Do Ketones Damage Kidneys?

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Abnormal Contents Of Urine

Normally, urine contains water and wastes, such as urea, uric acid, creatinine, and some ions. However, some of these substances may be abnormally elevated, which usually indicates that something is wrong with the body. The following are some of the abnormal constituents of urine and some possible causes. Albumin Albumin is a type of protein, which is a normal component of plasma—the fluid component of blood. When albumin is found to be excessive in the urine, it may indicate that the tiny filtering units in the kidney, called nephrons, are damaged or destroyed. Elevated albumin in the urine is termed albuminuria. Bilrubin Bilirubin, when modified by the kidneys, contributes to the classical yellow color of urine. It is a byproduct that results from the breakdown of hemoglobin—the red pigment in red blood cells. When levels of bilirubin in urine is above normal, the condition is called bilirubinuria. This may indicate liver disease or obstructive biliary disease. Glucose The presence of glucose or blood sugar in urine is called glucosuria. It may indicate that the person has diabetes. Ketone bodies The presence of ketone bodies in the urine may indicate diabetes or anorexia. It Continue reading >>

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  1. Injecto

    I can't seem to find anything that backs this up. I know that high BG will damage them over time (duh!!), but what about ketones?

  2. fgummett

    Ketone bodies are water-soluble compounds that are produced as by-products when fatty acids are broken down for energy. They are a vital source of energy during fasting -- such as overnight.
    The brain gets its energy from ketone bodies when insufficient glucose is available. In the event of low blood glucose, most other tissues have additional energy sources besides ketone bodies (such as fatty acids), but the brain does not.
    Remember that when you are not fasting, the body can use Amino Acids (from dietary Protein) to synthesize Glucose (Gluconeogenesis).
    Any production of Ketones is called ketogenesis, and this is necessary in small amounts. When even larger amounts of ketone bodies accumulate such that the blood's pH is lowered to dangerously acidic levels, this state is called ketoacidosis. This happens in untreated Type I diabetes (DKA).
    In short, the human body has evolved over the millennia to burn either Glucose or Fatty Acids -- think of these as the short-term fuel and longer-term reserve, respectively.
    So if it is normal to burn Fatty Acids and produce Ketones why would they be harmful unless they accumulate to dangerous levels? Yes I know... we always get the "dangerous levels" lecture but consider that BG can be toxic at high enough levels... that does not mean it is bad for us at any level


    can we get the production of ketones correct??
    The primary cause of ketogenesis in the body is.....
    gluconeogenesis from dietary protein, when there is insufficient dietary glucose to fill the body needs, aka the ketogenic diet.
    The process of gluconeogenesis utilises a key component of the citric acid cycle (oxaloacetate), which blocks the oxidation of Acetyl CoA. Fatty acid (and glucose oxidation) require their conversion to Acetyl CoA. It is Acetyl CoA which is converted to ketone bodies and this process occurs pretty exclusively in the liver (also happens in the kidney)
    Normally oxidation of fatty acids does NOT produce ketone bodies, even during fasting overnight, as usually there are more than sufficient stores of glycogen.
    - starvation is an entirely different matter. Fasting for longer than a day or so can be sufficient for ketogenesis to start.
    Astrocytes in the brain can produce ketone bodies in response to hypoglycemia, but this will not provide adequate protection in the event of hypoglycemia caused by insulin overdose.
    The simple reason why ketogenesis as caused by a ketogenic diet is probably safe is because ketones only transiently rise in response to food, and the levels sustained should not be sufficient to disturb the body's buffer system.
    if however you spent long periods without food, or lacking insulin then that is a very different matter.
    I can't find anything definitive about ketones and kidney function - the only thing of note is an association with kidney stones for children on ketogenic diets to control epilepsy - but this could be due to the components of the diet (high protein) rather than ketones. There are no long term safety studies on ketogenic diets, but they are though to be safe (probably).
    Those on this forum on low carbohydrate diets 50g to 120g of carbs probably do not experience ketogenesis to any significant degree. Significant ketogenesis only occurs at <30g.

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In order to run cool on those hot summer days, your engine needs to have a consistent flow of coolant supplied from the radiator throughout the engine. The water pump is the primary component responsible for maintaining this flow. When it works properly, your car will maintain a consistent operating temperature, run smoothly, and take you anywhere you need to travel. When the water pump fails or is beginning to wear out, it can lead to complete engine failure. When the water cooled (as opposed to air cooled) engine was introduced, many automotive experts believed that the water pump circulating coolant through the engine block was just as critical to engine protection as oil. This philosophy holds true even as technology has improved over the years to create more efficient cooling systems in today's modern cars. Your cars water pump is the key to making the entire system work. It is an impeller pump and is usually buried under the timing belt cover on the side of the engine. The pump is operated by the engines drive belt as the belt turns, the pump turns. Blades on the pump force coolant to flow through the engine and back to the radiator to be cooled by a forced air cooling fan.

Why Fasting Is Bad For You

Lots of buzzwords pop up when fasting is mentioned. "Cleansing", "Toxins", "Spiritual", "Holistic"…its a long list that recently inducted Anna Hazare in it's litany. Science, however doesn't advise a diet that leaves you looking like Mahatma Gandhi (even if you're feeling like Mahatma Gandhi). This is why. There's a man in America named James Randi. He'll pay a million dollars to anyone who can successfully prove, under controlled conditions, any alternative remedy that actually works. India's abundance of mixing myth and fact, however is first tested by the Indian Rationalist Association, known for debunking such phenomenon and exposing lies behind Indian superstitions. They busted the sleight-of-hand tricks of Sri Sai Baba, successfully explained the mechanics behind milk-drinking statues and the sweet sea water of Mahim Creek, Mumbai. IRA's founder and President President Sanal Edumarku even took on a tantrik's threat of death by Indian black magic on national TV, sitting calmly throughout the India TV episode called The Great Tantra Challenge that drew millions. The few pseudo-scientific practitioners of breatharianism (a school of fasting) have all died - yes, died - after c Continue reading >>

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  1. driven1

    OK.... I'm a keto newbie, on Day 9 of the 12 day start up. As and aside, I feel great and am loving the food choices.
    ANYWAY... I have a girl friend who is an RN (and a very good one), who has cautioned me that ketones are 'hard on the kidneys'.
    Now, I love my GF to death, and I know that she means only the best, but I have very little confidence in the conventional medical community. After all, this is an industry that makes it's money from people being sick...
    My research has turned up that ketones are NOT damaging to the kidneys. On the contrary, the kidney uses ketones as a preferred fuel source when they can get them. The heart and brain as well as other major organs prefer them too...
    Seems as though the confusion is with the fact that a lot of medical professionals consider the excessive protein while on a keto diet damaging to the kidneys. I have also found research that dispels this... showing that only individuals who already have compromised kidney functions MIGHT have a problem with excess protein in the diet.
    I'm looking for comments from those who are experienced with the keto lifestyle. What do you know??

  2. titebuoy

    excessive dietary protein causes your kidneys to work harder to remove excess nitrogen. however, the keto is a high fat diet, not a high protein diet so i wouldnt be worried about it unless your macros are out of wack. some people have trouble with foamy urine on the diet, but most people dont experience kidney trouble on keto.

  3. stew9812

    I'm new to this too.
    I think what they teach the doctors/nurses is whats best for the general public. (people that don't work out, and don't necessarily get enough water ect..) So they may not always have the best answers for people like us.
    I would say to just drink plenty of water, and you will be fine.
    Just my opinion here, but like you say there is plenty of people who have done this diet with no bad side effects, and there is plenty of research supporting this to be a healthy diet as well.
    just my .02

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I have noticed foams in my urine together with flank pain in both sides following a UTI 7 months ago. After waching many videos in youtube and doing some google research about foamy urine, I was convinced that something was wrong with my kidneys. I went to see my nephrologist and 3 consequent tests with monthly intervals showed that my total protein excretion is below 150 mg/day and albumin excretion is 3 mg/day with normal functioning kidneys. So everything seems to be OK. I made this video to show people concerned like me what real proteinuria is. There are plenty of videos here without any information about the excretion rate or if any proteinuria is present. So if you see some bubbles in the toilet dont panic. Just go and consult your doctor. I am not trying to diagnose anything at all. Just sharing my experince.

What Is Proteinuria?

Proteinuria is a type of Nephrotoxicity. Proteinuria is an excess of protein in the blood. Protein is an important component in our blood, as it carries food, hormones, and many other things through our blood stream. Once the blood is cleansed of excess wastes, the proteins will continue to flow through the body, carrying out their important functions. Protein is not filtered out of the body, as the large protein molecules are too big to through the tiny kidneys. When there has been damage to the kidneys, depending on the cause, you may develop protein in your urine. Causes of Proteinuria": You may develop proteinuria as a result of: Chemotherapy drugs such as: Streptozocin Biologic therapies such as: Interleukin-2 Certain diseases or conditions - Multiple myeloma will cause you to have a special kind of protein in your urine, called the "M-protein", "myeloma protein", or Bence-Jones protein. These are all terms for the same kind of protein. If Protienuria is among your symptoms of kidney problems, your doctor or healthcare provider will monitor your urine proteins periodically - either monthly, or yearly, depending on the severity and activity of your disease. Systemic lupus eryth Continue reading >>

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  1. Timothy

    I recently told my friend, a professor of medicine at a large university, about my six-week-old PB eating habits (now largely carnivorous). He advised me that it's not good to keep your body "carb-starved" and in ketosis all the time, and that eating so much protein strains the liver's ability to produce urea and the kidneys' ability to process and excrete it. The long-term effects can include liver and kidney damage, he said.
    I've heard something like this before, but it seems to run counter to the research on MDA as well as the experiences of real-life carnivores.
    Do you know anyone who has sustained kidney/liver damage from eating too much protein? Is Tarlach on course for renal failure? Or is this just CW run amok again?

  2. Athena

    Ive heard it from bodybuilders who eat ungodly amounts of protein (mostly from powders) that they have kidney problems. I always heard as long as you keep hydrated your kidneys shouldnt have an issue, especially if u get your protein from meat sources. Although I can't back that up with anything other than broscience. Im interested to see some evidence though

  3. Prowler

    Absolute bull.
    1. What is the incidence of liver or kidney damage among the Inuit practicing their traditional diet?
    2. What is the incidence of liver or kidney damage among the Masai practicing their traditional diet?
    3. The venerable Dr. Atkins himself used ketosis to treat thousands of patients at his clinic over the course of several decades, and he challenged anyone to show one case where ketosis caused kidney damage. Not one case has ever been documented.
    Case closed. Ketosis is a safe and natural state, and any speculation about potential harm is just that: pure unfounded speculation.

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