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Fasting Blood Glucose On Keto

High Blood Sugar In Ketogenic Dieters! Plus A Special Surprise (hint: Genotypes And Metabolism)!

High Blood Sugar In Ketogenic Dieters! Plus A Special Surprise (hint: Genotypes And Metabolism)!

A while ago Michael and I were discussing future article topics. There are truly a plethora of avenues to go down in this area of research and there is no lack of things to research and comment on. But even though I have a couple of pretty cool MCT articles sitting around on my desk, I want an interesting topic. I want something new. Something challenging. Besides, everyone is drinking the MCT koolaid these days. It’s become passe. (Also, it upsets my stomach and I have a personal vendetta against it. So there.) What’s new? There has to be something new! Michael pointed me to one of his old articles on physiological insulin resistance as an idea. I brushed it off at first. Dismissed it as a quirk. But then I thought about it. WHY does blood glucose rise in response to a low carb diet? It truly is an interesting question. What does it say about low carb diets if they induce an almost diabetic effect on circulating glucose? Thus my research began. This short abstract confirmed that it is normal for people on low carb diets to experience a rise in blood glucose levels. Because it’s a non-open journal (shame!), there’s a one-sentence explanation given: A decrease in first-phase insulin secretion may partially contribute to the short-term LC/HFD-induced increase in postprandial plasma glucose levels. First phase insulin secretion? There’s a first phase? So… There’s more than one phase to insulin secretion? I had no idea. Call me ignorant but I had no idea until this point that there was more than one phase to insulin secretion. This article delves deeper into the signaling involved in (what I learned is called) biphasic insulin secretion. The first phase of insulin secretion lasts approximately 10 minutes, and the second phase of insulin secretion picks up afte Continue reading >>

Video: What Eating “high-fat” Or “keto” Does To Your Blood Sugar

Video: What Eating “high-fat” Or “keto” Does To Your Blood Sugar

What happens to your blood sugar when you eat fat? The steps you need to stabilize your blood sugar and increase your fat-burning hormones (by following a Fat Fueled, keto eating style). Up until I found keto (high-fat, low-carb living) I was in the “eat every 2-3 hours in order to control blood sugar” camp. What I didn’t know, was that the constant eating; generally of carbohydrates, was exactly what was causing my blood sugar irregularities – constant “hangry” feelings, hypoglycemia, insulin resistance, and more. After a couple of weeks of eating Fat Fueled, keto, I no longer struggled with hypoglycemia. It was as if my sugar lows just… disappeared. And I’m not the only one that’s experienced massive changes to blood sugar shortly after shifting to a Fat Fueled, keto life. I invited Dietitian Cassie on the show today to help explain exactly what happens to our blood sugar when we eat fat – the ins and outs of insulin resistance, actions that affect blood sugar, how to use carb-ups to heal insulin resistance and much more. Today’s keto video encourages us to use dietary fat as our ally, to rely on it to support balanced blood sugar, thriving hormones and a healthy body. For video transcription, scroll down. Highlights… What foods affect blood sugar How dietary fat affects your blood sugar If combining carbohydrates and fat is a good thing How fat cells are created How to get into fat-burning mode Signs and symptoms of insulin resistance and insulin sensitivity How cortisol (and a poor sleep) affects your blood sugar How carb cycling and carb refeeding can help bust through insulin resistance How to heal yourself from insulin resistance Resources… Watch the video: When to know it’s time to carb-up (and how to do it) Step-by-step guide on goin Continue reading >>

Differential Fasting Plasma Glucose And Ketone Body Levels In Ghrko Versus 3xtg-ad Mice: A Potential Contributor To Aging-related Cognitive Status?

Differential Fasting Plasma Glucose And Ketone Body Levels In Ghrko Versus 3xtg-ad Mice: A Potential Contributor To Aging-related Cognitive Status?

Differential Fasting Plasma Glucose and Ketone Body Levels in GHRKO versus 3xTg-AD Mice: A Potential Contributor to Aging-Related Cognitive Status? 1Department of Physiology, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA 2Center for Integrated Research in Cognitive and Neural Sciences, Southern Illinois University, Carbondale, IL 62901, USA 3Division of Geriatrics Research, Department of Internal Medicine, Southern Illinois University School of Medicine, P.O. Box 19628, Springfield, IL 62794-9628, USA 4Department of Anatomy, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA Correspondence should be addressed to Peter R. Patrylo Received 20 December 2016; Revised 11 April 2017; Accepted 26 April 2017; Published 30 May 2017 Copyright 2017 Chelsea M. Griffith et al. This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cognitive function declines with age and appears to correlate with decreased cerebral metabolic rate (CMR). Caloric restriction, an antiaging manipulation that extends life-span and can preserve cognitive function, is associated with decreased glucose uptake, decreased lactate levels, and increased ketone body (KB) levels in the brain. Since the majority of brain nutrients come from the periphery, this study examined whether the capacity to regulate peripheral glucose levels and KB production differs in animals with successful cognitive aging (growth hormone receptor knockouts, GHRKOs) versus unsuccessful cognitive aging (the 3xTg-AD mouse model of Alzheimers disease). Animals were fasted for 5 hours with their plasma glucose and KB levels subse Continue reading >>

What Is A Glucose Ketone Index And Why You Should Care

What Is A Glucose Ketone Index And Why You Should Care

Having high levels of ketones doesn’t mean you’re automatically getting all of the benefits. Luckily, research shows us that there’s an easy way to know if you’re in prime therapeutic mode so you can be confident you’re getting the best results. Ketosis can already be complicated if you don’t test and figure out what kicks you out. Once you start getting serious about ketosis and tracking ketone levels, you can usually step things up a notch with a simple calculation. You can become more specific with what works for you as an individual. How you do that is by calculating your glucose ketone index. The Glucose Ketone Index, or the GKI, is a ratio that researcher Dr. Thomas Seyfried has been using in his studies relating to both fasting and the ketogenic diet. There’s nothing fancy to this index, it is just a ratio of blood glucose levels to blood ketone levels. Having high level of ketones are great and all, but if you also have a super high level of blood glucose, you’re really just spinning your wheels and not getting any benefits of ketosis. And the real key here is to make sure that the ratio between glucose and ketone levels is as low as possible. If you’ve been following along, you’ll note I was pretty big on this glucose ketone index on my recent my four day fast and it actually dictated the time spent in the fast. But why did I care about this ratio, and why should you care? Why Should You Care? Dr. Seyfried does a lot of his research in the realm of cancer treatment and has noticed increasingly impressive therapeutic outcomes with the lower the glucose ketone index ratio gets. Dr. Seyfried claims that a GKI of lower than 1.0 is prime therapy for patients with cancer, and he has plenty of data to back this up. The graph above shows how tumor g Continue reading >>

How To Easily Track Your Glucose Ketone Index (gki) On Your Ketogenic Diet

How To Easily Track Your Glucose Ketone Index (gki) On Your Ketogenic Diet

Tracking ketone levels is a large part of success on the ketogenic diet. It helps you know how far you are into ketosis and where we might need to make changes. But did you know that there’s an even better way to step it up a notch? The glucose ketone index is a simple calculation that allows you to find out how ketosis works best for you individually. Without it, you could be in full, high-level ketosis yet still not getting the full benefits. In this post, we’ll be looking at how to easily track your glucose ketone index for different aspects of health along with your ketogenic diet. Basics of the Glucose Ketone Index Here’s what you need to know about the glucose ketone index (GKI): Researchers have used the index in studies on the ketogenic diet, fasting, and more. Additionally, it has been used for tracking changes and progress regarding weight loss, athletic performance, management of metabolic diseases like type 2 diabetes, and even cancer treatment. Now that we’ve covered the basics of what the GKI does, let’s talk about how you can use tracking it to your advantage. Tracking Your Glucose Ketone Index What’s so special about the glucose ketone index is that it lets you track both glucose and ketones at the same time, taking into account how they work together. It’s a way to know your optimal state for addressing all sorts of health conditions. Tracking this number benefits you over simply measuring ketone levels. That’s because even if you’re deeply in ketosis, you could still have high blood glucose levels that throw things off and affect your health. Essentially, it gives you a more full picture of your metabolic health. The numbers you can expect to target depend on your intentions for being in ketosis. Is your goal weight loss, better overa Continue reading >>

Glucose Numbers And Ketogenic Diet

Glucose Numbers And Ketogenic Diet

GLUCOSE NUMBERS and KETOGENIC DIET When eating a ketogenic diet, the most exposure to carbohydrates is overnight especially towards morning as the liver produces glucose to keep your brain fueled and to prepare you for getting up. Therefore, if you are eating a very ketogenic diet, the blood ketones go up during the day as you burn more fat for fuel (as apposed to a high carb diet where the opposite happens). Something to consider, a ketogenic diet rapidly induces insulin resistance. This is a normal physiological response to carb restriction. Carb restriction drops insulin levels. Low insulin levels activate hormone sensitive lipase. This breaks down fatty tissue into ketone bodies (blood ketones). Your muscles prefer to run on ketones and so they become insulin resistant leaving the glucose in your blood for other cells (like the brain). However, while muscles are in “refusal mode” for glucose any glucose put into your bloodstream, from food or gluconeogenesis (blood glucose made from protein or other tissues), will rapidly spike blood glucose. This is fine if you stick to LC in your eating. It also means that if you take an oral glucose tolerance test you will fail and be labelled diabetic. In fact, even a single high fat meal can do this, extending insulin resistance in to the next day. So if you are getting a blood glucose test, you can increase your carbs to 150 grams a day for 3 days prior and your blood glucose levels will show normal according to the standards. Otherwise, you can look at a better marker for metabolic syndrome which is you HbA1c levels. If these are low (5.5 or less is what a doctor will define as low diabetes risk, 5 or less is ideal), it doesn’t matter what your fasting blood glucose levels are. Also an interesting note, when mice in a r Continue reading >>

Monitoring Ketone And Blood Glucose Levels On A Low Carb Diet

Monitoring Ketone And Blood Glucose Levels On A Low Carb Diet

By Mary T. Newport M.D. While it is not necessary to measure ketone levels, many people who make the change to a low carb, ketogenic diet and/or use ketone salts would like to have some positive proof that their ketone levels are, in fact, elevated. When transitioning from a higher carb to a low carb, ketogenic type diet, it can take several days to begin to see an increase in ketone levels and the ketone level may continue to rise for two or three weeks before it levels off. The ketone level can fluctuate somewhat throughout the day and can vary considerably from person to person. Using ketone salts, such as Prüvit KETO//OS® or KETO//OS Max, as a supplement can give you a jump start on getting into ketosis and increase ketone levels within 30 to 60 minutes of taking the product. Using coconut oil and MCT oil as part of the diet can help increase and sustain ketone levels as well. There are several ways available to measure ketone levels in urine, blood or by using a breath analyzer. When blood levels of ketones become elevated, the excess ketones will filter out of the blood into the urine. Urine ketone test strips were originally developed for diabetics to help determine if they are going into diabetic ketoacidosis when the blood sugar is elevated. There are a number of companies that sell urine test strips that change color when ketone levels are elevated – usually the deeper the color, the higher the ketone level. This will not tell you what your actual blood ketone level is but can give you a rough idea of whether you are in ketosis or not. However, one of the drawbacks to using urine test strips is that they only measure the ketone acetoacetate and not beta-hydroxybutyrate, which tends to be much more elevated than acetoacetate during ketosis. Also, Prüvit ke Continue reading >>

High Fasting Blood Sugar On Keto?

High Fasting Blood Sugar On Keto?

The more I coach people through a ketogenic lifestyle, the more I become familiar with small nuances that can affect different peoples experience. For example, there are a number of people who experience high fasting blood sugar upon waking in the morning. These individuals would express that they were following a ketogenic diet and were in a fasted state so it doesnt make sense to have elevated blood sugar. What you are going to find out in this article is that this effect may actually be much more normal than you think. In fact, it may not even be an issue. That being said, for some people it may actually be a sign of something undesirable going on with their metabolism. This article will help you troubleshoot what is likely to be causing your high fasting blood sugar. When someone has elevated fasting blood sugar and is NOT following a ketogenic lifestyle, it is likely that they are suffering from insulin resistance. Insulin resistance is characteristic of pre-diabetes and diabetes , as well as metabolic syndrome. This is when your cells stop listening to insulins signals to let glucose into the cell and instead allow glucose to continue circulating in the blood. This is often due to a high sugar diet that constantly bombards insulin receptors to the point where they become desensitized. Think Little Boy Who Cried Wolf, but with your cells. This is called pathologic insulin resistance as it is considered a disorder and increases your risk of many different diseases . In diabetics, there are 2 common ways that high fasting morning blood sugar arises. The first reason is the Dawn Phenomenon and this impacts individuals who are following a ketogenic lifestyle as well. Overnight as we sleep between the hours of 2-8am a slurry of hormones including cortisol, growth hormo Continue reading >>

Why Your Fasting Blood Sugar Might Still Be High On Low Carb

Why Your Fasting Blood Sugar Might Still Be High On Low Carb

It’s not too uncommon to have slightly high fasting blood sugar on low carb and keto diets. Is this a problem? It depends on your insulin levels, as outlined by Dr. Ted Naiman below. If you’re insulin sensitive, and have slightly higher fasting blood glucose, it’s likely just fine. More The dawn phenomenon – why are blood sugars high in the morning? Insulin Advanced low-carb topics Diabetes Dr. Naiman Earlier with Dr. Naiman All earlier posts about Dr. Naiman Continue reading >>

5 Reasons For High Fasting Blood Glucose Other Than Low Carb Or Keto

5 Reasons For High Fasting Blood Glucose Other Than Low Carb Or Keto

Many people are probably wondering why is their fasting blood sugar higher on low carb. As a matter of fact, dozens of paleo and ketogenic forums have discussions on this topic. Some of the information with unsubstantiated claims is that low-carb diet might trigger diabetes. Some people even quit their keto diet since they had high FBGs, i.e., fasting blood glucose. However,you should not jump into conclusions, there are 5 things you should know. 1. Glucose Meters Can Give False Readings You should bear in mind that technical reasons can lead to higher sugar readings. The US Federal Drug Administration, i.e., FDA allows home sugar monitors to have a variance of 15 percent in the results. This means that one reading of 100 mg or dl may be as high as 115 and as low as 85 which is a big variation. The software engineer, Dave Feldman, said that he had a huge variation in the results. Although he expected high blood sugar due to his long-term keto eating low in carbs. Therefore, now whenever he gets a result he was not expecting, he does 3 readings within few minutes and averages the obtained result. According to other researchers, false readings might occur because of other reasons . Reasons like pricking a finger for blood with a hand which has minute traces of food or sugar (for example just touching fruit). In addition, dehydration can increase results. Therefore, it is crucial to wash the hands before testing. However, you should bear in mind that certain soaps have additives such as honey which can distort readings. Other factors which may lead to lower or higher readings are environmental conditions such as high altitudes. And also strips which are too cold or too hot. Therefore, when you get an unexpected high reading , do one more. 2. Understand Cortisol and Its In Continue reading >>

Blood Sugar Levels In Ketosis: Part Ii

Blood Sugar Levels In Ketosis: Part Ii

Welcome to Keto Sister. Last week’s post explained what happens to blood glucose levels as a result of eating a ketogenic diet. In sum, blood glucose (also known as blood sugar) decreases and is replaced in large part by a new fuel source, ketone bodies. Humans are always being fueled by two energy substrates: glucose and fatty acids. A person who eats a high carbohydrate diet burns more glucose as fuel, and a person who eats a high fat diet burns more fat as fuel. However, there is never a time at which a person stops burning one or the other. The implication for someone eating a low carb diet is that the body never replaces all glucose utilization with ketone bodies. Instead, the body reduces its glucose needs to the bare minimum and then it makes any needed glucose not taken in through the diet through gluconeogenesis. This is the normal, healthy process of fueling the body in the absence of dietary glucose. Elevated Blood Glucose There are many benefits of ketogenic nutrition when a ketogenic diet is implemented correctly. One of the benefits of eating low carb is blood glucose control, and this can be a big benefit to those who struggle with type 2 diabetes and obesity. As I mentioned last week, ideal blood glucose levels are between 81 and 109 milligrams per deciliter (see this post for details). However, it is a common occurrence for those following a very low carb diet to have elevated blood glucose levels. I mentioned the first two causes last week, but there is a third that is rarely discussed by those in the low carb arena. Admittedly, these concepts are not well understood by most people. Nevertheless, here is what we know about elevated blood sugar levels in ketosis: Physiological Insulin Resistance (PhIR). Eating a low carb diet in and of itself can indu Continue reading >>

Optimal Ketone And Blood Sugar Levels For Ketosis

Optimal Ketone And Blood Sugar Levels For Ketosis

A low carb helps reduce blood sugars and insulin levels and helps with the management of many of the diseases of modern civilisation (e.g. diabetes, heart disease, stroke, cancer, Parkinson’s and Alzheimer’s). We become insulin resistant when our body fat can’t store any more energy. Excess energy is then stored in the liver, pancreas, heart, brain and other organs that are more insulin sensitive. We also see increased levels of energy in our blood in the form of glucose, fat and elevated ketone. Endogenous ketosis occurs when we eat less food than we need. Our insulin and blood sugar levels decrease and ketones rise to supply the energy we need. Exogenous ketosis occurs when we eat lots fat and/or take exogenous ketones. Blood ketones rise, but our insulin levels will also rise because we have an excess of energy coming from our diet. Most of the good things associated with ketosis occur due to endogenous ketosis. Most people following a ketogenic diet over the long term have ketone values lower than what some people consider to be “optimal ketosis”. If your goal is blood sugar control, longevity or weight loss then endogenous ketosis with lower blood sugars and lower ketones is likely a better place to be than chasing higher blood ketones. I have seen a lot of interest and confusion recently from people following a ketogenic about ideal ketone and blood sugar levels. In an effort to try to clear this up, this article reviews blood ketone (BHB), breath ketone (acetone) and blood sugar data from a large number of people who are following a low carb or ketogenic diet to understand what “normal” and “optimal” look like. Many people initiate a low carb diet to manage their blood glucose levels, insulin resistance or diabetes. As shown in the chart below, Continue reading >>

Is Your Fasting Blood Glucose Higher On Low Carb Or Keto? Five Things To Know

Is Your Fasting Blood Glucose Higher On Low Carb Or Keto? Five Things To Know

This past spring, after 18 months of great success on the keto diet, I tested my fasting blood sugar on my home glucose monitor for the first time in many months. The result shocked me. I had purchased the device, which also tests ketones, when I was diagnosed with pre-diabetes in the fall of 2015. As I embarked on low-carb keto eating, I tested my blood regularly. Soon my fasting blood sugar was once again in the healthy range. I was in optimal ketosis day after day. Not only that, I lost 10 lbs (5 kg) and felt fantastic — full of energy with no hunger or cravings. Before long I could predict the meter’s results based on what I was eating or doing. I put the meter away and got on with my happy, healthy keto life. When my doctor ordered some lab tests this spring, I brought the meter out again. While I had no health complaints, excellent blood pressure and stable weight, she wanted to see how my cholesterol, lipids, HbA1c, and fasting glucose were doing on my keto diet — and I was curious, too. To check the accuracy of my meter against the lab results, on the morning of the test I sat in my car outside the clinic at 7:30 am, and pricked my finger. I was expecting to see a lovely fasting blood glucose (FBG) of 4.7 or 4.8 mmol/l (85 mg/dl). It was 5.8! (103 mg/dl). What? I bailed on the tests and drove home — I didn’t want my doctor warning me I was pre-diabetic again when I had no explanation for that higher result. The next morning I tested again: 5.9! (104). Huh??? For the next two weeks I tested every morning. No matter what I did, my FBG would be in 5.7 to 6.0 (102 to 106 mg/dl), the pre-diabetic range again. One morning after a restless sleep it was even 6.2 mmol/l (113 mg/dl). But my ketones were still reading an optimal 1.5-2.5 mmol/l. I was still burnin Continue reading >>

The Ketogenic Diet And Insulin Resistance

The Ketogenic Diet And Insulin Resistance

We recently touched on how you can use the ketogenic diet to control symptoms of diabetes such as elevated glucose and triglycerides. In this article, we examine research showing the impact that the ketogenic diet has on levels of the hormone insulin, a key regulator of blood sugar in the body. What is Insulin’s Role in the Body? Before we look at the research, we need to know our main players. Insulin is a protein-based hormone produced by beta-cells located in the pancreas. The pancreas, which is located under the stomach, also produces enzymes that aid with digestion. Insulin’s primary purpose is to regulate the metabolism of fats and carbohydrates. The digestive system breaks down carbohydrates, such as sugars and starches, into a molecule called glucose. This compound can be used by cells to produce energy through a process called cellular respiration. Insulin allows cells in the body absorb glucose, ultimately lowering levels of glucose in the blood stream. After a meal is consumed, blood glucose levels increase and the pancreas responds by releasing insulin into the blood. Insulin assists fat, liver, and muscle cells absorb glucose from the blood, resulting in lower levels of blood glucose. Insulin stimulates liver and muscle tissues to store excess glucose as a molecule called glycogen and also reduces glucose production by the liver. When blood sugar is low, the hormone glucagon (produced by alpha-cells in the pancreas) stimulate cells to break down glycogen into glucose that is subsequently released into the blood stream. In healthy people who do not have type II diabetes, these functions allow levels of blood glucose and insulin to stay in a normal range. What Is Insulin Resistance and Why Is It a Problem? Unfortunately, for many Americans and other peopl Continue reading >>

The High Blood Glucose Dilemma On Low Carb (lc) Diets

The High Blood Glucose Dilemma On Low Carb (lc) Diets

If you are on a ketogenic or very low carb (VLC) diet (e.g. with 50-100gr carb/day and/or eating ketone producing MCT oils such as coconut oil), you may have a dilemma of having high Blood Glucose (BG) despite eating LC: If you are keto adapted, that is, your body is using ketones and even though you have sufficient insulin (say >5 microU/ml) your body tries to keep your BG higher than necessary, e.g. above 100-110 mg/dl. That is your BG set-point is always high. If you try to lower the set-point to say 80s, by water Intermittent Fasting (IF), then your body starts to convert your muscles into glucose to keep its high BG set-point. So, you may have a slightly lower BG, but you lose some muscle mass. Having a high set-point has many other problems, e.g. if you eat something with a little bit more carb, say a small fruit, your BG shoots up to 130s and stays there for hours. This may be due to something called "Physiological Insulin Resistance (PhIR) by Petro Dobromylskyj. He wrote many good articles about it -???thanks Petro--in his blog Hyperlipid. Apparently, PhIR is a normal reaction of the body and quite different from Pathological Insulin Resistance (PaIR). It seems that the main difference between PhIR and PaIR is that insulin is at a normal level in the former and abnormally high in the latter. (PaIR is obviously type2 diabetes.) If I understand correctly, PhIR is kind of IR only in the muscle tissue, that is only the muscles do not react to insulin and NOT use glucose even though it is available. However, if you are eating too much protein, the liver may also be considered IR, because it tries to keep the BG high by converting proteins to glucose, even though BG is already too high, that is, it also may not be responding to insulin. (I think working muscles can us Continue reading >>

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