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Our guest for episode 5 of Data-Driven Health Radio is Chuck Hazzard! Chuck is the VP of Sales at OURA - the world's most advanced smart ring designed for restorative sleep, empowering people to lead better, healthier lives by seeing how their lifestyle impacts their bodies and minds. Chuck earned his BA in Computer Science and Mathematics from the University of Maine, where he also earned his JD at their School of Law. An entrepreneur and technologist, he assists companies w...ith management guidance, product development, and marketing strategies. His career has focused on the use of technology to leverage substantial business growth, repeatedly increasing revenue, profitability, ROI, and market share in both startup and Fortune 500 environments. The founder of The Human Optimization Project, a website centered on "increasing human potential and fitness through science-based nutrition and technology," Chuck merges his passion for fitness, health, and tech, sharing his biohacking wisdom with those seeking to become their optimal selves. He lives in Norwich, Vermont. [Use the code -- HeadsUpHealth -- to get $100 off the Gen 2 pre-order!] Continue reading >>
Tracking The Glucose Ketone Index
In this post we will examine the “glucose ketone index” as a biomarker for tracking metabolic health. We will also explore some of the primary use cases for tracking the glucose ketone index including cancer treatment, weight loss, metabolic disease management and athletic performance. Lastly, we will demonstrate how you can use Heads Up Health to track the glucose ketone index along with all of your other important health data. If you want to skip ahead, click the button below to create an account with Heads Up and start tracking the glucose-ketone index alongside all of your other health metrics. Or, read on for more information on tracking the glucose ketone index. What is the Glucose Ketone Index? The glucose ketone index is simply a way to measure the relationship between your ketone levels and your glucose levels at any moment in time. It is measured by dividing your blood glucose level (mmol/L) by your blood ketone level (mmol/L). The result is a single number we can use an indicator of one’s metabolic state. The index has its roots in brain cancer treatment, where researchers using metabolic therapy found best results when glucose and ketones maintained a very precise relationship in the patient [1]. Since there are many aspects of daily life (stress, exercise, nutrition etc.) that can upset glucose or ketone levels in the body, thereby throwing off the optimal glucose-ketone ratio, the index was developed to ensure both metrics (glucose and ketones) are maintaining the ideal ratio for optimal treatment outcomes. Example: If my fasting blood sugar first thing in the morning is 4.6 mmol/L (82 mg/dL) and my ketone reading is 0.8 mmol/L, I would record a glucose ketone index of 5.75 (4.6 / 0.8). Despite its roots in cancer treatment, the index can also be ver Continue reading >>
The Glucose Ketone Index Calculator: A Simple Tool To Monitor Therapeutic Efficacy For Metabolic Management Of Brain Cancer
The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic management of brain cancer Joshua J Meidenbauer - Boston College Purna Mukherjee - Boston College Thomas N Seyfried - Boston College BACKGROUND: Metabolic therapy using ketogenic diets (KD) is emerging as an alternative or complementary approach to the current standard of care for brain cancer management. This therapeutic strategy targets the aerobic fermentation of glucose (Warburg effect), which is the common metabolic malady of most cancers including brain tumors. The KD targets tumor energy metabolism by lowering blood glucose and elevating blood ketones (-hydroxybutyrate). Brain tumor cells, unlike normal brain cells, cannot use ketone bodies effectively for energy when glucose becomes limiting. Although plasma levels of glucose and ketone bodies have been used separately to predict the therapeutic success of metabolic therapy, daily glucose levels can fluctuate widely in brain cancer patients. This can create difficulty in linking changes in blood glucose and ketones to efficacy of metabolic therapy. METHODS: A program was developed (Glucose Ketone Index Calculator, GKIC) that tracks the ratio of blood glucose to ketones as a single value. We have termed this ratio the Glucose Ketone Index (GKI). RESULTS: The GKIC was used to compute the GKI for data published on blood glucose and ketone levels in humans and mice with brain tumors. The results showed a clear relationship between the GKI and therapeutic efficacy using ketogenic diets and calorie restriction. CONCLUSIONS: The GKIC is a simple tool that can help monitor the efficacy of metabolic therapy in preclinical animal models and in clinical trials for malignant brain cancer and possibly other cancers that express Continue reading >>
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Glucose Ketone Index For Metabolictherapy - The Trustees Of Boston College
Glucose Ketone Index for MetabolicTherapy United States Patent Application 20160078782 The ratio of blood glucose to blood ketones as a single Glucose Ketone Index value is tracked to manage metabolic treatment. This ratio identifies a metabolic state of health and has potential use for monitoring the progression of a metabolic or inflammatory disease or indication for all types of cancer, neurological disorders, and chronic inflammatory diseases. The tracking can be performed by a device or kit, such as a Glucose Ketone Index Calculator. Meidenbauer, Joshua J. (Auburndale, MA, US) THE TRUSTEES OF BOSTON COLLEGE (Chestnut Hill, MA, US) Bond Schoeneck & King, PLLC (350 Linden Oaks 3rd Floor Rochester NY 14625) 1. A method for managing the metabolic treatment of a subject comprising: administering a diet to the subject, wherein the diet reduces blood glucose levels and elevates blood ketone levels in the subject; tracking the ratio of blood glucose to blood ketone levels in the subject as a single Glucose Ketone Index value; and maintaining the tracked Glucose Ketone Index value within a target range. 2. The method of claim 1, wherein the maintaining the tracked Glucose Ketone Index value within a target range comprises altering the diet administered to the subject. 3. The method of claim 1, wherein the diet comprises at least one of a ketogenic diet, calorie restricted diet, nutritional supplementation, pharmacological therapy, low carbohydrate diets, ketone ester supplementation, and therapeutic fasting. 4. The method of claim 1, wherein the target range is a Glucose Ketone Index value from about 0.5 to about 5. 5. The method of claim 1, wherein the metabolic treatment comprises treatment for a metabolic or inflammatory disease or indication. 6. The method of claim 5, Continue reading >>
Glucose Ketone Index Calculator For Cancer Management
Glucose Ketone Index Calculator For Cancer Management This is a fantastic article statingthe incredible benefits of using ketogenic diet for the metabolic management of cancer. To calculate your index you will need to have a blood glucose monitor and a blood ketone monitor to obtain your Glucose Ketone Index (GKI). Paying attention to the optimal ratio of your glucose and ketones has been scientifically proven to be a powerful tool for the metabolic management of brain tumors (and other aggressive and inoperable cancers). Mary Beauchamp is a Registered Nurse, Therapeutic Nutritionist and Mind Body Specialist. She is a world traveler, food alchemist, and student of ancient healing traditions. She has four beautiful children and two grandchildren. With her knowledge of nutritional science, medical research, plant medicines, ancient super foods and indigenous healing rituals, she formulates food products for the natural foods industry and is a private health coach, specializing in healing the metabolism. Mary works with a team of Naturopathic doctors at Auburn Naturopathic Medicine in northern California. She alsooffers private and group online coaching programs. You can learn more about her work by visiting her website, www.ketogenicdietcoach.com . Mary is passionate about re-educating people about nutrition. She invites you to experience your body as a master communication system and facilitates this sacred encounter within to unlock the bodys innate intelligence to heal and thrive! Continue reading >>
Celebrating Therapeutic Glucose Ketone Index (gki) Of1!
The glucose ketone index is a ratiototrack your metabolic state. Dr. Thomas Seyfried suggests in his book, Cancer as a Metabolic Disease ,that you aim for a GKI between 0.7 to 2.o with a goal of 1. Today, Todd hit 1! When fighting cancer with the Ketogenic Diet, the goal is to depletethe supply of sugar/glucoseto thecancer cells and elevate the blood ketone level between 2-5 mmol depending on who you ask. Elevated ketone bodies have a very promising effect on shrinking tumors in lab & case studies. Getting your blood glucose down & ketones elevated can be a challenging task for some. What works for some may not for others. Through trial & error, Todd found out that tomatoes, almonds & too much dairy will kick him out of ketosis . There are many factors that play into the equation of raisingglucose including too much protein to any type of stress on the body. Heres how we got to 1. Precision Xtra monitor measure blood glucose in mg/dl and ketones in mmol so the glucose needs to be converted into mmol. Continue reading >>
What Is A Glucose Ketone Index And Why You Should Care
Having high levels of ketones doesn’t mean you’re automatically getting all of the benefits. Luckily, research shows us that there’s an easy way to know if you’re in prime therapeutic mode so you can be confident you’re getting the best results. Ketosis can already be complicated if you don’t test and figure out what kicks you out. Once you start getting serious about ketosis and tracking ketone levels, you can usually step things up a notch with a simple calculation. You can become more specific with what works for you as an individual. How you do that is by calculating your glucose ketone index. The Glucose Ketone Index, or the GKI, is a ratio that researcher Dr. Thomas Seyfried has been using in his studies relating to both fasting and the ketogenic diet. There’s nothing fancy to this index, it is just a ratio of blood glucose levels to blood ketone levels. Having high level of ketones are great and all, but if you also have a super high level of blood glucose, you’re really just spinning your wheels and not getting any benefits of ketosis. And the real key here is to make sure that the ratio between glucose and ketone levels is as low as possible. If you’ve been following along, you’ll note I was pretty big on this glucose ketone index on my recent my four day fast and it actually dictated the time spent in the fast. But why did I care about this ratio, and why should you care? Why Should You Care? Dr. Seyfried does a lot of his research in the realm of cancer treatment and has noticed increasingly impressive therapeutic outcomes with the lower the glucose ketone index ratio gets. Dr. Seyfried claims that a GKI of lower than 1.0 is prime therapy for patients with cancer, and he has plenty of data to back this up. The graph above shows how tumor g Continue reading >>
Biohacking: Using The Glucose Ketone Index
Looking for a way to measure metabolic health? One technique is to look at the ratio of blood glucose to blood ketones. The idea is to reduce carbohydrate intake which will result in lower blood sugar and higher ketone levels. The chart below explains the ideal ratios. The glucose ketone index is simply a way to measure the relationship between your ketone levels and your glucose levels at any moment in time. It is measured by dividing your blood glucose level (mmol/L) by your blood ketone level (mmol/L). The result is a single number we can use an indicator of one’s metabolic state. The index has its roots in brain cancer treatment, where researchers using metabolic therapy found best results when glucose and ketones maintained a very precise relationship in the patient [1]. Since there are many aspects of daily life (stress, exercise, nutrition etc.) that can upset glucose or ketone levels in the body, thereby throwing off the optimal glucose-ketone ratio, the index was developed to ensure both metrics (glucose and ketones) are maintaining the ideal ratio for optimal treatment outcomes. [ … Read More … ] I tend to stay in a solid level of ketosis most of the day and cycle out for just two hours. Using my numbers from the photo above look like: Convert Blood Glucose – 85 mg/dL / 18 = 4.72 mmol/L Divide Glucose by Ketones – 4.72 mmol/L / 1.6 mmol/L = 2.95 GKI No Comments No comments yet. Sorry, the comment form is closed at this time. Continue reading >>
How To Easily Track Your Glucose Ketone Index (gki) On Your Ketogenic Diet
Tracking ketone levels is a large part of success on the ketogenic diet. It helps you know how far you are into ketosis and where we might need to make changes. But did you know that there’s an even better way to step it up a notch? The glucose ketone index is a simple calculation that allows you to find out how ketosis works best for you individually. Without it, you could be in full, high-level ketosis yet still not getting the full benefits. In this post, we’ll be looking at how to easily track your glucose ketone index for different aspects of health along with your ketogenic diet. Basics of the Glucose Ketone Index Here’s what you need to know about the glucose ketone index (GKI): Researchers have used the index in studies on the ketogenic diet, fasting, and more. Additionally, it has been used for tracking changes and progress regarding weight loss, athletic performance, management of metabolic diseases like type 2 diabetes, and even cancer treatment. Now that we’ve covered the basics of what the GKI does, let’s talk about how you can use tracking it to your advantage. Tracking Your Glucose Ketone Index What’s so special about the glucose ketone index is that it lets you track both glucose and ketones at the same time, taking into account how they work together. It’s a way to know your optimal state for addressing all sorts of health conditions. Tracking this number benefits you over simply measuring ketone levels. That’s because even if you’re deeply in ketosis, you could still have high blood glucose levels that throw things off and affect your health. Essentially, it gives you a more full picture of your metabolic health. The numbers you can expect to target depend on your intentions for being in ketosis. Is your goal weight loss, better overa Continue reading >>
Us20160078782a1 - Glucose Ketone Index For Metabolictherapy - Google Patents
US20160078782A1 - Glucose Ketone Index for MetabolicTherapy - Google Patents Glucose Ketone Index for MetabolicTherapy US20160078782A1 US14854713 US201514854713A US2016078782A1 US 20160078782 A1 US20160078782 A1 US 20160078782A1 US 14854713 US14854713 US 14854713 US 201514854713 A US201514854713 A US 201514854713A US 2016078782 A1 US2016078782 A1 US 2016078782A1 Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.) Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.) G09EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS G09BEDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS G09B19/00Teaching not covered by other main groups of this subclass A61MEDICAL OR VETERINARY SCIENCE; HYGIENE A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue A61B5/14532Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement A61MEDICAL OR VETERINARY SCIENCE; H
The Glucose Ketone Index Calculator: A Simple Tool To Monitor Therapeutic Efficacy For Metabolic Management Of Brain Cancer
Go to: Abstract Background Metabolic therapy using ketogenic diets (KD) is emerging as an alternative or complementary approach to the current standard of care for brain cancer management. This therapeutic strategy targets the aerobic fermentation of glucose (Warburg effect), which is the common metabolic malady of most cancers including brain tumors. The KD targets tumor energy metabolism by lowering blood glucose and elevating blood ketones (β-hydroxybutyrate). Brain tumor cells, unlike normal brain cells, cannot use ketone bodies effectively for energy when glucose becomes limiting. Although plasma levels of glucose and ketone bodies have been used separately to predict the therapeutic success of metabolic therapy, daily glucose levels can fluctuate widely in brain cancer patients. This can create difficulty in linking changes in blood glucose and ketones to efficacy of metabolic therapy. A program was developed (Glucose Ketone Index Calculator, GKIC) that tracks the ratio of blood glucose to ketones as a single value. We have termed this ratio the Glucose Ketone Index (GKI). The GKIC was used to compute the GKI for data published on blood glucose and ketone levels in humans and mice with brain tumors. The results showed a clear relationship between the GKI and therapeutic efficacy using ketogenic diets and calorie restriction. The GKIC is a simple tool that can help monitor the efficacy of metabolic therapy in preclinical animal models and in clinical trials for malignant brain cancer and possibly other cancers that express aerobic fermentation. Electronic supplementary material The online version of this article (doi:10.1186/s12986-015-0009-2) contains supplementary material, which is available to authorized users. Keywords: Glucose, Beta-hydroxybutyrate, Calorie Continue reading >>
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Glucose Ketone Index (gki) – What Ratio Do I Need For Nutritional Ketosis Benefits?
Generally these blog posts are a result of scratching my own itch (answering my own question), and this post is no different. At the time of writing this, I’m doing a 5-day fast, and wanted to understand the readings I’m getting for my blood glucose and blood ketone levels. Initially I thought that blood ketones were all that mattered, and certainly a lot of people only talk about that reading. But looking at Dr Thomas Seyfried’s paper on treating brain cancer (glioblastomas). It suggests that its important to take into account blood glucose also. In their study, they acheieved optimal results when their patients maintained what they called ‘nutritional ketosis’. And as part of the paper, they included a formula for what this means. The chart below describes visually what they mean by nutritional ketosis, and how it affected the tumour growth. The red is an increase in ketones as a fictional patient goes deeper into ketosis. The black line represents blood glucose, that decreases to a plateau, as carbohydrate sources are removed from the diet, and glycogen stores decrease. So that sweet spot they reach at the end is an optimum level of nutritional ketosis. Now… obviously in our case we are (hopefully) not trying to slow the growth of a glioblastoma. But by getting into ketosis we’re hoping to achieve a number of benefits including: Reduced IGF-1 Immune system rejuvenation (perhaps mainly lymphocytes) Increased cellular autophagy Reduced inflammation (often measured by improved C-reactive protein levels) The extent of these benefits will depend if you’re eating a keto diet, or doing a water fast/fast mimicking diet. But all 3 should improve the biomarkers such that you have a reduced risk of major diseases such as diabetes, cancer and cardiovascular disea Continue reading >>
Glucose Ketone Index (gki)
Diabetes Forum The Global Diabetes Community Find support, ask questions and share your experiences. Join the community Michael here from Tasmania in Australia. Just briefly, I was obese and prediabetic for an excess of 15 years until I discovered intermittent and longer term fasting. I have now lost in excess of 20 kg and whilst I haven't tested my HbA1c for a while am probably no longer prediabetic. I will test my bloods again soon. When doing longer fasts (up to 21 days) I would regularly test my BSL and ketones. I learned that dividing BSL by ketones gives an index called GKI (glucose to ketone index). This is apparently an accurate way of assessing insulin levels in the blood. A GKI of 1 or less is optimal. This morning (my 7th and last day of my current modified water fast), my BSL was 3.1 and my ketones were 3.4. This gives me a GKI of less than 1. I'm happy with that, have lost just under 5 kg in 7 days (though I'm aware I will regain a couple of kilo in water), have absolutely no signs of hypoglycaemia and I feel good. My question is, does anyone else use GKI? Anyone got any research on the reliability and/or validity of using GKI to assess insulin levels in the blood. What a great forum. Very happy to have come across it. Hi @Tassiemike & welcome to the forum. I've only really encountered talk of the GKI in relation to neurological disorders & cancer treatment. You might have more luck if you post your question in the Low Carb Diet Forum Michael here from Tasmania in Australia. Just briefly, I was obese and prediabetic for an excess of 15 years until I discovered intermittent and longer term fasting. I have now lost in excess of 20 kg and whilst I haven't tested my HbA1c for a while am probably no longer prediabetic. I will test my bloods again soon. When doi Continue reading >>
It Really Is In Your Blood: Glucose To Ketone Ratios
I wrote awhile back about how I felt that I might be going a little mad obsessing over my blood numbers and measuring my blood glucose and ketone levels. This is one of the greatest differences, in my opinion, between people that follow a ketogenic or low carb lifestyle for overall health reasons or weight loss, and those of us who are experimenting with using a ketogenic approach as a specific disease therapy. I’m using the term “therapeutic ketosis” now for this, as you’ll know if you’re a Constant Reader here at Greymadder. I think people in the first category, with weight loss or general health goals, can definitely be helped by measuring ketones, and that this is vital to the success of the approach. However, in my personal experience using this approach to “starve” my brain tumour, I find I can become quite the data junkie, measuring blood levels of both glucose and ketones up to four times a day, because in my mind, the optimal levels of both are perhaps what’s required to have a therapeutic effect. I base this on the book Cancer as a Metabolic Disease by Dr. Thomas Seyfried, in which he advises that there is a window of effectiveness of therapeutic ketosis for cancer that uses a glucose to ketone ratio of 1.0. This essentially means that when measured in mmol/L (“millimolar”), blood glucose and ketones should be equal, or even achieving ketone levels that are higher than the glucose levels may be preferable. There is general agreement between my favourite go-to references (Ellen Davis, Dominic D’Agostino, Miriam Kalamian, all found in my Resources section) that this glucose to ketone ratio of 1.0 is best. Miriam Kalamian, in her ebook Get Started with the Ketogenic Diet for Cancer further notes that it should not be disregarded that a thera Continue reading >>
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Optimal Ketone And Blood Sugar Levels For Ketosis
A low carb helps reduce blood sugars and insulin levels and helps with the management of many of the diseases of modern civilisation (e.g. diabetes, heart disease, stroke, cancer, Parkinson’s and Alzheimer’s). We become insulin resistant when our body fat can’t store any more energy. Excess energy is then stored in the liver, pancreas, heart, brain and other organs that are more insulin sensitive. We also see increased levels of energy in our blood in the form of glucose, fat and elevated ketone. Endogenous ketosis occurs when we eat less food than we need. Our insulin and blood sugar levels decrease and ketones rise to supply the energy we need. Exogenous ketosis occurs when we eat lots fat and/or take exogenous ketones. Blood ketones rise, but our insulin levels will also rise because we have an excess of energy coming from our diet. Most of the good things associated with ketosis occur due to endogenous ketosis. Most people following a ketogenic diet over the long term have ketone values lower than what some people consider to be “optimal ketosis”. If your goal is blood sugar control, longevity or weight loss then endogenous ketosis with lower blood sugars and lower ketones is likely a better place to be than chasing higher blood ketones. I have seen a lot of interest and confusion recently from people following a ketogenic about ideal ketone and blood sugar levels. In an effort to try to clear this up, this article reviews blood ketone (BHB), breath ketone (acetone) and blood sugar data from a large number of people who are following a low carb or ketogenic diet to understand what “normal” and “optimal” look like. Many people initiate a low carb diet to manage their blood glucose levels, insulin resistance or diabetes. As shown in the chart below, Continue reading >>
