Drug And Chemical Induced Metabolic Acidosis

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Anion gap usmle - anion gap metabolic acidosis normal anion gap metabolic acidosis

Exercise-induced Metabolic Acidosis

The scientific method involves stringent criteria for the evaluation of knowledge, but the method is not perfect. Research findings and their interpretations can be raised prematurely to the status of a fact. Some of these facts can even become a pivotal component of a knowledge base, termed a construct. Consequently, continual re-evaluation of the content of any academic discipline or profession is essential to ensure that knowledge and practice is based on fact. In recent years I have come to question a construct that has been accepted by a wide range of academic, research and professional entities: that the increasing free proton concentration within contracting skeletal muscle is caused by the increased production of lactic acid. One only has to read any of the textbooks in exercise physiology or pure biochemistry to be informed that when pyruvic acid is converted to lactic acid, the pK of lactic acid results in an immediate, near complete dissociation of the proton from the carboxylic acid functional group. This interpretation results in the logical belief that the net result in vivo is the production of lactate ions and the release of a proton. A generic chemical equation us Continue reading >>

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  1. sharidoto


  2. ljessica0501

    It varies for everyone. For me personally...it took 4 days to register anything and almost 2 weeks to get purple...I have never seen the darkest purple shade. Some people will tell you not to use the sticks, but I like them. My doctor told me to use them 3 times a day for a week to see when my body is the highest. Again...everyone is different. I am highest in the morning, but I hear some people are highest at night.
    Your goals, minus your doubts, equal your reality. - Ralph Marston

  3. PeeFat

    Your body has to burn off all the stored sugar before it goes into ketosis. The shade on the stick should read ' moderate. ' Any higher means you aren't drinking enough water to flush out excess ketones. Too many ketones in your body is unhealthy. So don't think you have to be in the darkest purple range to be eating properly. Also the best time to test is first thing in the morning. Only diabetics need check more than once a day. On atkins we don't even need to use keto sticks. If you follow the rules you will be in ketosis.

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Opening and closing sequences from the programme to showcase the music of Skylight Music. Programme Daisybeck Music Skylight Music Excerpts used used by permission

Drug-induced Metabolic Acidosis A Link To The Article And Some Excerpts

For an excellent brief review of acid-base disorders see Acid-Base Interpretation Updated: Oct 30, 2015 from emedicine.medscape.com In addition to d-lactate, the D in GOLDMARK * [a mnemonic for the causes of anion gap metabolic acidosis] can also stand for drugs as a cause of metabolic acidosis. * This is the link to Best Case Ever 56 Anion Gap Metabolic Acidosis [link is to the podcast and shownotes] from Emergency Medicine Cases . An excellent article that discussesdrugs causing metabolic acidosis isDrug-Induced Metabolic Acidosis[ PubMed Abstract ] [ Full Text HTML ] [ Full Text PDF ].F1000Res. 2015 Dec 16;4. pii: F1000 Faculty Rev-1460. doi: 10.12688/f1000research.7006.1. eCollection 2015. What follows are the figuresfrom the above article [See article text for details]: Metabolic acidosis could emerge from diseases disrupting acid-base equilibrium or from drugs that induce similar derangements. . . .It is imperative that clinicians not only are fully aware of the list of drugs that may lead to metabolic acidosis but also understand the underlying pathogenic mechanisms. In this review, we categorized drug-induced metabolic acidosis in terms of pathophysiological mechanisms, as Continue reading >>

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  1. rumSmuggler

    I recently (couple weeks ago) started weights and also taking some protein powder (low carb - 1,8g per serving).
    As suggested I raised my protein intake and I'm somewhere around 1 to 1.2 protein ratio. Last couple days I used ketostix to test my ketones and it was negative. I'm sure I didn't exceed 20g carbs per day because I track all my food.
    Could that higher protein intake kick me out of ketosis?

  2. gupe

    As far as I've been able to discover, there are no absolutely definitive answers to the excess protein => additional glucose => inhibition of ketosis? causal chain question.
    This is a good article: "If You Eat Excess Protein, Does It Turn Into Excess Glucose?" on ketotic.org.
    And here is a recent discussion on "After workout protein needs" on /r/ketogains.
    An important unresolved question is: is gluconeogenesis (the manufacture of new glucose by the liver using proteins and fat) a supply-driven process or a demand-driven process?
    If it is a supply-driven process, then it seems more plausible that excess consumption of protein will lead to higher blood sugar levels.
    But if it's demand-driven, then excess glucose might just be due to the slower removal of glucose from the blood-stream after protein has been eaten, causing a bit of a build-up.
    I think that it might vary a lot from person to person. The best is to measure your own blood ketone concentration before and after eating protein. (The ketostix method is not as reliable, particularly if you've just finished a work-out.)
    Edit: fixed link.

  3. darthluiggi

    It can, but it depends on various factors such as weight, activity level, etc.
    I asked the science behind it to to /u/gogge and he gave a very good explanation in another post.
    Fact is, if you are doing strength training you will need to increase your protein intake, otherwise you will not grow muscle. Also protein comes into play if you are eating at a deficit.
    If you are completely sure that protein is taking you out of ketosis, then drop your intake to 1.0 and see if you get back.
    How much do you weight, what % BF do you have, what kind of excercises are you doing and for how long?
    As a side note: don't rely on ketostsix to see if you are in or out of keto.
    *Edited for grammar.

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What is BASAL METABOLIC RATE? What does BASAL METABOLIC RATE mean? BASAL METABOLIC RATE meaning - BASAL METABOLIC RATE definition - BASAL METABOLIC RATE explanation. Source: Wikipedia.org article, adapted under https://creativecommons.org/licenses/... license. Basal metabolic rate (BMR) is the minimal rate of energy expenditure per unit time by endothermic animals at rest. It is reported in energy units per unit time ranging from watt (joule/second) to ml O2/min or joule per hour per kg body mass J/(hkg)). Proper measurement requires a strict set of criteria be met. These criteria include being in a physically and psychologically undisturbed state, in a thermally neutral environment, while in the post-absorptive state (i.e., not actively digesting food). In bradymetabolic animals, such as fish and reptiles, the equivalent term standard metabolic rate (SMR) is used. It follows the same criteria as BMR, but requires the documentation of the temperature at which the metabolic rate was measured. This makes BMR a variant of standard metabolic rate measurement that excludes the temperature data, a practice that has led to problems in defining "standard" rates of metabolism for many mamma

Pharmacologically-induced Metabolic Acidosis: A Review.

Pharmacologically-induced metabolic acidosis: a review. Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece. Drug Saf. 2010 May 1;33(5):371-91. doi: 10.2165/11533790-000000000-00000. Metabolic acidosis may occasionally develop in the course of treatment with drugs used in everyday clinical practice, as well as with the exposure to certain chemicals. Drug-induced metabolic acidosis, although usually mild, may well be life-threatening, as in cases of lactic acidosis complicating antiretroviral therapy or treatment with biguanides. Therefore, a detailed medical history, with special attention to the recent use of culprit medications, is essential in patients with acid-base derangements. Effective clinical management can be handled through awareness of the adverse effect of certain pharmaceutical compounds on the acid-base status. In this review, we evaluate relevant literature with regard to metabolic acidosis associated with specific drug treatment, and discuss the clinical setting and underlying pathophysiological mechanisms. These mechanisms involve renal inability to excrete the dietary H+ load (including types I and IV renal tubular acid Continue reading >>

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  1. Peter_V

    Stopping Metformin, any side effects?

    Other than the obvious possibilty of increased blood glucose.
    My glucose readings have been so good lately I decided to try stopping the Metformin a couple weeks ago. I'm having to be a bit more careful of my carbs, but as long as I exercise I can keep my fasting glucose readings down (92 this morning)
    However, I have been feeling some low grade flu like symptoms (aches and pains, etc, especially when exercising)
    Just curious if these are common when discontinuing metformin or perhaps I've picked up a bug.

  2. jwags

    Metoformin will stay in your system for up to a month or so. So you really can't tell the effects until after that. I don't think you should see any symptoms going off of it. You may see some increased insulin resistance or even weight gain since that is what metformin works on. The aches and pains could be from anything or just a coincidence.

  3. RayH

    Are you stopping Metformin under medical supervision?? Sometimes, when medication does what it's supposed to be doing and they are inexpensive, we think they don't do anything.
    I ran out of Metformin for a few weeks and was unable to get the Rx moved to Costco for a bunch of reasons. I got scared. I'm a guy who doesn't scare easy on my numbers. I got scared.
    In a similar vein, I have a friend who stopped taking her thyroid medication for some reason. She's been in the hospital over 3 months struggling with failing organs...

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