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Can Ketone Bodies Be Converted To Glucose?

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Buy Me Bacon? http://paypal.me/KetointheUK Breathalyser I got on Amazon http://geni.us/breathketone if you like my content please consider supporting my channel via Patreon at http://www.patreon.com/ketointheuk MY FAVOURITE KETO RECIPE BOOKS BY MARTINA FROM KETODIETAPP http://geni.us/ketodietappbooks 28 DAY KETO PRIMAL MEAL PLAN + guide + weekly shopping list http://po.st/primalmealplan 28 DAY KETO PALEO MEAL PLAN + guide + weekly shopping list http://po.st/paleomealplan You live the keto Lifestyle? NOW WEAR IT! Ginger's Keto Merchandise is finally here https://shop.spreadshirt.co.uk/ketoin... Subscribe and hit the for upload notifications! Never miss a Ginger video! Articles and background on ketones reading as alcohol in breath: https://proteinpower.com/drmike/2007/... https://blog.ketointhe.uk/2018/10/ket... https://www.reddit.com/r/keto/comment... http://community.myfitnesspal.com/en/... http://eatingacademy.com/nutrition/ke... How do you test for ketones? Either you go uncertain with the cheap and easy Ketostix for Urianalisys or you prick your fingers multiple times a day to test for Blood Ketones. Or you breath in a regular alcohol Breathalyzer, a tenth of the cost of the Ketonix, and if you are in ketosis Acetone in your breath will read as Isopropanol, and there you can have a live reading of your ketones for a fraction of the cost of all other methods of testing for ketones. Want to make sure you get reminded with every new recipe? There's a Mailing List for that: http://eepurl.com/bwE9aX Come interact and share your recipes and ideas on Instagram: http://instagr.am/ketointhe.uk Our Facebook Group: https://www.facebook.com/groups/lowca... Facebook Page: https://www.facebook.com/lowcarbuk/ Twitter: http://twitter.com/KetoInTheUK Blog: http://blog.ketointhe.uk My Specs come from Firmoo, you can get 15% off through my link http://po.st/gingerglasses All of My videos in neat Playlists Ginger's Keto Recipes http://po.st/ketorecipes Ginger's Keto Talkies http://po.st/ketotalkies Keto Friendly Foods Tuesdays http://po.st/ketotuesdays No Stupid Questions Thursdays http://po.st/ketothursdays Keto Food Hauls and Shopping Lists http://po.st/ketohauls Basics Keto Recipes http://po.st/ketobasics How To Keto - The Essential Keto Beginner's Guide http://po.st/howtoketo Ginger's Livestreams Chit Chat Keto Q&As http://po.st/ketolivestreams This video is not designed to and does not provide medical advice, professional diagnosis, opinion, treatment or services to you or to any other individual. Through my videos, blog posts, website information, I give suggestions for you and your doctor to research and provide general information for educational purposes only. The information provided in this video or site, or through linkages to other sites, is not a substitute for medical or professional care, and you should not use the information in place of a visit, call consultation or the advice of your physician or other healthcare provider. Keto In The UK are not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this video or site.

Ketones

Ketones are a beneficial product of fat metabolism in the body. When carbohydrate intake is restricted, it lowers blood sugar and insulin levels. As insulin levels fall and energy is needed, fatty acids flow from the fat cells into the bloodstream and are taken up by various cells and metabolized in a process called beta-oxidation. The end result of beta-oxidation is a molecule called acetyl-coA, and as more fatty acids are released and metabolized, acetyl-coA levels in the cells rise. This causes a sort of metabolic “feedback loop” which triggers liver cells to shunt excess acetyl-Coa into ketogenesis, or the making of ketone bodies. Once created, the liver dumps the ketone bodies into the blood stream and they are taken up by skeletal and heart muscle cells at rates of availability. In addition, the brain begins to use ketones as an alternate fuel when blood levels are high enough to cross the blood brain barrier. Testing Laboratory Microbiology - Air Quality - Mold Asbestos - Environmental - Lead emsl.com There are three major types of ketone bodies present in the human blood stream when the metabolic process of ketosis is dominant: Acetoacetate (AcAc) is created first β-hy Continue reading >>

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  1. Doug Freyburger

    Others have mentioned the chemical details that lead to limits. That's only one side of the story. The other side is redundancy in energy production. Ketones can be used in anaerobic energy production. It's not as efficient but it is faster. There are times when fast beats efficient so redundancy gets selected for.

  2. Anand R

    Acetyl CoA can’t be circulated for two reasons: it’s a high energy compound and it’s labile. So it’s not a stable form for circulation to tissues. Also acetyl coA cannot cross cell membrane.
    Ketone bodies are an alternate fuel source. More importantly, they are water soluble analogs of fatty acids. This is important since, during starvation there is fat breakdown and excess fatty acids circulate in blood. However, fatty acids cannot be used by brain as fuel since, they cannot cross the blood brain barrier. Liver by producing ketone bodies helps brain cells during starvation.

    Also, these ketone bodies, as such, can be used by other tissues as well. There by other tissues refrain from using glucose. Hence, ketone bodies have a glucose-sparing effect. This glucose will be available for tissues like brain and red cells for use.

  3. Barry Gehm

    It’s because oxaloacetate is needed to metabolize acetyl-CoA (first step in the Krebs cycle is the reaction of acetyl-CoA with oxaloacetate) and is also needed (and used up) in gluconeogenesis (the production of glucose from amino acids and other small molecules, but NOT from acetyl groups or fatty acids). The liver is primarily responsible for gluconeogenesis, and if it uses up oxaloacetate on that, acetyl-CoA builds up and ties up all the coenzyme A in acetylated form. In order to alleviate this, the liver converts the acetyl-CoA into ketone bodies, and releases them into the blood. These, as the book says, are taken up by other tissues (such as brain and muscle) and converted back into acetyl-CoA. A key point is that these cells can use the acetyl-CoA because they are not depleted in oxaloacetate because they do not carry out gluconeogenesis.

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What is BASAL BODY? What does BASAL BODY mean? BASAL BODY meaning - BASAL BODY definition - BASAL BODY explanation. Source: Wikipedia.org article, adapted under https://creativecommons.org/licenses/... license. A basal body (synonymous with basal granule, kinetosome, and in older cytological literature with blepharoplast) is a protein structure found at the base of a eukaryotic undulipodium (cilium or flagellum). It is formed from a centriole and several additional protein structures, and is, essentially, a modified centriole. Basal body serves as a nucleation site for the growth of the axoneme microtubules. Centrioles, from which basal bodies are derived, act as anchoring sites for proteins that in turn anchor microtubules, and are known as the microtubule organizing center (MTOC). These microtubules provide structure and facilitate movement of vesicles and organelles within many eukaryotic cells. Cilia and basal bodies form during quiescence or the G1 phase of the cell cycle. Before the cell enters G1 phase, i.e. before the formation of the cilium, the mother centriole serves as a component of the centrosome. In cells that are destined to have only one primary cilium mother centriole differentiates into the basal body upon entry into G1 or quiescence. Thus, basal body in such cell is derived from the centriole. Basal body differs from the mother centriole in at least 2 aspects. First, basal bodies have basal feet, which are anchored to cytoplasmic microtubules and are necessary for polarized alignment of the cilium. Second, basal bodies have pinwheel-shaped transition fibers that originate from the appendages of mother centriole. In multiciliated cells, however, in many cases basal bodies are not made from centrioles but are generated de novo from a special protein structure called the deuterosome. During cell cycle quiescence, basal bodies organize primary cilia and reside at the cell cortex in proximity to plasma membrane. On cell cycle entry, cilia resorb and the basal body migrates to the nucleus where it functions to organize centrosomes. Centrioles, basal bodies, and cilia are important for mitosis, polarity, cell division, protein trafficking, signaling, motility, and sensation. Mutations affecting basal bodies are associated with several human diseases, most notably Bardet–Biedl syndrome. Regulation of basal body production and spatial orientation is a function of the nucleotide-binding domain of ?-tubulin. Plants lack centrioles and only lower plants (such as mosses and ferns) with motile sperm have flagella and basal bodies.

Does Fat Convert To Glucose In The Body?

Your body is an amazing machine that is able to extract energy from just about anything you eat. While glucose is your body's preferred energy source, you can't convert fat into glucose for energy; instead, fatty acids or ketones are used to supply your body with energy from fat. Video of the Day Fat is a concentrated source of energy, and it generally supplies about half the energy you burn daily. During digestion and metabolism, the fat in the food you eat is broken down into fatty acids and glycerol, which are emulsified and absorbed into your blood stream. While some tissues -- including your muscles -- can use fatty acids for energy, your brain can't convert fatty acids to fuel. If you eat more fat than your body needs, the extra is stored in fat cells for later use. Fat has more than twice as many calories per gram as carbs and protein, which makes it an efficient form of stored energy. It would take more than 20 pounds of glycogen -- a type of carbohydrate used for fuel -- to store the same amount of energy in just 10 pounds of fat. Your Body Makes Glucose From Carbs Almost all the glucose in your body originated from carbohydrates, which come from the fruit, vegetables, gra Continue reading >>

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Popular Questions

  1. Doug Freyburger

    Others have mentioned the chemical details that lead to limits. That's only one side of the story. The other side is redundancy in energy production. Ketones can be used in anaerobic energy production. It's not as efficient but it is faster. There are times when fast beats efficient so redundancy gets selected for.

  2. Anand R

    Acetyl CoA can’t be circulated for two reasons: it’s a high energy compound and it’s labile. So it’s not a stable form for circulation to tissues. Also acetyl coA cannot cross cell membrane.
    Ketone bodies are an alternate fuel source. More importantly, they are water soluble analogs of fatty acids. This is important since, during starvation there is fat breakdown and excess fatty acids circulate in blood. However, fatty acids cannot be used by brain as fuel since, they cannot cross the blood brain barrier. Liver by producing ketone bodies helps brain cells during starvation.

    Also, these ketone bodies, as such, can be used by other tissues as well. There by other tissues refrain from using glucose. Hence, ketone bodies have a glucose-sparing effect. This glucose will be available for tissues like brain and red cells for use.

  3. Barry Gehm

    It’s because oxaloacetate is needed to metabolize acetyl-CoA (first step in the Krebs cycle is the reaction of acetyl-CoA with oxaloacetate) and is also needed (and used up) in gluconeogenesis (the production of glucose from amino acids and other small molecules, but NOT from acetyl groups or fatty acids). The liver is primarily responsible for gluconeogenesis, and if it uses up oxaloacetate on that, acetyl-CoA builds up and ties up all the coenzyme A in acetylated form. In order to alleviate this, the liver converts the acetyl-CoA into ketone bodies, and releases them into the blood. These, as the book says, are taken up by other tissues (such as brain and muscle) and converted back into acetyl-CoA. A key point is that these cells can use the acetyl-CoA because they are not depleted in oxaloacetate because they do not carry out gluconeogenesis.

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Moof's Medical Biochemistry Video Course: http://moof-university.thinkific.com/... In this video, I detail the pathway of Ketone Body Synthesis, commonly known as Ketogenesis. Ketogenesis occurs in the mitochondrial matrix of hepatocytes (liver cells). The pathway begins with the condensation of two Acetyl-CoA molecules, forming an Acetoacetyl-CoA (catalyzed by Thiolase). The second step involves the condensation of another Acetyl-CoA molecule to form HMG-CoA (catalyzed by HMG-CoA Synthase). The third step is the cleavage of HMG-CoA, producing Acetoacetate (a ketone body), while releasing an Acetyl-CoA. Acetoacetate can 1) be decarboxylated (either spontaneous or enzymatically by Acetoacetate Decarboxylase) to yield Acetone (another ketone body) or 2) be reduced to D--Hydroxybutyrate by D--Hydroxybutyrate Dehydrogenase, requiring an NADH as a coenzyme. Its worth mentioning that this pathway does NOT occur to a great extent in healthy people under normal conditions. It happens to a very minimal extent, and very few ketone bodies are synthesized during normal physiology. For a suggested viewing order of the videos, information on tutoring, personalized video solutions, and an opportunity to support Moof University financially, visit MoofUniversity.com, and follow Moof University on the different social media platforms. Don't forget to LIKE, COMMENT, and SUBSCRIBE: http://www.youtube.com/subscription_c...

Ketone Body Metabolism

Ketone body metabolism includes ketone body synthesis (ketogenesis) and breakdown (ketolysis). When the body goes from the fed to the fasted state the liver switches from an organ of carbohydrate utilization and fatty acid synthesis to one of fatty acid oxidation and ketone body production. This metabolic switch is amplified in uncontrolled diabetes. In these states the fat-derived energy (ketone bodies) generated in the liver enter the blood stream and are used by other organs, such as the brain, heart, kidney cortex and skeletal muscle. Ketone bodies are particularly important for the brain which has no other substantial non-glucose-derived energy source. The two main ketone bodies are acetoacetate (AcAc) and 3-hydroxybutyrate (3HB) also referred to as β-hydroxybutyrate, with acetone the third, and least abundant. Ketone bodies are always present in the blood and their levels increase during fasting and prolonged exercise. After an over-night fast, ketone bodies supply 2–6% of the body's energy requirements, while they supply 30–40% of the energy needs after a 3-day fast. When they build up in the blood they spill over into the urine. The presence of elevated ketone bodies i Continue reading >>

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Popular Questions

  1. Doug Freyburger

    Others have mentioned the chemical details that lead to limits. That's only one side of the story. The other side is redundancy in energy production. Ketones can be used in anaerobic energy production. It's not as efficient but it is faster. There are times when fast beats efficient so redundancy gets selected for.

  2. Anand R

    Acetyl CoA can’t be circulated for two reasons: it’s a high energy compound and it’s labile. So it’s not a stable form for circulation to tissues. Also acetyl coA cannot cross cell membrane.
    Ketone bodies are an alternate fuel source. More importantly, they are water soluble analogs of fatty acids. This is important since, during starvation there is fat breakdown and excess fatty acids circulate in blood. However, fatty acids cannot be used by brain as fuel since, they cannot cross the blood brain barrier. Liver by producing ketone bodies helps brain cells during starvation.

    Also, these ketone bodies, as such, can be used by other tissues as well. There by other tissues refrain from using glucose. Hence, ketone bodies have a glucose-sparing effect. This glucose will be available for tissues like brain and red cells for use.

  3. Barry Gehm

    It’s because oxaloacetate is needed to metabolize acetyl-CoA (first step in the Krebs cycle is the reaction of acetyl-CoA with oxaloacetate) and is also needed (and used up) in gluconeogenesis (the production of glucose from amino acids and other small molecules, but NOT from acetyl groups or fatty acids). The liver is primarily responsible for gluconeogenesis, and if it uses up oxaloacetate on that, acetyl-CoA builds up and ties up all the coenzyme A in acetylated form. In order to alleviate this, the liver converts the acetyl-CoA into ketone bodies, and releases them into the blood. These, as the book says, are taken up by other tissues (such as brain and muscle) and converted back into acetyl-CoA. A key point is that these cells can use the acetyl-CoA because they are not depleted in oxaloacetate because they do not carry out gluconeogenesis.

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