Euglycemic Dka Medscape

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Dr. Christopher Cannon discusses using JARDIANCE to Reduce Cardiovascular Death Risks in Adults with Type 2 Diabetes Guest Bio: Dr. Christopher Paul Cannon is a cardiovascular medicine specialist at Brigham and Womens Hospital (BWH) and a professor of medicine at Harvard Medical School (HMS). Dr. Cannon is the executive director of cardiometabolic trials at the Harvard Clinical Research Institute. Dr. Cannon earned his medical degree from Columbia University College of Physicians and Surgeons. He completed an internal medicine residency at New York-Presbyterian Hospital and a cardiology fellowship at BWH. Dr. Cannon is board certified in internal medicine. Segment overview: Dr. Christopher Cannon, discusses JARDIANCE, a treatment that can help reduce the risk of cardiovascular death in adults with type 2 diabetes and known cardiovascular disease. For more information about this interview, visit this link: http://healthprofessionalradio.com.au...

Type 1 And New Drug Jardiance

Furthermore, to add to my earlier comment about DKA, the term euglycemic DKA is the proper one. It is where (usually) type 1s exhibit all the symptoms of traditional DKA but without the uncontrolled BGs. This link details the patients who exhibited this that lead to the Invokana warnings: In everything Ive read, euglycemic DKA is far more prevalent in type 1s than type 2s. Reason being type 2s generally are producing enough insulin to keep keptones at bay, even when within normal diet-induced ketosis. Type 1s, of course, dont have that luxury. Heres another case study of euglycemic DKA: The bottom line is, ESPECIALLY for type 1s on this type of med, to closely monitor ketones. My rule of thumb to balance the risk with the rewards of Jardiance AND incorporating the lowest possible carb diet. is NEVER get above moderate ketones. Thats the danger zone. When I hit moderate, I immediately eat a fairly carby meal with my normal bolus. Ketones clear within 6-8 hours. Oh, and lots of water (which I do anyway living in Phoenix). Thanks @DanP , Ive been following all this in detail as well. The trouble we have is that the occurrence of euglycemic DKA is associated both with ketones being pr Continue reading >>

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  1. FatJessica

    > Ketosis taste in mouth?

    I caught a glimpse of a thread somewhere mentioning a taste in the mouth that some people get when they are in ketosis....anyone know what I'm talking about?

  2. MorganMac

    Yep, it's rather common. Ketone bodies (such as acetone) are excreted from the body in the breath and urine. Many people get "keto breath" for awhile when they start a LC diet :)

  3. FatJessica

    What does it smell like?

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Diabetic Ketoacidosis In A Patient With Type 1 Diabetes On Sodium-glucose Co-transporter-2 Inhibitorsa Case Report

US Endocrinology,2017;13(2):724 DOI: We describe a case of a 26-year-old female with long-standing type 1 diabetes (T1D), on multiple subcutaneous insulin injections, who had been taking empagliflozin for the past year. She was detected to have severe diabetic ketoacidosis (DKA) with relatively lower blood glucose values during hospitalisation for dengue fever. The factors that precipitated the DKA are discussed, along with the unique challenges in the management of her metabolic status. While sodium-glucose co-transporter-2 (SGLT2) inhibitors have several potential benefits as adjunctive add-on therapy to insulin in T1D, the evidence is limited to short-term studies. However, their off-label use is increasing and there have been concerns related to increased risk of diabetic ketoacidosis. At present, SGLT2 inhibitors are not approved for use in T1D, and the risks should be discussed at length with the patient. Keywords: Type 1 diabetes, diabetic ketoacidosis, euglycaemic diabetic ketoacidosis, sodium-glucose co-transporter-2 (SGLT2) inhibitors, empagliflozin Disclosure: Gagan Priya and Vishal Bhambri have nothing to declare in relation to this article. No funding was received in Continue reading >>

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  1. Mark Simpson

    (edit: it's worth pointing out that "Ketosis " on it's own is not a bad thing, but Diabetic ketoacidosis is. I assume this is the point of the question)
    Diabetic Ketoacidosis comes from High (hyper) Blood Sugar not Low (Hypo). They could happen together, if you had high blood sugar for too long, the Ketoacidosis happened then you over treated the high and it went low. In this case you'd have 2 separate problems. Hypoglaycemia and Ketoacidosis. Low blood sugar will make you pass out and go into a coma eventually. Ketoacidosis is very painful and horrible to be part of. But I wouldn't say they increase each others danger very much.
    (i am a diabetic, not a medical professional)


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  2. Dennis Kitainik

    I'm not a doctor, but from what I know of diabetic conditions, both of these can be dangerous, and especially if they occur together (especially since ketosis would probably indicate serious hypoglycemia).

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SGLT2 inhibitors show no significant risk of DKA, study reports Follow this link: http://tinyurl.com/6irc9o5ia89 SGLT2 inhibitors show no significant risk of DKA, study reports click here full resolution --- for more information go to-http://tinyurl.com/pvwe7iu879/ Adults with type 2 diabetes who take SGLT2 inhibitors are less likely to experience diabetic ketoacidosis (DKA) than those on insulin treatment, a study suggests.These findings existed for those with type 2 diabetes either prescribed SGLT2 inhibitors as a single treatment or in combination with another drug.Scientists from the Steno Diabetes Center, Copenhagen, Denmark examined 415,670 people with type 2 diabetes during 1995-2017, all of whom were treated with medication, including insulin.They sought to evaluate the rates of DKA within patients to assess if any association could be made between DKA, a dangerous short-term complication, and SGLT2 inhibitors.SGLT2 inhibitors work by helping the kidneys to lower blood glucose levels, with excess blood glucose removed through urine. for more information go to-http://tinyurl.com/82d95inail/ type 2 diabetes, SGLT2 inhibitors, dka

Sglt2 Inhibitors And Diabetic Ketoacidosis: What's All The Fuss About? - #cme, #medscape #dka #euglycemia #euglycemic #diabetic #ketoacidosis, #sgl | Pinteres

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  1. red_reader

    Neonatal ketosis -

    Neonatal ketosis -
    Suckling Ketogenesis (Williams, 1997)
    After normal blood glucose decline in first 3 hours, brisk ketogenic response in breastfed infants
    Ketone bodies provide alternative energy source for neonatal brain
    Breastfed babies tolerate lower blood glucose levels because their ketone body levels are elevated
    LGA infants of non-diabetic mothers will mount a sufficient ketogenic response to low blood sugar levels Link to PDF I realize this is not an actual study. I am looking for those specific references.
    Babies are in deep ketosis at birth and continue to be so until they are weaned off breast milk. I haven't looked to see how fast that decline out of ketosis happens after babies are weened off breast milk.
    Link to a list of scientific studies
    This leads me to believe that being in ketosis is actually the natural state, and out of ketosis is a result of excessive carbs ... ( crap your body doesn't need )

  2. bollockitis

    This leads me to believe that being in ketosis is actually the natural state, and out of ketosis is a result of excessive carbs ... ( crap your body doesn't need )
    The research is interesting, but I don't think it warrants that conclusion. Using that logic, you could say that because babies drink only breast milk, drinking breast milk is the natural state and eating anything else is unnatural.

  3. red_reader

    My conclusion is slightly different. Since breast milk is so high in fat ( causing the ketosis ) I feel that our natural diet should consist of high fat. Of note is that as soon as babies are taken off of breast milk and placed on ( man made ) formula, they fall out of ketosis.

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