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Consequences Of Metabolic Acidosis

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Anion gap usmle - anion gap metabolic acidosis normal anion gap metabolic acidosis

Endocrine Consequences Of Metabolic Acidosis

Endocrine Consequences of Metabolic Acidosis Metabolic acidosis, particularly its chronic form, is a systemic process with systemic consequences that includes disturbances in the function of some endocrine systems. Such disturbances likely have short-term adverse consequences such as less sensitivity to the actions of hormones that might require higher hormone levels, e.g., insulin, to obtain needed hormonal effects. These disturbances might also have long-term consequences, however, like the association of decreased insulin sensitivity with increased cardiovascular mortality. For example, because some studies support that metabolic acidosis decreases insulin sensitivity, correction of chronic metabolic acidosis might improve insulin sensitivity and thereby possibly reduce cardiovascular mortality. These consequences point out the increasing need for clinicians to identify chronic metabolic acidosis and to treat it to confer the resulting benefits on patients supported by published studies. Regarding the latter, there are few published studies examining the benefit of correction of metabolic acidosis on endocrine systems, a deficit that must be corrected. Insulin sensitivityGrowth Continue reading >>

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Popular Questions

  1. Emacfarland

    I'm confused about what defines being in nutritional ketosis based on blood levels. The Diet Doctor website says 1.5 is considered ketosis while I've heard on Keto Talk from Doc Nally that fit and active people can be in ketosis at levels of .3 or .4 and that higher levels don't necessarily mean better. So I'm not sure what the heck I'm aiming for! If I get readings below 1.5 am I doing something wrong? I am fit and active and Doc Nally has said this can make blood ketone level readings lower because an active persons body is using the ketones more efficiently. Should I be aiming for higher levels?

  2. BillJay

    It seems that the longer someone is keto-adapted, the more their body produces just the right amount of ketones and what we measure in the blood is only what's not actually being used, therefore it seems not only possible, but likely that people are in ketosis even with lower betahydroxybutyrate (BHB) levels - the ketone in the blood that these meters measure.
    This is somewhat frustrating for me since I'd like for there to be an objective measurement of being in ketosis, but that seems to be elusive.
    Therefore, a better indication is your level of carbs since it is HIGHLY unlikely that anything over 50 carbs is in ketosis and more likely that keeping carbs under 20 grams is a safe bet. Another indication is keeping protein at moderate levels which is 1.0 to 1.5 grams per kilogram of lean body weight.
    Once the macro-nutrients are in the proper range, I think that signs of keto-adapation are more poignant and below is a post from Mark Sisson on Dr. Mercola's site that explains many of the signs of being keto-adapted.

    What Does It Mean to Be Fat Adapted?
    543

  3. richard

    Dr Phinney invented the term so he gets to define it.
    In his book "The art and science of low carbohydrate living" he gives the range from 0.5 to 3.0 mmol/l
    But recently he mentioned that some of Dr Volek's very athletic subjects were clearly in ketosis at 0.2 mmol/l.
    My personal range is from 0.2 to 0.8 mmol/l, and I have been in ketosis for almost 3 years. Prof Tim Noakes is also normally in the same range 0.2-0.8.
    I suspect when we first start we aren't good at using them so we make too many and use too little so we end up with a lot left in our blood. After we become better adapted we end up in whatever physiological range our bodys feel best ensures our survival. And people who are trained and good fat burners may be able to get away with less because they can make it easily.
    When I fast for 3 days and then do 3 hours of exercise my ketones can go as high as 3.5. But I know people who regularly get up to 7.
    It's worth pointing out that Dr Nally has mentioned in his most recent podcast that he eats exogenous ketones 3 times a day. And he sells them.

    Personally I wouldn't be worried. I think you are doing fine.

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Respiratory acidosis #sign and symptoms of Respiratory acidosis Respiratory acidosis ABGs Analyse https://youtu.be/L5MWy1iHacI Plz share n subscribe my chanel is a condition that occurs when the lungs cant remove enough of the Suctioning https://youtu.be/hMJGkxvXTW0 carbon dioxide (CO2) produced by the body. Excess CO2 causes the pH of blood and other bodily fluids to decrease, making them too acidic. Normally, the body is able to balance the ions that control acidity. This balance is measured on a pH scale from 0 to 14. Acidosis occurs when the pH of the blood falls below 7.35 (normal blood pH is between 7.35 and 7.45).Rinku Chaudhary NSG officer AMU ALIGARH https://www.facebook.com/rinkutch/ Respiratory acidosis is typically caused by an underlying disease or condition. This is also called respiratory failure or ventilatory failure. Suctioning https://youtu.be/hMJGkxvXTW0 Normally, the lungs take in oxygen and exhale CO2. Oxygen passes from the lungs into the blood. CO2 passes from the blood into the lungs. However, sometimes the lungs cant remove enough CO2. This may be due to a decrease in respiratory rate or decrease in air movement due to an underlying condition such as: asthma COPD pneumonia sleep apnea TYPES Forms of respiratory acidosis There are two forms of respiratory acidosis: acute and chronic. Acute respiratory acidosis occurs quickly. Its a medical emergency. Left untreated, symptoms will get progressively worse. It can become life-threatening. Chronic respiratory acidosis develops over time. It doesnt cause symptoms. Instead, the body adapts to the increased acidity. For example, the kidneys produce more bicarbonate to help maintain balance. Chronic respiratory acidosis may not cause symptoms. Developing another illness may cause chronic respiratory acidosis to worsen and become acute respiratory acidosis. SYMPTOMS Symptoms of respiratory acidosis Initial signs of acute respiratory acidosis include: headache anxiety blurred vision restlessness confusion Without treatment, other symptoms may occur. These include: https://www.healthline.com/health/res... sleepiness or fatigue lethargy delirium or confusion shortness of breath coma The chronic form of respiratory acidosis doesnt typically cause any noticeable symptoms. Signs are subtle and nonspecific and may include: memory loss sleep disturbances personality changes CAUSES Common causes of respiratory acidosis The lungs and the kidneys are the major organs that help regulate your bloods pH. The lungs remove acid by exhaling CO2, and the kidneys excrete acids through the urine. The kidneys also regulate your bloods concentration of bicarbonate (a base). Respiratory acidosis is usually caused by a lung disease or condition that affects normal breathing or impairs the lungs ability to remove CO2. Some common causes of the chronic form are: asthma chronic obstructive pulmonary disease (COPD) acute pulmonary edema severe obesity (which can interfere with expansion of the lungs) neuromuscular disorders (such as multiple sclerosis or muscular dystrophy) scoliosis Some common causes of the acute form are: lung disorders (COPD, emphysema, asthma, pneumonia) conditions that affect the rate of breathing muscle weakness that affects breathing or taking a deep breath obstructed airways (due to choking or other causes) sedative overdose cardiac arrest DIAGNOSIS How is respiratory acidosis diagnosed? The goal of diagnostic tests for respiratory acidosis is to look for any pH imbalance, to determine the severity of the imbalance, and to determine the condition causing the imbalance. Several tools can help doctors diagnose respiratory acidosis. Blood gas measurement Blood gas is a series of tests used to measure oxygen and CO2 in the blood. A healthcare provider will take a sample of blood from your artery. High levels of CO2 can indicate acidosis.

Metabolic Acidosis: Causes, Symptoms, And Treatment

The Terrible Effects of Acid Acid corrosion is a well-known fact. Acid rain can peel the paint off of a car. Acidifying ocean water bleaches and destroys coral reefs. Acid can burn a giant hole through metal. It can also burn holes, called cavities, into your teeth. I think I've made my point. Acid, regardless of where it's at, is going to hurt. And when your body is full of acid, then it's going to destroy your fragile, soft, internal organs even more quickly than it can destroy your bony teeth and chunks of thick metal. What Is Metabolic Acidosis? The condition that fills your body with proportionately too much acid is known as metabolic acidosis. Metabolic acidosis refers to a physiological state characterized by an increase in the amount of acid produced or ingested by the body, the decreased renal excretion of acid, or bicarbonate loss from the body. Metabolism is a word that refers to a set of biochemical processes within your body that produce energy and sustain life. If these processes go haywire, due to disease, then they can cause an excess production of hydrogen (H+) ions. These ions are acidic, and therefore the level of acidity in your body increases, leading to acidem Continue reading >>

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  1. Aaron1963

    Peter Attia on people who don't do well on a Ketogenic Diet

    I know there's a few people around here who don't do well on a ketogenic diet. I know for myself, who does extremely well with this way of eating, it's sometimes hard to understand why it doesn't work for everyone. And I think sometimes the people who it doesn't work well for get exasperated with all the talk of LCHF and ketogenic diets. Well, Peter Attia, who I have a lot of respect for, talks some in this podcast about how there are some people who just don't do well on a ketogenic diet. I don't know if it would be of any interest for those of you who have this problem or not:
    http://timferriss.libsyn.com/ep-65-s...dr-peter-attia
    He doesn't go into a lot of detail about it, but it's more that it's just interesting that there is a minority of people who do have this problem.

  2. furball64801

    Its amazing how all things do not work well for everyone. Ah the saying none of us is exactly alike. I did real well on a low carb diet when I was 25 only wanted to lose about 15 lbs then, was not diabetic had energy coming out my ears. Tried it 20 yrs later and did not change my numbers that much, yes better but not to normal. I hear from some weight falls right off them and numbers turn to normal, nice if you can get it maybe pancreas function should be measured who knows why or what causes this.

  3. Aaron1963

    Just to be clear, this wasn't in relation to diabetes, but people in general who want to go on a ketogenic diet but apparently have problems with eating all that fat.

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Block 2, Week 8, Faculty Objective 6

Physiological Effects Of Hyperchloraemia And Acidosis

Physiological effects of hyperchloraemia and acidosis Chelsea and Westminster NHS Foundation Trust Chelsea and Westminster NHS Foundation Trust BJA: British Journal of Anaesthesia, Volume 101, Issue 2, 1 August 2008, Pages 141150, J. M. Handy, N. Soni; Physiological effects of hyperchloraemia and acidosis, BJA: British Journal of Anaesthesia, Volume 101, Issue 2, 1 August 2008, Pages 141150, The advent of balanced solutions for i.v. fluid resuscitation and replacement is imminent and will affect any specialty involved in fluid management. Part of the background to their introduction has focused on the non-physiological nature of normal saline solution and the developing science about the potential problems of hyperchloraemic acidosis. This review assesses the physiological significance of hyperchloraemic acidosis and of acidosis in general. It aims to differentiate the effects of the causes of acidosis from the physiological consequences of acidosis. It is intended to provide an assessment of the importance of hyperchloraemic acidosis and thereby the likely benefits of balanced solutions. Hyperchloraemic acidosis is increasingly recognized as a clinical entity, a new enemy within, Continue reading >>

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  1. Johanna

    I have found various sources saying that ketones are acidic (pKa=20), and then relate it to the formation of the enolate ion. However, isn't an enolate ion of a ketone basic due to the oxygen's negative charge and all the pairs of electrons surrounding it?

  2. bon

    I think you need to recall the definition of an acid (in the Bronsted-Lowry scheme). An acid is a proton donor. A base is a proton acceptor. When a acid dissociates, it forms a hydrogen ion and the conjugate base of the acid. Remember, acid and base are only relative terms. The species which loses a proton in the reaction is acting as an acid and that which gains a proton is a base.
    In the example above, the ketone is acting as an acid because it donates a proton. The hydride anion is acting a base because it accepts a proton. The resulting enolate anion is stabilised by delocalisation of the negative charge onto the oxygen. In the reverse reaction, the enolate would act as a base, accepting a proton from hydrogen (this is unlikely to happen though because the hydrogen will be liberated as a gas).

  3. DraggyWolf

    It will shift the places of the double bond and one of the hydrogen atoms, which will end up in a compound with a double bond between two of the carbon atoms.
    That makes an enol which isn't as stable as a Ketone. The enol and Ketone are in a equilibrium which causes the enol to lose an hydrogen ion which then - the enol will become an enolate.

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