diabetestalk.net

Can Metformin Cause A Heart Attack?

Your Early Response To Metformin May Predict Future Heart Disease Risk

Your Early Response To Metformin May Predict Future Heart Disease Risk

Researchers have linked a lower risk for cardiovascular events and death in type 2 diabetes patients if within 6 months of starting metformin a patient is able to lower their HbA1c by a large degree and reach a low A1c level. According to a Medwire News release, the study authors explained that lowering A1c levels to under 7 precent “has been a recommended target in treatment guidelines for more than a decade” for many type 2 diabetes patients. However, they added that, “it remains debated whether even tighter glucose control (such as HbA1c<6.5%) may be more beneficial or harmful.” Study Results Show Low A1c May Be Beneficial In the Danish study, researchers conducted a population-based cohort study which included 24,752 patients who had just started on metformin and had HbA1c tests in Northern Denmark between 2000 and 2012. The median age for the patients was 62.5 years of age and 55 percent were males. After 6 months of metformin, 11,849 patients reached an HbA1c level under 6.5 percent. The researchers found that 6,579 patients who had A1c levels between 6.5-6.99 percent had a 1.18-fold increased risk for heart attack, stroke, or death over a median follow-up of just 2.6 years. Researchers factored for demographics, baseline HbA1c, diabetic complications, and medication use. The risk increased with A1c levels. For the 3,035 patients with A1c levels of 7.0-7.49 percent, there was a 1.23-fold increased risk for adverse outcomes compared to those getting A1c levels under 6.5 percent. By the time A1c levels got to 8 percent and above there was a 1.59-fold increased risk. The researchers also saw a link between the magnitude of HbA1c change and outcome. Those patients with an A1c reduction of 4 percentage points had a 20 percent reduced risk for all the outcomes c Continue reading >>

Metformin Side Effects On The Heart

Metformin Side Effects On The Heart

Metformin, sold under the brand name Glucophage, is an anti-hyperglycemic medication used alone or in combination with other medication, such as insulin, to control blood glucose levels in those with Type 2 diabetes. It belongs in the biguanide class of medication. According to Drugs.com, metformin works by decreasing the amount of glucose obtained from food and glucose produced by the liver, lowering blood glucose levels. Video of the Day According to DiabetesNet.com, the chemical structure of metformin resembles that of the French lilac plant, which was used long ago to lower blood sugar but found to be too toxic. Metformin is shorter-acting than French lilac and can in rare cases produce the same toxic reaction, called lactic acidosis. Lactic acidosis--which can be fatal--is a condition in which there is too much lactate in the blood, which lowers the pH. It can occur when metformin levels build up and cannot be cleared from the body. Symptoms of lactic acidosis include slow heartbeat, or bradycardia, and low blood pressure, or hypoptension. Other symptoms include shallow breathing, diarrhea and extreme weakness and fatigue. Alcohol consumption and a reaction with the medication Tagamet can increase the chances for lactic acidosis to develop. Metformin should not be taken by those with congestive heart failure or heart disease. Chest pain is a rare but serious side effect of taking metformin, according to PubMed Health. Notify your physician immediately if you experience any chest pain while taking metformin. Metformin has been well studied in many clinical trials and found to be safe in most instances. The side effects reported by those taking metformin are compared against any side effects experienced by those taking a placebo. It has been determined that taking th Continue reading >>

Ten Myths About Metformin

Ten Myths About Metformin

Is metformin (Glucophage) bad for you? There is quite a bit of misinformation out there about this commonly used medication. Metformin therapy may cause diarrhea and lower vitamin B12 levels, but most things you hear about metformin aren’t true. Here are some common metformin myths. Metformin is bad for your kidneys. It’s not. What may be confusing folks here is that until 2016 patients with a creatinine level above 1.5 were advised not to take metformin. Metformin does not cause the kidney problems and in fact, 2016 labeling on Metformin was changed to indicate it should not be used only in those with late-stage chronic kidney disease stage IV or V. Metformin is bad for your liver. Truth is, it’s not. Metformin isn’t metabolized at all by the liver and instead is excreted unchanged in the urine. Metformin-induced liver injury is a rare, but possible adverse drug reaction that usually occurs at 4-8 weeks of therapy. Metformin is dangerous to take if you want to become pregnant. This is not true, and in fact may be the opposite. Metformin therapy during pregnancy in women with PCOS is associated with a reduction in miscarriage rate and gestational diabetes and did not adversely affect birth weight or development at 3 and 6 months of life. Metformin causes dementia. No. In fact a recent study of 17,000 diabetic vets found that taking metformin was associated with a lower risk of dementia than sulfonylureas like glyburide or glipizide. Other studies have shown metformin use to be associated with reduced rates of dementia and improved cognitive function. Metformin is bad for your heart. This is one I hear quite a bit from patients and it’s not true. Metformin has been suggested to exhibit cardioprotective effects in the setting of a heart attack. Metformin therapy Continue reading >>

Metformin For Protection Against Alzheimer's, Cancer And Heart Disease?

Metformin For Protection Against Alzheimer's, Cancer And Heart Disease?

With commentary by Nir Barzilai, MD, director of the Institute for Aging Research, Albert Einstein College of Medicine, and Brian Kennedy, PhD, president and CEO of the Buck Institute for Research on Aging. Metformin may influence fundamental aging factors that underlie many age-related conditions, including cancer, heart disease and Alzheimer's, says Nir Barzilai, MD, director of the Institute for Aging Research at Albert Einstein College of Medicine, the Bronx. "Metformin is generic, and it's cheap," Dr. Barzilai says. And accumulating data suggests that ''it interferes with the biology of aging." Aging, he says, is a primary risk factor for not only diabetes but also most of our big killers, such as Alzheimer's, heart disease and cancer. In animal and human studies, metformin has shown promise in slowing the aging process and halting diseases. To study the potential of metformin further, Dr. Barzilai plans to launch a large-scale study, Targeting Aging with METformin (TAME), to look at the effects of metformin compared to placebo. His team has already completed the MILES study, Metformin in Longevity, and are analyzing the results. In that study, they gave some participants metformin, at 1,700 milligrams a day, and others placebo. The aim was to see if the metformin could restore the gene expression profile of an older person with blood sugar problems known as impaired glucose tolerance (but not yet diabetic), to that of a younger person. Dr. Barzilai knows he has critics of his approach. He brushed them off, saying the people who don't see the value of the research ''don't understand the biology of aging and that it can be changed." He doesn't see the research as testing an anti-aging drug. "Aging is not a disease and we don't want it to be a disease," he says. Howe Continue reading >>

The Best (and Worst) Diabetes Drugs—for Your Heart

The Best (and Worst) Diabetes Drugs—for Your Heart

Heart disease is the number-one killer of people with type 2 diabetes, so you would think drugs that help control diabetes would be good for the heart. But the opposite is sometimes true—some commonly prescribed diabetes drugs actually increase your risk for heart disease. There are many ways this can happen, explains Debabrata Mukherjee, MD, chief of cardiovascular medicine at Texas Tech University Health Sciences Center El Paso. “Sometimes they can cause hypoglycemia—low blood sugar—which can reduce the amount of nutrients going to the heart. Sometimes they raise bad lipids and lower good cholesterol, or increase water retention [which raises blood pressure]or reduce the ability of the coronary arteries to dilate properly. And some, we don’t understand why they raise the risk for heart disease.” How could these drugs be developed by the pharmaceutical industry and be approved by the Food and Drug Administration (FDA) yet make people with diabetes more likely to develop heart disease? Read on to find out how we got into this mess—and learn which diabetes drugs actually protect your heart. RESEARCHING DRUGS…WITH BLINDERS ON Until 2008, clinical studies needed to get diabetes drugs approved by the FDA didn’t have to even look at cardiovascular effects. They just had to show that the drugs lowered blood sugar (glucose). That’s a crucial omission, since the risk for stroke, heart disease and death from heart disease in patients with diabetes is at least twice that of patients without diabetes. So that year, the FDA made it clear to drug manufacturers that it wanted to see new drugs for type 2 diabetes undergo clinical trials to demonstrate cardiovascular safety—in addition to blood glucose effects. Now we’re seeing the results of these studies. One Continue reading >>

Metformin (glucophage) Side Effects & Complications

Metformin (glucophage) Side Effects & Complications

The fascinating compound called metformin was discovered nearly a century ago. Scientists realized that it could lower blood sugar in an animal model (rabbits) as early as 1929, but it wasn’t until the late 1950s that a French researcher came up with the name Glucophage (roughly translated as glucose eater). The FDA gave metformin (Glucophage) the green light for the treatment of type 2 diabetes in 1994, 36 years after it had been approved for this use in Britain. Uses of Generic Metformin: Glucophage lost its patent protection in the U.S. in 2002 and now most prescriptions are filled with generic metformin. This drug is recognized as a first line treatment to control blood sugar by improving the cells’ response to insulin and reducing the amount of sugar that the liver makes. Unlike some other oral diabetes drugs, it doesn’t lead to weight gain and may even help people get their weight under control. Starting early in 2000, sales of metformin (Glucophage) were challenged by a new class of diabetes drugs. First Avandia and then Actos challenged metformin for leadership in diabetes treatment. Avandia later lost its luster because it was linked to heart attacks and strokes. Sales of this drug are now miniscule because of tight FDA regulations. Actos is coming under increasing scrutiny as well. The drug has been banned in France and Germany because of a link to bladder cancer. The FDA has also required Actos to carry its strictest black box warning about an increased risk of congestive heart failure brought on by the drug. Newer diabetes drugs like liraglutide (Victoza), saxagliptin (Onglyza) and sitagliptin (Januvia) have become very successful. But metformin remains a mainstay of diabetes treatment. It is prescribed on its own or sometimes combined with the newer d Continue reading >>

Metformin And Heart Failure

Metformin And Heart Failure

Innocent until proven guilty Throughout the world and for many years, metformin has been a mainstay of therapy for patients with type 2 diabetes. This highly effective and usually well-tolerated oral agent is, to date, the only one demonstrated to reduce cardiovascular disease (CVD) complications in newly diagnosed type 2 diabetic patients (1). It's precise mechanism of action remains enigmatic, although it clearly results in a reduction of endogenous glucose production, primarily hepatic gluconeogenesis, most likely involving the stimulation of AMP-activated protein kinase activity (2). A peripheral insulin-sensitizing effect in skeletal muscle has also been demonstrated by some, but not all, investigators (3). In small studies, metformin appears to exert benefit on various other fundamental biological processes that influence atherogenesis, such as lipid metabolism, inflammation, and vascular endothelial function (4). Another insulin sensitizer category, the thiazolidinediones (TZDs), has also been proposed to reduce CVD risk, but that class carries with it concerns of weight gain and fluid retention. As a result, TZDs remain more popular in combination therapy regimens. Perhaps of greatest import to clinicians is the recognition that metformin is the only oral antidiabetic agent associated with weight loss. Accordingly, metformin remains, in the eyes of many authorities, the optimal initial drug choice in most type 2 diabetic patients if diet and exercise have not succeeded in adequately reducing blood glucose levels (5). Approval of metformin in the U.S. was delayed because of previous experience with phenformin, which was associated with lactic acidosis. Although the risk of such metabolic decompensation with metformin was known to be significantly lower than with Continue reading >>

Does Metformin Cause Heart Attacks 620098 Jim Shaw

Does Metformin Cause Heart Attacks 620098 Jim Shaw

Diabetes drug metformin could cause heart and Mail Online A drug widely prescribed to those with diabetes could cause thyroid, heart and a host of other health problems, a study has warned. Metformin is commonly used to Does Metformin cause Heart Attack? Treato Can Metformin cause Heart Attack? Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. Diabetes, Metformin And Heart Attacks Metformin Side Effects How Does Heart Attack Survivors Respond to Taking Metformin? a group of researchers aimed to discover how heart attack survivors that were diagnosed with diabetes Metformin Affects Hearts of Men and Women Differently The buy cialis oral diabetes medicine metformin affects the hearts of men and women differently, disease is the leading cause of heart. But in women, metformin had Metformin Side Effects on the Heart | LIVESTRONG.COM Metformin Side Effects on the Heart. Metformin should not be taken by those with congestive heart failure or heart disease. for metformin to cause heart Metformin and Heart Failure | Diabetes Care Metformin and Heart Failure If a benefit from metformin therapy in heart failure does NIDDM and its metabolic control predict coronary heart disease in Metformin Linked To Heart Failure In Men Real Diabetes Metformin Linked To Heart Failure In Men. leading to harmful changes that could cause heart while slashing their risks of cancer and heart disease at the Will you have cialis over the counter Heart attack with Metformin from FDA reports Could Metformin cause Heart attack? We studied 199,020 Metformin users who have side effects from FDA and eHealthme. Among them, 4,773 have Heart attack. See what we Diabetes Drug Metformin May Lower Risk of Heart Attacks and Metformin, which is a popular d Continue reading >>

Side Effects Of Metformin: What You Should Know

Side Effects Of Metformin: What You Should Know

Metformin is a prescription drug used to treat type 2 diabetes. It belongs to a class of medications called biguanides. People with type 2 diabetes have blood sugar (glucose) levels that rise higher than normal. Metformin doesn’t cure diabetes. Instead, it helps lower your blood sugar levels to a safe range. Metformin needs to be taken long-term. This may make you wonder what side effects it can cause. Metformin can cause mild and serious side effects, which are the same in men and women. Here’s what you need to know about these side effects and when you should call your doctor. Find out: Can metformin be used to treat type 1 diabetes? » Metformin causes some common side effects. These can occur when you first start taking metformin, but usually go away over time. Tell your doctor if any of these symptoms are severe or cause a problem for you. The more common side effects of metformin include: heartburn stomach pain nausea or vomiting bloating gas diarrhea constipation weight loss headache unpleasant metallic taste in mouth Lactic acidosis The most serious side effect metformin can cause is lactic acidosis. In fact, metformin has a boxed warning about this risk. A boxed warning is the most severe warning from the Food and Drug Administration (FDA). Lactic acidosis is a rare but serious problem that can occur due to a buildup of metformin in your body. It’s a medical emergency that must be treated right away in the hospital. See Precautions for factors that raise your risk of lactic acidosis. Call your doctor right away if you have any of the following symptoms of lactic acidosis. If you have trouble breathing, call 911 right away or go to the nearest emergency room. extreme tiredness weakness decreased appetite nausea vomiting trouble breathing dizziness lighthea Continue reading >>

Can A Common Diabetes Drug Help Heart Attack Recovery?

Can A Common Diabetes Drug Help Heart Attack Recovery?

Better understanding of drug’s mechanism of action can lead the way to new treatment options for heart disease in diabetes patients. Heart disease accounts for more than half of all fatalities in patients with diabetes. The diabetes drug metformin is used by patients with diabetes to help prevent heart disease; however, not all patients can take metformin. New research recently explored for the first time the mechanism by which metformin helps prevent heart disease. By better understanding the mechanism of action, the hope is that it will pave the way for new drugs. The researchers, from Newcastle University, Queen Elizabeth Hospital, Saudi Arabia, constructed a model that allowed them to simulate a heart attack in the lab, using stem cells from cord blood and cells from umbilical. They found new blood vessel formation, which is essential for heart attack recovery, and established metformin enhances the physiological process through which new blood vessels form. Their finding is that during a heart attack in patients with diabetes, there is a lack of oxygen in the presence of high glucose levels, which delays blood vessel formation. Metformin seems to reverse that process, while also affecting multiple genes, which help to promote the growth of new blood vessels. Dr. Jolanta Weaver, Senior Lecturer in Diabetes Medicine at Newcastle University, who led the study, said: “The outcome of heart disease interventions in patients with diabetes is much worse in comparison with non-diabetic individuals. As a result, there is a demand for improved treatment approaches to enhance the outcomes of those with diabetes in order to increase heart attack survival rates. “Our research is exciting as it can instantly make a difference to the treatments we are exploring, offering a n Continue reading >>

Glyburide And Metformin (oral Route)

Glyburide And Metformin (oral Route)

Glyburide and metformin combination is used to treat high blood sugar levels caused by a type of diabetes mellitus (sugar diabetes) called type 2 diabetes. Normally, after you eat, your pancreas releases insulin to help your body store excess sugar for later use. This process occurs during normal digestion of food. In type 2 diabetes, your body does not work properly to store excess sugar and the sugar remains in your bloodstream. Chronic high blood sugar can lead to serious health problems in the future. Proper diet is the first step in managing type 2 diabetes, but often medicines are needed to help your body. With two actions, the combination of glyburide and metformin helps your body cope with high blood sugar. Glyburide causes your pancreas to release more insulin into the bloodstream. Metformin reduces the absorption of sugar, reduces the release of stored sugar from the liver, and helps your body's cells use sugar better. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Appropriate studies have not been performed on the relationship of age to the effects of glyburide and metformin combination in the pediatric population. Safety and efficacy have not been establi Continue reading >>

Deterring Heart Disease If You Have Diabetes

Deterring Heart Disease If You Have Diabetes

Deterring heart disease if you have diabetes Lifestyle changes are vital, but new medications may help. a_namenko; Halfpoint | Thinkstock; zaretskaya | GettyImages Two of the most prevalent health problems in this country type 2 diabetes and heart disease are closely linked. People with diabetes are more than twice as likely to die from heart disease than those without diabetes. An array of overlapping risk factors (such as being overweight and having high blood pressure and cholesterol levels) probably explains part of this association. On the plus side, a diet that emphasizes vegetables, fruits, whole grains, lean protein, and healthy fats, coupled with regular moderate exercise (at least 30 minutes daily, most days of the week) can help people dodge the dangers associated with both heart disease and type 2 diabetes. Even so, most people with type 2 diabetes must also take the drug metformin (or other medications) to help reduce their high blood sugar levels, the hallmark of the disease. For those who take metformin but still struggle to keep their blood sugar under control, doctors typically prescribe an additional drug. Two newer drugs, empagliflozin (Jardiance) and liraglutide (Victoza), have been shown to lower the risk of dying of cardiovascular disease and reduce blood sugar levels in high-risk diabetes patients. "These are promising drugs that may be good choices for people with diabetes at high risk of heart disease," says Dr. Joanna Mitri, a physician at Harvard-affiliated Joslin Diabetes Center. However, the new drugs are very expensive, costing hundreds of dollars per month, she notes. A number of older, less expensive generic drugs are still viable options to help people manage their diabetes. In addition, it's not known whether the new drugs offer heart Continue reading >>

Diabetes News: This Drug Could Reduce Risk Of Heart Attack In Type 1 Sufferers

Diabetes News: This Drug Could Reduce Risk Of Heart Attack In Type 1 Sufferers

Type 1 diabetes accounts for about ten per cent of adults with the condition, according to Diabetes UK. Unlike type 2 diabetes, people with type 1 tend to be born with the inability to produce insulin, meaning that glucose cannot be moved from the bloodstream into cells. It comes with a higher risk of heart disease. Indeed, heart attacks and other cardiovascular problems cause the death of three in four people with type 1 diabetes. The University of Glasgow has discovered that a first-line treatment for type 2 diabetes may also help reduce heart problems in type 1 diabetes sufferers. This is compared to one in four of the overall population for the same issues. However, a cheap and versatile drug could reduce this risk. The University of Glasgow has discovered that a first-line treatment for type 2 diabetes may also help reduce heart problems in type 1 diabetes sufferers. They discovered that the drug - metformin - has a positive effect on cardiovascular and metabolic outcomes. 10 foods to prevent heart disease Mon, August 15, 2016 Here are out top 10 foods to prevent heart disease. It’s already given to type 1 diabetes sufferers to reduce insulin requirement and stabilise weight. However, its effects on the heart and blood vessels has so far been unknown. Prof John Petrie, lead study author from the University of Glasgow’s Institute of Cardiovascular and Medical Sciences, said: “The results from this trial are significant because currently cardiovascular disease is a major cause of reduced life expectancy in type 1 diabetes, and cardiovascular disease rates are more than double those of the background population. “Type 1 diabetes is not caused by lifestyle issues. Insulin therapy is required to control glucose and reduce complications but can cause weight gain Continue reading >>

Metformin And The Risk Of Heart Disease

Metformin And The Risk Of Heart Disease

One of the drugs used to treat type 2 diabetes is metformin. Metformin has been around for almost 50 years. In the last two decades a lot of data has been published about metformin and its role in inducing weight loss and lowering the risk of heart disease. The drug is readily available and is relatively cheap. As an oral hypoglycemic agent, it is very effective for type 2 diabetes. However, its ability to reduce the risk of heart disease is now been refuted. Researchers from France working at the Clinical Investigator Center in Lyon looked at several large studies of metformin and its effect on the heart. What the researchers found was that metformin did not lower the risk of heart disease, as had been previously reported. (1) This is a very surprising finding because metformin has been considered to be the first line drug for diabetes for more than a decade. The initial work from the UK Prospective Diabetes Study published in 1988 showed a significant reduction in mortality in obese patients with diabetes when treated with metformin. Most physicians adopted the findings from this this study and started to prescribe metformin for their patients. (2) Another surprising finding from the French analysis was that in non-obese patients with diabetes, metformin may actually increase the risk of death. However, some researchers from the United States have criticized this study because the researchers only looked at studies which had followed metformin use for a short time period. The French investigators only looked at four studies which followed patients for more three years. On the other hand, the UK study had followed patients over a period of more than 12 years. In any case, the short term analysis by the French investigators still showed that metformin did not lower the Continue reading >>

Metformin, Oral Tablet

Metformin, Oral Tablet

Metformin oral tablet is available as both a generic and brand-name drug. Brand names: Glucophage, Glucophage XR, Fortamet, and Glumetza. Metformin is also available as an oral solution but only in the brand-name drug Riomet. Metformin is used to treat high blood sugar levels caused by type 2 diabetes. FDA warning: Lactic acidosis warning This drug has a Black Box Warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to potentially dangerous effects. Lactic acidosis is a rare but serious side effect of this drug. In this condition, lactic acid builds up in your blood. This is a medical emergency that requires treatment in the hospital. Lactic acidosis is fatal in about half of people who develop it. You should stop taking this drug and call your doctor right away or go to the emergency room if you have signs of lactic acidosis. Symptoms include tiredness, weakness, unusual muscle pain, trouble breathing, unusual sleepiness, stomach pains, nausea (or vomiting), dizziness (or lightheadedness), and slow or irregular heart rate. Alcohol use warning: You shouldn’t drink alcohol while taking this drug. Alcohol can affect your blood sugar levels unpredictably and increase your risk of lactic acidosis. Kidney problems warning: If you have moderate to severe kidney problems, you have a higher risk of lactic acidosis. You shouldn’t take this drug. Liver problems warning: Liver disease is a risk factor for lactic acidosis. You shouldn’t take this drug if you have liver problems. Metformin oral tablet is a prescription drug that’s available as the brand name drugs Glucophage, Glucophage XR, Fortamet, and Glumetza. Glucophage is an immediate-release tablet. All of the other brands are extended-r Continue reading >>

More in ketosis