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Exogenous Ketones And Depression

Depression: Why Not Start With A Nutritional Solution?

Depression: Why Not Start With A Nutritional Solution?

If you experience depression, you will typically be prescribed an antidepressant, an SSRI or other agent. If you consult a psychologist or counselor, the underlying psychological underpinnings (if any) are explored, strategies devised to cope. But there will almost never be talk about your diet, nutritional deficiencies that amplify dark moods, the life habits that allow demons to emerge. Yet there are some very powerful strategies available that have potential to substantially lift mood. Such solutions won’t, of course, erase the effects of childhood trauma or grieving from personal loss, but they can help smooth the emotional impact of such life events, elevate the hormones of mood, and make life easier easily and naturally. Among the most powerful nutritional and natural mood lifters: Wheat and grain elimination–By removing such foods, you are removing mind active drugs that derive from the gliadin protein of wheat and related proteins of other grains. These opiates exert a variety of effects, depending on individual susceptibility, ranging from paranoia in people with schizophrenia, to mania in people with bipolar disorder, to impulsivity in children with ADHD, to depression in people prone to depression. The solution: remove the source of gliadin derived opiates, wheat and grains. Vitamin D restoration–Even before I implemented wheat and grain elimination in patients in my cardiology practice, I added vitamin D at doses sufficient to achieve 25-hydroxy vitamin D blood levels of 60-70 ng/ml (typically 4000 too 8000 units per day in oil-based gelcap form). I witnessed marked improvements in mood, particularly that associated with shortening daylight cycles in fall and winter, though the mood benefits are not confined to this seasonal effect. Fish oil–for its Continue reading >>

Ketogenic Diet: 25 Proven Benefits And How To Know If It’s Right For You

Ketogenic Diet: 25 Proven Benefits And How To Know If It’s Right For You

The ketogenic diet has been touted for its many health benefits such as weight loss, cognitive function, neurodegenerative diseases, and cancer. In this post, we cover: Different ways to get into ketosis Physiology and pathways that are changed when you are in ketosis, which explains how the ketogenic diet derives its benefits Genetic factors that may affect the safety and effectiveness of ketosis 17 Health conditions that may be helped by the ketogenic diet Negative effects of ketosis and how to mitigate them Ketogenic Diets Improve Cognitive Function and Brain Health Ketogenic Diet as a Cancer Treatment Ketogenic diets are defined by a low carbohydrate (typically under 50 grams/day) and high fat intake, leading to an elevation of free fatty acids and ketone bodies in the blood (R). The first ketogenic diets in the medical literature are noted in publications in the 1920s, although wider popularity and increased research was not seen in medical literature until the 1960s (R). Variations of the diets have remained popular for the past 20-30 years, with proponents claiming that the diets boost weight loss and energy while offering protection from certain metabolic diseases (R). A ketogenic diet and fasting affect the body similarly. Both deplete the body’s glucose reserves, so the body starts turning fatty acids into ketones (R). When the body doesn’t have enough carbohydrates from food, it burns fat by producing ketones or ketone bodies (R, R). In non-diabetics, ketosis can be achieved in 3 ways, i.e. Fasting or severe caloric restriction (R) Prolonged physical exercise in fasted state, depending on intensity and duration (R, R2) Nutritional ketosis, i.e. by consuming a very low carbohydrate diet Supplementation, such as by supplementing with medium chain triglyceri Continue reading >>

The Keto Diet Podcast Ep. #041: Responsible Exogenous Ketone Usage

The Keto Diet Podcast Ep. #041: Responsible Exogenous Ketone Usage

Interview with Dr. Gustin, a board certified sports physician and functional medicine practitioner, chatting about exogenous ketones – what they are, how they work, when and how to use exogenous ketones, ingredients in exogenous ketones, problems with the exogenous ketone market, and so much more. I’ll be the first to admit that I never, ever, thought in a million years that I’d be supplementing with exogenous ketones, let alone sharing them with you. But meeting many of you on the book tour, and speaking to individuals that have supplemented with ketones to compliment their ketogenic diet and help make the transition easier, I owed it to our crew to do some additional research, and here we are. Today, I interviewed the down-to-earth owner of Perfect Keto, asking him about all things exogenous ketones. From what they are, signs that you need them, signs that you don’t, the difference in products, ingredients used in exogenous ketones, whether they’re FODMAP or not, diet culture surrounding the product, accessibility issues, how exogenous ketones are digested, whether they lead to limited fat burn, and more. No stone left unturned. For podcast transcript, scroll down. SHOW NOTES + LINKS Subscribe on iTunes or your favorite podcast app Check out more from Dr. Gustin here and here TIMESTAMPS Problems with exogenous ketone supplementation (24:20) Ketone esters vs. salts (36:46) Exogenous ketone misconceptions (48:10) PARTNERS OF THE KETO DIET PODCAST The podcast is partnered with Wolfe Clinic Royal Flora, my choice in soil-based probiotics. Get 20% off your soil-based probiotics with the coupon code GUT at checkout. Thrive Market 35% savings – get an instant 35% off your favorite premium organic products. All you have to do is enter your email address, and the d Continue reading >>

My Experience With Exogenous Ketones & Red Wine

My Experience With Exogenous Ketones & Red Wine

Yesterday was the 8th day of my journey into ketosis. I started on Monday 11th July and was intending to go for a couple of weeks. See my first post here. My first 2 days were the most ‘painful’ in terms of hunger pangs and headaches. I also struggled to sleep well when I finished eating before 9pm and went to bed on an empty stomach. I was in Ketosis on Wednesday and proved this by using ketone strips. These are strips that detect ketones in your urine. I was going ‘darker’ on Thursday and Friday and at a fitness convention in LA called IDEA Fit, I came across exogenous ketones. Find my Facebook live video here which I filmed there. You might have to like the page to see the videos. These are a ketones that you take in externally that put you into, what I think can be called, a ‘false’ state of ketosis, within 30 minutes. This means your liver is actually producing ketones without being starved of carbohydrates for several days. This seems like a very cool bio-hack as it apparently puts you into fat burning mode. I’ve come across these before but I haven’t tested them. The main point about them, is that they help you to get through the “keto flu” – this is when you experience headaches, hunger pangs, dizziness and inability to think properly. Your body literally has to transition energy source from glucose to ketones and it’s a little uncomfortable to say the least. I had heard that you can take these exogenous ketones whilst still eating carbohydrates so I posed this question to this ketone expert at the conference. He confirmed that you can still produce ketones whilst eating carbohydrates using these exogenous ketones. I then asked about alcohol as I said I’d like to have a glass of wine or two that night (it was Friday after all). He said Continue reading >>

Avoid This Ketogenic Rip-off

Avoid This Ketogenic Rip-off

The Truth About Exogenous Ketones Ketones are all the rage among low carbers. And like most things in nutrition and performance, we've found a way to get them in supplement form so we don't have to do any actual work. What are ketones? They're a byproduct of ketosis caused by the process of converting fat to fuel. Your body makes them when it's in a calorie or carb restricted state. What do they do? The body and brain can use them as fuel without the presence of glucose in the blood. And now, you can take ketone supplements (salts and esters), known as exogenous ketones, without actually restricting anything. According to those promoting this nasty-tasting supplement, that means you can have a brain and body fuelled by ketones, along with all of the supposed health benefits that come with running on fat. Well, don't fall for it. Exogenous Ketones = Endogenous Fat Storage? The problem with ketone supplementation (EXOgenous) is that it's not even close to the same thing as being in ketosis (ENDOgenous ketone production). And just like the butter-blended-into-coffee trend, it's a farce. Ketones may be depressing dieters' hunger and giving them a hit of energy and cognitive enhancement, but it's INHIBITING their ability to burn fat, providing zero nourishment, and doing nothing for their metabolic health. There's an assortment of evidence suggesting that it's probably making things worse. Think of exogenous ketones kind of like alcohol. When they're consumed, everything is stored and nothing else is burned. So any lipolysis (fat burning) that would be taking place is halted; any glucose and fatty acids in your blood that were circulating are stored; and the ingested ketones are burned until there aren't any left. More importantly, this clearance of alternative fuels (glucos Continue reading >>

Inflammation, Ketones And Depression

Inflammation, Ketones And Depression

New theories on how inflammation may be a cause of depression, and how the ketogenic diet may be a novel treatment option Depression is the most commonly diagnosed neuropsychiatric disorder, (Chen, 2017) characterized by persistent feeling of sadness, loss of interest and hopelessness. Is it estimated that >16 million people in US have suffered from a depressive episode in the past year, which represents 6.7% of all American adults. The cause of depression has typically been blamed on a chemical imbalance in the brain, specifically a decrease in the monoamine neurotransmitters (serotonin, noradrenaline and dopamine). Most of the anti-depressant medications work by increasing the levels of these monoamines neurotransmitters. It is estimated that a third of depressed patients treated with these anti-depressant medications however, do not improve. (Miller, 2016) (Yamanashi, 2017) So maybe the pathophysiology of depression is not that simple. Scientific evidence now suggests that inflammation plays a role in the pathophysiology of depression. Psychosocial stress is a very common risk factor for the development of depression. Studies have shown that stress, especially early life-trauma, is associated with an increase risk for developing depression. (Miller, 2016) Stress has been shown to cause many pathological changes in the body including increased inflammation. When the body is stressed, the NLRP3 inflammasome is activated. When activated the NLRP3 inflammasome causes the release of the pro-inflammatory cytokines (interleukin 1 beta, interleukin -6 and tumor necrosis factor alpha). These pro-inflammatory cytokines, which are markers for inflammation, have been noted to be significantly higher in the brains of patients with depression and in people who have committed suici Continue reading >>

Ketones For Ketone's Sake?

Ketones For Ketone's Sake?

Minor Update: Sorry, sometimes I hit Publish instead of Close when I'm in a rush and want to make sure I have most recent version saved. I had intended to include this video -- Instant Ketosis -- along with this "report" on the MLM angle in my post -- Pruvit Review – Another Ketones Based MLM Company? My first thought from that title is a question: "There are others?" The tagline on this article reads: Will Pruvit's core products and MLM-modeled opportunity have what it takes to make it in the ketones health space? Let's prove it one way or another for you. I want to also make very clear that I am NOT encouraging anyone to get into this or any other MLM -- matters not the code words used to sell something. Indeed I warn strongly against such. If you search on MLM truth, or MLM scams, or MLM fraud, or any number of short phrases, you'll hit on ... well hits too numerous to count. Here's one I suggest: MLM-theTruth.com 5 Step Eval Furthermore, if you're still tempted by any MLM pitch, look into the people behind the MLM. Chances are you'll find they were involved in previous MLMs and often in very diverse fields. For example, Logan Stout -- who heads up the "paleo" (as in Paleo f(x) Norrises and others) MLM IDLife -- has a long list of Ponzi schemes to his credit, and his most recent before IDLife was an energy company. My reason for mentioning this is that it seems as if "exogenous ketones" has skipped even the "infomercial miracle" route and gone straight to the MLMs. This does not engender faith that the product is solid, because MLMs are not about selling product. Ketones are A fuel that can be "burned" by cells to provide the energy needed for running the works in various cells. In a starving person, ketones are virtually essential to substitute for some of the glu Continue reading >>

The Current Status Of The Ketogenic Diet In Psychiatry

The Current Status Of The Ketogenic Diet In Psychiatry

Go to: Abstract Background The ketogenic diet (KD) has been used in treatment-resistant epilepsy since the 1920s. It has been researched in a variety of neurological conditions in both animal models and human trials. The aim of this review is to clarify the potential role of KD in psychiatry. Results The search yielded 15 studies that related the use of KD in mental disorders including anxiety, depression, bipolar disorder, schizophrenia, autism spectrum disorder (ASD), and attention deficit hyperactivity disorder (ADHD). These studies comprised nine animal models, four case studies, and two open-label studies in humans. In anxiety, exogenous ketone supplementation reduced anxiety-related behaviors in a rat model. In depression, KD significantly reduced depression-like behaviors in rat and mice models in two controlled studies. In bipolar disorder, one case study reported a reduction in symptomatology, while a second case study reported no improvement. In schizophrenia, an open-label study in female patients (n = 10) reported reduced symptoms after 2 weeks of KD, a single case study reported no improvement. In a brief report, 3 weeks of KD in a mouse model normalized pathological behaviors. In ASD, an open-label study in children (n = 30) reported no significant improvement; one case study reported a pronounced and sustained response to KD. In ASD, in four controlled animal studies, KD significantly reduced ASD-related behaviors in mice and rats. In ADHD, in one controlled trial of KD in dogs with comorbid epilepsy, both conditions significantly improved. Conclusion Despite its long history in neurology, the role of KD in mental disorders is unclear. Half of the published studies are based on animal models of mental disorders with limited generalizability to the analog Continue reading >>

Exogenous Ketone Supplements Reduce Anxiety-related Behavior In Sprague-dawley And Wistar Albino Glaxo/rijswijk Rats

Exogenous Ketone Supplements Reduce Anxiety-related Behavior In Sprague-dawley And Wistar Albino Glaxo/rijswijk Rats

Go to: Introduction Anxiety disorders, such as generalized anxiety disorder, phobia and panic disorder, are the most prevalent type of mental disorders (Li, 2012). Anxiety can be associated with psychiatric morbidity, disability, increased healthcare burden and mortality in the general population (Teri et al., 1999). These symptoms can cause significant distress interfering with a person’s quality of life, while they commonly occur along with other mental or physical illnesses, which may mask anxiety symptoms or aggravate them. Some symptoms, like fear and worry, occur in all anxiety disorders including generalized anxiety disorders, panic disorder and social anxiety disorder (Stahl, 2003; Mula, 2013). Our knowledge relating to exact cause and pathomechanism(s) of anxiety disorders is far from complete; however, it is known that the amygdala is determinant in the experience of fear and anxiety by mediating the autonomic and endocrine responses through the output to the hypothalamus, and avoidance behavior through the output to the periaqueductal gray matter (Stahl, 2003; Engin and Treit, 2008; Li, 2012; Mula, 2013). Previous studies also show that serotonergic, glutamatergic as well as GABAergic system have a role in the regulation of anxiety (Nagy et al., 1979; Kakui et al., 2009; Li, 2012; Dias et al., 2013). Anxiety and depression are common problems affecting people with epilepsy and Alzheimer’s disease (AD), and can exacerbate symptoms of Glucose transporter type-1 deficiency syndrome (GLUT1 DS). Comorbidity between anxiety, depression and AD has been recognized (Teri et al., 1999; Hamid et al., 2011; Mula, 2013), and anxiety plays a key role in suicidality among patients with depression (Placidi et al., 2000). Interestingly, the same brain regions involved in Continue reading >>

Treating Concussions With Ketones

Treating Concussions With Ketones

What is a Concussion? Head injury, whether it is from a concussion or a severe traumatic brain injury, can have long term and serious consequences. Concussions are typically described as mild traumatic brain injury. Concussions are most commonly occur from sports related injuries, such as from being tackled in football, to hitting a soccer ball off of head, or falling off a bicycle. In the US, there is estimated between 1.6 to 3.8 million sports related concussions that occur every year. The rates for concussion are highest in pediatric and adolescent age ranges. Even though concussions often do not cause structural damage to the brain, they still can causes significant symptoms. Headaches are the most common symptom seen with a concussion, but other post concussion symptoms include problems sleeping, impaired memory, dizziness, balance problems, attention problems and depression. These symptoms can last from weeks to months and in some cases even longer. (Giza, 2014) Concussions have come to the forefront of pubic awareness with the recently discovered disease, chronic traumatic encephalopathy, which was the topic of the movie ‘Concussion’. Chronic traumatic encephalopathy (CTE) is the neurodegenerative changes that occur in the brains of individuals who have sustain multiple concussions earlier in their lives. CTE results in long-term neurological symptoms including behavioral, cognitive and motor symptoms. The behavioral symptoms include depression, mood swings, aggression and possibly suicide. The cognitive deficits can range from memory problems to dementia. The motor symptoms vary from parkinsonian tremors to ataxia and even possibly a motor neuron disease. (Jordan, 2014) What is the treatment of concussion? Currently, there is no medical treatment for concuss Continue reading >>

Exogenous Ketones: What They Are, Benefits Of Use And How They Work

Exogenous Ketones: What They Are, Benefits Of Use And How They Work

Exogenous ketones have become a popular nutritional supplement since their introduction in 2014. Like with any new supplement, though, there tends to be a lot of misinformation that you have to sift your way through to find the reliable data. So, this article does the hard work for you and gets right to what the true benefits and drawbacks of exogenous ketones are. We also cover what forms of ketones to consider, how they function in the body, and their role in future research. What Are Ketones? Our bodies use ketones via our mitochondria to generate energy. They are an alternative fuel source to glucose. Ketones are simple compounds because of their small molecular structure and weight. Specifically, they are organic (carbon-based) compounds that contain a central carbon atom double-bonded to an oxygen atom and two carbon-containing substituents, denoted by “R” (see chemical structure below). In humans, there are 3 different ketones produced by the mitochondria of the liver. These are also often referred to as ketone bodies. The three ketones are: Acetone Acetoacetic Acid Beta-Hydroxybutyric Acid (also known Beta Hydroxybuyrate or BHB). Other chemical names include 3-hydroxybutyric acid or 3-hydroxybutyrate. BHB is not technically a ketone since it contains a reactive OH-group in place of where a double-bonded oxygen normally would be as you can see in the diagram below. Yet, BHB still functions like a ketone in the body and converts into energy much like acetoacetate and acetone. This happens via the acetoacetate and acetyl-CoA pathway. Note that acetone conversion to acetyl-CoA is not efficient due to the need to convert acetone to acetoacetate via decarboxylation. However, BHB still functions like a ketone in the body and can be converted to energy (via acetoace Continue reading >>

#018 Keto Prime, Depression + Carb Ups, And Keto Side Effects

#018 Keto Prime, Depression + Carb Ups, And Keto Side Effects

Solo episode, chatting about exogenous ketones, what to do when you experience depression after a carb-up, steps on removing birth control, how to test ketones, side effects of keto, and how long to do keto until you decide it’s not working for you. TOPICS:: ** Bulletproof Keto Prime. (05:46) ** Depression after a carb-up. (16:09) ** Side effects of going keto. (26:22) ** How to know when keto isn’t working. (38:34) NOTES:: Show notes: healthfulpursuit.com/podcast/e18. Leave a review at healthfulpursuit.com/review. Episode suggestions: [email protected] PARTNERS:: Get nourished with Vital Proteins: amzn.to/2sEKNKQ. Paleovalley instant 20% off: paleovalley.com/keto. Thrive Market Free Almond Butter (US-only): thrivemarket.com/hp. SHOW LINKS:: Start your high-fat, keto life: bit.ly/TheKetoBundle. Free 7-day keto meal plan: healthfulpursuit.com/ketomeal. Bulletproof chocolate fuel bars: bit.ly/2jtMBPl. Bulletproof keto prime: bit.ly/2j7KkJf. 30-day keto experience video: healthfulpursuit.com/jyf2W. TweetPopout Listen on iPhoneListen on Android Continue reading >>

My Experience With Exogenous Ketones: Tale And Truth

My Experience With Exogenous Ketones: Tale And Truth

97 Comments I woke up the morning of the ceremony with butterflies in my stomach. I’d done the necessary prep. I’d abstained from carbs the past week and food the past 24 hours. I’d performed four consecutive full-body circuit workouts to deplete muscle glycogen, and undergone a liver biopsy to confirm full depletion of liver glycogen. I wasn’t taking any chances. Although I had extensive experience generating endogenous ketones and subsisting on my own body fat, exogenous ketones were another matter entirely. You don’t want to mess around with a holy sacrament without doing due diligence. Holy sacrament? Yes. According to ethnographic accounts from early Arctic explorers who encountered the sacred compound, the exogenous ketone was developed by traditional peoples of the wintry north. No one’s quite sure where it arose first—Siberia, Greenland, Alaska, Lapland. What they do know is that these societies revered the type 1 diabetic, a rare find in the pre-contact Arctic. Using an admittedly grisly and cruel process, these groups would starve the tribe’s diabetic to induce ketoacidosis, harvest the ketone-rich urine, and reduce it slowly to a ketone-rich tar over a wood fire. Tribe shamans would dissolve the tar in pine needle tea and distribute it to members exclusively before hunting trips, warfare, and any other activity requiring optimal physical and mental function to boost energy and improve performance. As Mark Twain famously quipped, “The strongest coffee I ever had was a Laplander’s piss.” So when I showed up to the small building on the edge of town on a rainy evening, I was anxious. What was I in for? The solemn countenances worn by my two guides for the day—Dr. Peter Attia, wearing dark robes and swinging a thurible loaded with burning Continue reading >>

Intermittent Fasting And The Ketogenic Diet With Dr. Mike Vanderschelden

Intermittent Fasting And The Ketogenic Diet With Dr. Mike Vanderschelden

Dr. Michael VanDerschelden is a brilliant doctor out of Huntington Beach, California. He has a book out called The Scientific Approach to Intermittent Fasting available on Amazon. He also has an amazing YouTube channel and co-hosts the Owners-Guide, which is a podcast started by Dr. Bergman. Today on the podcast, Dr. Mike educates us on intermittent fasting, the Ketogenic diet and so much more. Please welcome Dr. Mike VanDe. Listen To The Episode Here: Intermittent Fasting and the Ketogenic Diet with Dr. Mike VanDerschelden Dr. Mike, where are you from? I am from Seattle, Washington originally. I just say Seattle because really, it is 45 minutes south of Seattle in a place called Lake Tapps, which no one’s heard of. I keep it simple and say the Seattle name that everyone’s heard about. I hear it’s absolutely beautiful up there. I would say beautiful in the summer. That’s a keyword there. Hence, I’m in Southern California now because you hear about the gloom going on up there and it’s real. The seasonal depression is definitely real up there. It’s real. They have the cleanest air, the most greenery, green trees everywhere, beautiful mountains with great nature stuff. The snowboarding and stuff in the winter kept me afloat there but the sunshine is very important to me so I’m here. Mike, what made you want to move to beautiful Huntington Beach and start chiropractic school? Funny story, I actually think you know Andrew, my brother’s roommate. Me and him had a pact that when I was in undergrad, I basically got a pre-dental degree. That’s right because your dad is a dentist, right? My dad is a dentist. He owns three to four practices so I pretty much had the whole entire gates open for me that come in there, take over the practices. If I was just looking Continue reading >>

How To Increase Athletic Performance With Exogenous Ketones

How To Increase Athletic Performance With Exogenous Ketones

Traditional sports nutrition wisdom tells endurance athletes that loading up on carbohydrates prior to long-distance training/events is ideal for optimal performance. However, as sports nutrition research grows, we are learning that there may be more efficacious ways to fuel your endurance training goals. Enter exogenous ketones (Ketone Supplements). The unique nutritional benefits of exogenous ketones, particularly beta-hydroxybutyrate (BHB) salts, are extensive, ranging from nootropic (brain enhancing) properties, enhanced glucose utilisation, physical performance improvements, and reduced inflammation. For endurance athletes, exogenous ketones present a superior nutritional supplement adjunct to pre-training carbohydrate ingestion. If you’re not familiar with what exactly exogenous ketones are and how they work, be sure to check out our FREE Exogenous Ketone eBook that teaches you everything you’ll need to know before moving forward. Why Endurance Athletes Should Use Exogenous Ketones Before we jump into the data behind exogenous ketones and endurance training, let’s get a better grasp of what exactly exogenous ketones do in the human body. In short, ketones are an alternative energy source for your body, specifically mitochondria - the ‘engine’ of cells. While endurance athletes typically think of carb-based sports beverages as the ideal energy source for aerobic exercise, recent studies suggest that exogenous ketones, like BHB salts, bolster the benefits of carbohydrates. In other words, combining ketones with carbohydrates results in better performance and recovery than carbohydrates alone. In fact, adding Essential Amino Acids (EAA’s) like that found in AMINO SWITCH™ may prove to be even more effective as previous studies support the combination of Continue reading >>

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