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Euglycemic Diabetic Ketoacidosis Symptoms

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Euglycemic Diabetic Ketoacidosis In A 27 Year-old Female Patient With Type-1-diabetes Treated With Sodium-glucose Cotransporter-2 (sglt2) Inhibitor Canagliflozin

Received 2015 October 17; Revised 2016 January 30; Revised 2016 March 14; Revised 2016 March 17; Accepted 2016 March 25. Copyright : Pakistan Journal of Medical Sciences This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. We are reporting a timely case of atypical euglycemic diabetic ketoacidosis in a type 1 diabetic patient treated with sodium-glucose cotransporter-2 (SGLT-2) inhibitor canagliflozin. The clinical history, physical examination findings and laboratory values are described. Other causes of acidosis such as salicylate toxicity or alcohol intoxication were excluded. Ketoacidosis resolved after increasing dextrose and insulin doses supporting the hypothesis that SGLT-2 inhibitors may lead to hypoinsulinemia. Euglycemic ketoacidosis did not recur in our patient after discontinuing canagliflozin. We recommend reserving SGLT2 inhibitor therapy to type 2 diabetics, discontinuing medication and treating patients presenting with ketoacidosis due to SGLT-2 inhibitors with higher concentrations of de Continue reading >>

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  1. BACONBURGER

    I will be watching what you post on this cause I never looked into probiotics and all that.
    so will learn as you go along, thanks
    Don't TRY----DO!
    over 50 lbs lost, zeroing in on goal
    Zero Carb for Life!

    current weight: 178.5



    234

    215.5

    197

    178.5

    160

  2. WOUBBIE

    Absolutely. I've tried a number of probiotic and prebiotic supplements but none of them have been anything to write home about. So I'm going to try one of the more aggressive ones that contains SBO's (soil based organisms):
    http://www.prescript-assist.com/intestin
    al-health/soil-probiotics/
    I'm also going to try to convert myself from beer to wine. All that yeast is not good for me. Watching the quantity is going to be the trick. I can portion-control beer, lol!!
    After that, it's research, research, research. Also I'm shopping for a new doctor this year and hoping to find an integrative practitioner.
    Love thy neighbor. No exceptions.
    Equal rights for others does not mean less rights for you. It's not pie.
    "You can't get into heaven without a permission slip from the poor." Reverend Jesse Jackson

  3. BACONBURGER

    Spitfire, wow, great for you. that is a massive improvement. you rock it out girl!!!!!
    woubbie, that is super interesting. huh. when you improve yourself or how you are going to tackle this will you post and your experiences? I never put gut with emotions??
    gotcha Maw !!
    Don't TRY----DO!
    over 50 lbs lost, zeroing in on goal
    Zero Carb for Life!

    current weight: 178.5



    234

    215.5

    197

    178.5

    160

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Euglycemic Diabetic Ketoacidosis: A Potential Complication Of Treatment With Sodiumglucose Cotransporter 2 Inhibition

Euglycemic Diabetic Ketoacidosis: A Potential Complication of Treatment With SodiumGlucose Cotransporter 2 Inhibition We are experimenting with display styles that make it easier to read articles in PMC. The ePub format uses eBook readers, which have several "ease of reading" features already built in. The ePub format is best viewed in the iBooks reader. You may notice problems with the display of certain parts of an article in other eReaders. Generating an ePub file may take a long time, please be patient. Euglycemic Diabetic Ketoacidosis: A Potential Complication of Treatment With SodiumGlucose Cotransporter 2 Inhibition Anne L. Peters, Elizabeth O. Buschur, [...], and Irl B. Hirsch Sodiumglucose cotransporter 2 (SGLT-2) inhibitors are the most recently approved antihyperglycemic medications. We sought to describe their association with euglycemic diabetic ketoacidosis (euDKA) in hopes that it will enhance recognition of this potentially life-threatening complication. Cases identified incidentally are described. We identified 13 episodes of SGLT-2 inhibitorassociated euDKA or ketosis in nine individuals, seven with type 1 diabetes and two with type 2 diabetes, from various pract Continue reading >>

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  1. Nick

    I'm on a ketogenic diet and have stopped taking protein shakes (excepting post-workout protein powder with water) because I've heard that it may cause an insulin spike. Is it true that protein powder with water will knock you out of ketosis? The one I'm using in particular is Optimum Nutrition Gold Standard 100% Whey.

  2. MattyP

    Yes it can.
    Protein is made up of seven different aminos, some of which (just as j.rightly correctly pointed out) can knock you out of ketosis because they are broken down into glucose in your blood.
    j.rightly is corrct. Do some research and it will confirm that protein can knock you out of keto. Anyone who says it can't doesn't understand the science behind it.
    That is why you are meant to eat about 65% of your diet from fats, 30% protein and no more than about 5% carbs (which will be incidental from your fat & protein based meals) to be sure you stay in ketosis.

  3. JoJo

    No.
    Ketosis is the deprivation of carbs. High end protein shakes, such as your ON Gold, don't contain many carbs. Thus, drinking your protein shake won't remove you from your ketogenic state. On the other hand, cheap proteins (Muscle Milk) and any protein labeled as "mass builder" will contain carbs to prevent ketosis.
    Your comment about protein shakes spiking insulin is wrong. Insulin is secreted to process sugar. Your ON Gold with water has hardly any sugar. Thus, drinking your protein shake will not spike your insulin. Insulin spikes usually only occur when you eat simple carbs from fruit, candy, etc...

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What is DIABETIC KETOACIDOSIS? What does DIABETIC KETOACIDOSIS mean? DIABETIC KETOACIDOSIS meaning - DIABETIC KETOACIDOSIS definition - DIABETIC KETOACIDOSIS explanation. Source: Wikipedia.org article, adapted under https://creativecommons.org/licenses/... license. SUBSCRIBE to our Google Earth flights channel - https://www.youtube.com/channel/UC6Uu... Diabetic ketoacidosis (DKA) is a potentially life-threatening complication of diabetes mellitus. Signs and symptoms may include vomiting, abdominal pain, deep gasping breathing, increased urination, weakness, confusion, and occasionally loss of consciousness. A person's breath may develop a specific smell. Onset of symptoms is usually rapid. In some cases people may not realize they previously had diabetes. DKA happens most often in those with type 1 diabetes, but can also occur in those with other types of diabetes under certain circumstances. Triggers may include infection, not taking insulin correctly, stroke, and certain medications such as steroids. DKA results from a shortage of insulin; in response the body switches to burning fatty acids which produces acidic ketone bodies. DKA is typically diagnosed when testing finds high b

Euglycemic Diabetic Ketoacidosis: A Review

Euglycemic Diabetic Ketoacidosis: A Review Author(s): Anar Modi , Department of Endocrinology, Diabetes & Metabolism, Cooper University Hospital, Camden, New Jersey, United States Abhinav Agrawal* , Department of Medicine, Monmouth Medical Center, 300 Second Avenue, Long Branch, New Jersey, United States Farah Morgan . Department of Endocrinology, Diabetes & Metabolism, Cooper University Hospital, Camden, New Jersey, United States Introduction: Diabetic ketoacidosis (DKA) is one of the most serious complications of diabetes.It is characterised by the triad of hyperglycemia (blood sugar >250 mg/dl), metabolic acidosis(arterial pH <7.3 and serum bicarbonate <18 mEq/L) and ketosis. Rarely these patients can present withblood glucose (BG) levels of less than 200 mg/dl, which is defined as euglycemic DKA. The possibleetiology of euglycemic DKA includes the recent use of insulin, decreased caloric intake, heavy alcoholconsumption, chronic liver disease and glycogen storage disorders. DKA in pregnancy has also beenreported to present with euglycemia. The recent use of sodium glucose cotransporter 2 (SGLT2) inhibitorshas shed light on another possible mechanism of euglycemic DKA. Clinicia Continue reading >>

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  1. an ex

    Title.
    Let's say you follow a ketogenic diet for 2 weeks, and then perhaps over the weekend you eat A LOT of carbs! everything your heart desires! enough to knock you out of ketosis basically, then how long does it take to get back into ketosis after resuming keto diet?
    and what's happening to your body during that time?
    For those very knowledgeable regarding ketogenic diet and ketosis, please help shed some light.

  2. Cyborg_Minerva

    IME, if you were in a good strong ketosis before, it shouldn't take too long. You have to burn through the extra carbs you just ate, plus however many you eat on top of that. So if you eat none (going full keto from here on out, or fasting entirely), it may only take 12-24 hours. If you go back to your regular low carb it might take 36-48 hours. But it shouldn't take like, 3 days or anything.
    ...I mean, how many carbs are we talking, lol

  3. an ex

    Cyborg_Minerva, on 16 Sept 2017 - 1:19 PM, said:
    IME, if you were in a good strong ketosis before, it shouldn't take too long. You have to burn through the extra carbs you just ate, plus however many you eat on top of that. So if you eat none (going full keto from here on out, or fasting entirely), it may only take 12-24 hours. If you go back to your regular low carb it might take 36-48 hours. But it shouldn't take like, 3 days or anything.
    ...I mean, how many carbs are we talking, lol
    So i have to deplete my body of the carbs i ate before flowing back into ketosis; that makes sense!! the more carbs i eat the longer it takes \
    thank u very much!!

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