You need to be able to identify these four molecules if they are presented to you. Recognize the amino acid by the presence of nitrogen and the 'R' (variable) group. The fatty acids can have multiple [CH2] groups so look for it written in this shorthand way, or with the CH2's written out in full. The ribose and glucose (both carbohydrate monomers, or monosaccharides) can be distinguished because the ribose only has 5 carbon atoms whereas the glucose has 6 carbon atoms.
We Really Can Make Glucose From Fatty Acids After All! O Textbook, How Thy Biochemistry Hast Deceived Me!
Biochemistry textbooks generally tell us that we can’t turn fatty acids into glucose. For example, on page 634 of the 2006 and 2008 editions of Biochemistry by Berg, Tymoczko, and Stryer, we find the following: Animals Cannot Convert Fatty Acids to Glucose It is important to note that animals are unable to effect the net synthesis of glucose from fatty acids. Specficially, acetyl CoA cannot be converted into pyruvate or oxaloacetate in animals. In fact this is so important that it should be written in italics and have its own bold heading! But it’s not quite right. Making glucose from fatty acids is low-paying work. It’s not the type of alchemy that would allow us to build imperial palaces out of sugar cubes or offer hourly sweet sacrifices upon the altar of the glorious god of glucose (God forbid!). But it can be done, and it’ll help pay the bills when times are tight. All Aboard the Acetyl CoA! When we’re running primarily on fatty acids, our livers break the bulk of these fatty acids down into two-carbon units called acetate. When acetate hangs out all by its lonesome like it does in a bottle of vinegar, it’s called acetic acid and it gives vinegar its characteristic
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Multiple Choice Quiz 1
(See related pages) 1 Which one of the following would not be a nutrient? 2 Most vitamins, minerals, and water all have this in common: 3 When the body metabolizes nutrients for energy, fats yield about _______ times the energy as carbohydrates or proteins. 4 A calorie is the amount of energy necessary to raise the temperature of one gram of _________ one degree __________. 5 One piece of apple pie would yield about 6 The disaccharide that most people think of as table sugar is 7 When lactose is digested, it yields two monosaccharides called 8 The complex carbohydrate (polysaccharide) that is digested to the monosaccharide, glucose, and is found in vegetables, fruits, and grains and is called 9 If excess glucose is present in the body, the glucose first will be stored as __________ in muscle and the liver. 10 Triglycerides that contain one or more double covalent bonds between carbon atoms of their fatty acids are called 11 Bubbling hydrogen gas through polyunsaturated vegetable oil will cause the oil to become more 12 The lipid that is a component of the plasma membrane and can be used to form bile salts and steroid hormones is 13 The American Heart Association recommends that sat
Here's why carbs spare the need for protein in a way that fat can't. Anaplerosis means to fill up and refers to substrates and reactions that fill up a metabolic pathway as its own substrates leak out for other purposes. The citric acid cycle is a central example of this because its intermediates are often used to synthesize other components the cell needs. On a mixed diet where carbohydrate provides much of the energy, pyruvate serves as the main anaplerotic substrate. During carbohydrate restriction, protein takes over. Fat is the least anaplerotic of the macronutrients because the main product of fatty acid metabolism, acetyl CoA, is not directly anaplerotic. There are several very minor pathways that allow some anaplerosis from fat, but they are unlikely to eclipse the need for protein to support this purpose during carbohydrate restriction. Thus, carbs and protein are the two primary sources of anaplerosis. This means carbs can spare the need for protein, and that protein requirements rise on a carb-restricted diet. MWM videos are free and broadcast Mondays and Wednesdays on YouTube and Facebook. Sign up for MWM Pro at https://chrismasterjohnphd.com/pro for early access to content, enhanced keyword searching, self-pacing tools, downloadable audio and transcripts, a rich array of hyperlinked further reading suggestions, and a community with a forum for each lesson.
Evolving Health: Why Can't We Convert Fat To Glucose?
As evident by many sugar-laden soda pop "potbellies" of North America, lipogenesis can obviously occur from drinking and eating too much sugar (1). Wouldnt it be just grand to reverse the process and be able to lose all that fat via gluconeogenesis? Unfortunately mammals do not have the ability to synthesize glucose from fats (1). The fact is that once glucose is converted to acetyl coA there is no method of getting back to glucose. The pyruvate dehydrogenase reaction that converts pyruvate to acetyl CoA is not reversible (1p252). Because lipid metabolism produces acetyl CoA via beta-oxidation, there can be no conversion to pyruvate or oxaloacetate that may have been used for gluconeogenesis (1p252). Further, the two carbons in the acetyl CoA molecule are lost upon entering the citric acid cycle (1p252). Thus, the acetyl CoA is used for energy (1p252). There are some fatty acids that have an odd number of carbon atoms that can be converted to glucose, but these are not common in the diet (1p253). Maybe they should be made more common. Do they taste good? 1. Gropper SS, Smith JL, Groff JL. Advanced Nutrition and Human Metabolism. Belmont, CA: Thomson Wadsworth, 2009.
The body uses three main nutrients to function-carbohydrate, protein, and fat. These nutrients are digested into simpler compounds. Carbohydrates are used for energy (glucose). Fats are used for energy after they are broken into fatty acids. Protein can also be used for energy, but the first job is to help with making hormones, muscle, and other proteins. Nutrients needed by the body and what they are used for Type of nutrient Where it is found H ...
As evident by many sugar-laden soda pop "potbellies" of North America, lipogenesis can obviously occur from drinking and eating too much sugar (1). Wouldnt it be just grand to reverse the process and be able to lose all that fat via gluconeogenesis? Unfortunately mammals do not have the ability to synthesize glucose from fats (1). The fact is that once glucose is converted to acetyl coA there is no method of getting back to glucose. The pyruvate ...
MORE Insulin resistance is a metabolic disorder that occurs when the body's cells cannot properly intake insulin. Insulin, which is produced in the pancreas, is a hormone that helps the body use energy from blood glucose, or blood sugar from digested food, according to the National Institute of Diabetes and Digestive and Kidney Diseases. "Think of insulin as the key that unlocks the door to their cells. That door needs to be opened in order for g ...
Here's what you need to know... While it's biochemically possible for protein to turn into fat by ingesting extremely high numbers of calories or extremely large amounts of protein, it's unlikely you'll ever be in that situation. You can pretty much eat as much protein as you want and it won't turn to fat. That old chestnut about only being able to absorb 30 grams of protein in one sitting is bunk. Aside from building muscle, protein provides ess ...
The amount of fat in the average diet and the amount of stored fat in the average body make the notion of converting that fat into usable energy appealing. Glycogen, a form of energy stored in muscles for quick use, is what the body draws on first to perform movements, and higher glycogen levels result in higher usable energy. It is not possible for fats to be converted directly into glycogen because they are not made up glucose, but it is possib ...
If you care about your weight, there are probably few phrases that strike as much fear in your heart as FAT BOMB. As in, "That fettuccine Alfredo is a total fat bomb. It's got more calories than you need in a day!" or "A supersize cheeseburger and fries is one of the worst things you can eat. It's a real fat bomb." But these days, mounting evidence says fat—especially the unsaturated kind—is really good for you. Research shows that it can fil ...