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Exogenous Ketones And Depression

My Experience With Exogenous Ketones: Tale And Truth

My Experience With Exogenous Ketones: Tale And Truth

97 Comments I woke up the morning of the ceremony with butterflies in my stomach. I’d done the necessary prep. I’d abstained from carbs the past week and food the past 24 hours. I’d performed four consecutive full-body circuit workouts to deplete muscle glycogen, and undergone a liver biopsy to confirm full depletion of liver glycogen. I wasn’t taking any chances. Although I had extensive experience generating endogenous ketones and subsisting on my own body fat, exogenous ketones were another matter entirely. You don’t want to mess around with a holy sacrament without doing due diligence. Holy sacrament? Yes. According to ethnographic accounts from early Arctic explorers who encountered the sacred compound, the exogenous ketone was developed by traditional peoples of the wintry north. No one’s quite sure where it arose first—Siberia, Greenland, Alaska, Lapland. What they do know is that these societies revered the type 1 diabetic, a rare find in the pre-contact Arctic. Using an admittedly grisly and cruel process, these groups would starve the tribe’s diabetic to induce ketoacidosis, harvest the ketone-rich urine, and reduce it slowly to a ketone-rich tar over a wood fire. Tribe shamans would dissolve the tar in pine needle tea and distribute it to members exclusively before hunting trips, warfare, and any other activity requiring optimal physical and mental function to boost energy and improve performance. As Mark Twain famously quipped, “The strongest coffee I ever had was a Laplander’s piss.” So when I showed up to the small building on the edge of town on a rainy evening, I was anxious. What was I in for? The solemn countenances worn by my two guides for the day—Dr. Peter Attia, wearing dark robes and swinging a thurible loaded with burning Continue reading >>

Ketosis For Depression

Ketosis For Depression

Depression is so common these days that it seems hard to meet anyone who hasn’t experienced it in some degree. While this has perhaps become the new normal, it doesn’t need to be. Our eating choices not only affect our physical health but our mental health as well—so if you’ve been wondering whether the ketogenic diet can positively impact your emotional state, read on for the use of ketosis for depression. Diet and Depression It’s no secret that most people are overworked, under-rested, and living on a poor diet. It’s also no coincidence that the modern advice to eat a diet high in carbohydrates, low in fat, and with constant snacking or small meals throughout the day has coincided with a rise in diabetes, obesity, and mental issues like anxiety and depression. Let’s take a look at why this difference in diet could be causing these problems—and how ketosis and a ketogenic diet can help. Ketogenic Nutrition and Depression Most of us can agree that a high intake of sugar has a negative impact on mood. Just think of the sugar highs and crashes that result from eating high-carb foods. What follows is feelings of crankiness, low-energy, and maybe even depression. Now, think about how a steady intake of fats from a ketogenic diet could have a positive impact on mood and endorphin levels. Many people who start eating keto have come from a background of eating the Standard American Diet and not exercising enough. Starting a ketogenic diet, removing high-carb refined foods, losing weight, and eating whole foods is bound to help with mood and make you happier. This alone could have benefits for those with depression. In addition, there are some interesting links between ketones and many conditions of the brain similar to depression, including epilepsy and Alzheim Continue reading >>

#018 Keto Prime, Depression + Carb Ups, And Keto Side Effects

#018 Keto Prime, Depression + Carb Ups, And Keto Side Effects

Solo episode, chatting about exogenous ketones, what to do when you experience depression after a carb-up, steps on removing birth control, how to test ketones, side effects of keto, and how long to do keto until you decide it’s not working for you. TOPICS:: ** Bulletproof Keto Prime. (05:46) ** Depression after a carb-up. (16:09) ** Side effects of going keto. (26:22) ** How to know when keto isn’t working. (38:34) NOTES:: Show notes: healthfulpursuit.com/podcast/e18. Leave a review at healthfulpursuit.com/review. Episode suggestions: [email protected] PARTNERS:: Get nourished with Vital Proteins: amzn.to/2sEKNKQ. Paleovalley instant 20% off: paleovalley.com/keto. Thrive Market Free Almond Butter (US-only): thrivemarket.com/hp. SHOW LINKS:: Start your high-fat, keto life: bit.ly/TheKetoBundle. Free 7-day keto meal plan: healthfulpursuit.com/ketomeal. Bulletproof chocolate fuel bars: bit.ly/2jtMBPl. Bulletproof keto prime: bit.ly/2j7KkJf. 30-day keto experience video: healthfulpursuit.com/jyf2W. Continue reading >>

Ketosis & Depression

Ketosis & Depression

According to the British National Health Service, or NHS, ketosis results when too many ketones build up in your blood. Ketones are chemicals that your body produces as a byproduct of burning fat for fuel. Ketosis is a goal of some very-low-carb diets. Some people may experience increased symptoms of depression during ketosis because their bodies may have a hard time producing the mood-elevating chemical called serotonin. Video of the Day Carbs are your body's fuel of choice. When your body has very little carbohydrate available -- as it would after a week or so on a very-low-carb diet -- it is forced to start breaking down and using fat for energy. This process is called fat metabolism. The byproducts of fat metabolism include ketones, which are acidic chemicals that exit your body through urine and breath. Depressed people typically have a persistent feeling of sadness, worthlessness and emptiness. There are many possible reasons for depression; in some cases, depression results from a lack of the brain chemical serotonin, a compound that makes people feel naturally happy. According to MayoClinic.com, having too little serotonin can disrupt communication between your brain cells, making depression worse. Your body has to make serotonin; you can't get it from the food you eat. MedlinePlus explains that your body uses tryptophan, a type of protein, to make serotonin. You can find tryptophan in protein-rich foods like turkey, eggs and fish -- all foods that are allowed on a low-carb diet. So it would seem that people on low-carb diets should have all the tryptophan they need to make serotonin in excess, but that's not the end of the story. There is a tiny amount of tryptophan available compared to all the other kinds of protein in eggs. Since only so much protein can cro Continue reading >>

How To Increase Athletic Performance With Exogenous Ketones

How To Increase Athletic Performance With Exogenous Ketones

Traditional sports nutrition wisdom tells endurance athletes that loading up on carbohydrates prior to long-distance training/events is ideal for optimal performance. However, as sports nutrition research grows, we are learning that there may be more efficacious ways to fuel your endurance training goals. Enter exogenous ketones (Ketone Supplements). The unique nutritional benefits of exogenous ketones, particularly beta-hydroxybutyrate (BHB) salts, are extensive, ranging from nootropic (brain enhancing) properties, enhanced glucose utilisation, physical performance improvements, and reduced inflammation. For endurance athletes, exogenous ketones present a superior nutritional supplement adjunct to pre-training carbohydrate ingestion. If you’re not familiar with what exactly exogenous ketones are and how they work, be sure to check out our FREE Exogenous Ketone eBook that teaches you everything you’ll need to know before moving forward. Why Endurance Athletes Should Use Exogenous Ketones Before we jump into the data behind exogenous ketones and endurance training, let’s get a better grasp of what exactly exogenous ketones do in the human body. In short, ketones are an alternative energy source for your body, specifically mitochondria - the ‘engine’ of cells. While endurance athletes typically think of carb-based sports beverages as the ideal energy source for aerobic exercise, recent studies suggest that exogenous ketones, like BHB salts, bolster the benefits of carbohydrates. In other words, combining ketones with carbohydrates results in better performance and recovery than carbohydrates alone. In fact, adding Essential Amino Acids (EAA’s) like that found in AMINO SWITCH™ may prove to be even more effective as previous studies support the combination of Continue reading >>

The Current Status Of The Ketogenic Diet In Psychiatry

The Current Status Of The Ketogenic Diet In Psychiatry

Go to: Abstract Background The ketogenic diet (KD) has been used in treatment-resistant epilepsy since the 1920s. It has been researched in a variety of neurological conditions in both animal models and human trials. The aim of this review is to clarify the potential role of KD in psychiatry. Results The search yielded 15 studies that related the use of KD in mental disorders including anxiety, depression, bipolar disorder, schizophrenia, autism spectrum disorder (ASD), and attention deficit hyperactivity disorder (ADHD). These studies comprised nine animal models, four case studies, and two open-label studies in humans. In anxiety, exogenous ketone supplementation reduced anxiety-related behaviors in a rat model. In depression, KD significantly reduced depression-like behaviors in rat and mice models in two controlled studies. In bipolar disorder, one case study reported a reduction in symptomatology, while a second case study reported no improvement. In schizophrenia, an open-label study in female patients (n = 10) reported reduced symptoms after 2 weeks of KD, a single case study reported no improvement. In a brief report, 3 weeks of KD in a mouse model normalized pathological behaviors. In ASD, an open-label study in children (n = 30) reported no significant improvement; one case study reported a pronounced and sustained response to KD. In ASD, in four controlled animal studies, KD significantly reduced ASD-related behaviors in mice and rats. In ADHD, in one controlled trial of KD in dogs with comorbid epilepsy, both conditions significantly improved. Conclusion Despite its long history in neurology, the role of KD in mental disorders is unclear. Half of the published studies are based on animal models of mental disorders with limited generalizability to the analog Continue reading >>

Avoid This Ketogenic Rip-off

Avoid This Ketogenic Rip-off

The Truth About Exogenous Ketones Ketones are all the rage among low carbers. And like most things in nutrition and performance, we've found a way to get them in supplement form so we don't have to do any actual work. What are ketones? They're a byproduct of ketosis caused by the process of converting fat to fuel. Your body makes them when it's in a calorie or carb restricted state. What do they do? The body and brain can use them as fuel without the presence of glucose in the blood. And now, you can take ketone supplements (salts and esters), known as exogenous ketones, without actually restricting anything. According to those promoting this nasty-tasting supplement, that means you can have a brain and body fuelled by ketones, along with all of the supposed health benefits that come with running on fat. Well, don't fall for it. Exogenous Ketones = Endogenous Fat Storage? The problem with ketone supplementation (EXOgenous) is that it's not even close to the same thing as being in ketosis (ENDOgenous ketone production). And just like the butter-blended-into-coffee trend, it's a farce. Ketones may be depressing dieters' hunger and giving them a hit of energy and cognitive enhancement, but it's INHIBITING their ability to burn fat, providing zero nourishment, and doing nothing for their metabolic health. There's an assortment of evidence suggesting that it's probably making things worse. Think of exogenous ketones kind of like alcohol. When they're consumed, everything is stored and nothing else is burned. So any lipolysis (fat burning) that would be taking place is halted; any glucose and fatty acids in your blood that were circulating are stored; and the ingested ketones are burned until there aren't any left. More importantly, this clearance of alternative fuels (glucos Continue reading >>

Ketones For Ketone's Sake?

Ketones For Ketone's Sake?

Minor Update: Sorry, sometimes I hit Publish instead of Close when I'm in a rush and want to make sure I have most recent version saved. I had intended to include this video -- Instant Ketosis -- along with this "report" on the MLM angle in my post -- Pruvit Review – Another Ketones Based MLM Company? My first thought from that title is a question: "There are others?" The tagline on this article reads: Will Pruvit's core products and MLM-modeled opportunity have what it takes to make it in the ketones health space? Let's prove it one way or another for you. I want to also make very clear that I am NOT encouraging anyone to get into this or any other MLM -- matters not the code words used to sell something. Indeed I warn strongly against such. If you search on MLM truth, or MLM scams, or MLM fraud, or any number of short phrases, you'll hit on ... well hits too numerous to count. Here's one I suggest: MLM-theTruth.com 5 Step Eval Furthermore, if you're still tempted by any MLM pitch, look into the people behind the MLM. Chances are you'll find they were involved in previous MLMs and often in very diverse fields. For example, Logan Stout -- who heads up the "paleo" (as in Paleo f(x) Norrises and others) MLM IDLife -- has a long list of Ponzi schemes to his credit, and his most recent before IDLife was an energy company. My reason for mentioning this is that it seems as if "exogenous ketones" has skipped even the "infomercial miracle" route and gone straight to the MLMs. This does not engender faith that the product is solid, because MLMs are not about selling product. Ketones are A fuel that can be "burned" by cells to provide the energy needed for running the works in various cells. In a starving person, ketones are virtually essential to substitute for some of the glu Continue reading >>

Inflammation, Ketones And Depression

Inflammation, Ketones And Depression

New theories on how inflammation may be a cause of depression, and how the ketogenic diet may be a novel treatment option Depression is the most commonly diagnosed neuropsychiatric disorder, (Chen, 2017) characterized by persistent feeling of sadness, loss of interest and hopelessness. Is it estimated that >16 million people in US have suffered from a depressive episode in the past year, which represents 6.7% of all American adults. The cause of depression has typically been blamed on a chemical imbalance in the brain, specifically a decrease in the monoamine neurotransmitters (serotonin, noradrenaline and dopamine). Most of the anti-depressant medications work by increasing the levels of these monoamines neurotransmitters. It is estimated that a third of depressed patients treated with these anti-depressant medications however, do not improve. (Miller, 2016) (Yamanashi, 2017) So maybe the pathophysiology of depression is not that simple. Scientific evidence now suggests that inflammation plays a role in the pathophysiology of depression. Psychosocial stress is a very common risk factor for the development of depression. Studies have shown that stress, especially early life-trauma, is associated with an increase risk for developing depression. (Miller, 2016) Stress has been shown to cause many pathological changes in the body including increased inflammation. When the body is stressed, the NLRP3 inflammasome is activated. When activated the NLRP3 inflammasome causes the release of the pro-inflammatory cytokines (interleukin 1 beta, interleukin -6 and tumor necrosis factor alpha). These pro-inflammatory cytokines, which are markers for inflammation, have been noted to be significantly higher in the brains of patients with depression and in people who have committed suici Continue reading >>

Ketogenic Diet Benefits

Ketogenic Diet Benefits

I should title this episode "A Funny Thing Happened on the Way to the Doctor's Office." I set out to get a physical and my blood work done about a week ago, and a terrific snowstorm whipped up while I was en route - coming down so fast there was nothing you could do but crawl along, and visibility was greatly diminished. Multiple people were sliding, some off the road. By the time I arrived at the office, I was extremely anxious, and remained so for the rest of the appointment. The doctor was pleased that my weight was down, and I told her I'm trying a ketogenic diet and that I'm avoiding gluten. She explained to me that she too, avoids gluten. My blood was drawn shortly before I left the office, and the roads were still horrible, but I made it home fine, after passing by many accidents. My fasting glucose came back in at 53. 53!!?? I wasn't faint, and besides that isn't any where close to where my glucose monitor reads in the morning. My hemoglobin A1C was near the top of within normal limits. I was flummoxed when I read the report. I called them and they suggested I have repeat blood work done in 3 months, after which I will meet with my doctor again. I'm wondering if the anxiety had anything to do with these weird numbers. I don't want to be THAT ketogenic. Oh well. Continue reading >>

Exogenous Ketones: What They Are, Benefits Of Use And How They Work

Exogenous Ketones: What They Are, Benefits Of Use And How They Work

Exogenous ketones have become a popular nutritional supplement since their introduction in 2014. Like with any new supplement, though, there tends to be a lot of misinformation that you have to sift your way through to find the reliable data. So, this article does the hard work for you and gets right to what the true benefits and drawbacks of exogenous ketones are. We also cover what forms of ketones to consider, how they function in the body, and their role in future research. What Are Ketones? Our bodies use ketones via our mitochondria to generate energy. They are an alternative fuel source to glucose. Ketones are simple compounds because of their small molecular structure and weight. Specifically, they are organic (carbon-based) compounds that contain a central carbon atom double-bonded to an oxygen atom and two carbon-containing substituents, denoted by “R” (see chemical structure below). In humans, there are 3 different ketones produced by the mitochondria of the liver. These are also often referred to as ketone bodies. The three ketones are: Acetone Acetoacetic Acid Beta-Hydroxybutyric Acid (also known Beta Hydroxybuyrate or BHB). Other chemical names include 3-hydroxybutyric acid or 3-hydroxybutyrate. BHB is not technically a ketone since it contains a reactive OH-group in place of where a double-bonded oxygen normally would be as you can see in the diagram below. Yet, BHB still functions like a ketone in the body and converts into energy much like acetoacetate and acetone. This happens via the acetoacetate and acetyl-CoA pathway. Note that acetone conversion to acetyl-CoA is not efficient due to the need to convert acetone to acetoacetate via decarboxylation. However, BHB still functions like a ketone in the body and can be converted to energy (via acetoace Continue reading >>

Exogenous Ketone Supplements Reduce Anxiety-related Behavior In Sprague-dawley And Wistar Albino Glaxo/rijswijk Rats

Exogenous Ketone Supplements Reduce Anxiety-related Behavior In Sprague-dawley And Wistar Albino Glaxo/rijswijk Rats

Go to: Introduction Anxiety disorders, such as generalized anxiety disorder, phobia and panic disorder, are the most prevalent type of mental disorders (Li, 2012). Anxiety can be associated with psychiatric morbidity, disability, increased healthcare burden and mortality in the general population (Teri et al., 1999). These symptoms can cause significant distress interfering with a person’s quality of life, while they commonly occur along with other mental or physical illnesses, which may mask anxiety symptoms or aggravate them. Some symptoms, like fear and worry, occur in all anxiety disorders including generalized anxiety disorders, panic disorder and social anxiety disorder (Stahl, 2003; Mula, 2013). Our knowledge relating to exact cause and pathomechanism(s) of anxiety disorders is far from complete; however, it is known that the amygdala is determinant in the experience of fear and anxiety by mediating the autonomic and endocrine responses through the output to the hypothalamus, and avoidance behavior through the output to the periaqueductal gray matter (Stahl, 2003; Engin and Treit, 2008; Li, 2012; Mula, 2013). Previous studies also show that serotonergic, glutamatergic as well as GABAergic system have a role in the regulation of anxiety (Nagy et al., 1979; Kakui et al., 2009; Li, 2012; Dias et al., 2013). Anxiety and depression are common problems affecting people with epilepsy and Alzheimer’s disease (AD), and can exacerbate symptoms of Glucose transporter type-1 deficiency syndrome (GLUT1 DS). Comorbidity between anxiety, depression and AD has been recognized (Teri et al., 1999; Hamid et al., 2011; Mula, 2013), and anxiety plays a key role in suicidality among patients with depression (Placidi et al., 2000). Interestingly, the same brain regions involved in Continue reading >>

Pruvit - Pure Exogenous Ketones (ketosis I...

Pruvit - Pure Exogenous Ketones (ketosis I...

About Us I began living the Ketogenic Lifestyle in March of 2017. I was overweight and suffered from depression, anxiety, low self esteem, reflux, daily heart burn, low energy levels and plantar fasciitis. Since my journey began I have learned so much about myself and I have learned to love my self again. WEIGHT - work in progress ENERGY - off the chart SLEEP - like a log MOOD - HAPPY PLANTAR FASCIITIS- gone BRAIN FOG - cleared DEPRESSION - symptoms getting better ANXIETY - what anxiety?! Continue reading >>

Conditions Shown To Benefit From A Ketogenic Diet

Conditions Shown To Benefit From A Ketogenic Diet

Obesity and heart disease, Alzheimer’s and cancer have something significant in common — they’re all rooted in insulin and leptin resistance By eating a high-quality fat, low-carbohydrate diet, you achieve nutritional ketosis; a metabolic state in which your body burns fat rather than glucose as its primary fuel. Maintaining nutritional ketosis may have health benefits in diseases such as obesity, diabetes, cancer, epilepsy, Alzheimer’s, Parkinson’s, ALS, MS, autism, migraines, traumatic brain injuries, polycystic ovary syndrome and much more By Dr. Mercola Obesity and top killers such as diabetes, heart disease, Alzheimer's and cancer have something significant in common — they're all rooted in insulin and leptin resistance. In other words, the underlying problem is metabolic dysfunction that develops as a result of consuming too many net carbohydrates (total carbs minus fiber) and/or protein. Sugars found in processed foods and grains are the primary culprits, and the standard American diet is chockfull of both. Once you develop insulin and leptin resistance, it triggers biochemical cascades that not only make your body hold on to fat, but produce inflammation and cellular damage as well. Hence, whether you're struggling with weight and/or chronic health issues, the treatment protocols are the same. This is good news, as it significantly simplifies your approach to improving your health. You won't need a different set of strategies to address each condition. In short, by optimizing your metabolic and mitochondrial function, you set yourself squarely on the path to better health. So how do you correct these metabolic imbalances? Your diet is key. The timing of your meals can also play an important role. Nutritional Ketosis May Be Key for Optimal Health By e Continue reading >>

Depression: Why Not Start With A Nutritional Solution?

Depression: Why Not Start With A Nutritional Solution?

If you experience depression, you will typically be prescribed an antidepressant, an SSRI or other agent. If you consult a psychologist or counselor, the underlying psychological underpinnings (if any) are explored, strategies devised to cope. But there will almost never be talk about your diet, nutritional deficiencies that amplify dark moods, the life habits that allow demons to emerge. Yet there are some very powerful strategies available that have potential to substantially lift mood. Such solutions won’t, of course, erase the effects of childhood trauma or grieving from personal loss, but they can help smooth the emotional impact of such life events, elevate the hormones of mood, and make life easier easily and naturally. Among the most powerful nutritional and natural mood lifters: Wheat and grain elimination–By removing such foods, you are removing mind active drugs that derive from the gliadin protein of wheat and related proteins of other grains. These opiates exert a variety of effects, depending on individual susceptibility, ranging from paranoia in people with schizophrenia, to mania in people with bipolar disorder, to impulsivity in children with ADHD, to depression in people prone to depression. The solution: remove the source of gliadin derived opiates, wheat and grains. Vitamin D restoration–Even before I implemented wheat and grain elimination in patients in my cardiology practice, I added vitamin D at doses sufficient to achieve 25-hydroxy vitamin D blood levels of 60-70 ng/ml (typically 4000 too 8000 units per day in oil-based gelcap form). I witnessed marked improvements in mood, particularly that associated with shortening daylight cycles in fall and winter, though the mood benefits are not confined to this seasonal effect. Fish oil–for its Continue reading >>

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