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High Fat Diet May Be Able To Reverse Kidney Failure
Scientists, in experiments with mice, have demonstrated for the first time that a special high-fat, low-carbohydrate diet called the ketogenic diet can reverse kidney failure caused by type 1 or type 2 diabetes. See also: A new exercise prescription for diabetes. If the findings can be replicated in humans, the diet would have profound implications for personal health and for the nation's health care, says neuroscientist Charles Mobbs of Mount Sinai School of Medicine in New York. "This is the first study to show that a dietary intervention alone is enough to reverse this serious complication of diabetes," says Mobbs, senior author of a paper published online in PLoS One on April 20. The mice, bred to develop type 1 or type 2 diabetes, were allowed to develop kidney failure, known as diabetic nephropathy. Then half were fed a standard high-carbohydrate diet while the other half ate a high-fat ketogenic diet, typically used to control epilepsy in children. After eight weeks, kidney failure was reversed in the mice on the ketogenic diet. Their blood glucose returned to normal and the presence of the protein albumin in urine, a strong predictor of the progression of kidney disease, also was corrected. Controlling blood glucose and blood pressure slows the progression of diabetic kidney disease, but once the kidneys are damaged there currently is no way to repair them. If they fail, dialysis or a kidney transplant is the only option, experts say, which means that reversing the disease would be far more valuable than simply delaying it. "I believe that glucose metabolism in the cells drives diabetic complications," says Mobbs. "But controlling blood glucose levels alone doesn't correct the complications. We had to go beyond simply correcting blood glucose." In monitoring the Continue reading >>
Kidney Disease Healing Naturally
I just have to tell you, just to remind you, I am a type 1 diabetic and have been for 34 years. My kidney function has been going down gradually for several years including 4 points from June of this year to August. My GFR score was 42 in August, which I was told was stage 3 kidney failure. As of October 24 — I just got the results today — but as of October 24 my GFR score was 57 — 60 is considered normal. My kidney doctor said that he has never seen anything like that before and wanted to know what I was doing. I told him that I was doing a combination of a ketogenic diet and daily coffee enemas. He couldn’t believe his ears. I had to explain what each one of those things were. Anyway, I just thought I would let you know. Everyone is shocked that my kidney disease healing the way it is. And by the way, my HgA1C was 5.7 as of a week ago. Again almost into normal range which is my goal. Now, that is due to the ketogenic lifestyle. Oh, and by the way, I am going to see my “local” (80 minutes away) Maximized Living Chiropractor and getting great care. I have been really impressed with his office and “bed-side-manner.” I can’t believe all the things that he is doing to help improve my health. I have been to a few chiropractors before, but none ever even suggested they could do that. I told him that I had purchased your material on the ketogenic diet. He said that he knew you. His name is Dr. Josh Johnson. You may have heard of him. He said that he went to school with you. I thought that was pretty cool. Small world sometimes. Thanks again for all your help! Pastor Eric Sawyer Continue reading >>
Eating A Ketogenic Diet May Reverse Kidney Damaged Caused By Type 1 And Type 2 Diabetes
(RxWiki News) Changing your diet can help with many different health problems. New research supports this point by showing that patients who eat a certain kind of diet can protect their kidneys from the damage caused by diabetes. Both type 1 and type 2 diabetes can cause patients' kidneys to stop working. However, doctors may be able to reverse kidney failure in people with diabetes by putting those patients on a ketogenic diet - a diet that is low in carbohydrates but high in fat. "Changing your diet may save your kidneys from diabetes." This study is the first to show that a diet change on its own is enough to reverse kidney failure caused by diabetes, says research leader Charles Mobbs, Ph.D., Professor of Neuroscience and Geriatrics and Palliative Care Medicine at Mount Sinai School of Medicine. This finding, Mobbs adds, could help the tens of thousands of people in the United States who are diagnosed with diabetic kidney failure every year. Knowing how the ketogenic diet reverses kidney failure will help researchers make new drugs and other treatments that have similar effects as the diet, he concludes. In Depth For their study, Dr. Mobbs and colleagues looked at the effects of the ketogenic diet on mice with diabetic kidney failure. Half of the mice they studied were put on the low-carbohydrate ketogenic diet, while the other half kept a high-carbohydrate diet. After eight weeks, kidney failure was reversed in the mice on the ketogenic diet. The ketogenic diet - a high-fat, adequate-protein, low-carbohydrate diet - is usually used to help children with epilepsy control their seizures. While some cells get their energy from glucose, others get their energy from ketones - molecules that the blood makes when some has low glucose levels and high blood fat levels. When Continue reading >>
How Does The Ketogenic Diet Impact The Kidneys? Is A Ketogenic Diet Safe For Kidneys?
This concern mainly comes from people believing a ketogenic diet is high in protein, which can increase the occurrence of kidney stones and kidney damage. But this is not true. The ketogenic is high in fat and only recommends an adequate intake of protein. If you do have kidney problems, discuss these changes with your healthcare professional and monitor the situation because everybody is unique and can respond differently. The kidneys clean the blood and flush out toxins and by products from metabolism, during ketosis it is important to keep well hydrated to keep the kidneys functioning optimally. Continue reading >>
Diet 'can Reverse Kidney Failure'
A controlled diet high in fat and low in carbohydrate can repair kidney damage in diabetic mice, according to US scientists. The study, published in journal PLoS ONE, showed a "ketogenic diet" could reverse damage caused to tubes in the kidneys by too much sugar in the blood. In the UK around a third of the 2.8m people with either type 1 or 2 diabetes go on to develop kidney damage. Diabetes UK said it was "questionable" whether humans could sustain the diet. Damage reversed The researchers at the Mount Sinai School of Medicine in New York used mice with both type 1 and type 2 diabetes. Once kidney damage had developed, half the mice were put onto the ketogenic diet for eight weeks. It is also questionable whether the diet used in this model would be sustainable for humans, even in the short term.Dr Iain Frame, Diabetes UK The highly controlled diet, which is 87% fat, mimics the effect of starvation and should not be used without medical advice. After eight weeks the researchers noted that kidney damage was reversed. Professor Charles Mobbs, who led the research at Mount Sinai School of Medicine, said: "Our study is the first to show that a dietary intervention alone is enough to reverse this serious complication of diabetes. "I certainly think it has promise, but I can't recommend it until we have done clinical trials." The researchers also need to figure out the exact process that leads to repair. Dr Iain Frame, director of research at Diabetes UK, said: "This research was carried out in mice so it is difficult to see how these results would translate into any real benefits for people with diabetes at this stage. "It is too simple to say that kidney failure could be prevented by diet alone and it is also questionable whether the diet used in this model would be sustai Continue reading >>
Bring In The Research Supporting The Blood Sugars You Want To Achieve Will Work.
One of the worst things high blood sugars do to your body is that they slowly destroy your kidneys. Unfortunately, as is the case with so many "diabetic" complications, this organ destruction also appears to begin long before many people are given a diabetes diagnosis. The landmark UKPDS study found that one out of eight people diagnosed with diabetes already were leaking small amounts of protein into their urine. This symptom, called "microalbuminuria." is an early sign that kidneys have been damaged. Though there is no total agreement as to why this occurs, some factors that promote kidney damage are: 1. High blood pressure. When blood pressure is high, large protein molecules, including those that are glycosylated (covered with sticky excess sugar molecules) are pushed through the pores of the kidney's filtration units, damaging them. 2. High blood sugar. When normal glucose regulation fails, the kidneys must remove excess glucose from the blood, leading to high concentrations of glucose in the kidneys. These glucose molecules clog up tiny capillaries in the kidneys as they do those elsewhere in the body. Eventually this clogging destroys the glomeruli, the filtration units of the kidney. An eleven year study of over 1800 people with diabetes found a straight line relationship between the risk of developing chronic kidney disease and the A1c. The risk began to increase significantly when the A1c rose over 6.0%. Poor Glycemic Control in Diabetes and the Risk of Incident Chronic Kidney Disease Even in the Absence of Albuminuria and Retinopathy: Atherosclerosis Risk in Communities (ARIC) Study. Lori D. Bash et al. Arch Intern Med. Vol. 168 No. 22, Dec 8/22, 2008 Another study, that followed people with Type 1 diabetes for more than a decade found that those who had achi Continue reading >>
Is Kidney Disease Reversible Through Diet In People With Diabetes ?
Anyone with diabetes and chronic kidney disease would gladly accept a treatment that could reverse their kidney disease. That’s why this topic in an article I recently ran across caught my attention. A report from Mount Sinai School of Medicine researchers indicate a ketogenic diet may help people who have kidney disease related to Type 1 and Type 2 diabetes. A ketogenic diet is low in carbohydrate, high in fat and contains a moderate amount of protein. For years this type of diet has been used for seizure control in children with epilepsy. When this type of diet is consumed, the body produces ketones because fat is burned as the primary energy source. Charles Mobbs, PhD, Professor of Neuroscience and Geriatrics and Palliative Care Medicine at Mount Sinai School of Medicine, says “Our study is the first to show that a dietary intervention alone is enough to reverse this serious complication of diabetes. This finding has significant implications for the tens of thousands of Americans diagnosed with diabetic kidney failure, and possibly other complications, each year.” Researchers believe the ketogenic diet works by blocking the toxic effects that high glucose levels have on the kidneys. Future research to find out how the ketogenic diet works to reverse nephropathy may lead to drug therapy to mimic the ketogenic diet effect. The research may also help with treatments for other long-term diabetes complications such as retinopathy and neuropathy. A few considerations are in order before you change your current diet. These findings are from research on mice; human trials are needed before this type of diet could become a part of the treatment plan for people with diabetes. Any changes in your usual intake of carbohydrate will have an impact on glucose levels. Lower gl Continue reading >>
How Low-carb Diets May Be Causing More Kidney Stones
Like many busy people, David Crossley often used to find himself so wrapped up in his working day that he would go without lunch, and often barely stopped for a cup of tea. In fact, David, 63, a musculoskeletal therapist from Birmingham, admits: 'I would often be so busy at the clinic that I'd forget to drink any liquid at all, other than the odd cup of tea or coffee. It had been the same way for years - although I would drink more water at weekends.' Last year, this habit caught up with him. He noticed a vague ache in his abdomen, stretching around to his back. 'It wasn't agonising but it just didn't feel quite right, so I went to the GP,' he says. 'As I had some bloating, he sent me for an ultrasound.' This revealed two large stones in his right kidney - a direct result, his doctors believe, of his low fluid intake. A CT scan showed that the stones were so large (6 mm across) they could not be passed naturally, and he needed surgery. One in ten of us will develop a kidney stone, and the numbers are rising dramatically. They are the result of waste products in the blood forming crystals inside the kidneys, which eventually build up into a solid lump. They can be excruciatingly painful - on a level, say experts, with childbirth. The stones often remain symptomless while they're in the kidney. They start causing pain - known as renal colic - once they travel down the ureter, the narrow tube that carries urine from the kidney to the bladder. 'Renal colic is caused by the stone suddenly blocking the ureter,' says Mr Leye Ajayi, consultant urological surgeon at the Hospital of St John & St Elizabeth, London. The pain often comes on suddenly and can cause the patient to 'writhe around in agony', he adds. The pain can be intense enough to cause nausea and vomiting. Once on th Continue reading >>
Are Ketogenic Diets Bad For People With Kidney And Liver Issues?
There is an international organization of doctors and other professionals who have clinical experience with ketogenic diets. It's called the International Ketogenic Diet Study Group. They publish guidelines for safe use of ketogenic diets. The guidelines include a list of medical conditions (contraindications) which would make a ketogenic diet unsafe. At least one of the conditions on the list (carnitine deficiency) can cause liver dysfunction. You don't say exactly what sort of liver problem you have in mind. If you personally have a disease that affects the liver, maybe you should look at the list of contraindications carefully. Another condition on the list, beta-oxidation defects, can cause the liver to lack the ability to oxidize fatty acids. Regarding this condition the guidelines say, "An inborn metabolic error at any point along this pathway can lead to a devastating catabolic crisis (i.e., coma, death) in a patient fasted or placed on a [ketogenic diet]." Ketogenic diets increase the risk of kidney stones. Doctors often prescribe potassium citrate to people on medical ketogenic diets as a prophylactic measure against kidney stones. Here is a link to the full text of the guidelines. Contradindications are in Table 2. The title says "children" because virtually all clinical experience with ketogenic diets has been with kids. If you want to read more about the risks of ketogenic diets, click here to see a bibliography on my website (with many links to full text) of articles about risks and prevention. Some people seem to believe that ketogenic diets are harmless, risk-free, totally wonderful things. This isn't true. Ketogenic diets are like medications. They bring benefits but they also bring risks and harmful side effects. They involve tradeoffs. I'm not against Continue reading >>
Kidney Disease Diet For Patients Not On Dialysis
Kidney Disease Diet for Patients Not on Dialysis For patients with chronic kidney disease (CKD) but who are not on dialysis, it is useful to know some basic information before learning about their dietary needs. For example, kidney function is sometimes expressed as the glomerular filtration rate (GFR). Normal GFR is 90 to 130 milliliters (mL)/minute. Blood urea nitrogen (BUN) is normally 5 to 25 mL/deciliter (dL). Urea is a product from the metabolism of protein. Normal kidneys maintain the BUN range of 5 to 25 mg/dL. When the kidneys begin to fail to eliminate urea in the urine, urea will build up in the blood, and BUN levels will increase. The 5 stages of kidney disease, according to the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), are: Stage 1GFR is more than 90 mL/minute, with persistent protein in the urine Stage 2GFR is 6089 mL/minute, with persistent protein in the urine (mild disease) Stage 3GFR is 3059 mL/minute (moderate disease) Stage 5GFR is less than 15 or individual is on dialysis (kidney failure) Approximately 14% of people in the United States have some stage of kidney disease. Many of these people have diabetes or high blood pressure. At present, about 460,000 people are on dialysis (Stage 5) (NIH NIDDK). _____________________________________________________________________________ Continue reading >>
I’ll See Your Ketoacidosis And Raise You A Renal Failure
A while back I posted on a paper that appeared in The Lancet about an obese woman who came to the emergency room with gastroenteritis and was misdiagnosed as being in diabetic ketoacidosis (a life-threatening disorder). She was misdiagnosed because the pinheads covering the ER couldn’t get past the fact that she had been on a low-carb diet. At the time I posted on this travesty I noted that this Lancet paper would from here on out be waved in the face of anyone who was following or advocated a low-carb diet as proof that such a diet is dangerous and can cause diabetic ketoacidosis (DKA). Well, now we’ve got an answer. Next time someone tells you that it has been proven that low-carb diets are dangerous and can cause ketoacidosis, you can resort to poker terminology and reply that you’ll see their ketoacidosis and raise them a renal failure. A few days ago I got wind of a paper published a few years ago that can be used as a counterpoint to the above mentioned idiotic paper in The Lancet that has given low-carbers such a bad time. This paper, published in the journal Renal Failure in 1998, is, like the other paper, a case report. The short version is as follows: An obese young man arrived comatose in the emergency room. In an effort to lose weight he had been consuming a high-carbohydrate canned beverage as his sole source of nutrition for the two weeks prior. His blood sugar–at about 20 times normal–was extremely elevated and led to a diagnosis of diabetic ketoacidosis. The physicians on staff treated the patient appropriately, and he, over the next 20 hours or so, regained consciousness as his blood sugar levels and other lab parameters began to normalize. During a lab analysis 22 hours after admission the doctors found the patient to be breaking down and rel Continue reading >>
Diabetes, Kidney Damage, And Ketogenic Diets
Take a look at this PBS video sent to me by one of our readers – and try not to punch your monitor near the end: So close … Okay, let’s focus on the positive for now. I was delighted to hear one of the on-screen experts explain that high glucose levels appear to cause repeated injury to the kidneys. Well-meaning people have tried to warn me over that a “high protein” diet is hard on the kidneys. Why? Because damaged kidneys leak protein. But that doesn’t mean protein is causing the damage. If your kitchen pipes start leaking water, do you assume the damage was caused by water? Of course not. The kidneys are damaged by excess glucose, and then they leak protein. I was delighted again to hear a researcher explain that ketones can be used as an alternate energy source by most cells in the body, and that on a ketogenic diet the body switches from being primarily a glucose-metabolizing machine to a fat-and-ketone metabolizing machine. As I like to explain it to people, you can be sugar-burner or a fat-burner. I find life as a fat-burner much more pleasant … more consistent energy, better mood, no more creeping weight gain, and no more ravenous hunger if I skip a meal. As I write this, I’m 23 hours into a 24-hour intermittent fasting day, and I feel fine. I was delighted yet again when the researchers speculated that removing glucose from the picture might help the kidneys recover, then discovered that putting mice on a ketogenic diet did indeed reverse the kidney damage caused by diabetes. Sure, it’s just a rodent study with results that may or may not apply to humans, but as the researcher said, it’s a proof of principle, an avenue to be explored. All right! Cool! Great story so far. I was anxiously waiting for the part where he suggests we try the same Continue reading >>
Dangers Of Zero-carb Diets, Iv: Kidney Stones
Kidney stones are a frequent occurrence on the ketogenic diet for epilepsy. [1, 2, 3] About 1 in 20 children on the ketogenic diet develop kidney stones per year, compared with one in several thousand among the general population. [4] On children who follow the ketogenic diet for six years, the incidence of kidney stones is about 25% [5]. A 100-fold odds ratio is hardly ever seen in medicine. There must be some fundamental cause of kidney stones that is dramatically promoted by clinical ketogenic diets. Just over half of ketogenic diet kidney stones are composed of uric acid and just under half of calcium oxalate mixed with calcium phosphate or uric acid. Among the general public, about 85% of stones are calcium oxalate mixes and about 10% are uric acid. So, roughly speaking, uric acid kidney stones are 500-fold more frequent on the ketogenic diet and calcium oxalate stones are 50-fold more frequent. Causes are Poorly Understood In the nephrology literature, kidney stones are a rather mysterious condition. Wikipedia has a summary of the reasons offered in the literature for high stone formation on the ketogenic diet [4]: Kidney stone formation (nephrolithiasis) is associated with the diet for four reasons: Excess calcium in the urine (hypercalciuria) occurs due to increased bone demineralisation with acidosis. Bones are mainly composed of calcium phosphate. The phosphate reacts with the acid, and the calcium is excreted by the kidneys. Hypocitraturia: the urine has an abnormally low concentration of citrate, which normally helps to dissolve free calcium. The urine has a low pH, which stops uric acid from dissolving, leading to crystals that act as a nidus for calcium stone formation. Many institutions traditionally restricted the water intake of patients on the diet to Continue reading >>
Diabetic Kidney Failure May Be Reversed With Low-carbohydrate Diet
Researchers have found that by administering a low-carb, high-fat diet in mice, that diabetic kidney damage was reversed, and also uncovered an array of genes associated with kidney failure. Researchers from Mount Sinai School of Medicine have for the first time determined that the ketogenic diet, a specialized high-fat, low carbohydrate diet, may reverse impaired kidney function in Type 1 and Type 2 diabetes. They also identified a previously unreported panel of genes associated with diabetes-related kidney damage, whose changes in expression were reversed by the diet. The findings were published online in the peer-reviewed journal PLoS ONE. Charles Mobbs, PhD, Professor of Neuroscience and Geriatrics and Palliative Care Medicine at Mount Sinai School of Medicine, and his research team evaluated mice that were genetically predisposed to have Type 1 or 2 diabetes. The mice were allowed to develop diabetic nephropathy, or kidney damage. Half of the mice were put on the ketogenic diet, while the control group maintained a standard high carbohydrate diet. The researchers found that after eight weeks, molecular and functional indicators of kidney damage were reversed in the mice on the ketogenic diet. Microscopic analysis showed that kidney pathology in the model of Type 2 diabetes was partially reversed. "Our study is the first to show that a dietary intervention alone is enough to reverse this serious complication of diabetes," said Dr. Mobbs. "This finding has significant implications for the tens of thousands of Americans diagnosed with diabetic kidney failure, and possibly other complications, each year." The ketogenic diet is a low-carbohydrate, moderate protein, and high-fat diet typically used to control seizures in children with epilepsy. Many cells can get their e Continue reading >>
