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Can Metformin Cause A Heart Attack?

Your Early Response To Metformin May Predict Future Heart Disease Risk

Your Early Response To Metformin May Predict Future Heart Disease Risk

Researchers have linked a lower risk for cardiovascular events and death in type 2 diabetes patients if within 6 months of starting metformin a patient is able to lower their HbA1c by a large degree and reach a low A1c level. According to a Medwire News release, the study authors explained that lowering A1c levels to under 7 precent “has been a recommended target in treatment guidelines for more than a decade” for many type 2 diabetes patients. However, they added that, “it remains debated whether even tighter glucose control (such as HbA1c<6.5%) may be more beneficial or harmful.” Study Results Show Low A1c May Be Beneficial In the Danish study, researchers conducted a population-based cohort study which included 24,752 patients who had just started on metformin and had HbA1c tests in Northern Denmark between 2000 and 2012. The median age for the patients was 62.5 years of age and 55 percent were males. After 6 months of metformin, 11,849 patients reached an HbA1c level under 6.5 percent. The researchers found that 6,579 patients who had A1c levels between 6.5-6.99 percent had a 1.18-fold increased risk for heart attack, stroke, or death over a median follow-up of just 2.6 years. Researchers factored for demographics, baseline HbA1c, diabetic complications, and medication use. The risk increased with A1c levels. For the 3,035 patients with A1c levels of 7.0-7.49 percent, there was a 1.23-fold increased risk for adverse outcomes compared to those getting A1c levels under 6.5 percent. By the time A1c levels got to 8 percent and above there was a 1.59-fold increased risk. The researchers also saw a link between the magnitude of HbA1c change and outcome. Those patients with an A1c reduction of 4 percentage points had a 20 percent reduced risk for all the outcomes c Continue reading >>

Common Diabetes Drugs Associated With Increased Risk Of Death

Common Diabetes Drugs Associated With Increased Risk Of Death

Follow all of ScienceDaily's latest research news and top science headlines ! Common diabetes drugs associated with increased risk of death Compared to another popular drug, three widely used diabetes medications are associated with a greater risk of death, a large new analysis finds. Compared to another popular drug, three widely used diabetes medications are associated with a greater risk of death, a large new analysis finds. The results were presented June 25 at The Endocrine Society's 94th Annual Meeting in Houston. The drugs, glipizide, glyburide, and glimepiride, are known as sulfonylureas, which help decrease blood-sugar levels among type 2 diabetes patients by stimulating the pancreas to produce insulin. In the past, these medications were considered comparable to one another in terms of effectiveness and safety. Recently, however, research has shown some sulfonylureas may be safer than others. These findings led to this latest research, which compared them to another type of blood-sugar-reducing drug known as metformin. All four medications are available under low-cost, generic labels. "We have clearly demonstrated that metformin is associated with a substantial reduction in mortality risk, and, thus, should be the preferred first-line agent, if one has a choice between metformin and a sulfonylurea," said study lead author Kevin M. Pantalone, D.O., an endocrinologist at Summa Western Reserve Hospital in Cuyahoga Falls, OH, who conducted this study in conjunction with a team of researchers from Cleveland Clinic in Cleveland, OH. In the United States, nearly 26 million people, or 8 percent of the population, have diabetes, according to the Centers for Disease Control and Prevention. Many of these patients also have other underlying medical conditions, including Continue reading >>

Glyburide And Metformin (oral Route)

Glyburide And Metformin (oral Route)

Glyburide and metformin combination is used to treat high blood sugar levels caused by a type of diabetes mellitus (sugar diabetes) called type 2 diabetes. Normally, after you eat, your pancreas releases insulin to help your body store excess sugar for later use. This process occurs during normal digestion of food. In type 2 diabetes, your body does not work properly to store excess sugar and the sugar remains in your bloodstream. Chronic high blood sugar can lead to serious health problems in the future. Proper diet is the first step in managing type 2 diabetes, but often medicines are needed to help your body. With two actions, the combination of glyburide and metformin helps your body cope with high blood sugar. Glyburide causes your pancreas to release more insulin into the bloodstream. Metformin reduces the absorption of sugar, reduces the release of stored sugar from the liver, and helps your body's cells use sugar better. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Appropriate studies have not been performed on the relationship of age to the effects of glyburide and metformin combination in the pediatric population. Safety and efficacy have not been establi Continue reading >>

Metformin - Oral, Glucophage

Metformin - Oral, Glucophage

are allergic to dapagliflozin or any of the ingredients in FARXIGA. Symptoms of a serious allergic reaction may include skin rash, raised red patches on your skin (hives), swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing. If you have any of these symptoms, stop taking FARXIGA and contact your healthcare provider or go to the nearest hospital emergency room right away have severe kidney problems or are on dialysis. Your healthcare provider should do blood tests to check how well your kidneys are working before and during your treatment with FARXIGA Dehydration (the loss of body water and salt), which may cause you to feel dizzy, faint, lightheaded, or weak, especially when you stand up (orthostatic hypotension). You may be at a higher risk of dehydration if you have low blood pressure; take medicines to lower your blood pressure, including water pills (diuretics); are 65 years of age or older; are on a low salt diet, or have kidney problems Ketoacidosis occurred in people with type 1 and type 2 diabetes during treatment with FARXIGA. Ketoacidosis is a serious condition which may require hospitalization and may lead to death. Symptoms may include nausea, tiredness, vomiting, trouble breathing, and abdominal pain. If you get any of these symptoms, stop taking FARXIGA and call your healthcare provider right away. If possible, check for ketones in your urine or blood, even if your blood sugar is less than 250 mg/dL Kidney problems. Sudden kidney injury occurred in people taking FARXIGA. Talk to your doctor right away if you reduce the amount you eat or drink, or if you lose liquids; for example, from vomiting, diarrhea, or excessive heat exposure Serious urinary tract infections (UTI), some that lead to hospitalization, occu Continue reading >>

Wrongfully Accused: Metformin Use In Heart Failure

Wrongfully Accused: Metformin Use In Heart Failure

Expert Rev Cardiovasc Ther.2011;9(2):147-150. Metformin has long been the cornerstone of therapy for glycemic control in patients with Type 2 diabetes worldwide. It is recommended as first-line therapy by all major diabetes clinical practice guidelines owing to its efficacy, favorable tolerability profile and beneficial effects in limiting weight gain. Moreover, metformin is the only oral anthyperglycemic agent shown in randomized controlled trials to reduce mortality in newly diagnosed patients with Type 2 diabetes. However, the use of metformin has not been without controversy, in particular in patients with heart failure. This article will review a recent observational study by Aguilar et al. published in Circulation Heart Failure that reported improved outcomes associated with metformin therapy in patients with diabetes and heart failure. Heart failure is a very common comorbidity present in 2540% of all adults with diabetes.[ 1 ] Diabetes also portends poorer outcomes in patients with heart failure and hyperglycemia is associated with increased risk of hospital admission.[ 2 ] Historically, the use of metformin in patients with comorbid heart failure was considered 'absolutely' contraindicated owing to the perceived increased risk of lactic acidosis. Recently, regulatory bodies in both Canada (Health Canada) and the USA (US FDA) have removed the heart failure contraindication from product labeling for metformin, although a 'black box' warning for the cautious use of metformin in this population still exists. How best to control blood glucose in patients with diabetes and heart failure still remains controversial owing to the lack of randomized controlled trial evidence. Indeed, except for one small randomized controlled trial (n = 222),[ 3 ] patients with heart fa Continue reading >>

Diabetes News: This Drug Could Reduce Risk Of Heart Attack In Type 1 Sufferers

Diabetes News: This Drug Could Reduce Risk Of Heart Attack In Type 1 Sufferers

Type 1 diabetes accounts for about ten per cent of adults with the condition, according to Diabetes UK. Unlike type 2 diabetes, people with type 1 tend to be born with the inability to produce insulin, meaning that glucose cannot be moved from the bloodstream into cells. It comes with a higher risk of heart disease. Indeed, heart attacks and other cardiovascular problems cause the death of three in four people with type 1 diabetes. The University of Glasgow has discovered that a first-line treatment for type 2 diabetes may also help reduce heart problems in type 1 diabetes sufferers. This is compared to one in four of the overall population for the same issues. However, a cheap and versatile drug could reduce this risk. The University of Glasgow has discovered that a first-line treatment for type 2 diabetes may also help reduce heart problems in type 1 diabetes sufferers. They discovered that the drug - metformin - has a positive effect on cardiovascular and metabolic outcomes. 10 foods to prevent heart disease Mon, August 15, 2016 Here are out top 10 foods to prevent heart disease. It’s already given to type 1 diabetes sufferers to reduce insulin requirement and stabilise weight. However, its effects on the heart and blood vessels has so far been unknown. Prof John Petrie, lead study author from the University of Glasgow’s Institute of Cardiovascular and Medical Sciences, said: “The results from this trial are significant because currently cardiovascular disease is a major cause of reduced life expectancy in type 1 diabetes, and cardiovascular disease rates are more than double those of the background population. “Type 1 diabetes is not caused by lifestyle issues. Insulin therapy is required to control glucose and reduce complications but can cause weight gain Continue reading >>

Does Metformin Cause Heart Attacks 620098 Jim Shaw

Does Metformin Cause Heart Attacks 620098 Jim Shaw

Diabetes drug metformin could cause heart and Mail Online A drug widely prescribed to those with diabetes could cause thyroid, heart and a host of other health problems, a study has warned. Metformin is commonly used to Does Metformin cause Heart Attack? Treato Can Metformin cause Heart Attack? Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. Diabetes, Metformin And Heart Attacks Metformin Side Effects How Does Heart Attack Survivors Respond to Taking Metformin? a group of researchers aimed to discover how heart attack survivors that were diagnosed with diabetes Metformin Affects Hearts of Men and Women Differently The buy cialis oral diabetes medicine metformin affects the hearts of men and women differently, disease is the leading cause of heart. But in women, metformin had Metformin Side Effects on the Heart | LIVESTRONG.COM Metformin Side Effects on the Heart. Metformin should not be taken by those with congestive heart failure or heart disease. for metformin to cause heart Metformin and Heart Failure | Diabetes Care Metformin and Heart Failure If a benefit from metformin therapy in heart failure does NIDDM and its metabolic control predict coronary heart disease in Metformin Linked To Heart Failure In Men Real Diabetes Metformin Linked To Heart Failure In Men. leading to harmful changes that could cause heart while slashing their risks of cancer and heart disease at the Will you have cialis over the counter Heart attack with Metformin from FDA reports Could Metformin cause Heart attack? We studied 199,020 Metformin users who have side effects from FDA and eHealthme. Among them, 4,773 have Heart attack. See what we Diabetes Drug Metformin May Lower Risk of Heart Attacks and Metformin, which is a popular d Continue reading >>

Diabetes Drug, Metformin, Lowers Risk Of Heart Disease Deaths Better Than Sulfonylureas, New Analysis Shows

Diabetes Drug, Metformin, Lowers Risk Of Heart Disease Deaths Better Than Sulfonylureas, New Analysis Shows

Study confirms metformin should be first-line therapy for treatment of #diabetes.- Click to Tweet #Diabetes drug metformin found more effective at lowering risk of heart disease deaths than sulfonylureas.- Click to Tweet Metformin outperforms other #diabetes drugs; doesn’t cause weight gain like other drugs, study confirms. - Click to Tweet A new analysis of 204 studies involving more than 1.4 million people suggests that metformin, the most frequently prescribed stand-alone drug for type 2 diabetes, reduces the relative risk of a patient dying from heart disease by about 30 to 40 percent compared to its closest competitor drug, sulfonylurea. The study, designed to assess the comparative — not absolute or individual — benefits and risks of more than a dozen FDA-approved drugs for lowering blood sugar in type 2 diabetes, is described in the April 19 issue of the Annals of Internal Medicine. Diabetes now affects almost 10 percent of the U.S. population and poses a growing public health threat, and most people will eventually need drug treatment, the researchers say. “Metformin looks like a clear winner,” says Nisa Maruthur, M.D., M.H.S., assistant professor of medicine at the Johns Hopkins University School of Medicine. “This is likely the biggest bit of evidence to guide treatment of type 2 diabetes for the next two to three years.” Maruthur, the lead author on the meta-analysis, notes that cardiovascular fatalities — heart attacks and strokes — are major risks for people with uncontrolled blood sugar, but it has never been clear if one diabetes drug is better than another at lowering these fatalities. Other diabetes-related complications include blindness, kidney failure and limb amputations. This review, Maruthur says, provides a much-needed update to Continue reading >>

Metformin And Heart Failure

Metformin And Heart Failure

Innocent until proven guilty Throughout the world and for many years, metformin has been a mainstay of therapy for patients with type 2 diabetes. This highly effective and usually well-tolerated oral agent is, to date, the only one demonstrated to reduce cardiovascular disease (CVD) complications in newly diagnosed type 2 diabetic patients (1). It's precise mechanism of action remains enigmatic, although it clearly results in a reduction of endogenous glucose production, primarily hepatic gluconeogenesis, most likely involving the stimulation of AMP-activated protein kinase activity (2). A peripheral insulin-sensitizing effect in skeletal muscle has also been demonstrated by some, but not all, investigators (3). In small studies, metformin appears to exert benefit on various other fundamental biological processes that influence atherogenesis, such as lipid metabolism, inflammation, and vascular endothelial function (4). Another insulin sensitizer category, the thiazolidinediones (TZDs), has also been proposed to reduce CVD risk, but that class carries with it concerns of weight gain and fluid retention. As a result, TZDs remain more popular in combination therapy regimens. Perhaps of greatest import to clinicians is the recognition that metformin is the only oral antidiabetic agent associated with weight loss. Accordingly, metformin remains, in the eyes of many authorities, the optimal initial drug choice in most type 2 diabetic patients if diet and exercise have not succeeded in adequately reducing blood glucose levels (5). Approval of metformin in the U.S. was delayed because of previous experience with phenformin, which was associated with lactic acidosis. Although the risk of such metabolic decompensation with metformin was known to be significantly lower than with Continue reading >>

Ten Myths About Metformin

Ten Myths About Metformin

Is metformin (Glucophage) bad for you? There is quite a bit of misinformation out there about this commonly used medication. Metformin therapy may cause diarrhea and lower vitamin B12 levels, but most things you hear about metformin aren’t true. Here are some common metformin myths. Metformin is bad for your kidneys. It’s not. What may be confusing folks here is that until 2016 patients with a creatinine level above 1.5 were advised not to take metformin. Metformin does not cause the kidney problems and in fact, 2016 labeling on Metformin was changed to indicate it should not be used only in those with late-stage chronic kidney disease stage IV or V. Metformin is bad for your liver. Truth is, it’s not. Metformin isn’t metabolized at all by the liver and instead is excreted unchanged in the urine. Metformin-induced liver injury is a rare, but possible adverse drug reaction that usually occurs at 4-8 weeks of therapy. Metformin is dangerous to take if you want to become pregnant. This is not true, and in fact may be the opposite. Metformin therapy during pregnancy in women with PCOS is associated with a reduction in miscarriage rate and gestational diabetes and did not adversely affect birth weight or development at 3 and 6 months of life. Metformin causes dementia. No. In fact a recent study of 17,000 diabetic vets found that taking metformin was associated with a lower risk of dementia than sulfonylureas like glyburide or glipizide. Other studies have shown metformin use to be associated with reduced rates of dementia and improved cognitive function. Metformin is bad for your heart. This is one I hear quite a bit from patients and it’s not true. Metformin has been suggested to exhibit cardioprotective effects in the setting of a heart attack. Metformin therapy Continue reading >>

Metformin, Heart Failure, And Lactic Acidosis: Is Metformin Absolutely Contraindicated?

Metformin, Heart Failure, And Lactic Acidosis: Is Metformin Absolutely Contraindicated?

Many patients with type 2 diabetes are denied treatment with metformin because of “contraindications” such as cardiac failure, which may not be absolute contraindications Summary points Treatment with metformin is not associated with an increased risk of lactic acidosis among patients with type 2 diabetes mellitus who have no cardiac, renal, or liver failure Despite increasing disregard of contraindications to metformin by physicians, the incidence of lactic acidosis has not increased, so metformin may be safe even in patients with “contraindications” The vast majority of case reports relating metformin to lactic acidosis report at least one other disease/illness that could result in lactic acidosis Use of metformin in patients with heart failure might be associated with lower mortality and morbidity, with no increase in hospital admissions and no documented increased risk of lactic acidosis Further studies are needed to assess the risk of lactic acidosis in patients with type 2 diabetes and traditional contraindications to metformin Metformin first became available in the United Kingdom in 1957 but was first prescribed in the United States only in 1995.w1 The mechanism of action has been extensively reviewed.w2 w3 The UK prospective diabetes study showed that metformin was associated with a lower mortality from cardiovascular disease than sulphonylureas or insulin in obese patients with type 2 diabetes mellitus.1 It was also associated with reduced all cause mortality, which was not seen in patients with equally well controlled blood glucose treated with sulphonylureas or insulin.1 Despite the evidence base for the benefits of metformin, concerns remain about its side effects and especially the perceived risk of lactic acidosis in the presence of renal, hepatic Continue reading >>

Metformin, Oral Tablet

Metformin, Oral Tablet

Metformin oral tablet is available as both a generic and brand-name drug. Brand names: Glucophage, Glucophage XR, Fortamet, and Glumetza. Metformin is also available as an oral solution but only in the brand-name drug Riomet. Metformin is used to treat high blood sugar levels caused by type 2 diabetes. FDA warning: Lactic acidosis warning This drug has a Black Box Warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to potentially dangerous effects. Lactic acidosis is a rare but serious side effect of this drug. In this condition, lactic acid builds up in your blood. This is a medical emergency that requires treatment in the hospital. Lactic acidosis is fatal in about half of people who develop it. You should stop taking this drug and call your doctor right away or go to the emergency room if you have signs of lactic acidosis. Symptoms include tiredness, weakness, unusual muscle pain, trouble breathing, unusual sleepiness, stomach pains, nausea (or vomiting), dizziness (or lightheadedness), and slow or irregular heart rate. Alcohol use warning: You shouldn’t drink alcohol while taking this drug. Alcohol can affect your blood sugar levels unpredictably and increase your risk of lactic acidosis. Kidney problems warning: If you have moderate to severe kidney problems, you have a higher risk of lactic acidosis. You shouldn’t take this drug. Liver problems warning: Liver disease is a risk factor for lactic acidosis. You shouldn’t take this drug if you have liver problems. Metformin oral tablet is a prescription drug that’s available as the brand name drugs Glucophage, Glucophage XR, Fortamet, and Glumetza. Glucophage is an immediate-release tablet. All of the other brands are extended-r Continue reading >>

Metformin (glucophage) Side Effects & Complications

Metformin (glucophage) Side Effects & Complications

The fascinating compound called metformin was discovered nearly a century ago. Scientists realized that it could lower blood sugar in an animal model (rabbits) as early as 1929, but it wasn’t until the late 1950s that a French researcher came up with the name Glucophage (roughly translated as glucose eater). The FDA gave metformin (Glucophage) the green light for the treatment of type 2 diabetes in 1994, 36 years after it had been approved for this use in Britain. Uses of Generic Metformin: Glucophage lost its patent protection in the U.S. in 2002 and now most prescriptions are filled with generic metformin. This drug is recognized as a first line treatment to control blood sugar by improving the cells’ response to insulin and reducing the amount of sugar that the liver makes. Unlike some other oral diabetes drugs, it doesn’t lead to weight gain and may even help people get their weight under control. Starting early in 2000, sales of metformin (Glucophage) were challenged by a new class of diabetes drugs. First Avandia and then Actos challenged metformin for leadership in diabetes treatment. Avandia later lost its luster because it was linked to heart attacks and strokes. Sales of this drug are now miniscule because of tight FDA regulations. Actos is coming under increasing scrutiny as well. The drug has been banned in France and Germany because of a link to bladder cancer. The FDA has also required Actos to carry its strictest black box warning about an increased risk of congestive heart failure brought on by the drug. Newer diabetes drugs like liraglutide (Victoza), saxagliptin (Onglyza) and sitagliptin (Januvia) have become very successful. But metformin remains a mainstay of diabetes treatment. It is prescribed on its own or sometimes combined with the newer d Continue reading >>

Metformin Side Effects On The Heart

Metformin Side Effects On The Heart

Metformin, sold under the brand name Glucophage, is an anti-hyperglycemic medication used alone or in combination with other medication, such as insulin, to control blood glucose levels in those with Type 2 diabetes. It belongs in the biguanide class of medication. According to Drugs.com, metformin works by decreasing the amount of glucose obtained from food and glucose produced by the liver, lowering blood glucose levels. Video of the Day According to DiabetesNet.com, the chemical structure of metformin resembles that of the French lilac plant, which was used long ago to lower blood sugar but found to be too toxic. Metformin is shorter-acting than French lilac and can in rare cases produce the same toxic reaction, called lactic acidosis. Lactic acidosis--which can be fatal--is a condition in which there is too much lactate in the blood, which lowers the pH. It can occur when metformin levels build up and cannot be cleared from the body. Symptoms of lactic acidosis include slow heartbeat, or bradycardia, and low blood pressure, or hypoptension. Other symptoms include shallow breathing, diarrhea and extreme weakness and fatigue. Alcohol consumption and a reaction with the medication Tagamet can increase the chances for lactic acidosis to develop. Metformin should not be taken by those with congestive heart failure or heart disease. Chest pain is a rare but serious side effect of taking metformin, according to PubMed Health. Notify your physician immediately if you experience any chest pain while taking metformin. Metformin has been well studied in many clinical trials and found to be safe in most instances. The side effects reported by those taking metformin are compared against any side effects experienced by those taking a placebo. It has been determined that taking th Continue reading >>

Metformin Affects Hearts Of Men And Women Differently

Metformin Affects Hearts Of Men And Women Differently

The oral diabetes medicine metformin affects the hearts of men and women differently, according to new research from the Washington University School of Medicine in St. Louis. Metformin is the most widely used diabetes drug in the world, with more than 61 million prescriptions being filled in the United States alone in 2012. Cardiovascular disease is the leading cause of death in people who have diabetes. To determine whether sex has an effect on the heart’s response to diabetes treatments, researchers randomly assigned 43 women and 35 men with Type 2 to one of three groups: The first group received metformin alone, the second received metformin plus rosiglitazone (brand name Avandia), and the third received metformin plus Lovaza, a type of fish oil prescribed to lower blood fats known as triglycerides. At the start of the study and at three months in, each participant had a PET scan to evaluate oxygen levels, blood flow, and glucose and fatty acid uptake in the heart; blood tests to measure glucose and free fatty acid levels; and an echocardiogram to evaluate heart function. Blood glucose levels were well controlled in all three groups. When the groups were compared without separating men and women, no differences were seen in heart metabolism. But when the participants were separated by gender, it became clear that the medicines had different, and sometimes opposite, effects on cardiac function. The biggest difference between men and women was seen in the group taking metformin alone. The drug appeared to improve heart function in women, but it caused the hearts of men to burn less sugar and more fat — a shift that can eventually cause changes in heart muscle, leading to heart failure. “Instead of making heart metabolism more normal in men, metformin alone made Continue reading >>

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