Can Fasting Cause Ketoacidosis?

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Fasting Induces Ketoacidosis And Hypothermia In Pdhk2/pdhk4-double-knockout Mice

Go to: Introduction The PDH complex (pyruvate dehydrogenase complex) plays a pivotal role in controlling the concentrations of glucose in the fed and fasted state [1]. In the well-fed state, the PDH complex is highly active, promoting glucose oxidation by generating acetyl-CoA, which can be oxidized by the citric acid cycle or used for fatty acid and cholesterol synthesis. In the fasted state, the PDH complex is inactivated by phosphorylation by PDHKs (pyruvate dehydrogenase kinases) to conserve three carbon compounds for the production of glucose [2]. The four PDHK isoenzymes responsible for phosphorylating the PDH complex are expressed in a tissue-specific manner [3–5]. Among the four, PDHK2 and PDHK4 are most abundantly expressed in the heart [5–7], skeletal muscle [5,8–10] and liver [5,11–14] of fasted mice. Of these two, PDHK2 is of interest because of its greater sensitivity to activation by acetyl-CoA and NADH and inhibition by pyruvate [15]. However, PDHK4 has received greater attention because its expression is increased in many tissues by fasting and diabetes [12] and transcription of its gene is regulated by insulin, glucocorticoids, thyroid hormone and fatty aci Continue reading >>

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Popular Questions

  1. Lambi🐏

    Has anyone else had bad lower back pain at the start of a ketogenic diet? It passed for me after the first week or two, but it concerned me. I thought I threw by back out! (Felt like badly pulled muscles) I searched online and other people have experienced it too, but I never read about a definitive reason for it. Was it a "keto flu" symptom (feeling achy?) or is there another explanation?

  2. celluloid_duchess

    a lot of people get this while fasting, some think that it's a temporary accumulation of toxins, others think that it's your body revisiting an old injury that it never got a chance to heal. i don't think anyone knows for sure what it is.

  3. Lambi🐏

    Thank you for that information! Since I started doing keto, I had to raise my daily calories a bit (from 850 to 1,000) so I'm not sure what to make of it! It could be an old injury though. Fortunately it passed, but at the time I was worried I was damaging my kidneys or something, so I upped my water intake too.

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