your Glucose Ketone Index What’s so special about the glucose ketone index is that it lets you track both glucose and ketones at the same time, taking into account how they work together. It’s a way to know your optimal state for addressing all sorts of health conditions. Tracking this number benefits you over simply measuring ketone levels. That’s because even if you’re deeply in ketosis, you could still have high blood glucose levels that throw things off and affect your health. Essentially, it gives you a more full picture of your metabolic health. The numbers you can expect to target depend on your intentions for being in ketosis. Is your goal weight loss, better overa Continue reading >>
Glucose Ketone Index For Metabolictherapy - The Trustees Of Boston College
Glucose Ketone Index for MetabolicTherapy United States Patent Application 20160078782 The ratio of blood glucose to blood ketones as a single Glucose Ketone Index value is tracked to manage metabolic treatment. This ratio identifies a metabolic state of health and has potential use for monitoring the progression of a metabolic or inflammatory disease or indication for all types of cancer, neurological disorders, and chronic inflammatory diseases. The tracking can be performed by a device or kit, such as a Glucose Ketone Index Calculator. Meidenbauer, Joshua J. (Auburndale, MA, US) THE TRUSTEES OF BOSTON COLLEGE (Chestnut Hill, MA, US) Bond Schoeneck & King, PLLC (350 Linden Oaks 3rd Floor Rochester NY 14625) 1. A method for managing the metabolic treatment of a subject comprising: administering a diet to the subject, wherein the diet reduces blood glucose levels and elevates blood ketone levels in the subject; tracking the ratio of blood glucose to blood ketone levels in the subject as a single Glucose Ketone Index value; and maintaining the tracked Glucose Ketone Index value within a target range. 2. The method of claim 1, wherein the maintaining the tracked Glucose Ketone Index value within a target range comprises altering the diet administered to the subject. 3. The method of claim 1, wherein the diet comprises at least one of a ketogenic diet, calorie restricted diet, nutritional supplementation, pharmacological therapy, low carbohydrate diets, ketone ester supplementation, and therapeutic fasting. 4. The method of claim 1, wherein the target range is a Glucose Ketone Index value from about 0.5 to about 5. 5. The method of claim 1, wherein the metabolic treatment comprises treatment for a metabolic or inflammatory disease or indication. 6. The method of claim 5, Continue reading >>
The Glucose-ketone Index Approach To Cancer Therapy Some Early Insights
The Glucose-Ketone Index Approach to Cancer Therapy Some Early Insights Written by Chris on June 01, 2015 No comments This recent article appeared in March 2015. Thomas Seyfried and colleagues came up with a way to monitor the therapeutic efficacy for managing brain cancer by introducing the glucose ketone index. This tool measures the ratio of blood glucose to ketones (BOHB) and its helpful because it outputs a single number that would tell if a patient is predominantly burning ketones or glucose. It would assess whether the patient is successful into implementing a ketogenic dietary approach (or a fasting approach) to managing different pathological conditions. The Glucose Ketone Index (GKI) was created to track the zone of metabolic management for brain tumor management. The GKI is a biomarker that refers to the molar ratio of circulating glucose over -OHB, which is the major circulating ketone body. A mathematical tool called the Glucose Ketone Index Calculator was developed that can calculate the GKI and monitor changes in this parameter on a daily basis. The GKIC generates a single value that can assess the relationship of the major fermentable tumor fuel (glucose) to the non-fermentable fuel (ketone bodies). The formula is quite comprehensive and it can be used with different unit systems and devices: The graphics above show you how you can switch between mg/dL and mM (millimolar). So, far theyve used the calculator to estimate the GKI for mice and humans with brain tumors that were treated with either calorie restriction or ketogenic diets from five previously published reports.[1] They noticed that the optimal results in terms of the efficacy of the treatment would be when GKI was around 1, or lower. I suspect that lower than 1 would be even better. This would Continue reading >>
Glucose Ketone Index Calculator | Optimising Nutrition
A low carb helps reduce blood sugars and insulin levels. Blood glucose control and improved metabolic health will help to reduce your risk of many of the diseases of modern civilisation such as diabetes, heart disease, stroke, cancer, Parkinsons and Alzheimers. We become insulin resistant when our body fat cant store more energy. Once our adipose tissue becomes insulin resistant, excess energy is stored in theliver, pancreas, heart, brain, eyes and other organs that are more insulin sensitive. Once our body fat cant hold the excess, we see increased levels of energy in our blood in the form of glucose, ketones and triglycerides. Endogenous ketosis occurs when weeat less food than we need. Our insulin and blood sugar levels decrease and ketones rise to supply the energy we need. Exogenous ketosis occurs when we eat lots fat and/or take exogenous ketones. Blood ketones rise, but our insulin levels will also increase because we have an excess of energy coming from our diet. While a low carb or ketogenic diet helps to stabilise blood sugars, most of the good things associated with ketosis occur due to endogenous ketosis, that is, when we drive lower levels of energy in our system. If your goal isblood sugarcontrol, longevity orweight loss then endogenous ketosis with lower blood sugars and lower ketones is likely a better place to be than higher blood ketones. There has been a lot of interest and confusion recently from people following a ketogenic about ideal ketone and blood sugar levels. In an effort to try to clear this up, this article reviews blood ketone (BHB), breath ketone (acetone) and blood sugar data from a large number of people who are following a low carb or ketogenic diet to understand what normal and optimal look like. low carb diets reduce blood glucose l Continue reading >>
The Glucose Ketone Index Calculator: A Simple Tool To Monitor Therapeutic Efficacy For Metabolic Management Of Brain Cancer
The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic Joshua J Meidenbauer, Purna Mukherjee and Thomas N Seyfried Background: Metabolic therapy using ketogenic diets (KD) is emerging as an alternative or complementary approach to the current standard of care for brain cancer management. This therapeutic strategy targets the aerobic fermentation of glucose (Warburg effect), w hich i s the common metabolic malady of most cancers including brain tumors. The KD targets tumor energy metabolism by lowering blood glucose and elevating blood ketones (-hydroxybutyrate). Brain tumor cells, unlike normal brain cells, cannot use ketone bodies effectively for energy when glucose becomes limiting. Although plasma levels of glucose and ketone bodies have been used separately to predict the therapeutic success of metabolic therapy, daily glucose levels can fluctuate widely in brain cancer patients. This can create difficulty in linking changes in blood glucose and ketones to efficacy of metabolic therapy. Methods: A program was developed (Glucose Ketone Index Calculator, GKIC) that tracks the ratio of blood glucose to ketones as a single value. We have termed this ratio the Glucose Ketone Index (GKI). Results: The GKIC was used to compute the GKI for data published on blood glucose and ketone levels in humans and mice with brain tumors. The results showed a clear relationship between the GKI and therapeutic efficacy using Conclusions: The GKIC is a simple tool that can help monitor the efficacy of metabolic therapy in preclinical animal models and in clinical trials for malignant brain cancer and possibly other cancers that express aerobic fermentation. Keywords: Glucose, Beta-hydroxybutyrate, Calorie restriction, Metabolic therapy, Glioblast Continue reading >>
- Mobile App-Based Interventions to Support Diabetes Self-Management: A Systematic Review of Randomized Controlled Trials to Identify Functions Associated with Glycemic Efficacy
- Diabetes And Your Brain: Understand The Connection & Safeguard Your Brain
- SAY GOODBYE TO BRAIN HEMORRHAGES, DIABETES, HYPERTENSION, ALZHEIMER’S AND MORE WITH THE USE OF THESE SIMPLE LEAVES!
The Glucose Ketone Index Calculator: A Simple Tool To Monitor Therapeutic Efficacy For Metabolic Management Of Brain Cancer
The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic management of brain cancer Background:Metabolic therapy using ketogenic diets (KD) is emerging as an alternative or complementary approach to the current standard of care for brain cancer management. This therapeutic strategy targets the aerobic fermentation of glucose (Warburg effect), which is the common metabolic malady of most cancers including brain tumors. The KD targets tumor energy metabolism by lowering blood glucose and elevating blood ketones (-hydroxybutyrate). Brain tumor cells, unlike normal brain cells, cannot use ketone bodies effectively for energy when glucose becomes limiting. Although plasma levels of glucose and ketone bodies have been used separately to predict the therapeutic success of metabolic therapy, daily glucose levels can fluctuate widely in brain cancer patients. This can create difficulty in linking changes in blood glucose and ketones to efficacy of metabolic therapy.Methods:A program was developed (Glucose Ketone Index Calculator, GKIC) that tracks the ratio of blood glucose to ketones as a single value. We have termed this ratio the Glucose Ketone Index (GKI).Results:The GKIC was used to compute the GKI for data published on blood glucose and ketone levels in humans and mice with brain tumors. The results showed a clear relationship between the GKI and therapeutic efficacy using ketogenic diets and calorie restriction.Conclusions:The GKIC is a simple tool that can help monitor the efficacy of metabolic therapy in preclinical animal models and in clinical trials for malignant brain cancer and possibly other cancers that express aerobic fermentation. Continue reading >>
- Mobile App-Based Interventions to Support Diabetes Self-Management: A Systematic Review of Randomized Controlled Trials to Identify Functions Associated with Glycemic Efficacy
- Diabetes And Your Brain: Understand The Connection & Safeguard Your Brain
- SAY GOODBYE TO BRAIN HEMORRHAGES, DIABETES, HYPERTENSION, ALZHEIMER’S AND MORE WITH THE USE OF THESE SIMPLE LEAVES!
Maxximumforum Poglej Temo - Keto/low Carb Tudije
The effects of ketogenic dieting on skeletal muscle and fat mass Jacob T Rauch, Jeremy E Silva, Ryan P Lowery, Sean A McCleary, Kevin A Shields, Jacob A Ormes, Matthew H Sharp, Steven I Weiner, John I Georges, Jeff S Volek, Dominic P Dagostino, Jacob M Wilson This is the first study ever to research very low carbohydrate ketogenic dieting (VLCKD) relative to a traditional high carbohydrate diet in resistance trained athletes. Methods Twenty-six college aged resistance trained men volunteered to participate in this study and were divided into VLCKD (5 % CHO, 75 % Fat, 20 % Pro) or a traditional western diet (55 % CHO, 25 % fat, 20 % pro). All subjects participated in a periodized resistance-training program 3x per week. Body fat and lean mass were determined via dual xray absorptiometry (DXA), while muscle mass was determined via ultrasonography analysis of the quadriceps. All measures were taken at week 0 and 11. Lean body mass increased to a greater extent in the VLCKD (4.3 1.7 kgs ) as compared to the traditional group (2.2 kg 1.7). Ultrasound determined muscle mass increased to a greater extent in the VLCKD group (0.4 0.25 cm) as compared to the traditional western group (0.19 0.26 cm). Finally fat mass decreased to a greater extent in the VLCKD group (-2.2 kg 1.2 kg) as compared to the traditional group (- 1.5 1.6 kg). These results indicate that VLCKD may have more favorable changes in LBM, muscle mass, and body fatness as compared to a traditional western diet in resistance trained males. Vabljeni na moje spletne strani: www.gaspergrom.com The effects of very high fat, very low carbohydrate diets on safety, blood lipid profile, and anabolic hormone status There were no differences in any of the safety parameters measured (CBC / CMP) in either the VLCKD or traditi Continue reading >>
The Glucose Ketone Index Calculator: A Simple Tool To Monitor Therapeutic Efficacy For Metabolic Management Of Brain Cancer
The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic management of brain cancer Meidenbauer et al.; licensee BioMed Central.2015 Metabolic therapy using ketogenic diets (KD) is emerging as an alternative or complementary approach to the current standard of care for brain cancer management. This therapeutic strategy targets the aerobic fermentation of glucose (Warburg effect), which is the common metabolic malady of most cancers including brain tumors. The KD targets tumor energy metabolism by lowering blood glucose and elevating blood ketones (-hydroxybutyrate). Brain tumor cells, unlike normal brain cells, cannot use ketone bodies effectively for energy when glucose becomes limiting. Although plasma levels of glucose and ketone bodies have been used separately to predict the therapeutic success of metabolic therapy, daily glucose levels can fluctuate widely in brain cancer patients. This can create difficulty in linking changes in blood glucose and ketones to efficacy of metabolic therapy. A program was developed (Glucose Ketone Index Calculator, GKIC) that tracks the ratio of blood glucose to ketones as a single value. We have termed this ratio the Glucose Ketone Index (GKI). The GKIC was used to compute the GKI for data published on blood glucose and ketone levels in humans and mice with brain tumors. The results showed a clear relationship between the GKI and therapeutic efficacy using ketogenic diets and calorie restriction. The GKIC is a simple tool that can help monitor the efficacy of metabolic therapy in preclinical animal models and in clinical trials for malignant brain cancer and possibly other cancers that express aerobic fermentation. GlucoseBeta-hydroxybutyrateCalorie restrictionMetabolic therapyGlioblastomaWar Continue reading >>
- Mobile App-Based Interventions to Support Diabetes Self-Management: A Systematic Review of Randomized Controlled Trials to Identify Functions Associated with Glycemic Efficacy
- Diabetes And Your Brain: Understand The Connection & Safeguard Your Brain
- SAY GOODBYE TO BRAIN HEMORRHAGES, DIABETES, HYPERTENSION, ALZHEIMER’S AND MORE WITH THE USE OF THESE SIMPLE LEAVES!
Ketogenic_diet_in_glioblastoma [operative Neurosurgery]
Glucose and glutamine are suggested to facilitate tumor progression. Recent evidence suggests that many glioblastoma GBMs are infected with cytomegalovirus , which could further enhance glucose and glutamine metabolism in the tumor cells. Emerging evidence also suggests that neoplastic macrophages/microglia, arising through possible fusion hybridization, can comprise an invasive cell subpopulation within GBM. Glucose and glutamine are major fuels for myeloid cells, as well as for the more rapidly proliferating cancer stem cells. Therapies that increase inflammation and energy metabolites in the GBM microenvironment can enhance tumor progression. In contrast to current GBM therapies, metabolic therapy is designed to target the metabolic malady common to all tumor cells (aerobic fermentation), while enhancing the health and vitality of normal brain cells and the entire body. The calorie restricted ketogenic diet (KD-R) is an anti-angiogenic, anti-inflammatory and pro-apoptotic metabolic therapy that also reduces fermentable fuels in the tumor microenvironment. Metabolic therapy, as an alternative to the standard of care, has the potential to improve outcome for patients with GBM and other malignant brain cancers 1) . There are two ongoing clinical trial s set to be completed by 2016 studying the efficacy of a Ketogenic Diet (KD) in Glioblastoma (GBM) patients: a Phase 1 randomized controlled trial / Phase 2 randomized controlled trial and a Phase II trial. In the Phase I/II trial, GBM patients will be administered a traditional 4:1 ratio of fat to carbohydrate KD while being treated chemoradiotherapy for six weeks. Monthly chemotherapy will be given afterwards. Patients will have an initial MRI scan, weekly blood test s to monitor ketone levels and a final MRI test 2) . Continue reading >>
