Can Sepsis Cause Metabolic Acidosis?

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Hypercapnia And Acidosis In Sepsis:a Double-edged Sword? | Anesthesiology | Asa Publications

The effects of hypercapnia in sepsis may be a function of the hypercapnia or the acidosis per se . As discussed, the effects of HCA on the immune response seem to be predominantly a function of the acidosis, rather than the hypercapnia per se , but the fact that the acidosis is hypercapnic rather than metabolic is of importance. The potential exists for hypercapnia to exert direct effects, independent of pH changes. A specific example is the binding of carbon dioxide to free amine groups on proteins to form carbamates, which can alter certain protein behavior or activity. The classic example is hemoglobin in which carbamino formation alters HbO2affinity. In addition, the potential for buffering of a HCA to modulate its effects in sepsis is also of importance. Buffered hypercapnia, that is, hypercapnia in the presence of normal pH, seems to worsen lung injury induced by intrapulmonary bacterial instillation. 36 To avoid the confounding effects of the administration of exogenous acid and/or alkali, animals were first exposed to environmental hypercapnia until renal buffering had restored pH to the normal range. These animals were then subjected to intrapulmonary inoculation of E. co Continue reading >>

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  1. twosix

    Where can I buy ketostix? Been to many pharmacies like Guardian and NTUC around city area and all of them do not carry it.

  2. Gustoftw

    I bought mine from NTUC unity bukit timah plaza

  3. twosix

    Gustoftw wrote:
    I bought mine from NTUC unity bukit timah plaza Thanks, but the location is far from my place.

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In this video we discuss the progression of a systemic infection including systemic inflammatory response syndrome, sepsis, severe sepsis, septic shock and multi organ dysfunction syndrome.

Physicochemical Characterization Of Metabolic Acidosis Induced By Normal Saline Resuscitation Of Patients With Severe Sepsis And Septic Shock

OBJECTIVE: The aim of this study was to characterize and quantify metabolic acidosis that was caused by initial volume expansion during the reanimation of patients with severe sepsis and septic shock. METHODS: A blood sample was drawn for physicochemical characterization of the patient's acid-base equilibrium both before and after volume expansion using 30 mL/kg 0.9% saline solution. The diagnosis and quantification of metabolic acidosis were based on the standard base excess (SBE). RESULTS: Eight patients with a mean age of 58 13 years and mean APACHE II scores of 20 4 were expanded using 2,000 370 mL of 0.9% saline solution. Blood pH dropped from 7.404 0.080 to 7.367 0.086 (p=0.018), and PCO2 increased from 30 5 to 32 2 mmHg (p=0.215); SBE dropped from -4.4 5.6 to -6.0 5.7 mEq/L (p=0.039). The drop in SBE was associated with the acidifying power of two factors, namely, a significant increase in the strong ion gap (SIG) from 6.1 3.4 to 7.7 4.0 mEq/L (p = 0.134) and a non-significant drop in the apparent inorganic strong ion differences (SIDai) from 40 5 to 38 4 mEq/L (p = 0.318). Conversely, the serum albumin levels decreased from 3.1 1.0 to 2.6 0.8 mEq/L (p = 0.003) with an alka Continue reading >>

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  1. inhopesoflosing10

    I woke up this morning feeling sweaty and I could have sworn I smelled cat pee.
    Feeling a bit frightened that perhaps my cat had left me a surprise in my bedroom, I sniffed around but the smell followed me everywhere. That's when I gave myself a good sniff and voila, discovered that the odor was coming from me.
    Yay, I am "smelly cat" from Friends.
    Anywho, I was wondering if this is a sign of ketosis. I have heard that sweat and urine take on a fruity acetone odor, but I have never heard anyone describe it as cat pee before. Just a bit curious.
    Also, how do you manage to not um, reek when around other people? Body sprays and such are an obvious solution, but the way I am sweating....probably have to spray myself with half the bottle to cover up my litter box scent.
    On a positive note, I am feeling better. Have more energy and was able to jog last night. Only issue I had with jogging was that my stomach began to cramp. I am thinking that is possibly from dehydration so I am going to push more water and see if maybe my potassium levels are off.
    Hope everyone is having a great weekend!

  2. inhopesoflosing10

    Okay, now my pee smells like buttered popcorn. Maybe my sweat smelled like cat pee this morning because I had coffee way early in the morning with my breakfast before taking a nap.
    Perhaps the coffee seeped out through my sweat while I slept?
    Just scared me a bit. I read that it could be a sign of muscle being used as fuel due to carb intake being too low. I am not measuring the net carbs with the subtraction of the fiber grams, but measuring the grams of carbs as grams of carbs.
    The last two days my total daily carb intake has been extremely low, like 4% or lower.
    Wondering if I am eating too much protein and too little fat?
    According to ******.com my percentages are as follows:
    fat 63%, carbs 4%, protein 31% and fiber 5.2 grams
    That seems okay.
    Just don't want to make myself sick or so something dangerous. To top it all off I discovered that the Atkins book I ordered was the wrong one....so I put an order in for the DANDR which I am hoping will arrive here soon.
    Thank you all for reading

  3. Prodigy

    Try drinking more water. 8-10 8oz glasses a day should be fine. When in ketosis your body has to eliminate the ketones from the fat and you will smell different than normal. Your breath will smell bad as well...I just chew sugar free gum and brush several times a day. Once you are sufficiently hydrated the odors will be a lot better. Pick up the original Atkins book. It actually explains a lot of the science of this.

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If you have a hard time feeling your pecs working when you bench press, THIS is for you. It's an excellent technique for forcing the pecs into a better position to contract when doing a bench press...and this will help you build a bigger chest faster! http://www.thebestchestexercises.com To use this technique, you'll need a bench and a single square Step riser/platform...(you'll likely have to raid the cardio section of your gym to find one of these). I got mine for dirt cheap at a garage sale and found it to be an extremely versatile piece of training equipment, beyond just doing stepping exercises. The elevation of the upper back forces the chest to expand due to the arch in the lower back. This helps get your shoulders back, which reduces their involvement in the press. (I also find that because my head is not pressing into the bench, the base of support is primarily the upper back, which tends to load the pecs a bit more effectively.) So essentially, instead of your chest being in a flat, pancake position (which can easily happen when pressing for more than 1 rep), your chest is puffed out and your pecs are in a MUCH better anatomical position to contract through the entire set

Hemodynamic Consequences Of Severe Lactic Acidosis In Shock States: From Bench To Bedside

Hemodynamic consequences of severe lactic acidosis in shock states: from bench to bedside Kimmoun et al.; licensee BioMed Central.2015 The Erratum to this article has been published in Critical Care 2017 21:40 Lactic acidosis is a very common biological issue for shock patients. Experimental data clearly demonstrate that metabolic acidosis, including lactic acidosis, participates in the reduction of cardiac contractility and in the vascular hyporesponsiveness to vasopressors through various mechanisms. However, the contributions of each mechanism responsible for these deleterious effects have not been fully determined and their respective consequences on organ failure are still poorly defined, particularly in humans. Despite some convincing experimental data, no clinical trial has established the level at which pH becomes deleterious for hemodynamics. Consequently, the essential treatment for lactic acidosis in shock patients is to correct the cause. It is unknown, however, whether symptomatic pH correction is beneficial in shock patients. The latest Surviving Sepsis Campaign guidelines recommend against the use of buffer therapy with pH 7.15 and issue no recommendation for pH lev Continue reading >>

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  1. Tresmemphis

    I have a question. Im having a difficult time consuming my 1080 calories a day. Im getting between 600-800. But they are in the percentage of 70-80 percent fat, 15 percent protein and 5 percent carb. My question is due to low calories can I get knocked out of ketosis?

  2. mummydee

    It is What you eat , not how much that puts you into ketosis. Your body will burn sugars first for energy and by removing all sugars in every form your body then moves into using fat for energy.
    If you are on Atkins induction you still must eat 20 net grams of carbs but only from veggies creams and cheeses.
    You will get knocked out of ketosis the moment you eat any sugars.
    If it is a plant, eat it, if it comes from a plant, don't!

  3. k9gold

    If your on induction and on Atkins 20 you should be eating 20 NC with 12-15 of them coming from foundation veggies. You should be having 4 to 6 oz of protein with each of the three meals. The cheese limit is 4oz a day and some people find to lose they need to consume less than 4oz. Calories for women are 1500-1800. The Atkins site has the list of foods for all phases. If you eat to little calories your body goes into starvation mode and holds on to everything. Hope this helps

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