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Diabetic Ketoacidosis And Hyperglycemic Hyperosmolar Syndrome

In Brief Diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic syndrome (HHS) are two acute complications of diabetes that can result in increased morbidity and mortality if not efficiently and effectively treated. Mortality rates are 2–5% for DKA and 15% for HHS, and mortality is usually a consequence of the underlying precipitating cause(s) rather than a result of the metabolic changes of hyperglycemia. Effective standardized treatment protocols, as well as prompt identification and treatment of the precipitating cause, are important factors affecting outcome. The two most common life-threatening complications of diabetes mellitus include diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar syndrome (HHS). Although there are important differences in their pathogenesis, the basic underlying mechanism for both disorders is a reduction in the net effective concentration of circulating insulin coupled with a concomitant elevation of counterregulatory hormones (glucagon, catecholamines, cortisol, and growth hormone). These hyperglycemic emergencies continue to be important causes of morbidity and mortality among patients with diabetes. DKA is reported to be responsible fo Continue reading >>

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Popular Questions

  1. Craig Stephenson

    So....apparently I have placed my self in a state of ketosis by loosely following the paleo diet....(very limited grains, and or processed foods) I base this on the fact that my wife finds my breath similar to sucking on a sock soaked in paint thinner....
    I have spent some time researching this topic both here on the board and elsewhere on the web....still, I am confused. Some say its bad, some say its not.....some say protein sparing, some say liver damaging.....
    Does anyone really know? Am I in a happy place?... or should I be concerned that my brain and liver are going to revolt against me? I might add that I was not necessarily trying to obtain ketosis....I am 6'3" 200# ~11% BF....so I am not really trying to loose wt...I caught the paleo bug and like how I feel following it....however....if it is causing this ketosis and it is "bad"...maybe I need to re-evaluate or at least adjust what I am doing.
    Anybody have any advice??
    Thanks
    Craig "ELI" Stephenson

  2. Sarah Clent

    How is your body feeling?
    Do you feel lethargic? Full of energy? Unusual soreness after workouts? etc?
    Do you eat alot of fruit and veg?
    I have done the atkins diet in the past and been in ketosis... I didnt harm my body but it seems its mainly for weight loss? And it seems you dont need weight loss
    I am loosley following paleo in zone and i havent tested if i am in ketosis... would be interesting to see as i have cut all wheat and grains (except corn) for the last week... As for it harming you, i guess you need to work out how your body is feeling... if you are feeling good and healthy and if you are eating alot of veggies and fruit and lean meat... i dont see how it could be damaging to you? your body might just have a higher requirement for carbs?

  3. Frank E Morel

    Quote:

    Originally Posted by Craig Stephenson
    So....apparently I have placed my self in a state of ketosis by loosely following the paleo diet....(very limited grains, and or processed foods) I base this on the fact that my wife finds my breath similar to sucking on a sock soaked in paint thinner....
    I have spent some time researching this topic both here on the board and elsewhere on the web....still, I am confused. Some say its bad, some say its not.....some say protein sparing, some say liver damaging.....
    Does anyone really know? Am I in a happy place?... or should I be concerned that my brain and liver are going to revolt against me? I might add that I was not necessarily trying to obtain ketosis....I am 6'3" 200# ~11% BF....so I am not really trying to loose wt...I caught the paleo bug and like how I feel following it....however....if it is causing this ketosis and it is "bad"...maybe I need to re-evaluate or at least adjust what I am doing.
    Anybody have any advice??
    Thanks
    Craig "ELI" Stephenson well you must be cycling in and out of ketosis as if your inconstant state of ketosis.. you get a really bad case of brain fog. Out of ketsis, your giving your brain enough glucose/carbs for it to function.
    cardiac arrthymias from electrolyte imbalances, increased risk of osteoporosis from urinary calcium losses, gout, kidney stones and nausea, lethargy and general weakness associated with prolonged ketosis. not many studies address this but there is enough anecdotal events ( mass famines ) that its not a wise thing to in for a prolonged period.
    http://www.ajur.uni.edu/v4n1/Harris%...0pp%201-18.pdf wfs warning ..boring

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