diabetestalk.net

Euglycemic Ketoacidosis Causes

Share on facebook

Susan Cornell, PharmD, CDE, FAPhA, FAADE, describes the risks for ketoacidosis and serious urinary tract infection associated with use of SGLT2 inhibitors. This video was recorded at APhA's 2016 Annual Meeting and Exposition in Baltimore, Maryland.

Euglycemic Diabetic Ketoacidosis Sometimes Seen With Sglt2 Inhibitors

Euglycemic Diabetic Ketoacidosis Sometimes Seen with SGLT2 Inhibitors Diabetic ketoacidosis (DKA) in patients with presenting serum blood glucose <200 mg/dL isnt common. More often, its seen in patients with type 1 diabetes in conjunction with starvation and acute illness.1 Its difficult to determine an incidence of euglycemic DKA (euDKA) among all DKA cases in the literature, given the migration of the serum glucose cutoff from 300 mg/dL to 200 mg/dL. The best estimation based on an analysis of case reports suggests an incidence anywhere between 0.8% and 7.5%.1 However, the sodium-glucose cotransporter-2 (SGLT2) inhibitors canagliflozin, dapagliflozin, and empagliflozin can apparently induce this once-rare form of DKA.2,3 SGLT2 inhibitors are a class of oral hypoglycemic drugs indicated only for type 2 diabetes. Their novel mechanism of action prevents glucose reabsorption from the proximal renal tubules, resulting in increased glucosuria and decreasing plasma glucose. SGLT2 inhibitors lower serum glucose and HBA1C levels, and even produce weight loss. However, the increased glucose concentration in the bladder is a terrific incubation environment for fungi and bacteria, so much Continue reading >>

Share on facebook

Popular Questions

  1. Raviv

    I'd take it with a grain of salt.
    Yes, exercising too much can raise your cortisol and cause your body to cling to its fat stores for dear life.
    But I'm not sure I'd say 10,000 steps a day would be considered excessive. It's really close to what someone who is is naturally active would do.
    So they have the right theory - "chronic cardio" stalls weight loss - but I don't think it applies in this situation.
    *******
    FitBit One
    "You should really wear a helmet."
    5K 9/2015 - 36:59.57
    *******

  2. HeatherRayne

    Thank you for your reply!
    That sparks another question for me. I have to walk on the treadmill at least 90 mins at 3-3.5mph (this is just where my endurance is at this point...was MUCH lower only a couple of months ago) in order to get to 10k...this includes daily activities around the house/grocery store, etc. I know I get frustrated because I am not where I was before surgery or where most people I know are...but this seems like A LOT of walking for a mere 10k. It seems in the past week or so it has gotten to where I have to work harder for the same amount of steps. I don't get it. Nothing has changed.

  3. HeatherRayne

    As an example - yesterday I went grocery shopping and to physical therapy. Also did several loads of laundry (up and down a flight of stairs). This was on top of 105 mins on the treadmill. I only logged 10,380 steps. Very frustrating.

  4. -> Continue reading
read more
Share on facebook

What is DIABETIC KETOACIDOSIS? What does DIABETIC KETOACIDOSIS mean? DIABETIC KETOACIDOSIS meaning - DIABETIC KETOACIDOSIS definition - DIABETIC KETOACIDOSIS explanation. Source: Wikipedia.org article, adapted under https://creativecommons.org/licenses/... license. SUBSCRIBE to our Google Earth flights channel - https://www.youtube.com/channel/UC6Uu... Diabetic ketoacidosis (DKA) is a potentially life-threatening complication of diabetes mellitus. Signs and symptoms may include vomiting, abdominal pain, deep gasping breathing, increased urination, weakness, confusion, and occasionally loss of consciousness. A person's breath may develop a specific smell. Onset of symptoms is usually rapid. In some cases people may not realize they previously had diabetes. DKA happens most often in those with type 1 diabetes, but can also occur in those with other types of diabetes under certain circumstances. Triggers may include infection, not taking insulin correctly, stroke, and certain medications such as steroids. DKA results from a shortage of insulin; in response the body switches to burning fatty acids which produces acidic ketone bodies. DKA is typically diagnosed when testing finds high b

Euglycemic Ketoacidosis

The purpose of this ariticle is to highlight the importance of not relying exclusively on blood glucose measurements when assessing sick type I diabetics. Urinary ketones and venous bicarbonate are essential in making the diagnosis of relatively low blood glucose plus ketoacidosis, that we call euglycaemic ketoacidosis. Pak J Med Sci January - March 2008 Vol. 24 No. 1 161-162 1. Dr. Muhammad Shahzad Rauf, MBBS, MRCP, Core Medical Training Aberdeen Royal Infirmary, * Received for Publication: October 31, 2007 The condition is defined as diabetic ketoacidosis with a bicarbonate level of less than 10mEq/L and a glucose level of less than 16.7mmol/l or 300mg% along with ketonemia or ketonuria, Euglycemic ketoacidosis occurred in 30% of patients admitted to the hospital on account of diabetic ketoacidosis. 1 True euglycaemic ketoacidosis (initial blood glucose 10mmol/l (180mg%) or less) is rare, occurring in 0.81.1% of all episodes depending on the defining plasma bicarbonate concentration.2 Clinically Euglycaemic ketoacidosis is usually manifested by vomiting. In addition some patient can present with, abdominal pain dysuria, productive cough, thirst, nausea. The cause of preserved "e Continue reading >>

Share on facebook

Popular Questions

  1. aliensarecool

    i saw this guy on reddit say this about testosterone/hair loss....is it true?

    "To deal with "male pattern baldness", you should know that most of it simply comes from not having enough sex. If you do not have enough sex, too much testosterone floats around in your bloodstream. And too much testosterone kills your hair follicles, in later life. Men mostly, but even women will suffer some hair loss if their bodies needs are not properly taken care of. If you do not have sex at least every other day, your hair will fall out. The common stereotype of the "old bald friar" is a very true one, they are bald because they are celibate. That will not work, if you want to keep your hair.
    Too much testosterone floating around in your bloodstream kills your hair follicles after about the age of forty. (Mostly after forty, but some men produce so much testosterone that they begin losing hair at the age of twenty or thirty, however the remedy is still exactly the same.) Excess testosterone is dissipated simply by having sex. That is the only way. Why does the football coach always tell the team to abstain from sex before the big game? Because that will lower their testosterone levels.
    However, that is just what is needed as you get older, to save your hair."

  2. LeoDaVinci

    No, it's not true. Modern medicine has not found a cure for baldness yet, and they've looked under most rocks.

  3. TheFallOfRome

    broscience is strong in here
    How come every teenager going through puberty doesn't lose their hair lol.

  4. -> Continue reading
read more
Share on facebook

Euglycemic Ketoacidosis Caused By Sodiumglucose Cotransporter 2 Inhibitors: A Case Report

Euglycemic Ketoacidosis Caused by SodiumGlucose Cotransporter 2 Inhibitors: A Case Report Shane A. Bobart, MD; Benjamin Gleason, MD; Nydia Martinez, MD; Keith Norris, MD, PhD; Sandra F. Williams, MD From Cleveland Clinic Florida, Weston, Florida, and University of California, Los Angeles, Los Angeles, California. From Cleveland Clinic Florida, Weston, Florida, and University of California, Los Angeles, Los Angeles, California. From Cleveland Clinic Florida, Weston, Florida, and University of California, Los Angeles, Los Angeles, California. From Cleveland Clinic Florida, Weston, Florida, and University of California, Los Angeles, Los Angeles, California. Author, Article, and Disclosure Information From Cleveland Clinic Florida, Weston, Florida, and University of California, Los Angeles, Los Angeles, California. Presented in part at the American College of Physicians' 2015 Florida Annual Chapter Scientific Meeting, Tampa, Florida, 1113 September 2015. Acknowledgment: The authors thank Jonathan Schroeder, MD. Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L15-0535 . Background: Sod Continue reading >>

Share on facebook

Popular Questions

  1. NooNoo1970

    Just a quick word about ketostix.
    I had run out last week any way went off to our local new chemist at our asda store asked for stix the woman brought them out and when I asked how much she said £8.60!!!!!!!!! I nearly fell over!
    Any way explained to her that was really expensive and I usually only pay about £5-6. Decided to leave it and go to the other chemist in town where I have bought them from before. Went there today and bought a pack for £5.18 thats more like it!! (both were for a pack of 50)
    The woman in asda said if I did get them for £5 ish to go back and let her know...so when I go in tomorrow I will take my receipt in and the box just to let her know how much they are over charging by. I know they can vary by a pound or so...but that was just extortionate!!!
    Anyone else experienced this variation in price??
    Lou X

  2. beentheredonethat

    I paid 14euro for a pack of 50 in Ireland. I nearly fell over too. But I couldn't get them anywhere else. I think if I imported them from the UK, paid postage, etc. It still wouldn't cost 14 flippin euro.

  3. DQ

    Wow, that is MEGA expensive!!

  4. -> Continue reading
read more

No more pages to load

Related Articles

  • Euglycemic Diabetic Ketoacidosis Symptoms

    SESSION TITLE: Critical Care Student/Resident Case Report Posters I SESSION TYPE: Student/Resident Case Report Poster INTRODUCTION: A 47 year-old woman with type 1 diabetes presented with euglycemic diabetic ketoacidosis (DKA) that initially went undiagnosed. Recognition and treatment with insulin resulted in rapid resolution of her clinical condition. CASE PRESENTATION: A 47 year-old woman presented to our hospital with four days of fever, abdom ...

    ketosis Apr 29, 2018
  • What Is Euglycemic Diabetic Ketoacidosis?

    Diabetic ketoacidosis (DKA) is an acute complication of diabetes mellitus. It is characterized by the triad of hyperglycemia, ketosis, and metabolic acidosis.1 DKA complicates mainly patients with Type 1 diabetes mellitus, where it may be the first manifestation of the disease, and rarely people with Type 2 diabetes.1 A special heterogeneous syndrome of "ketosis – prone diabetes (KPD)," in usually adult patients who may lack the typical clinica ...

    diabetes Jan 4, 2018
  • Euglycemic Ketoacidosis Mechanism

    Euglycemic diabetic ketoacidosis: a diagnostic and therapeutic dilemma 1Department of Internal Medicine, Memorial Hospital of Martinsville and Henry County, Martinsville, Virginia, USA, 2Texas Tech University Health Sciences Center, El Paso, Texas, USA, 3Senior Research Associate, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA, 4Department of Pharmacology, St Johns Medical College, Bangalore, India, Rece ...

    ketosis Apr 27, 2018
  • Euglycemic Ketoacidosis Definition

    Tweet Diabetic ketoacidosis (DKA) is a dangerous complication faced by people with diabetes which happens when the body starts running out of insulin. DKA is most commonly associated with type 1 diabetes, however, people with type 2 diabetes that produce very little of their own insulin may also be affected. Ketoacidosis is a serious short term complication which can result in coma or even death if it is not treated quickly. Read about Diabetes a ...

    ketosis Apr 25, 2018
  • Euglycemic Diabetic Ketoacidosis Treatment

    Background: Diabetic ketoacidosis (DKA) is traditionally defined as a triad of hyperglycemia (>250mg/dL), anion gap acidosis, and increased plasma ketones. There is another entity that providers must be aware of known as euglycemic DKA (euDKA), which is essentially DKA without the hyperglycemia (Serum glucose <200 mg/dL). Euglycemic DKA is a rare entity that mostly occurs in patients with type 1 diabetes, but can possibly occur in type 2 diabetes ...

    ketosis Apr 7, 2018
  • Euglycemic Ketoacidosis Causes

    Diabetic ketoacidosis (DKA) is a potentially life-threatening complication of diabetes mellitus.[1] Signs and symptoms may include vomiting, abdominal pain, deep gasping breathing, increased urination, weakness, confusion, and occasionally loss of consciousness.[1] A person's breath may develop a specific smell.[1] Onset of symptoms is usually rapid.[1] In some cases people may not realize they previously had diabetes.[1] DKA happens most often i ...

    ketosis May 29, 2018

Popular Articles

More in ketosis