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Anti-il-1 Treatment In Children Diabetic Keto-acidosis (dka) At Diagnosis Of Type 1 Diabetes

This is a randomized, double-blind, placebo-controlled phase 2 study. Specific aim is to evaluate feasibility and safety of anti-IL-1 (interleukin 1) treatment in the course of standard therapy for diabetic ketoacidosis in children and its effect on intracranial pressure. Anakinra is a fully human IL-1ra (interleukin 1 receptor agonist) licensed in 2001 by FDA for the treatment of rheumatoid arthritis. It competitively binds to the IL-1 receptor, thus blocking IL-1 signaling. It is a short-acting agent that requires daily subcutaneous administration at 1-2 mg/kg, maximum 100 mg/dose. It has been effective in lowering HbA1c (glycated haemoglobin) in T2D (type 2 diabetes) and a randomized trial of anakinra in recent onset T1D (type 1 diabetes) is underway in Europe. Overall, anakinra has been used in adults and children with a good safety record, for more than 10 years. Infrequent side effects include infections, neutropenia, nausea, diarrhea, cardiopulmonary arrest, influenza-like symptoms, and production of anti-anakinra antibodies. Study Design: A double-blinded placebo-controlled RCT (randomized controlled trial) with 2:1 allocation (14 active treatment vs. 7 placebo). Anakinra t Continue reading >>

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Popular Questions

  1. furball64801

    Actually my thin 85 lb aunts lived to 88 with being diabetic. Yes you can but I never knew what it ran, my mom also very thin and it was cancer that killed her she never ingested anything harmful unless ice tea is in that. I do get your thinking but its your life your numbers, to me its about preventing damage I am 68 as of last month, I dodged a lot of bullets and for me being in control is important got to see all the grand kids graduate and get marries then see great grand kits oh my I am getting old.

  2. jwags

    A non diabetic will usually have numbers under 100 most of the day. I have tested my nonndiabetic family members and they are always under 100 even after eating. As diabetic's we are asked to keep our bgs between 100-140 which is not easy for a lot of us. It is said that blood vessel damage starts when bgs go above 140.

  3. sangdoux

    At this point, I don't think it really matters if stress was a proximate cause of your autoimmune diabetes. Whatever initiated the process, nothing that I know of is going to reverse it. My speculation is that my autoimmune response went haywire after I had a bout with the flu. If that's the case, I didn't develop obvious symptoms until several years later. Once the process started, I don't I could have done anything to change the outcome, certainly not after I showed up at a GP's office with BG of 425, A1c of 11.2, and various obvious indications of blood sugar out of control. I was misdiagnosed as Type 2 (I was 60 years old). I started on Lantus a week after diagnosis and managed OK for 5 years. Once I was on Lantus, my BG stayed under 200 and, as I recall, my next A1c was under 6.5. It took me a few weeks to feel "normal" when my BG was, in fact, "normal," and I had some pain and numbness in my lower extremities (probably from nerve damage) that eventually went away.
    After five years, when I began to lose control with once daily shots of Lantus, I finally got a GAD-65 autoantibody test to prove to my GP that I was Type 1 (LADA). I was referred to an endo, who added MDI Humalog.
    In any event, if you are a LADA, you are going to have to use insulin. If your BG regularly stays above 200, you're much more likely to develop complications than if you have decent control. For some excellent advice on managing diabetes with insulin, check out Gary Scheiner's book "Think Like a Pancreas."

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