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What Is The History Of The Ketogenic Diet?

As early as 500BC, Greek and Indian doctors recognized that fasting for extended periods would have positive effects on patients with epilepsy. Cures were documented after a period of abstaining completely from "food and drink" (I doubt this was a realistic long-term plan, though). In the early 1900s, fasting as a treatment for epilepsy became popular again. However, with the introduction of medicines to control epileptic episodes, the treatment dropped off. Nevertheless, 20-30% of patients remained unresponsive to the drugs and for these individuals, especially children, fasting diets continued to be used. It was in 1921 that endocrinologist Rollin Woodyatt noted that three water-soluble compounds, acetone, β-hydroxybutyrate and acetoacetate (together called ketone bodies) were produced by the liver as a result of starvation or if they followed a diet rich in fat and low in carbohydrates. Russel Wilder from the Mayo Clinic called this the “ketogenic diet” and used it as a treatment for epilepsy, also in 1921. This is a significant finding because it shows that you can create a "starvation" state in the body without actually starving. Yay! Finally, a long-term plan that is fea Continue reading >>

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  1. sk8wh33ler

    I looked around here and in the web, but could not find a clear answer. So the situation is: I am in ketosis around 6 month and started to get higher blood sugar 2 month ago. Before I was around 70 - 90. Now I am around 100 to 120, no matter when I meassure. Blood-Ketone level is always around 0.4 to 1.2. My macros are ok and I felt good most of the time. The last 2 weeks though I started to feel a bit down so I started to worry a bit and read into the high BG thing I found 2 articles which leaves a lot of questions unanswered.
    article1!
    article2!
    They are a bit old, so there might be more information by now? I am really worried that I have to stop keto just because of this.... can anyone help by making a holding argument? Can I just ignore this? Thanks in advance.

  2. DavePD

    Given your BHB of .4 to 1.2, I think it's more likely you still need to limit carbs and/or protein as there's likely too much glucose still in play. Check your postprandial glucose 1, 2, and 3 hours after meals and see if you spike above 120. If so, your meal is still too high in carbs and/or protein when coupled with your existing insulin response.
    When you get your next blood test, be sure to ask for "Fasting Insulin" too. (This should actually be standard in ALL metabolic panels, but isn't.)
    I'm about 17 months into the diet and I've observed my fasting blood glucose bottom out at 70s to start, then slowly increase to 90s (or even low 100s about 15% of the time), yet my blood BHB is typically between 1.8-3.8. I'm confident this is glucose sparing as my fasting insulin tests are now at the bottom of their range (3.3 with reference range 2.6-24.9) AND I check my postprandial glucose which rarely climbs above 120.
    To add to /u/Solol123's point -- protein is tricky because I find if I have too much within a single meal (such as large steak), it will bring up my glucose postprandial and even have a lasting margin into the next morning with higher glucose and lower BHB.

  3. sk8wh33ler

    thanks for the advice. I will try to control protein even more and will stay with mostly 77g a day.

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