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Drugs That Prevent Ketosis

The Fat-fueled Brain: Unnatural Or Advantageous?

The Fat-fueled Brain: Unnatural Or Advantageous?

Disclaimer: First things first. Please note that I am in no way endorsing nutritional ketosis as a supplement to, or a replacement for medication. As you’ll see below, data exploring the potential neuroprotective effects of ketosis are still scarce, and we don’t yet know the side effects of a long-term ketogenic diet. This post talks about the SCIENCE behind ketosis, and is not meant in any way as medical advice. The ketogenic diet is a nutritionist’s nightmare. High in saturated fat and VERY low in carbohydrates, “keto” is adopted by a growing population to paradoxically promote weight loss and mental well-being. Drinking coffee with butter? Eating a block of cream cheese? Little to no fruit? To the uninitiated, keto defies all common sense, inviting skeptics to wave it off as an unnatural “bacon-and-steak” fad diet. Yet versions of the ketogenic diet have been used to successfully treat drug-resistant epilepsy in children since the 1920s – potentially even back in the biblical ages. Emerging evidence from animal models and clinical trials suggest keto may be therapeutically used in many other neurological disorders, including head ache, neurodegenerative diseases, sleep disorders, bipolar disorder, autism and brain cancer. With no apparent side effects. Sound too good to be true? I feel ya! Where are these neuroprotective effects coming from? What’s going on in the brain on a ketogenic diet? Ketosis in a nutshell In essence, a ketogenic diet mimics starvation, allowing the body to go into a metabolic state called ketosis (key-tow-sis). Normally, human bodies are sugar-driven machines: ingested carbohydrates are broken down into glucose, which is mainly transported and used as energy or stored as glycogen in liver and muscle tissue. When deprived of d Continue reading >>

Ketogenic Diet

Ketogenic Diet

The ketogenic diet is one of the oldest treatments for epilepsy, especially in children with difficult-to-control seizures. It’s a special high-fat, low carbohydrate diet recommended for children whose seizures have not responded to treatment with traditional anticonvulsant medications alone. A high level of carbohydrate intake can be correlated to the lack of seizure control and dietary modifications to reduce the intake of high carbohydrate substances is a cornerstone of the ketogenic diet. In addition to dietary changes and monitoring nutritional intake, compounded medications that conform to the ketogenic diet can be taken to increase the diet’s effectiveness in controlling seizures. They are an excellent alternative to commercially manufactured medications because they contain no sugar or sorbitol and are carb free. Contemporary pharmacy compounding is the process of preparing customized medications for individual patients. We formulate compound medications that fit the dietary and nutritional requirements of a ketogenic diet by using the raw chemical, rather than the commercially available drug. Commercially available tablet and liquid forms of medication may contain lactose and other carbs which reduce the effectiveness of the ketogenic diet in controlling seizures. We recommend liquid medications rather than crushing tablets and dissolving them in a liquid. Particles of the crushed tablet may not dissolve completely and there is a risk of clogging a feeding tube. Many commercially available liquids do not clog the feeding tube, but are not sugar or carb free. The ingredients used in specially compounded liquid medicines comply with the guidelines of the ketogenic diet. A compounding pharmacist, working closely with your child’s pediatrician can prescribe m Continue reading >>

Can Ketosis Help You Pass A Drug Test?

Can Ketosis Help You Pass A Drug Test?

Just like most potheads, I’m into my health and have tried a few different types of diets. I would say that at least half to most of the year, I’m in ketosis. It isn’t too hard to maintain and has a number of health benefits, but can you use ketosis to pass a drug test? Ketosis: Whats is Ketosis? How to do the Ketogenic Diet? When are you Keto-Adaptive? Detox with Ketosis Using Ketosis as a THC Detox Ketosis Can Mess Up Urine Drug Test Results? Trigger a false positive for a urine drug test? How Long Does It Take To Detox Weed With Ketosis? Improving your chances Whats is Ketosis? Ketosis is actually a metabolic state that results from a prolonged lack of carbohydrates in your diet. By cutting carbohydrates from your diet, your body will naturally switch from using glycogen for energy to Fat. When you eat carbs, your body is in the “normal” metabolic state of Glycolysis. That means your body is converting carbs and sugars into Glycogen, a simple and readily available form of energy. Eating carbs triggers insulin, a hormone that travels through the blood and stores nutrients and fat from your bloodstream. When your are in the state of ketogenesis, insulin levels stay almost flat. So instead of storing fat and nutrients like THC into fat cells, your body burns it. top How to do the Ketogenic Diet As stated above, the ketosis diet is simple to follow. Just don’t eat carbs, that means staying away from bread, sweets, fruits, starchy vegetables and sugar. You are only allowed to eat foods high in fats, proteins and fiber. So basically that would include leafy greens, meats and cheeses. Its all so important to note, that increasing your fiber and electrolytes intake is crucial! 90% of all the bad stuff you hear about the ketosis diet is do lack of electrolytes and Continue reading >>

The Ketogenic Diet: High Fat, High Hopes

The Ketogenic Diet: High Fat, High Hopes

In 1921, an endocrinologist named Dr Henry Rawle Geyelin arrived at the annual meeting of the American Medical Association to deliver a talk on therapeutic fasting in the treatment of epileptic seizures. Ninety years later, Geyelin would probably be surprised to find that the same diet is being heralded as the latest magic weight-loss programme. The ketogenic diet has been called the “new Atkins” and is being taken up by an increasing number of people. But Professor Thomas Seyfried from Boston College, who has conducted research on the regimen, urges caution. “This diet is not to be taken lightly and there are healthcare professionals who work specifically in administering it,” he says. “Done incorrectly, you can alter your blood lipid parameters, which is not healthy. But when done the correct way, the blood parameters for the heart look beautiful.” That the diet exists at all is down to the persistence of Geyelin, who was also one of the first doctors in New York to use insulin as a treatment for diabetes. But his ideas were not new. The ancient Greeks had discovered that one of the best ways to manage epileptic seizures was to stop eating, a finding that particularly fascinated Hippocrates. Unfortunately, it clearly was not a long-term solution. Both Hippocrates and Geyelin discovered that once fasting was over, the seizures invariably returned. Epileptic seizures are brought on by abnormal electrical activity in the brain. The causes can vary, from a defective gene to a head injury, but one common mechanism of the condition is chronic inflammation throughout the whole body. Geyelin wondered what precisely happens during fasting that might be acting to counter this. He found changes in two particular molecules in the blood: falling blood glucose and raise Continue reading >>

Diet Stops Seizures When Epilepsy Drugs Fail

Diet Stops Seizures When Epilepsy Drugs Fail

When Jackson Small began having seizures at 7, his parents hoped and assumed at least one of the many epilepsy drugs on the market would be enough to get things under control. But one seizure quickly spiraled to as many as 30 a day. "He would stop in his tracks and not be aware of what was going on for 20 or 30 seconds or so," his mother Shana Small told CBS News. Jackson was eventually diagnosed with juvenile myoclonic epilepsy, a type of epilepsy characterized by brief but often frequent muscle jerking or twitching. But a number of medications typically prescribed to patients with this type of epilepsy were not effective. And so the quest to help Jackson gain control over his seizures led the family from their home in Orlando, Florida, to the office of a registered dietician at the NYU Langone Comprehensive Epilepsy Center in New York City. They were there to discuss the medical benefits of heavy cream, mayonnaise, eggs, sausage, bacon and butter. A lot of butter. The plan was to treat Jackson with a diet that is heavy in fat, low in protein and includes almost no carbohydrates. It's known as the ketogenic diet and has long been in the arsenal of last-resort options for patients with epilepsy who are unresponsive to medication. Doctors may recommend a patient go on this special diet after unsuccessfully trying two or three prescriptions. The diet works by putting the body in a "fasting" state, known as ketosis. "When we're fasting the body needs to find fuel so our body will break down fat storage and break down their own fat and enter a state of ketosis," Courtney Glick, the registered dietician who coordinated and fine-tuned Jackson's diet plan, told CBS News. "But with this diet, instead of breaking down the body's fat, the body breaks down dietary fat." The ketoge Continue reading >>

The Ketogenic Diet And Antiepileptic Drugs: A Good Mix?

The Ketogenic Diet And Antiepileptic Drugs: A Good Mix?

The Ketogenic Diet and Antiepileptic Drugs: A Good Mix? Learn / Seizure and Epilepsy News / Keto News / The Ketogenic Diet and Antiepileptic Drugs: A Good Mix? The Ketogenic Diet and Antiepileptic Drugs: A Good Mix? Although the ketogenic diet is increasingly being used as a first-line treatment for certain types of epilepsy, it is more commonly used in children with difficult to control seizures. Because of this, the diet is often initiated in patients who are already on one or more medications. In addition, some patients are also treated with other nonpharmacologic therapies, such as the vagus nerve stimulator (VNS). Despite this, relatively little is known about how drugs and the VNS work in combination with the diet. Do certain combinations work well or poorly together? Some research has addressed this question in terms of side effects, and more information is becoming available about efficacy. Ketogenic diet and medication combinations The ketogenic diet is commonly used in conjunction with one of more anticonvulsant medication, and more is being learned about the risks and benefits of these combinations. To begin with, the ketogenic diet does not seem to change the blood (plasma) levels of common anticonvulsant medications in any significant way. Investigators have measured plasma levels both before and after diet initiation and found no significant differences. (Dahlin et al., 2007). It seems that you dont need to decrease or increase any medications when starting the diet to keep blood levels the same. Regarding tolerability, valproic acid, topiramate and zonisamide have garnered the most concern, as the side effects of the ketogenic diet and these medications overlap. Traditionally, there has been a perception that valproic acid and the ketogenic diet should n Continue reading >>

Is There A Dark Side Of Ketosis?

Is There A Dark Side Of Ketosis?

I can’t remember what appetizer she pointed to, but the woman sitting to the left of me said this so casually, and several folks at the table knew exactly what she meant, confirming what I’d long suspected: Ketogenic diets have officially gone mainstream – or recognizable at a party mainstream at least – in 2017. Let’s back up and demystify ketosis, which simply means you’re utilizing ketone bodies – more commonly called ketones – rather than glucose as your body’s primary fuel. Just like your car uses gasoline, your body needs fuel. That usually means glucose. But let’s say you’re on a very-low carbohydrate, higher-fat diet. Your body doesn’t get a lot of glucose, which primarily comes from carbohydrate and to a lesser degree protein. That means your liver’s backup glucose (glycogen) also becomes in short supply. Unlike your car, your body doesn’t just shut down. Thankfully, you have an alternative fuel source called ketones. Ketones are organic compounds your liver always makes. You’re cranking out ketones right now as you read this. During starvation or (more likely) when you restrict carbohydrate and increase fat intake, your body uses ketones as its primary fuel. In other words, when your body doesn’t receive or can’t make enough glucose, it shifts to this alternative fuel. Almost every organ can utilize ketones except for your red blood cells (which don’t have ketone-metabolizing mitochondria) and liver. Your liver, in fact, does the heavy lifting. This hardworking organ metabolizes fat into three ketone bodies: acetoacetate (ACA), beta-hydroxybutyrate (BHB), and acetone.(1) BHB is the first substrate that kicks ketosis into action. Among its benefits, BHB reduces chronic inflammation and restores healthy inflammation levels. In Continue reading >>

Low-carb Questions & Answers

Low-carb Questions & Answers

Weight loss I’m not losing weight as fast as I want to or I have plateaued. What to do? There are a few things you can think about in order to lose weight, where the ones that might have the greatest impact are: Eat a strict low-carb diet with less than 20 grams of carbs per day. Eat only when hungry and avoid snacking. Try intermittent fasting. Sleep enough (7 or even 8+ hours per night) and avoid excessive stress. Note that as you get closer to reaching your ideal weight, the rate of weight loss will most likely slow down. It’s normal to reach a temporary plateau at some point. Also weight fluctuations of several pounds happen every day. This is all OK, just keep on doing what you’re doing. However if your weight loss stops for many weeks or even months, or if you want to speed it up, here are more things to consider: How to Lose Weight Do people who stop a low-carb diet and return to their old eating habits regain weight fast? Can low-carb diets cause “carb intolerance”? When following low-carb diets people lose more weight than on other diets (on average). So it is logical that when people return to their old diet they regain more. It is simply a bigger step in the wrong direction, compared to going off other diets. There’s no evidence for the speculation that low carb would cause carb intolerance. However, a temporary “cheat day” may lead to filling up stored sugars in the body (glycogen), which binds more water, adding weight. This water weight (perhaps 1-2 pounds) quickly disappears within days when you go low carb again. How do I STOP losing weight? For some people it is very easy to drop a significant amount of weight on low carb. Normally weight loss stabilizes within the normal weight range, as long as you eat when hungry and don’t starve yo Continue reading >>

Quieting The Bipolar Mind: Can A Ketogenic Diet Stabilize Mood?

Quieting The Bipolar Mind: Can A Ketogenic Diet Stabilize Mood?

Disclaimer: Please note that I am in no way endorsing nutritional ketosis as a supplement to, or a replacement for medication. There is very little data actually supporting the use of a ketogenic diet as a treatment for bipolar, and a well-documented case where a bipolar patient on valporic acid developed full-blown mania with psychosis after starting a ketogenic diet (thanks to @neurocritic for pointing me to this report; read about it below). This post talks about the theory behind using keto for bipolar disorder and a few recorded clinical cases. Bipolar disorder is often described as a dizzying, sinister and emotionally draining roller-coaster ride. It is marked by dark periods of severe depression interspersed with mania or hypomania – insane energy levels, difficulty concentrating, distorted thinking, euphoria and thoughts that tumble around and around in the brain. To date there is no cure for bipolar disorder, but mood swings can be managed effectively with lithium or anti-seizure medication, such as valporic acid. While effective in many cases, these drugs unfortunately come with a price: in some women lithium may lower thyroid levels causing rapid cycling of depressive-maniac cycles; valporic acid may increase the level of testosterone in young women leading to disruption of menstrual cycles and excess body hair. Many drugs also suffer from the “rebound effect”, where suddenly stopping the medication may worsen bipolar symptoms. In many cases, using a lower drug dose may minimize side effects, but sometimes at the cost of decreased efficacy. What if there’s an alternative way –say, a diet – to stabilize mood in conjunction with drugs? Lucky for mood clinicians, there is in fact a successful pre-existing case: the use of the ketogenic diet to treat Continue reading >>

Why Some Doctors Are Saying A Ketogenic Diet Is More Powerful Than Medication

Why Some Doctors Are Saying A Ketogenic Diet Is More Powerful Than Medication

The high-fat, low-carb ketogenic diet, known for helping out folks who have inflammation issues (so basically, everyone) has been on the up-and-up the wellness world. And according to a Psychology Today article, the benefits of the 100-year-old, celeb-beloved keto diet go way deeper than just treating physical ailments and promoting weight loss: It could actually be more powerful than psychoactive medications. Chris Palmer, MD, a psychiatrist at Harvard Medical School’s McLean Hospital, reported seeing two successes come from schizoaffective patients—those who suffer from schizophrenia-associated psychosis in addition to depression, suicidal thoughts, and mood swings—who went on the ketogenic diet. Their symptoms improved and their moods stabilized; they began to live their lives in a way that their disorders had prevented. “You really don’t want people in any way thinking they should stop their antipsychotic medication and start a ketogenic diet.”—Dr. Drew Ramsey But, don’t trash your prescriptions just yet. These patients compromise a case report, not a study, and Drew Ramsey, MD, brain-health pro, psychiatrist, and Well+Good council member cited a few red flags with the findings. While Dr. Ramsey admitted that Dr. Palmer’s hypothesis that glucose metabolism being a possible cause of the illness merits more investigation, he added, “you really don’t want people in any way thinking they should stop their antipsychotic medication and start a ketogenic diet.” Dr. Ramsey is hardly against food prescription. In fact, not only does he utilize the practice himself, but his experience with schizophrenic patients inspired him to implement the strategy—but not to treat symptoms. “There are so many side effects associated with [these patients] that we Continue reading >>

Ketogenic Diet Often Better Than Drugs For The Treatment Of Epilepsy

Ketogenic Diet Often Better Than Drugs For The Treatment Of Epilepsy

“First Do No Harm,” a film directed by Jim Abrahams, based on real life events, relates to the successful treatment of one boy’s severe case of epilepsy using a ketogenic diet Children suffering from epilepsy often remain seizure free after discontinuing a ketogenic diet, and many eventually are able to resume a normal diet A ketogenic diet has also been shown to be effective in the treatment of ALS, autism, cancer, Parkinson’s disease and Type 2 diabetes, but you don’t have to be seriously ill to benefit from it By Dr. Mercola This year marks the 20th anniversary of "First Do No Harm," a film directed by American movie director and writer Jim Abrahams. Based on real life events, the film relates the successful treatment of one boy's severe case of epilepsy using a ketogenic diet. Prior to the fictionalized family's discovery of the diet, their youngest son, Robbie, was given many pharmaceutical medications, some of which caused constipation, fevers, rashes and other harmful side effects, including at least one near-death episode. Aspects of the storyline mirror Abrahams' own experience with his infant son Charlie, who makes a brief cameo appearance in the film as one of Robbie's playmates in the hospital. Charlie was diagnosed with epilepsy when he was just 11 months old. Similar to the mother in the movie, played by Meryl Streep, after Abrahams watched his son suffer through multiple daily seizures, the accompanying accidents and injuries, and a slew of pharmaceutical drugs, he became aware of the ketogenic diet through personal research. As with the boy in the movie, within the first month of implementing the diet, Charlie became seizure and drug free. Charlie continued on the ketogenic diet for five years, after which he resumed eating regular food, and ha Continue reading >>

Ketogenic Diets And Migraines: What You Need To Know

Ketogenic Diets And Migraines: What You Need To Know

The links between diet and migraine are well established. Most migraineurs recognize certain foods that either trigger an attack or make an episode worse. Avoiding personal food triggers soon becomes a lifestyle choice that’s vital in managing the condition. Research into diet and the ways in which what we eat affects our bodies is constantly evolving, with new or alternative ideas appearing all the time. The ketogenic diet, while not new, has been found to have a beneficial effect for some migraine patients, and research into how this diet works provides interesting links to migraine causes that may encourage sufferers to experiment. How Does a Keto Diet Work for Migraines? At its most basic level, a ketogenic diet is one that stimulates the liver to produce ketones. But what does that mean? Ketones are produced when the body burns fat for energy instead of carbohydrates (glucose). A ketogenic diet is very low in carbohydrates, and has several alternative names including the low-carb diet or a low carb high fat (LCHF) diet. DOWNLOAD OUR FREE MIGRAINE DIARY TODAY! » In a normal regular diet, one that contains a high amount of carbohydrate, the body uses glucose as the main form of energy. Being the easiest molecule to convert into energy, the body chooses glucose over other energy sources, producing insulin to process the glucose and carry it around the body. When glucose is used as the main energy source, other fats are not needed so the body stores them. The most common reason for adopting a ketogenic diet is to lose weight, since when we drastically lower our carbohydrate intake we put the body into a state of ketosis. This is a natural physical defense to protect against starvation when food intake is very low. Deliberately introducing this particular metabolic s Continue reading >>

Four New, Cutting-edge Ways To Easily Shift Your Body Into Fat-burning Mode & Ketosis.

Four New, Cutting-edge Ways To Easily Shift Your Body Into Fat-burning Mode & Ketosis.

Great article. You actually answered my question as to the ratio of the 3 BHB salts which is quite helpful for me. For me, I had Keto O/S and found it quite good – my favorite was the chocolate swirl. But it was and is very expensive. Only 15-20 servings and would break the bank. So I turned to KetoCaNa and I’ve tried two flavours. Both of them were so salty that I almost threw up every time. Like flavoured sea water. Also only 15 serving per bottle. Then I turned to Ketond which is okay – Tigers Blood and Caramel Macchiato. What I like about Ketond is that it has a full 30 servings and is very transparent with it’s ingredients. It’s also the same price as Keto OS but you get 30 servings. But still, not the best taste. So in the end, I ordered 1kg of pure BHB Magnesium from a supplier in China and I will be developing my own Ketone product with 30 servings as a lower price than all the competitors, and with more Magnesium, and Calcium in it than Sodium so that it tastes the best and actually helps with weight loss (which Magnesium is proven to do at the right amount). What the companies don’t tell you is that actually Sodium BHB is the cheapest, then Calcium BHB and then Magnesium BHB to source so I would be interested in knowing if what you wrote is actually true or just an excuse to make the product cheaper. Probably a mix of both. So I have 2 questions Ben: 1. If you had to split the 11.7g of BHB into Sodium, Ca, and Mg, what ratio would you do for the best health results and potential weight loss? The current products on the market are about an 80/12/8 split. I would think it should be the other way around. 2. When I develop my own product and sell it, would you be up for sampling it and reviewing it on your website here? What flavours do you like/would Continue reading >>

What Is Ketosis? | Ali Miller Rd

What Is Ketosis? | Ali Miller Rd

What is ketosis? Many of us have heard the term, but lack a full understanding of what ketosis really is. Ketosis is the breakdown of fat (both dietary and stored body fat) into ketone bodies to be used as fuel for the body. The preferred source of fuel for the body is typically glucose coming from carbohydrates. A ketosis diet or ketogenic diet forces the body to breakdown fat for fuel rather than glucose. The Standard American Diet (SAD) is predominantly composed of carbohydrates making the body very good at breaking down carbohydrates for fuel but not as efficient at breaking down stored fat. The ketosis diet truly trains the body to burn fat for fuel and even after discontinuing a ketogenic plan the body is still much more efficient at breaking down stored body fat. Over the years the ketogenic diet has gained popularity as an accelerated weight loss diet. From Atkins to paleo; low carbohydrate diets have consistently remained the top successful diets used for weight loss. What most do not realize is that a ketogenic diet was first utilized in preventing and mitigating seizures particularly in pediatric patients. In the 1920s, doctors began to realize that when fed a high fat and extremely low carbohydrate diet their patients began to notice a remarkable reduction in frequency and severity of seizures. They found that the breakdown of dietary fat caused the body to produce ketones which have GABAergic and glutamatergic effects causing a reduction in nerve impulses thus having an anticonvulsant effect. The ketogenic diet was used as the mainstream therapy until the development of new anticonvulsant medications in the late 1930s. Most physicians favor the use of pharmaceutical drugs to control a patients seizures most likely due to patient compliance but a ketogenic Continue reading >>

Ketogenic Therapy And Anti-epileptic Medications

Ketogenic Therapy And Anti-epileptic Medications

Ketogenic Therapy and Anti-Epileptic Medications Home / Keto Therapies / Keto Management /Ketogenic Therapy and Anti-Epileptic Medications Ketogenic Therapy and Anti-Epileptic Medications matthew 2018-09-17T12:58:48+00:00 Ketogenic therapy and anti-epileptic medications Research Dietitian, Matthews Friends Clinics Honorary Research Associate, UCL Institute of Child Health Ketogenic therapy includes the classical ketogenic diet (KD), the medium chain triglyceride KD, the modified Atkins diet (MAD) (or variants which may be termed modified KD) and the low glycaemic index treatment. Many studies, including randomised trials, have reported reduced seizure frequency and severity in children and adults receiving ketogenic therapy. These diets are usually used to treat intractable seizures which have not responded to appropriate medication so most who start them will be on at least one concurrent anti-epileptic drug (AED); a reduced dependence on AEDs being a goal and frequently attained outcome of ketogenic therapy. This insight reviews the literature and discusses evidence for any interaction between ketogenic therapy and AEDs. Does ketogenic therapy affect blood levels of AEDs? Four studies have examined this question. The first measured plasma levels of valproic acid (VPA), lamotrigine, topiramate, clonazepam and phenobarbital in 51 children on the classical KD. Although some AED doses were adjusted, no significant effect on plasma concentrations was seen after three months on the diet and the authors concluded it is not necessary to adjust drug doses due to pharmacokinetic interactions when starting a KD (1). Another study measured plasma levels of VPA and phenobarbital in 36 children and adolescents after one month on the classical KD given as a ketogenic formula either Continue reading >>

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