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Do Ketones Damage Kidneys?

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Ketone Bodies

Ketone bodies Acetone Acetoacetic acid (R)-beta-Hydroxybutyric acid Ketone bodies are three water-soluble molecules (acetoacetate, beta-hydroxybutyrate, and their spontaneous breakdown product, acetone) that are produced by the liver from fatty acids[1] during periods of low food intake (fasting), carbohydrate restrictive diets, starvation, prolonged intense exercise,[2], alcoholism or in untreated (or inadequately treated) type 1 diabetes mellitus. These ketone bodies are readily picked up by the extra-hepatic tissues, and converted into acetyl-CoA which then enters the citric acid cycle and is oxidized in the mitochondria for energy.[3] In the brain, ketone bodies are also used to make acetyl-CoA into long-chain fatty acids. Ketone bodies are produced by the liver under the circumstances listed above (i.e. fasting, starving, low carbohydrate diets, prolonged exercise and untreated type 1 diabetes mellitus) as a result of intense gluconeogenesis, which is the production of glucose from non-carbohydrate sources (not including fatty acids).[1] They are therefore always released into the blood by the liver together with newly produced glucose, after the liver glycogen stores have bee Continue reading >>

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Popular Questions

  1. bbearsmama

    Ketones found in urine-is our diet bad for our kidneys?

    Hi there-
    I went to see my PCP for a urinary tract infection today and she said there was a lot of stuff in my urine-ketones, blood (which is always there-which is why I also see a nephrologist), and some protein. She thinks the ketones are because of my high protein diet and she told me to try to eat a more balanced diet (more carbs, fruits, veggies). How is this possible with such a tiny pouch? Has this happened to anyone else and if so-what did you do? Is it dangerous to have ketones in your urine? I do worry about my kidney function. My nephrologist likes to do labwork (blood/urine) every 6 months to keep an eye on things. He doesn't think my labs have warranted doing a kidney biopsy at this point. The last time I saw the nephrologist was before my RNY. I just don't want my diet to be damaging to my kidneys.
    Has this happened to anyone--kidney damage as a result of the post-op diet? I know that it will be easier to eat a more balanced diet as a I get further out, right?
    Thank you all for your advice and help!
    Sincerely,
    Pam

  2. RainbowRN

    I know that when the atkins diet was really popular, more people started talking about ketones in the urine. The big deal about it is that protein molecules are actually really big and more difficult for the kidneys to filter. Therefore the kidneys can be damaged overtime. Now, I'm not sure about how long it takes or how much protein it would take to do that. All I know is that, last year before I even considered WLS, my NUT put me on a protein sparing modified fast. It was a diet that was primarily protein only. It was very high amounts of protein. Greater than 140mg a day. I was told that I would do the diet for 3 months and then I had to go off of it for 3 months and then back on for three months simply because of the risk of damage to my kidneys. I don't consume that much protein since surgery. I try to make sure I get in 60mg a day. I would be curious to find out if kidney damage is a possibilty for us. In all my research I have not heard of that being a side effect.

  3. bbearsmama

    Before I had my surgery, I did talk to my nephrologist about the high protein diet and he thought it would be fine. He said that 60 g. of protein is really not that much. What is considered the "normal" intake of protein (for people who haven't had wls)? I think it's around 50 g. of protein. I'm not sure, though. And the reality is-I struggle to get 60 g. in per day. Most days I don't even get there-it's more like 50 or 55 g.
    That is interesting about the protein molecules being big.
    Thank you so much for your reply!
    Pam :)

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